Conserved Protein Domain Family
Dpy19L4

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cd20180: Dpy19L4 
C-mannosyltransferase Dpy-19-like protein 4 (Dpy19L4)
Dpy19 proteins are C-mannosyltransferases that mediate C-mannosylation of tryptophan residues on target proteins. C-mannosylation is the attachment of alpha-mannose to the indole C2 carbon of the first tryptophan residue in the consensus amino acid sequence Trp-Xaa-Xaa-Trp/Cys through a C-C bond. This reaction takes place in the endoplasmic reticulum (ER) lumen. Dpy19 is a transmembrane domain family whose name is derived from the Caenorhabditis elegans Dumpy mutant. The function of Dpy19L4 (also called protein Dpy-19 homolog 4) is unknown.
Statistics
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PSSM-Id: 439133
Aligned: 6 rows
Threshold Bit Score: 1250.12
Created: 6-Feb-2019
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1: putative glycosylation site [posttranslational modification site], 1 residue position
Conserved feature residue pattern:NClick to see conserved feature residue pattern help
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                                 #       
Q7Z388         51 KIFIGCLAAVTSGMMYALYLSAYHERKFWFsnrqelEREITFQGDSAIYYSYYKDMLKAPSFeRGVYELTHNNKTVSLKT 130  human
XP_006003506   44 KLFFGCMSAVISGMTYAVYLSTYHERRFWFssrqdfEREITFQADSGIYYSYYKQMLKAPTLqRGLLELAFDNKTVSLKT 123  coelacanth
KGL74689       49 KLFFGCLAAVTSGMMYAVYLSTYHERKFWFssrqelEREITFQGDSAIYYSFYKELLKAPSFeRGVYELTHNNRTVSLKT 128  white-throate...
AWP21313      431 KVFFGCVAAVGCGVLYAVYLSTYHDRTFWFstrqelEREITFQAGSGLYYYYFKHMLAAPSFeRGFYELIIDNRTVSGQT 510  turbot
Q5R8N9         14 KIFIGCLAAVTSGMMYALYLSAYHERKFWFsnrqelEREITFQGDSAIYYSYYKDMLKAPSFeRGVYELTHNNKTVSLKT 93   Sumatran oran...
A2AJQ3         50 KIVIGCLAAVISGMMHVFYLSAYHERKFWFsnrqelEREITFQGDSAIYYSYYKDMLKAPSFeRGVYELTHNNKTISLKT 129  house mouse
Feature 1                                                                                         
Q7Z388        131 INAVQQMSLYPELIASILYQATGSneiiEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFVINRVDTTRI 210  human
XP_006003506  124 INTIQQMTLYPELITSFLYQLTGSpeviEPIYFYIGLVFGLQAVYVTALFVSSWIMSGTWVAGMLAVVWYIINRTDTTRV 203  coelacanth
KGL74689      129 INAFQQMTLYPELIASVLYQASGSeeviEPVYFYIGIVFGLQGIYVTALFVTSWVMSGTWLAGMVTVAWFIINRTDTTRI 208  white-throate...
AWP21313      511 INAVERLSLYPELITSFVYRVTGSqdfvEPIYFYVGAVFGLQAVCVTALFVCSWVMSGTWVAGMLAVAWYVINRPDTTRV 590  turbot
Q5R8N9         94 INAVQQMSLYPELIASVLYQATGSkeiiEPVYFYIGIVFGLQGIYVTALFVTSWLMSGTWLAGMLTVAWFIINRVDTTRI 173  Sumatran oran...
A2AJQ3        130 INAMQQMSLYPELIASVLYQATGSneviEPVYFYIGIVFGLQGMYVTALFVTSWLMSGTWLAGMLTVAWFLINRVDTTRI 209  house mouse
Feature 1                                                                                         
Q7Z388        211 EYSIPLRENWALPYFACQIAALTGYLKSNlntygerFCYLLMSASTYTFMMMWEYSHYLLFLQAISLFLLDTFSVEqsdk 290  human
XP_006003506  204 EYAVPLRENWALPYFACQVTALTVFLKQNissavekFCYFLVSTSTFTFLMMWEHSHYVLFVQAIALFLLDSFDLIqsqk 283  coelacanth
KGL74689      209 DYSIPSRENWALPYFACQVAALTGYLKKNlncsaekFCYLLVSASTYTFMMMWEYSHYLLFIQAVSLFLLDSFALAqtek 288  white-throate...
AWP21313      591 DHAIPLRDNWALPYFSCQVAALTGFLSNNicsatemFCYLTMSATTFTFLLVWEHSHYVLFVQGLCLLLLDSFDLVpsrk 670  turbot
Q5R8N9        174 EYSIPLRENWALPYFACQIAALTGYLKSNlntygerFCYLLMSASTYTFMMMWEYSHYLLFLQVISLFLLDIFSVEqsdk 253  Sumatran oran...
A2AJQ3        210 EYSIPLRENWALPYFACQVAALTGYLKRNlntyaerFCYLLLSTSTYTFMMVWEYSHYVLFLQAVSLLLLDIFSVEqsdk 289  house mouse
Feature 1                                                                                         
Q7Z388        291 vyeVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQlnvkkgs-fvakiiKVINFYLVCTLTITLNIIMKmf 369  human
XP_006003506  284 vadVHKVYLCTLCLGYFLQFRNTVLLASPLLSLVAGSLLAKCIQknmkkgpfiarimkVMLHFYVVITITVTLNFIMKki 363  coelacanth
KGL74689      289 vheVYKIYLLSIFSGYLLQFENSALLVSPLLSLVGALMLSKCLQmnmrkgt-fmsrllKIMYIYLVLTVTVTLNFLLKmf 367  white-throate...
AWP21313      671 madIHKVYLSSLFLAYLFQFQNPALLSSPLLSLLIGSVLARYFQqkmkmgplvarvmkLFLHFHLVFTTGITFSYLVKkl 750  turbot
Q5R8N9        254 vyeVYKIYIFSLFLGYLLQFENPALLVSPLLSLVAALMLAKCLQlnvkkgs-fvakiiKVINFYLVCTLTITLNIIMKmf 332  Sumatran oran...
A2AJQ3        290 vyeVYKVYIFSLFLGYLLQFENPALLVSPLLSLVGAFMLVKCLQlngkkgt-fvakviKVFEFYLLCTLPVTLNLIVKmf 368  house mouse
Feature 1                                                                                         
Q7Z388        370 vphKENGHMLKfleVKFGLnmtkNFTMNWLLCQESLQaPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRingksl 449  human
XP_006003506  364 iplNESEYLFNfleVKLGLdttkNFTTSLLLCQESLQvPSQDFFLRLTQTSLLPFYIFVLVICFLSALQVIFRRlcgipa 443  coelacanth
KGL74689      368 iphKENEHLLKfleVKLGLnttkNFTMNWLLCQESLQaPSQDFFLRLTQSSLLPFYILVLIICLFSVTQVIFRRmcgepl 447  white-throate...
AWP21313      751 lpaSEGDFILKfleVKFGLntttDFVTNLLLCQESLQrPSQDLFLRLTQASVLPFYFLVLTVCLLSTLQTIYRRlsgqpm 830  turbot
Q5R8N9        333 vphKENGHMLKfleVKFGLnmtkNFTMNWLLCQESLQaPSQDFFLRLTQSSLLPFYILVLIICFLSMLQVIFRRingksl 412  Sumatran oran...
A2AJQ3        369 vphKENEHVLKfleVKFGLnmtkNFTLNWLLCQESLQaPSQDFFFRLTQSSLLPFYVLVLIICLLSMTQVFFRRmsgksk 448  house mouse
Feature 1                                                                                         
Q7Z388        450 ketvtledgrigerPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFkwlrlrtVHPILLALIL 529  human
XP_006003506  444 kdnvtledgrigerPDVVYHVFHSVLFGSFTMIFEGMKYLWTPYVCMIAAFGVCSPELWMTLFkwlrlrsVHPVLLALML 523  coelacanth
KGL74689      448 ketvkledgrigerPEIVYHVIHTILLGSLAMCLEGMKYLWTPYVCMLAAFGVCSPELWMTLFkwlrlkaVHPILLALIL 527  white-throate...
AWP21313      831 ktnlrledgrigeqPEVVYHVFHTLLFGGLTLLFDGMKYLWTPYVCMFTAFGVCSPDLWMTVFkwlrlksIHPLVLSLVL 910  turbot
Q5R8N9        413 ketitledgrigerPEIIYHVIHTILLGSLAMVIEGLKYIWIPYVCMLAAFGVCSPELWMTLFkwlrlrtVHPILLALIL 492  Sumatran oran...
A2AJQ3        449 ketvtledgrigerPEIIYHVIHTLLLGSLAMLMEGLKFIWTPYVCMLAAFGVCSPELWMTLLkwlrlrtVHPMLLALIL 528  house mouse
Feature 1                                                                                         
Q7Z388        530 SMAVPTIIglslwkefFPRLMTELMELQEFYDPDTVELMTWIKRQAPvAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDD 609  human
XP_006003506  524 STAVPTIIgfslwreyFPRVMTELSELREFYDPDIVELMTWIKRQAPvAAVFAGSPQIMGTVKLCTGWSVASLPLYNDGD 603  coelacanth
KGL74689      528 SMAVPTIIgfslwkefFPRIMTELSELQEFYDPDTVELMTWIKRQAPvAAVFAGSPQLMGVIKLCTGWMVSSLPTYNDDD 607  white-throate...
AWP21313      911 STAIPTIIgfslwreyCPRVLAELSDLQEYYNPDTVELMNWIRSQAPlAAVFAGSPQLLGTVKLCSGSAVTSLPLYSDIN 990  turbot
Q5R8N9        493 SMAVPTIIglslwkefFPRLMTELMELQEFYDPDTVELMTWIKRQAPvAAVFAGSPQLMGAIKLCTGWMVTSLPLYNDDD 572  Sumatran oran...
A2AJQ3        529 SMAVPTIIglslwkefFPRLITELTELQEFYDPDTVELMTWIKRQAPvAAVFAGSPQLMGVIKLCTGWTVTSLPLYSDDD 608  house mouse
Feature 1                                                                                         
Q7Z388        610 LLKRNEniYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGpmRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHE 689  human
XP_006003506  604 LLKRNEnlQQIYAMRSAEDIYKILTSYKANYVIIEETICNDMGtvRGCRVKDLLDVANGHVVYEDGEIYAYSKYGRFCNE 683  coelacanth
KGL74689      608 LLKRNEniYQIYSKRSAEDIYKILTSYKANFLIIEDSICNEVGpvRGCRVKDLLDIANGHVVCEEGDSYAYSKHGRFCHE 687  white-throate...
AWP21313      991 LLRRSEdtYQVYAMRSAEDIYKILTSQKTNYVIIEESICTELSinKGCRIKDLLDIANGHVVYDKGEIYSFSKHGRFCHE 1070 turbot
Q5R8N9        573 LLKRNEniYQIYSKRSAEDIYKILTSYKANYLIVEDAICNEVGpiRGCRVKDLLDIANGHMVCEEGDKLTYSKYGRFCHE 652  Sumatran oran...
A2AJQ3        609 LLQRNEniYQIYSKRSAEDIYKILTSYKANYLIVEDAICNELGttRGCRVKDLLDIANGHVVFEEGDKLTYSKYGRFCHE 688  house mouse
Feature 1                                  
Q7Z388        690 VKinYSPYVNYFTRVYWNRSYFVYK 714  human
XP_006003506  684 IKlsYSPYVNYFTRVFWNRSYHIYK 708  coelacanth
KGL74689      688 IKmnYSPYVNYFTRVYWNRSYFVYR 712  white-throated tinamou
AWP21313     1071 IKmnYSPYTNYFTRVFWNRSYHVYK 1095 turbot
Q5R8N9        653 VKinYSPYVNYFTRVYWNRSYFVYK 677  Sumatran orangutan
A2AJQ3        689 VKinYSPYVNYFTRVYWNRSYFVYK 713  house mouse

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