6XP5


Conserved Protein Domain Family
Med1

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pfam10744: Med1 
Mediator of RNA polymerase II transcription subunit 1
Mediator complexes are basic necessities for linking transcriptional regulators to RNA polymerase II. This domain, Med1, is conserved from plants to fungi to humans and forms part of the Med9 submodule of the Srb/Med complex. it is one of three subunits essential for viability of the whole organizm via its role in environmentally-directed cell-fate decisions. Med1 is part of the tail region of the Mediator complex.
Statistics
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PSSM-Id: 463183
Aligned: 59 rows
Threshold Bit Score: 155.596
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6XP5_a               118 EEVIHILSK--S-KGL-VSEAGLERLARSLELEFMwessmgsdnkrtLIVAGSALELLVEF-SQ-DVVQSVTLNFPDSpe 191  Chaeto...
OWR53822              60 QKCLDSLQHciKvSSLqSLIERLECLSRQLGLK-Fvvgt----sgvnLFISSDMFYLEILVeSS-GSVKDVKIHHEGKie 133 
WGS:AAPU:GI11550-PB   81 QSALDKLQHyiKvTSRhGLVERLESLSRQLGLKFMedq-------qtLFISTDMFYVEILLdAS-GNLSDVKVHHECKie 152 
ETN66938             116 QKTLDSMQYciKvTTRqGLVERLDCLTRQLGLklse-------dtsgLFISSDMFYLEIILdPLlGTVQDVKVHHECKmk 188 
XP_015210061          57 LDCLERLHKalNaTSFtDMVTRLEIIAKHKGLgshls-----psedvCYITSDIFYLEVLFqPA-GEVADVKVAHHGEap 130 
3_pfamImport           1 VRSLERLQDvfNvSSMkTMRSRLEMIAKQQGMG-Fhlt------eatCYLTADLFYLEVVLlPY-GGVAEVKVAPHGKap 72  
NP_001018472          54 AKCLQKINEalNvSSSaAMVSRLEMIAKQRGLgshls-----ptetvCYLTADLFYIEVLLlPG-GRVEDVRVAHHGEap 127 
XP_006638322          91 LTCLETLQRalKvSSLpAMTDRLESIARQNGLG-Shlsp----sgteCYITSDMFYVEVQLdSG-GQLVDVKVAHHGEnp 164 
XP_022365352          59 VSCLETLQKalKvTSLpAMTDRLESIARQNGLG-Shlsa----sgteCYITSDMFYVEVQLdPA-GQLCDVKVAHHGEnp 132 
XP_022529143           1 mrcqqklnealnvASVnAMMTRLEMIAKQKGLG-Shrsp----tetaCYLTADLFYLEVLLlPG-GGVQDVKVAQHGEap 74   Mexica...
6XP5_a               192 ivtkhaqKAGEILFNDLRlapgqsplTKSLARFAANFERLAVLDKLSi--lPGLNLYEAVADVYESLARLh------aWE 263  Chaeto...
OWR53822             134 qq------sceeLVQCIS--------RGDFADFTAQLEGLTAVYQLNaekkVKCKAFSALQSLEEDLCTLrqlq------ 193 
WGS:AAPU:GI11550-PB  153 qq-ssssASSTELLNCLR--------AGDFADFTVQLEGLSSIYQLNaepkVKKKAFVALQAMETDIFSLyqhqlqlqQQ 223 
ETN66938             189 qq------scseLVACLQ--------RGDFADFTTQLEGLASIYQLNaekkIKVNAFVALQALETDLHTLytlt------ 248 
XP_015210061         131 vs-------semLCNLLR--------LKNFEEFGKELEGLSSLFNTSgdseTNMKMFSALQFVEKDLLKMfqipr----- 190 
3_pfamImport          73 vp-------sesFLQLLR--------SKEFAEFSVKLAGLFTQYDIPgdseTRLKLFSSMQWLWKDLQQIsqlps----- 132 
NP_001018472         128 vs-------spsLLQLLR--------MKQFEEFSLKLDDLASFYNIPgdsdVKIKVYSSLRHLETDLFKIshlpr----- 187 
XP_006638322         165 as-------cpeLVQHLR--------ERNFEEFSKHLKGLVNLYKLPgdnkLKTKMYLALQSLEMDLTKMmhmf-rlaTN 228 
XP_022365352         133 vs-------cpeLVQQLR--------EKNFDEFSKHLKGLVNLYNLPgdnkLKTKMYLALQSLEQDLSKMavmy-wkaTN 196 
XP_022529143          75 es-------nsaLCQLLR--------MKKFKEFSVKLDDLASLYNIPgdsdTKIKVYASLQHLQKDLLKIsnlp------ 133  Mexica...
6XP5_a               264 lqklredpslagkddeyLENLVLcTKSGKPAMN--DRGRVG----------LaLDYWKEKHLLRTPEAevasw------- 324  Chaeto...
OWR53822             194 -------------------------sfiKDPWAqvHKSPIGflqrrrgghaLrLTYFVSPYELLDkekglqpltvdllts 248 
WGS:AAPU:GI11550-PB  224 ----------------------LsSSTDSYHIM--NNSSVGlvlqrrgghpVkLTYFCPPLHLIEKKVkgekvatssgta 279 
ETN66938             249 ------------------------anryTEIHSllLQSPLGvlqkrrgghpMrLTYFVPPYELLDSatrtmnvlsa---- 300 
XP_015210061         191 -----------------------pvssgDPWLDnvLHGRIGnvtprnngypMsIEYYISPYDLLEEKMkpes-------- 239 
3_pfamImport         133 -----------------------vpkdsDPRVDvmNHGRSGcliaekedfpMtIQFYAPPTDGMKTsdrqeta------- 182 
NP_001018472         188 -----------------------slresDLHIDliMNGRIGnvqsgregspMtIEYYISPADALMGLSstge-------- 236 
XP_006638322         229 ----------------------------ANTVEtiLHGSVGlvtarsgghlVtLQCYVSPYDVFEEetgallnlt----- 275 
XP_022365352         197 ----------------------------AGPLDkiLHGSVGyltprsgghlMnLKYYASPSDLLDDkttspiilh----- 243 
XP_022529143         134 --------------rrlIESDVH------VDMV--LNGRIGnfvpcregnpMsIQYYIRPSDVLMEMFcpge-------- 183  Mexica...
6XP5_a               325 -----------------iadnERTWSILIGCAPlr-------dlSINPVR--------I----------SDKWIGPnvvk 362  Chaeto...
OWR53822             249 gkpssssglaslvspshtpigHSATVLLEGSAAnklql-spiiaGGQRPgkgngp--------vyaqlvPQNSAML---- 315 
WGS:AAPU:GI11550-PB  280 sr------dlsieqvikspngLSVTLNLEASSAnk-------lqILPIVS--------I----------TNEAGLP---- 324 
ETN66938             301 ------------eliarerigCSVTVVLEAASAnklqi-qplliPGAGAgstggggtgtgstptyaaieKHNSTSL---- 363 
XP_015210061         240 -----------------rscgNKVFVTAEVTNTiqrlpsasviaDSPQMT--------NegfpvhatldDLVSMEL---- 290 
3_pfamImport         183 ---------------ateppvQAARVTVGVSDAahrlqmasllpQPPQLdpqghp--------vflssaEAPHETL---- 235 
NP_001018472         237 -----------------vsagRVALVTAGSTDSshrlqmeslisSPPQVdscgfp--------vfqpltEACSLLL---- 287 
XP_006638322         276 ------------dsnvprnlgVGVSVTIEGTSSvyklpiaplitGTHPVdnkgtp--------sfssvtNSNCVDL---- 331 
XP_022365352         244 ------------ennvprslgMNASVTIEGTSAmyklpiaplimGSHPVdnkwtp--------sfssitSANSVDL---- 299 
XP_022529143         184 ------------------gsrGQVAMVVVGASS-----------TTHMLQ--------M----------ESHILTP---- 212  Mexica...
6XP5_a               363 tslpdglhtgePIIDWLDPEPTFipatdqqqqqqqqqqqqqqqqqqqqQADAplLPPRLPEVAFHAVFDPPVHiPINLWQ 442  Chaeto...
OWR53822             316 ------------------------------------------------------------PACFTLKLSQPTPmCAGLAK 335 
WGS:AAPU:GI11550-PB  325 ----------------LEQPVYA-------------------------PLTQ--NNSMLMPATYVLRLSKPMPvCIESLR 361 
ETN66938             364 ------------------------------------------------------------PATFVLRLSKPIPiDGAMMS 383 
XP_015210061         291 ------------------------------------------------------------SACLFLKFPRPVPiLSCFIE 310 
3_pfamImport         236 ------------------------------------------------------------PACFLLKLQPAVPmTLSFVD 255 
NP_001018472         288 ------------------------------------------------------------PATFLLKLQPPLPvLTSFIE 307 
XP_006638322         332 ------------------------------------------------------------PACFFLKLRRPLPfSLSFIH 351 
XP_022365352         300 ------------------------------------------------------------PACFFLKFPQPIPvSRAFVQ 319 
XP_022529143         213 -----------PQFDSLGFPVFR-------------------------PMSE--VKTESLPAFFLLKLQPPVPtLNSFIQ 254  Mexica...
6XP5_a               443 HLQEMGC-VLPDETATqpfq-----qhhFRSFDslvipppqgketdatetrvfscrkktpfvpRRSGVRNGE------GA 510  Chaeto...
OWR53822             336 LIHATT-------DVEvagd-----wanAKPMLglv-----------------------------aqQAYNKlapgktV- 373 
WGS:AAPU:GI11550-PB  362 ALG-LPG-LTSNANEE------------TPTVMnli-------------------------vqTASRQLIRN------TQ 396 
ETN66938             384 AIRTVVG------RSEgsdesstaagtrNTSLMgli-----------------------------aqHASG--------- 419 
XP_015210061         311 EFHRLTG-ISVSEDLK------------QVPFYell-----------------------------mkTKMNVtt------ 342 
3_pfamImport         256 KLRHIT-------DIPipdv-----dlqWAPLPkll-----------------------------tgRSNG--------- 285 
NP_001018472         308 KMGKITDgVIAEKPLQ------------VEPLHkll-----------------------------lkTSRKYnpn----- 341 
XP_006638322         352 RMGNAT-------GIPlfet-----appLAPLYeli-----------------------------tqSQLQEegg----- 385 
XP_022365352         320 KLQNCT-------GIPlfet-----qptYVPLYeli-----------------------------tqFELSKdp------ 352 
XP_022529143         255 QMNQITD-VTPEADLQ------------VEPLFqli----------------------------kqLSLTEKtcesmcDE 293  Mexica...
6XP5_a               511 T------QKMEYRIHQNTLFVPKPVMC------------------R----TLTEMSFSHpQQLVSILPYLRQYAFLAQLL 562  Chaeto...
OWR53822             374 ---------ELNLSKG--LFVS--LPEqwqcyf------lcetrgLdg-cMVTSVPFTHpSHVPPLLSVLRQQALFNALL 433 
WGS:AAPU:GI11550-PB  397 K------GLYVNLPKETHCYFFTDNHR------------------Lkg-tMISSLPFTEpAQVPKIIAFLKKQALFYTLL 451 
ETN66938             420 ---------GTVQDLSRGLPVT--LPDqyhcyy------ltdnpsLrg-vMVGSIPFTEpQHVPKLLVYLRRAAVFNQLL 481 
XP_015210061         343 -----------wgSDSCCFLVT--LPGhhrqgyvi--sqqwwlkpWeg-aLVHKIPFTHpGHVPSLLSLLRHQTAFSTLI 406 
3_pfamImport         286 -------PGELPDEQDTIFTVP--LPDgalhryvllaaawgeapaQra-aAVDSIPFTHpAHVPALLQLLRHQSAINTLL 355 
NP_001018472         342 ----------tscTDGLQFLVP--LPGsechsyvfp-gaqwscenWng-aLMDAVPFSHpGHVPALLEILRHQSAISVLL 407 
XP_006638322         386 -------gaLPPLAHNMRFYAS--LPGqqhcyflnrdapvqdgrcLqg-aLVTKVPFRHpAQVPALLDIIRHQAAYNTLI 455 
XP_022365352         353 --------dPIPLNHNMRFYAA--LPGqqhcyflnkdaplpdgrsLqg-tLVSKITFQHpGRVPLILNLIRHQVAYNTLI 421 
XP_022529143         294 EashfhvTLPDAELHSYVFGGAEWKCD------------------LwkgaLIHAVPFTHpAHVPALLELLRHQSVINALL 355  Mexica...
6XP5_a               563 ENSFK 567  Chaetomium thermophilum var. thermophilum DSM 1495
OWR53822             434 ASCVR 438 
WGS:AAPU:GI11550-PB  452 SSCIR 456 
ETN66938             482 ASCIR 486 
XP_015210061         407 ASCVT 411 
3_pfamImport         356 RSCIG 360 
NP_001018472         408 ESCFS 412 
XP_006638322         456 GSCVK 460 
XP_022365352         422 GSCVK 426 
XP_022529143         356 ASCIT 360  Mexican tetra
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