Conserved Protein Domain Family
GT29_ST8SIA6
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cd23991: GT29_ST8SIA6 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).
Links
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Statistics
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PSSM-Id: 467719
Aligned: 7 rows
Threshold Bit Score: 508.14
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
Download Cn3D
 
putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                              ###       
P61647       120 EEYANFRAKLASCCDAVQNFVvsqnntpVGTNMSYEVeskkEIPIKknifHMFPVSQPFvdypyNQCAVVGNGGILnkSL 199 human
OCT75631     109 QEYSKFRLDLSSCCNGLKNFIvsqnntsLGSNITYEVeskkKILISeeiyRMLPKSQPFvgapfKQCAVVGNGGILanSS 188 African clawed ...
XP_007908901  56 RAVENFRWELRKCCRTLSGSFvtqrntpVGTELFYEAepkkKIKITpsifAIFPKDSPFrgrsiQRCAVVGNAGILhnSS 135 elephant shark
XP_005999075 137 EEHEKFRSELSVCCNAVRNFIvsqnntpLGTNMSYEVengrTFLITqrifKMFPQSQPFagypyNQCAVVGNGGILknSA 216 coelacanth
NP_001001603 120 EESAKFRSELASCCNAVHNFIasqnntpLGSNMSYEVdskkTILITedifRMLPVSSPLsvypfKNCAVVGNGGILknSS 199 chicken
XP_020369560  27 ASSPFERSELKQCCNSADNFVvtqkntpVGTELTYEGepkrKIKITeqifRLFPKNMSFrslqyKQCAVVGNGGNLvnSS 106 whale shark
XP_007896374  93 AAHTNFRAQLTNCCNAIQNFTvtqvntaLGANLTYDAqpkkKITITenifNLLPQTEPFkvpisKRCAVVGNGGILtnSS 172 elephant shark

Feature 1                     ##                     #                                           
P61647       200 CGTEIDKsDFVFRCNlPPTTGdvskDVGsKTNLVTINPSIItlkygnlkeKKALFLEDIAtygdAFFLLPAFsfrANTGT 279 human
OCT75631     189 CGAEIDQsDFVFRCNlPPVWGnisvDVGnKTNLVTVNPSIIsrkykklnkVKNIFLKNVSnygsSFLLLPAFsyrSNTAI 268 African clawed ...
XP_007908901 136 CGAEIDQaDFVFRCNlPPMGGnftkDVGsKTHLVTANPKVIieryaelhkRRKPFANTLViyndALLLFPAFyhsKNTAL 215 elephant shark
XP_005999075 217 CGTEIDQaDFVFRCNlPPTLGnisiDVGsKTSLVTLNPSIIthrfgklneKRKPFVETVShygeAFLLLPAFsfrSNTAL 296 coelacanth
NP_001001603 200 CGAEIDRsDFVFRCNlPPTMGsiskDVGnKTKLVTVNPSIIaqkynklneKKTEFVENVAvygdAFLLLPAFsfrSNTAT 279 chicken
XP_020369560 107 CGAEIDRvDFVFRCNlPPVGGkftqDVGlKTNLVTANPSIIaksyaelhnRRKPFYTDTIvynkALLLLPAFsypPNTAL 186 whale shark
XP_007896374 173 CGEEIDQaDFVFRCNlAPIIGre-dDVGsKTDLVTANPSIFsikyqnlnfRRKPFWESTQvygkALILLPAFaysAHTNM 251 elephant shark

Feature 1                                                  ###                 ##            ### 
P61647       280 SFKVYYTLEeskarQKVLFFhpKYLKDLALFWrtkgvtayrlSTGLMITSVAVElCKNVKLYGFWPFsktvedipVSHHY 359 human
OCT75631     269 SFEVHRILEknqakQKAIFFhpNYLKSLGQFWkgrgvrafrlSTGLMITSAAIElCEEVKLYGFWPFsknldgkpISHHY 348 African clawed ...
XP_007908901 216 SFRAHYTLQdfkskQRVIFFnpIYLKHLAHFWlskgmqvqnlSTGITVASMAMElCSEVWIYGFWPFgkntegelMSHHY 295 elephant shark
XP_005999075 297 SFKVYHTLEafrgkQKTIFFhpKYLKSLALFWrskgikvyrlSSGFMIANAAIElCKEVRLYGFWPFsknnegknISHHY 376 coelacanth
NP_001001603 280 SFKVYHTLQefkatQRAIFFhpTYLKNLAQFWrtkgvkayrlSSGFMITSAAVElCENVKLYGFWPFskstekmpISHHY 359 chicken
XP_020369560 187 SFRALYTLEdfqakQKVVFFnpIYIQHLTKFWlskgiqvkrlSTGLMIVSLALElCEEVCVYGFWPFaksiegkvMLHHY 266 whale shark
XP_007896374 252 VFKVSYTLEdfgskLQPIYLnpSYMVNITQFWksvgvtetrlSSGLIVLSAALElCDEVWLYGFWPFsknmegmkIFNHY 331 elephant shark

Feature 1                  #                      
P61647       360 YDNKlpkhgfHQMPKEYSQILQLHmkGILKLQF 392 human
OCT75631     349 YDNVlpkpgfHAMPKEFYQVLQLHhkGVLRLQI 381 African clawed frog
XP_007908901 296 FDSLlaepdlHSTSNEFYQLLRMHskGIVKLQM 328 elephant shark
XP_005999075 377 YDNQlpkpgiHSMPKEFYHFLKLHnkGIIKLQF 409 coelacanth
NP_001001603 360 YDNQlpkpgfHAMPKEYNQILQLHgkGIKKLQF 392 chicken
XP_020369560 267 YDNQlpkpnvHSMPTEFQHLLQMHskGIIKLQL 299 whale shark
XP_007896374 332 YDNIppkrsaHVMPREFYRLLQLHtkGILKLRA 364 elephant shark

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