Conserved Protein Domain Family
MENTAL

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pfam10457: MENTAL 
Cholesterol-capturing domain
Human meta-static lymph node (MLN) 64 is a late endosomal membrane protein, and carries this MENTAL (MLN64N-terminal) domain at its N-terminus. The domain is composed of four trans-membrane helices with three short intervening loops. The function of the domain is to capture cholesterol and pass it to the associated START domain pfam01852 for transfer to a cytosolic acceptor protein or membrane. In mammals, the MENTAL domain is involved in the localization of MLN64 and MENTHO in late endosomes, and also in homo-and of hetero-interactions of these two proteins.
Statistics
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PSSM-Id: 463097
Aligned: 23 rows
Threshold Bit Score: 203.673
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EFX88733      70 SAVRRFFCLFVTFDFLFTTLMWIICLVISGE-NIQQMLIDQIV-----HYT---IHGSLFDIVMASAGRFVILLLFYALL 140
1_pfamImport   1 SPIRRFFCLFVTFDLLLTCLIWLITLVLTGEfNFYTVIHKEIL-----HYT---IRTSSFDIVMASAARFIILLLFYALL 72 
EKC32179      70 SSVRRTFCLIALFDLCFCFILWVIYTQLTGSeTVWEAFEQQVA-----NYQ---FQTSLFDTVMVAALRFILIELGYALF 141
XP_001635683  31 SPSRRMFCLLTAFDFLFTLVAWVIYSHALKE-GLWLSFDTEVA-----HYK---FKSSLFDLLLLSLWRMVVLLLAYALF 101
Q19819        18 SKDRKRFIVITFFDTSITILLWLLCTVTRDD-DWDKVFFNEIN-----IFNpkfIRISLFDIVLLAVLRMLILGVVYGIC 91  Caenorhabditis ...
XP_008196392  60 STVRRFFCMFVTFDLLFTGLMWLICVMLKGE-NIMKALNEQIY-----HYN---VQTSLFDVVLAALCRFVVLLLFYALI 130
XP_012060883  55 SNVRRFFCLFITFDLLFTFLMWLICTMIAGE-SLRTAFTDQVI-----HYH---IKTSLFDIVMAAICRFTVLLLFYALL 125
XP_016773416  55 SNVRRFFCLFVTFDLLLTFLMWLICTMIAGE-SLESAFMNQIV-----HYH---IKTSLFDIVMAAICRFTVLLLFYALL 125
EFN83702      55 SHVRRSFCLFVTFDLLLTFLMWLICTMIAGQ-SLKAAFIDQVV-----HYH---IRTSLFDIVMAAICRFTVLLLFYALL 125
XP_002130557  87 SDPRRTFCLFVTFDFLITVLLWLTECGISST-NGKDPFFTILNfqmshFYK---PSESLFDVTMLAAVRFLFLVLSYAIL 162 vase tunicate
EFX88733     141 CINHWWVIAITTAGSCGFLIIKVFFFEWAK--ATNYTL--DVFLVLSSFVLSWGEAWFLDFRVLPQESLARD-FFRAI-- 213
1_pfamImport  73 RLNHWIIVAITTASTCFFLVAKVCLFDWDT--TGNQVL--QVMLILSSFILSWSEAWLLDIRVIPNERNAENgWFVLNt- 147
EKC32179     142 RLNHWWLIAISTSLTCIFLITKVFLFEFSHdgKAENPL--SYILLLTSFILTWIETWFLDFKVLPTEKKIL----LRGt- 214
XP_001635683 102 VSRKWYTIAVVTTVSTAFVVVKVFFYNFDD--SKGHPM--DFVLVTMSLVLCWIETWVLDFKVIPSENEVEQrSNAGSl- 176
Q19819        92 LVKQWYTVAFTTLASSAYILMKVLFY---FnhSSSAVP--PLLLIITSFTLCWSEFYLMPFQILPRERRYARrELDGI-- 164 Caenorhabditis ...
XP_008196392 131 YMNHWIIVSISTTLTCVFLTAKVFLYDWPH--STQPVF--EVLLVLTSFVLSWGEAWFLDFRVLPQESHARR-FLIT--- 202
XP_012060883 126 YLNHWIIVAISTATTCAFLIAKVFLFDWTS--ANQPVF--QVLLILTSFVLAWAEAWFFDFRVIPQETQARN-WILS--- 197
XP_016773416 126 HLDHWIIVALTTATTCAFLIAKVFLFDWTI--CNQPVF--QVLLILTSFVLPWVEAWFFDIRVLPQETQARN-WFRN--- 197
EFN83702     126 YINHWIIIAISTAATCVFLIGKVFVFDWSS--TNQPVF--QVLLIIISFVLAWAEAWFFDFRVIPQEIQARN-WFRN--- 197
XP_002130557 163 RIKHYWPVAVSTAVSDVLLILKIFGIFAMSkqTSSLNLpmTIVVVLADFVLTWIEVWFVDFKVLPAEMKLAQkTVRDFlq 242 vase tunicate
EFX88733     214 --------------SSDDERAPLLQNQAPSVRS---------HNLDD----------------FYSPIDS 244
1_pfamImport 148 -------------tTNFDERTPLLRNYPNIHSRlda----lsESIYS----------------FYSPAES 184
EKC32179     215 -------------hGEANERSGLLGRAEEGGNRvv-----hdDDKDR----------------YYSPAgs 250
XP_001635683 177 -------------eTTAGERRPLLGENYTGIYNtrt----wlSEHAS----------------FYTPHGS 213
Q19819       165 -------------------ENPEFSTDDEARSNnrhrrgrrqQNSGNqseaptavpsrvssgvFIASDYD 215 Caenorhabditis elegans
XP_008196392 203 --------------NTDSERAPLIQSYVRGLPSmy------tESVGN----------------FYSPLAS 236
XP_012060883 198 --------------FPDTERTPLLQGIVTESR----------QHAANvdhmstfftpvespthsddedis 243
XP_016773416 198 --------------FIDNEREPLLRGVISESRQyt-----nnEHAGT----------------FFTPMDS 232
EFN83702     198 --------------HSATERSPLIQATSESRQNv--------DHMST----------------FFTPMDS 229
XP_002130557 243 qsyqstppqddgrrFV---PRPSYGAT---------------SERAS----------------FYSPAat 278 vase tunicate
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