Conserved Protein Domain Family
Commd4
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cd04752: Commd4 
COMM_Domain containing protein 4. The COMM Domain is found at the C-terminus of a variety of proteins; presumably all COMM_Domain containing proteins are located in the nucleus and the COMM domain plays a role in protein-protein interactions. Several family members have been shown to bind and inhibit NF-kappaB.
Links
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Statistics
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PSSM-Id: 240100
Aligned: 7 rows
Threshold Bit Score: 278.159
Created: 12-Feb-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAQ20037      25 LTSVKMKLLCVQVVKDLLGqs-----------------------------idYDKVHKLTADAKYEAGDVKASIAALSFI 75  Branchiostoma b...
XP_642944      1 MTNIRIKLLTVQVITSLASgen----------------------------idFEKVEKLVKDAGFVIGDIKALIAAIHFI 52  Dictyostelium d...
NP_060298     25 MSSVKLRLLCSQVLKELLGqg-----------------------------idYEKILKLTADAKFESGDVKATVAVLSFI 75  human
XP_001233363  25 ISSVKLKLICAQVLRELLGet-----------------------------idYEKILKLTSDAKLESGDVKAAIAVLDFI 75  chicken
CAF98336      24 LSSVKMKLLCAQVLKDLLGegidvrfvnnraihfymlqprqlnlifffvffqYDKVTKLTADAKFESGDIKASVAVLSFI 103 Tetraodon nigro...
AAH77441      25 ISSVKLKLICAQVLKKQLGek-----------------------------idYEKIVKLTSDARFESGDIKATVAVLCFI 75  African clawed ...
XP_785030     31 ITSVKMKLLCGQVIKDLLGdn-----------------------------idFEKVYKLTADAKYESSDVKASIAALSFI 81  purple urchin

AAQ20037      76 LSSAAKYQVDGDSLSNELQQLGLPKEHSSSLCKTYADNLGNLQAQFMRQSLKLSQLESAEWRVDYILSSSELQEVQEPMV 155 Branchiostoma b...
XP_642944     53 IFNSVKNDVDESTLSTELQQLGLPKEHCDSISRAFREHKEKLRSIFHNNTLKLPSLHSLDWRVDFILSSNTIQEVNSPSV 132 Dictyostelium d...
NP_060298     76 LSSAAKHSVDGESLSSELQQLGLPKEHAASLCRCYEEKQSPLQKHLRVCSLRMNRLAGVGWRVDYTLSSSLLQSVEEPMV 155 human
XP_001233363  76 LSNAAKHNVDGESLSSELQQLGLPKEHATGLCRSYEEKQSSLQDSLRAGSLRLSRLDGVSWRVDYALSSSELQEVGEPLV 155 chicken
CAF98336     104 FSSAAKYDVDSESLSSELQQLGLPKEHTTALCKSYEDKHSALQERLKATSLRLGRLEAVSWRVDYTLSSSELQEVNEPLI 183 Tetraodon nigro...
AAH77441      76 LSSAAKHNVSSDSLSSELQQLGLPREHASSLCRSYEEKQNALQETLRESSLRLTRMSSLNWRVDQILSSSIMKQLNEPLV 155 African clawed ...
XP_785030     82 LSSAAKYNVDGESLSNELQQLGLPKEHSTALSRSYGDKREKMQESFRSRSLRLSKFDSVDWRVDYILGSSEIETIKEPNL 161 purple urchin

AAQ20037     156 QLRLRvrnpdtgnvtpHSFNMTADKFRLFVSELKQAHQVMEGL 198 Branchiostoma belcheri tsingtauense
XP_642944    133 QLNFKvknhsnneitnHPFEISAKKFNVLYYELKGAKLLMETV 175 Dictyostelium discoideum AX4
NP_060298    156 HLRLEvaaapgtpaqpVAMSLSADKFQVLLAELKQAQTLMSSL 198 human
XP_001233363 156 HLLLRvrhrehgepeaVPMAVSAEKFRVLLAELKQAQALMKTL 198 chicken
CAF98336     184 KLKLQhqgatpgsaetKVFSVSADKFRVLLAELKQAQAMMNAL 226 Tetraodon nigroviridis
AAH77441     156 HLNLTlsdge--cnqpLTMTVSASKLRVLITELKQALEMMNAL 196 African clawed frog
XP_785030    162 QLRLKlrdtdtdainvTSFSISSEKFRTLLSELQQTLTLMDGL 204 purple urchin
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