Conserved Protein Domain Family
Anoctamin

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pfam04547: Anoctamin 
Calcium-activated chloride channel
The family carries eight putative transmembrane domains, and, although it has no similarity to other known channel proteins, it is clearly a calcium-activated ionic channel. It is expressed in various secretory epithelia, the retina and sensory neurons, and mediates receptor-activated chloride currents in diverse physiological processes.
Statistics
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PSSM-Id: 461349
Aligned: 307 rows
Threshold Bit Score: 116.143
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_012364715  272 ICDYFGVKIAMYFAWLGFYTSAMVYPAVFGSVlyt----fteADqtSRDvSCVVFAL-FNVIWSTLFLEEWKRRGAELAY 346 
A0DTP9        676 LCQYFGESVGTYFYFLCFFSQMLLYQNCLGLLyyli-----------qipSKIIYLVfQLQI-TSLYTSKWEQQLKIFNQ 743  Paramecium te...
A0DAH3        688 ICSYYGEKIGLYFFFMSYYTKMLTFISVCGFGcslaewilnnqdgeasiiITMIFTF-VLIQWNSIVTDYWKQQQVRFNL 766  Paramecium te...
A0EAT8        668 ICGYYGEKIGLYFYFMSYFTEMTTPLAFSGLAcsliqwiiwdnesdfyilVTIIFAF-VQIHWSNVFTDLWKQKQIYFNL 746  Paramecium te...
A0E006        685 ICSYFGEKIGLYFEFSAYYIKYYGLLSLIGIIytiftylskfydedvftgIVSSFSI-LLIHWSSFVTDYWNQMQLTFNI 763  Paramecium te...
A0DHW5        686 ICSYFGEKIGLFLEFTTHHILCYSVLSILGFLftiamitskeldkqtytaIISIFSL-LVVLWNSFVTDYWKTTQIKFNI 764  Paramecium te...
A0C5J6        679 ICIYFGEKIGLYFKFSSYYIQFSTIMAALGVIfnmimystniqhndislvAQSIFSI-LIINLNCFLTDYWNQTQFAFNI 757  Paramecium te...
A0CHM6        689 ICLYFGEKVGLYFEFTSYFIKFSTPMAAFGLLfsvllytsqdydnevytaTMSVFSI-LLVHWSSFQTDCWYQQQLTFNL 767  Paramecium te...
A0CY40        679 ICSYFGEKIGLYFEFTSYFIKFSTPMAALGLLfsvlmyisqnynnevytaTVSVFSI-LIVHWNSFQTDCWHQQQLTFNL 757  Paramecium te...
A0DBP1        583 ICSYYGERIALYFMFLQFFVHELLPISYFGILtfivqilydvEAlaNKV-SIIFFTI-MIVFWSSTFQALWIRQEMQFQT 660  Paramecium te...
XP_012364715  347 KWGTldspGE----AVEep-------------rPQFRGVRR-I--SpitraeefyyPPWKr-------LLFQLLVSLpl- 398 
A0DTP9        744 SFGI----------NSQedidttsnkqigepkrSLIN-------------------DQMNvpsineldQIFRECVSMlif 794  Paramecium te...
A0DAH3        767 KYGQ----LNekekSTEr---------------SSFKGTFIrSleN----------DQLNsaaqddsdLVLRLFLASill 817  Paramecium te...
A0EAT8        747 KYGQ----NDqdqqQVQr---------------SKFKGKHIrSlvN----------DQLNsievlyheYLKRTLVSSmll 797  Paramecium te...
A0E006        764 KYGQ----NKnakeSFTr---------------TAFKGKHIrSvgN----------DQLNsqeaihseIIKRIIISVsvl 814  Paramecium te...
A0DHW5        765 RQGF----NKraqeKLIl---------------MSFKGQYIrSveN----------DELNslgssqaqIISKLIISIfil 815  Paramecium te...
A0C5J6        758 QNGQ----NNnykyNLIr---------------SSFKGEQIrSisT----------DQLNftgiihfqFFWRISISIfvl 808  Paramecium te...
A0CHM6        768 KFGQ----NRdvkeSIIr---------------SSFKGQNIrSieN----------DQLNsigvihskFIQRLIISIfil 818  Paramecium te...
A0CY40        758 KFGQ----NRnvkeSIIr---------------SSFKGQNVrSieS----------DELNsigvihskFIQRLVISIfil 808  Paramecium te...
A0DBP1        661 MFGL----EDmelnQVEl---------------IGFVGKPKrSiaN----------DKLNdlqysskeTWFKFFFNMilv 711  Paramecium te...
XP_012364715  399 ---cLaclVCVF--LLMLgcfqlqelvlsvkglpr------larflpkvmlallvsvS-Ae---GYKKLA----IWLNDM 459 
A0DTP9        795 illqL---LYSVifIALYflcawfqslfkqt-------------tainnseiiiiaiLhlglnkLYTFHAqktiQQLVDF 858  Paramecium te...
A0DAH3        818 vlliS---AYSG--LVVGlftlttalrnsfgsefsnvsvmslevtlsatinvfvqlfVdK----FYDYIS----TSVTDF 884  Paramecium te...
A0EAT8        798 fffiL---FYIG--IIVSlfvftvqlhnkyqeelkqfdiatievtsaaamnfiaqliAdN----IFDKIA----CQLTEY 864  Paramecium te...
A0E006        815 ifliG---SDIG--IIIGlyffnlflktildqagnef--qcleviisgslnygiqylIdS----YYEQIA----TILTDF 879  Paramecium te...
A0DHW5        816 illiG---SDFG--VIIAkfnefnnkfynlei------------iissslnfgiqklIeQ----YYEQIA----TFLTDF 870  Paramecium te...
A0C5J6        809 ilifG---SDVC--ITIGlyffnlylesifastsiqf--rnfeiivtailnyviqiiVeY----YYESIA----IVLTDF 873  Paramecium te...
A0CHM6        819 ifliG---SDIG--IFVGlyyfnlylktklddlgndf--qyfevivtaslnyiiqlvIdQ----FYEQIA----TILTDF 883  Paramecium te...
A0CY40        809 ifliG---SDIG--RIIGlyffnlylksefidlgnyf--qyfeiivtaslnyviqllIsS----FYEQIA----TILTDF 873  Paramecium te...
A0DBP1        712 aiflV---IEIV--IIVAlqllslylennpdvpnief--ielsvfipaliwvfigilLdN----IYRPVA----FFLTKW 776  Paramecium te...
XP_012364715  460 ENYRLESAYEKHLIIKVVLfqfvnsylsl-----------------------fyigfylkdmERLKEMLATLL---IT-- 511 
A0DTP9        859 EQQRTIQAVKLSYNLKLYSfsiiqqlgpllilrffnhsfqlvcqsdsceqyigyyfltyiiiKSVE-KLCVFL------- 930  Paramecium te...
A0DAH3        885 ENHKTMQKYETSFVVKKFIlyfcsyvvpllfigy-------------lngplnlycsksncsRHVQYYFSTIIiwqFL-- 949  Paramecium te...
A0EAT8        865 ENYKTVESYETSFVLKKFIfqffsyiapllfldy-------------lnqplnlycartnceRHVKYYFSAIViliLF-- 929  Paramecium te...
A0E006        880 ENYQTSLQYETSYIMKKYTlywfsqlfplmivcf-------------lhsplslycqeenckQQVQYLFGTTIcwiFC-- 944  Paramecium te...
A0DHW5        871 ENLQISNQYETSYTIKKYTlyslsglfpllviqf-------------lnspfylycweesckNEIQYFFATTIfwiFT-- 935  Paramecium te...
A0C5J6        874 ENFQTVEHYENSYCLKKYAlicfsqlfpllilcf-------------lngelnlkcsqnnciGQAQYFFGTTLlltIInv 940  Paramecium te...
A0CHM6        884 ENFQTSYQYETSYIIKKYTlycfsqlipllmisf-------------lhsplglyckdencqHNVEYYFGTTMmwiFL-- 948  Paramecium te...
A0CY40        874 ENFQTSYQYETSYIIKKYTlhcssqvvpllmvsf-------------lnsplqlyckeencrHNVEYYFGTTMmlmFL-- 938  Paramecium te...
A0DBP1        777 ENHKYLSQFETSFIIKNLLfstvnrlgqpfiiaf-------------fyeqtigcvndnycySQLQIYMRVVFiieFG-- 841  Paramecium te...
XP_012364715  512 ---RQFL-------------QNVR-EVL--------QPhlYRRLGRGELGlRAVwelarallgllslrrpgprrlepqad 566 
A0DTP9        931 ---FNFYslrrqplfiykfqQHDInEYI---------------------------------------------------- 955  Paramecium te...
A0DAH3        950 ---FKIL------------------QLFkfisdlakYP--KIK----YE--I---------------------------- 972  Paramecium te...
A0EAT8        930 ---KQIV------------------NFCiflfkltkIK--IKS----YD--Y---------------------------- 952  Paramecium te...
A0E006        945 ---AQVI------------------KFVklf------fqeKKNY---ESN-KQ--------------------------- 966  Paramecium te...
A0DHW5        936 ---LQFI------------------KYFrly------fkvKEQF---HIN-QQ--------------------------- 957  Paramecium te...
A0C5J6        941 krrIQQI------------------K--------------EKS----Y---S---------------------------- 953  Paramecium te...
A0CHM6        949 ---MQVI------------------RFLktffhelvKS--PQK----LY--P---------------------------- 971  Paramecium te...
A0CY40        939 ---MQVI------------------KFLmtfqndmvKN--PQK----LY--P---------------------------- 961  Paramecium te...
A0DBP1        842 --------------------KHILfGFI--------FP--IIKQIYQRARyGFVsivdf--------------------- 870  Paramecium te...
XP_012364715  567 egggggsggggrrclsggcgapeeeeeaaalverrrageggeegdgppggkeededdeeeedeeeeedeeegeegglldc 646 
A0DTP9            --------------------------------------------------------------------------------      Paramecium te...
A0DAH3            --------------------------------------------------------------------------------      Paramecium te...
A0EAT8            --------------------------------------------------------------------------------      Paramecium te...
A0E006            --------------------------------------------------------------------------------      Paramecium te...
A0DHW5            --------------------------------------------------------------------------------      Paramecium te...
A0C5J6            --------------------------------------------------------------------------------      Paramecium te...
A0CHM6            --------------------------------------------------------------------------------      Paramecium te...
A0CY40            --------------------------------------------------------------------------------      Paramecium te...
A0DBP1            --------------------------------------------------------------------------------      Paramecium te...
XP_012364715  647 glrlkkvsfaergagrrrpgpspealleegsptmvekglepgvftlaeeddeaegapgspereppaillrraggegrdqg 726 
A0DTP9            --------------------------------------------------------------------------------      Paramecium te...
A0DAH3            --------------------------------------------------------------------------------      Paramecium te...
A0EAT8            --------------------------------------------------------------------------------      Paramecium te...
A0E006            --------------------------------------------------------------------------------      Paramecium te...
A0DHW5            --------------------------------------------------------------------------------      Paramecium te...
A0C5J6            --------------------------------------------------------------------------------      Paramecium te...
A0CHM6            --------------------------------------------------------------------------------      Paramecium te...
A0CY40            --------------------------------------------------------------------------------      Paramecium te...
A0DBP1            --------------------------------------------------------------------------------      Paramecium te...
XP_012364715  727 pdggpdpepgsnsdstrrqrrQNRSSWIDPPEEEHSPQLTQAEL--EScMKKYedtfQ----DYQEMFV--------QFG 792 
A0DTP9        956 --------------------------------EVQSKKPSNIK--------------D----QYFNCIEenlqqnmvELT 985  Paramecium te...
A0DAH3        973 -----------------------N-DNDIHQFIDETSRRQSYAIspER-YGTL----E----DYMEILI--------LYS 1011 Paramecium te...
A0EAT8        953 -----------------------N-EIDIMEFVEDQSSRQPYSQdfER-YGTM----Q----DYMELFV--------LIS 991  Paramecium te...
A0E006        967 ----------------------QSLNLSLIQFIQEQEQKTPFQNsqEK-YGII----N----EYMEFFL--------LLA 1007 Paramecium te...
A0DHW5        958 ----------------------IQNTDSLLQLIQDQNSKVPFWRssEK-DGIV----D----EYMEFFL--------FST 998  Paramecium te...
A0C5J6        954 -----------------------S--KNLLTFIENQESKTPFQQtqEK-YGII----D----EYMKFFL--------LST 991  Paramecium te...
A0CHM6        972 -----------------------YNHSTLCDFIENQEKRIPFQKsiEK-YGNI----D----DYMDFFL--------QLT 1011 Paramecium te...
A0CY40        962 -----------------------NNQQSLCDFIEIQEQRIPFQKsvEK-YGNI----D----EHMDFFL--------QLT 1001 Paramecium te...
A0DBP1        871 ----------------ggslqKKTPYYHFNKSIEAETQKESFT------IDQV----DgtiwEYLELNL--------QFA 916  Paramecium te...
XP_012364715  793 YVVLFSSAFPLAALCALVNNLIEIRSDAFKLCTGLQR--PfGQRV-ESIGQWQKVMEAMGVLAI------VVNCYLIgqc 863 
A0DTP9        986 ILTYFAYIYPITYFMQWLLFVVQIYADKAQYLYYYQRpwP---QIdCFVKVWNNILQYIILSSViitsygLSNSLVFqdk 1062 Paramecium te...
A0DAH3       1012 LLIIFGYSFPLSYFLLWSFNILQLQVKKYSFMYCLQR--PwPQNE-SSLGIWNNILDLVNQIGI------LTNTGIItvl 1082 Paramecium te...
A0EAT8        992 FLSIFGYTFPFSFFILWISNIMQIQVKKNTFLYCLQR--PwPKNE-SSLGIWNFFLEIISLICL------LTNTGVVtiq 1062 Paramecium te...
A0E006       1008 LINLFGCLFPFSIALFWIWIIIQFQIQKYRLLYQIQR--PwPKGD-GSLGIWQEINQLINFVTL------LCNSGLIciy 1078 Paramecium te...
A0DHW5        999 LINLFGCVFPLSVTFFWIWMILQVQILKLRLCYQLQR--PwPKNE-GSLGVWDDLNQLINLVAI------LSNSGITsiy 1069 Paramecium te...
A0C5J6        992 LINMFGGLFPLSFTLFWIWMILQFQIVKFKLLYQIQR--PwPKGD-SSLGIWFEIHQFINFISL------LSNCSLIcvy 1062 Paramecium te...
A0CHM6       1012 LTNIFGCLFPFSITLFWIWNILQVQISKLKLLFLFQR--PwPKGD-GSLGIWDDFYQLINFVTL------LCNSGLIciy 1082 Paramecium te...
A0CY40       1002 LINIFGCLFPFSVTLFWIWTILQVQISKLRLLYISQR--PwPKGD-GSLGIWDDFFQLINYMTL------LSNTGLIcmy 1072 Paramecium te...
A0DBP1        917 LLANFGSPFPLIFITGLAMNYLELFLDKFKLIWLTKR--PtPQTA-RTIGPFVYYMNLISYISI------FINSGLLsys 987  Paramecium te...
XP_012364715  864 gqlqrlfpwlspeaaiVSVVV-LEHFALLLKYLIHVAIPDIPGWVAEEMAKL 914 
A0DTP9       1063 --------------sqIFVFVsFMLLSYTMNFVYQVWYSETPSYLQK----- 1095 Paramecium tetraurelia
A0DAH3       1083 ynk-------kygeqlVLVFLsLLISNSLFKFVIASVFGDTPFRLTQLTIRH 1127 Paramecium tetraurelia
A0EAT8       1063 ynk-------qfgyelIMVFLgVLIFNCFGKFFIGAIFGQIPDALGDLMKRH 1107 Paramecium tetraurelia
A0E006       1079 yyg-------klqdqvVLLFLpLLFYNFFVKYITMSLFGGTPTILEQIMRRC 1123 Paramecium tetraurelia
A0DHW5       1070 yks-------rllddiILLFLsLLFYHFLIKCITLGIFGNTPRIMQQIIQRG 1114 Paramecium tetraurelia
A0C5J6       1063 yyk-------ylqddvIQLFVtLLFYNFFIKYITNTTFLSPPLILEYIVKRG 1107 Paramecium tetraurelia
A0CHM6       1083 yyd-------klhdqiIILFLgLLFYNFFIKYLTNSIFGNSPIILDQIVKRS 1127 Paramecium tetraurelia
A0CY40       1073 yye-------tmkdqvIILFLaLLFYNFFIKYLTNSIFGNSPIILDQIVKRS 1117 Paramecium tetraurelia
A0DBP1        988 nqdv------fteinsFTLFAiLMIAFFLFKFVTDIIYGNTDSSAELVRQRH 1033 Paramecium tetraurelia
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