Conserved Protein Domain Family
Pacs-1

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pfam10254: Pacs-1 
PACS-1 cytosolic sorting protein
PACS-1 is a cytosolic sorting protein that directs the localization of membrane proteins in the trans-Golgi network (TGN)/endosomal system. PACS-1 connects the clathrin adaptor AP-1 to acidic cluster sorting motifs contained in the cytoplasmic domain of cargo proteins such as furin, the cation-independent mannose-6-phosphate receptor and in viral proteins such as human immunodeficiency virus type 1 Nef.
Statistics
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PSSM-Id: 463027
Aligned: 26 rows
Threshold Bit Score: 483.41
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q95R71       343 LLDQLSRVFAGEDSaIPEVVTIiSPPEALGGSalLAKlvTLFANSFkPaFVPQNTAEVKAVLQALMAKIQKYCNSNAKPP 422  fruit fly
ESO06793     456 FMEQMSSILSCDHN-SPEVIVMl-----------LAQ--ALQSTKH-RtICTCSPSEVRTIVSTIASKIQKCTNKSLTQE 520 
EFX79929     520 LLEQLVRCMPADDA-LPDHVVMvSGADLQGCN--LAG--RLAERQQ-RaVCTGGVADVRATIACLVSKIQKFCNCSAKPP 593 
XP_003247003 456 LMEQLSKVLPPEDK-MPEVLCLiHYADPLGCQ--LAS--KLQNYQF-KvITPAGLADVRATFVCIINKIQKYCNSNPKPP 529 
EEB13376     466 VVEQITKILGSDDS-LPDHLLIiSSNDPQGSL--LAS--RLQERQL-KvLPVVSTSEIRLTLTYLVNKIQKFCHSSAKPP 539 
EGI64595     491 LVEQLSRVLP-DDS-LPEAVSLiSIADPGGAV--LAA--KLQERNH-KvLTPASPADIRATFTCLVTRIQKFCNSSAKPP 563 
XP_002401914 471 VLDQLGQLFAGDEA-VPDRLLLvEAPW-------LAT--ALQRAALpGvLSLAHGADLKAALAALVSRIQKFCNCNSRAP 540 
2_pfamImport   1 VLDQLNHILFSDDQ-IPDSIILiNTTDWQGQY--LSE--VLFDQ---PiVCTVSTADVQAAFSAIIGRIQRFCNCNSQTP 72  
XP_026164529 508 VYDQLNQILISDER-LPESIILiNTMEWQGQY--VAE--LLHEQGQ-PiVSTCSAADVQAAFNTIVTRIQRFCNCNAQTP 581 
XP_008103131 451 VYDQLNQILVSDEQ-LPESIILvNITEWQGQY--LCD--QLQDHKQ-PiVSTCSMADVQAAFNTIVARIQRYCNCNSHMP 524  green anole
Q95R71       423 HTVKVLLIGGDWLQGATLRHYVELMGVrPPDWLNHLRFYLVPVGGSCgsV--ARHLSQMDQAYAV--MFGSDNWTQ-LCE 497  fruit fly
ESO06793     521 LPIKVAIVGGDKYISSVLRPYVELFSNkSSDWINYIRFLVVPLGPSI--I--GKNLSSIDNRYAG--LFNDSAWKDnVFE 594 
EFX79929     594 PAVKVVLMGPDSYVNSVLRCYVEQFSSkPPDWKNYLKFYIVPL------VtnSGYLASLDRYYNV--NFVSDSWRE-ALD 664 
XP_003247003 530 SQMKILLAGSDSFVNYVLRQYVEQLSFkPPDWMNYIKFYIIPLGINT--L--SRYLGTVDSYYGTtfLFKEDYWKE-QLE 604 
EEB13376     540 NTIKLMVVGSDAFINNILRQYVDQLSQkPPEWQGFIKFLIVPLGSSS--I--SRYLASVDSTYGA--YFAGEKWRD-LSE 612 
EGI64595     564 APIKVIIAGGDSFINAVLRHYVDLLSFrPPDWQNYMKFLVVPLGSNT--L--TRYLSSIDTKYSK--LFGDE-WKE-LLE 635 
XP_002401914 541 LTVRVGLLGSDPFLHSVVRLYVEHFSTkPPEWQAYLRFFFVPTGGSP--V--ARYLSSVDNCYAS--LFGDSSWRE-LVE 613 
2_pfamImport  73 PTMKVAVGGDQSYLTTVLCCFVEQLASkTSDWLSYIRFLIIPIGVHP--L--AKYLSSLDGKFSG--LFVDASWRE-LFG 145 
XP_026164529 582 PTMKVAVAGDQSYLSTILRFFVEQLANkTPDWLSYIRFLVIPIGSHP--L--AKYVASFDSRFNS--IFMDTAWRE-LFC 654 
XP_008103131 525 PPVKVAVAGDQSYLSIVLRFFVEQLASkTPDWLNYLRFLVVPLGSHP--L--AKYLGSVDNRYST--LFLDAAWRE-LFS 597  green anole
Q95R71       498 RAAATAAavsavttvnatalttnladaagvaksDIAELVQRIQRYLLAAGPCTQIPIAEAMVNYK--------------- 562  fruit fly
ESO06793     595 RFDFSNRfnq---------------------smDIGEVATRIVKYLNNARHMIQLPLSEAILTNKdk------------g 641 
EFX79929     665 RPAEKMLaa----------------------siNGGGVIHRLGRYLTSNGCTVQVPIAEAMITYRep-----------ns 711 
XP_003247003 605 CG-------------------------------DGTDIIGKIQNYIMEASNTIQLQIAEAMLSYKek-----------ss 642 
EEB13376     613 R--------------------------------EINEVVNKIGLYMNNGTSTIFLPVAEAMLTYKek-----------ss 649 
EGI64595     636 REGG-----------------------------GSSECAARASEYLVTANTILLLPIAEAMVTYRe-------------- 672 
XP_002401914 614 RGSP-----------------------------EAPELADRVADYLSGAHSCLQLPVAEAMVTYKgh-----------ss 653 
2_pfamImport 146 RPEPPPL------------------------------------------------------------------------- 152 
XP_026164529 655 RTERPAS--------------------------DNIDVAGRVVQYLAGANVSHQFPISEAMLTYKqk-----------sp 697 
XP_008103131 598 KLEPPNS--------------------------DAVDIPGRITQFISGANISHQLPISEAMLTYKqkrkrslyfdfyisp 651  green anole
Q95R71       563 DEDSCqIFVPFVSDVRI-----GYLDA-Q-----------ASLDleenaAGSnaVGSGLGSGSASSSAipigsqSSpnvh 625  fruit fly
ESO06793     642 IDDSShLIVPFLGEVRL-----GVMDVgNtsn-----ifsSLIDydetsN----ANASLSNSPPQSSHmishmtNMdkvk 707 
EFX79929     712 EEESTqVFIPFVSEVRI-----GFAESaAavmaaaaamtpGSVDaedgqQLSntGASSGPL------------------- 767 
XP_003247003 643 DDEALqTFIPFVNDVRI-----CSGDTaS-----------GSNDtddqcSIIidRKSILD-------------------- 686 
EEB13376     650 DDESSqIFVPFVNDVRL-----GSMDSaSg----------ASVDlddmqATC--GSSPP--------------------- 691 
EGI64595     673 tDDSSqIFIPFINDVRV-----GCPDSsSs----------TSVDleesnVSM--SGSPPSLPPPSLPVpt---------- 725 
XP_002401914 654 DDESTqVFIPFISVKKRkkfaeGEMTKpGc----------YAVDle---------eaLPGSSPPGGPMer---------- 704 
2_pfamImport 153 ----------------------GTSDYcPt-------------------------------------------------- 160 
XP_026164529 698 DEDSCqKFVPFIGVVKV-----GIVEQsLs----------TSVDsd-daMGG--NTSILSSPTPPSAGpy---gKEi--- 753 
XP_008103131 652 DEDSCqKFVPFVGVVKV-----GLVEQsFn----------TSVDsd-daTIC--TTSLLSSSSPSGGSvp--ytKEa--- 708  green anole
Q95R71       626 gvvSGSPPQQQSLGRISpplQTPPSSASshrerntseslstpssvqqqsfsgalaaAEAVELQVDYWPLVRPGEGHAKES 705  fruit fly
ESO06793     708 eniSHTPPESNNFLSTPtttTTASSTTTaa------------------------qnIDAFNLQVDYWLMSGTSSQSSNAT 763 
EFX79929     768 ---SGSPPHQSSVMETSstpGA-----------------------------------ESVELQVDYWFLATMAQAVKREK 809 
XP_003247003 687 ---KTTPPNSPNIGMQYlppPTKQVNWEl---------------------------CEPLELQLDYWLVPNTNKEVTTRG 736 
EEB13376     692 ---KITPPSSPNVNSMHitnHSRESNLV-----------------------------EPLELQIDYWTSNKSSEAKEVGK 739 
EGI64595     726 -pgKLTPPSSPNVGQPAregW------------------------------------EPVELQLDYWS------------ 756 
XP_002401914 705 --eSTTPPSSPSMSSAGlapAGCVST-------------------------------SAMDLQLDYWTLGPSARKGAEPS 751 
2_pfamImport 161 ---------------------------------------------------------EVMGLQVDYWSS-QGGGGGGERK 182 
XP_026164529 754 ---GGTPPQSPSVSTALsgaGSPCSGS------------------------------EVMGLQVDYWTW-QGPEKKKDGE 799 
XP_008103131 709 ---VGTPPPSPSVSSGLsgaGNLSPGV------------------------------EVMGLQVDYWTA-QGPEKKKEAE 754  green anole
Q95R71       706 KGgl-----------skGSDAGg-----------KNSIKSTFRNLQV-----WRLP-----------QHAqQLGDMfNGL 747  fruit fly
ESO06793     764 SNlptnlfnsdlksdllTNITSsasgkflskkdlKCSLKMMFRSVKI-----FRNSglqlsgdgsllAGGsNAG-----L 833 
EFX79929     810 PGpaeq-------------------------ssvKYTVKAGFRWIVV-----QRLPhsnvsssttasSSGsDASSL---F 856 
XP_003247003 737 NEpssk------------------------rvdtKFTLKTGFKSLHI-----SRLF-----------LTNeEPLAF---F 773 
EEB13376     740 GKdp-----------------------------nKSTLKTNFKAVQI-----QRIP-----------SPGeQPGSY---L 771 
EGI64595     757 ----------------------------------KQYVTSSFQSVAC-----AKTS-----------LIRrSSRTS---L 783 
XP_002401914 752 ----------------------------------KLTLKAWFRSVQArlhscSRRK-----------MVGkGVEALgPSL 786 
2_pfamImport 183 KE---------------I--GM------------KNTLKSNFRCLQV-----SRLS-----------GGE--------LM 209 
XP_026164529 800 KR---------------D--VGl-----------KNTLKSNFRSLQV-----SRLP-----------CGG-ELTPP-PSM 833 
XP_008103131 755 KR---------------E--TGi-----------KNTLKSNFRSLQV-----SRIP-----------GPG-ELTPP-STM 788  green anole
Q95R71       748 TVSFATKEKKQKq----------------IMRLGkKKDKERDLE-KEQCVEGVARLICSPKQSHPVpLRVYIDGTEWTGV 810  fruit fly
ESO06793     834 SMVVVTREKKQK-----------------IMRIG-KRSKESELN-KSQQIDGISRLICTSRSQNHP-LNVTIDGVDWSGI 893 
EFX79929     857 TMTFGLKEKKQK-----------------IMRLGkKKEKEKESEsKSQVVEGINRLVCQAKTHHSL-LKVVIDGVEWNNV 918 
XP_003247003 774 TVSYI-KEKKQK-----------------IMRLGkKKEKEKDLDpKNQVIDSVLRLICSPKTQHFP-LTITIDGYEWSGV 834 
EEB13376     772 LMNYITKEKKQK-----------------IMRLGkKKEKERETEnKNQQIEGVTRLICSPKTQALP-LKVSIDGVEWTGV 833 
EGI64595     784 VYEFHDKREKTKnnvqyikstlkencplsVMRLGkKKEKEKENEpKSQSVDGVTRLICSAKTHNIP-LRVSIDGTEWYGV 862 
XP_002401914 787 TLNYVTKEKKQK-----------------IMRLGkKKERESDRDaRCQLVEGVHRLICSCRNLQAP-LKVTIDSVEWTGV 848 
2_pfamImport 210 SMTVVTKEKNKK-----------------VIFLS-KKAKEKETEsRSQLIEGISRLICTSKHQHT--LRVSVDGVEWNDV 269 
XP_026164529 834 AMTVVTKEKNKK-----------------VIFLS-KKPKEKELDsKSQVIDGISRLICTAKHQHTM-LRVTIDGVEWNDV 894 
XP_008103131 789 AMTVVTKEKNKK-----------------VMFLS-KKPKEKDLEpKSQVIEGITRLICTAKHQNTM-LRVCIDGVEWNDV 849  green anole
Q95R71       811 KFFQVSSQWQTHVKNFPIALIGCT 834  fruit fly
ESO06793     894 KFFQVSSQWQTHIKYFPVLIFGDL 917 
EFX79929     919 KFFQLSSQWQTHIRHFPVALFTES 942 
XP_003247003 835 KFFQLSSQWQTHIKHFPVAVYSLD 858 
EEB13376     834 KFFQLSAQWQTHIKTFPVALFAQD 857 
EGI64595     863 KFFQLSAQWQTHIKTFPIALLEYN 886 
XP_002401914 849 KFFQLSSQWQTHIKYFPVGLYMAP 872 
2_pfamImport 270 KFFQLAAQWPTHVKHFPVGIFGYS 293 
XP_026164529 895 KFFQLAAQWPTHVKHFPVGIFGYT 918 
XP_008103131 850 KFFQLAAQWPTHVKHFPIGIFGYT 873  green anole
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