Conserved Protein Domain Family
GDEase
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cd01303: GDEase 
Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and therefore can play a role in the regulation of cellular GTP and the guanylate nucleotide pool.
Links
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Statistics
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PSSM-Id: 238628
Aligned: 19 rows
Threshold Bit Score: 561.514
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Aligned Rows:
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active site
Feature 1:active site [active site]
Evidence:
  • Comment:active site is based on homology to other members of the amidohydrolase family
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
P76641     11 VRGSFIdvtrtidnp--eeiasalrfIEDGLLLIkqgkvewfgewengk---------hqipdtirvrdyrgkLIVPGFV 79  Escherichia coli
CAB91408   11 FHGAVIhslstpghdleilpaallivEAQGVITAfhkdvkpgevgsli-----------dtatttlhylspsqFIIPGFI 79  Neurospora crassa
NP_816079   6 IKGTGFssknlqei----kvyeetlfCIDEAGVIqeiiepdaeayetvla--------eqkeaqrfqelpqdsYLLPGFV 73  Enterococcus faeca...
NP_346923  10 FKGNLIftktsdkft---imkdsyivVIDGKIASvssnlpdkyk-------------------gnpiidfrnnIIIPGMN 67  Clostridium acetob...
AAO50910   11 FKGTVIhsieigkve--ilpnsligiDEDGVIQHmksnyedlkqlekdvtmi---ctdngineqesvidmgnkFLIPGFI 85  Dictyostelium disc...
EAA33231   16 FYGTFIypktltdle--ylhntavavDQNGTIVAierdfdlsqaastlfprl---gwapdsvsihsslashnqFFFPGFI 90  Neurospora crassa
Q9Y2T3     13 FRGTFVhstwtcpme--vlrdhllgvSDSGKIVFleeasqqeklakew-----------cfkpceirelshheFFMPGLV 79  human
AAF52167    5 FLGTVVhtksf----------sefesFEGGFLAVddagkiigvgqdyhawas---snpahakgltevhlsdyqFLMPGFV 71  fruit fly
Q07729     21 FFGTFVdtpklgelr---irektsvgVLNGIIRFvnrnsldpvkdcldhdsslspedvtvvdiigkdktrnnsFYFPGFV 97  baker's yeast
O14057      9 FVGKLIhtpslgel----eitdatvgVYNGKIVFleksmtpktleeaksh--------hllkeatihklkplqFMFPGLI 76  fission yeast

Feature 1       # #                                                                           
P76641     80 DTHIHYPQSEmvga-ygeqLLEWLNKHTFPTERRYeDLEYAREMSAFFIKQLLRNGTTTALVFGTVHPQSVDALFEAASH 158 Escherichia coli
CAB91408   80 DTHNHAPQWAqrglgqgqhILDWLSAITFPNEGRFrDPSHAQRIYSSAIDGFLRQGITTASYYGSIHPEATNILADLCLA 159 Neurospora crassa
NP_816079  74 DLHVHAPQWAqsgtaldipLYEWLNTYTFPLESKFaDLAFAQQVYDELVTQLLANGTTTALYFATIHYEASRRLAEICAE 153 Enterococcus faeca...
NP_346923  68 DLHAHASQYKnlgigmdkeLLPWLNNYTFPEEAKFlNVDYAKKTYGRLIKDLIKNGTTRVALFATLHKDSTIELFNMLIK 147 Clostridium acetob...
AAO50910   86 DTHAHAPQYHnagtgtdlpLLKWLEKYTFPVESKFkDLIFAENVYGKVVDRMLRHGTTTCCYYATIHLEASELLAEIVSK 165 Dictyostelium disc...
EAA33231   91 DTHLHAPQYPnvgifgkstLLDWLETYTFPLEASLsDPAKARTVYNRVIRKTLSHGTTCAAYYATKDVTTTNLLADLCLR 170 Neurospora crassa
Q9Y2T3     80 DTHIHASQYSfagssidlpLLEWLTKYTFPAEHRFqNIDFAEEVYTRVVRRTLKNGTTTACYFATIHTDSSLLLADITDK 159 human
AAF52167   72 DCHIHAPQFAqlglgldmpLLDWLNTYTFPLEAKFsNHQYAQQVYQGVVEATLRCGTTLASYFATNHLESTLTLAREAVR 151 fruit fly
Q07729     98 DTHNHVSQYPnvgvfgnstLLDWLEKYTFPIEAALaNENIAREVYNKVISKTLSHGTTTVAYYNTIDLKSTKLLAQLSSL 177 baker's yeast
O14057     77 DTHIHAPQYPnsgigidvpLLQWLEKYTFPLESSLaDLEEARQVYKRVVERTLSNGTTFASYFSTLHTPTSALLAEICYS 156 fission yeast

Feature 1                                                                                     
P76641    159 InmRMIAGKVMMDRNa--PDYLLDtaes----syhqSKELIERWhkn-----grLLYAITPRFAPTSSPEQMAMAQRLKE 227 Escherichia coli
CAB91408  160 KgqRAFVGKCNMTRNs--PDYYRDasveq---slrdTESCIAHIrkidp-egmlLKHVLTPRFAISCDADGLAGLGQIAA 233 Neurospora crassa
NP_816079 154 KgqRGLIGKVVMDDLnenPEYYRDqttqq---aleeTERFIQEIqtlaqqtkqgVYPVVTPRFIPSCTEEALKGLGELAA 230 Enterococcus faeca...
NP_346923 148 SgiGAYVGKVNMDYNc--PDYLTEnyit----slndTEEIILKYkdk----sniVKPIITPRFVPSCSNELMDGLGKLSY 217 Clostridium acetob...
AAO50910  166 RgqRAFIGKVCMDRHs--PDHYVEtteq----sisnTKEFVDRIlakg---nplVQPIVTPRFAPSCTDELMVALGNLSH 236 Dictyostelium disc...
EAA33231  171 AgqRALVGRVCMDQLs--PKYYRDasaadsvaatreSITYIESIdpt----gtiVRPVITPRFAPSCSAPLMAELGKLAA 244 Neurospora crassa
Q9Y2T3    160 FgqRAFVGKVCMDLNdtfPEYKETtees-----ikeTERFVSEMlqkn---ysrVKPIVTPRFSLSCSETLMGELGNIAK 231 human
AAF52167  152 QgqRALIGKVCSNCNs--PEFYVEtaee----svsaTLAFVEGVrklg---spmVMPTITPRFALSCSKELLKSLGDIAK 222 fruit fly
Q07729    178 LgqRVLVGKVCMDTNg--PEYYIEdtkt----sfesTVKVVKYIreti--cdplVNPIVTPRFAPSCSRELMQQLSKLVK 249 baker's yeast
O14057    157 YgqRAYIGKCNMNNLs--PDHYCEksaes---sleaTRQLISYMsildp-kremVTPIITPRFAPSCTEDLLSGCGELAE 230 fission yeast

Feature 1              #  #                                          #                        
P76641    228 EYpdTWVHTHLCENKDEIAWVKSLYPd------hDGYLDVYHQYGLtg-knCVFAHCVHLeEKEWDRLSETKSSIAFCPT 300 Escherichia coli
CAB91408  234 KNpdLPIQTHFNEAEQEITATRELFPq------fSSEADLYHHYGLlt-krSILAHCCYMaPHEFDKLKELQCGVAHCPI 306 Neurospora crassa
NP_816079 231 KYq-VHVQSHCSESDWEHQFVQERFE--------KNDAQALNDFGLlt-ekAVMAHAGFLeEADMNLFHETGTAVAHCPI 300 Enterococcus faeca...
NP_346923 218 KYr-LPVQSHLSENLDEIAVVKSLHKk------sNFYGEVYDKFGLfgntpTLMAHCIHSsKEEINLIKRNNVTIVHCPT 290 Clostridium acetob...
AAO50910  237 EKq-TLIQSHLSENKDEIEWVKSLYPg------iESYTHVYKHFNLln-erTIMAHCVHLsDEEIKLISTQQTAISHCPI 308 Dictyostelium disc...
EAA33231  245 ETg-LPVQTHISENEGEIALVKEMFPakkigakgDTYTHVYDTFGLlt-dkTILAHGVHLsEEEVQIIKARGSKVSHCPC 322 Neurospora crassa
Q9Y2T3    232 TRd-LHIQSHISENRDEVEAVKNLYPs------yKNYTSVYDKNNLlt-nkTVMAHGCYLsAEELNVFHERGASIAHCPN 303 human
AAF52167  223 RFd-LHIQSHISENLEEIEMVKGIFK--------TSYAGAYDEAGLlt-nkTVLAHGVHLeDDEVALLKVRGCSVAHCPT 292 fruit fly
Q07729    250 DEn-IHVQTHLSENKEEIQWVQDLFPe------cESYTDVYDKYGLlt-ekTVLAHCIHLtDAEARVIKQRRCGISHCPI 321 baker's yeast
O14057    231 KHn-LPIQTHISENTSEIELVKELFPe------rKSYADVYDYYKLlt-pqTILAHAIHLeDEEIELLTKRSSGISHCPT 302 fission yeast

Feature 1                                 #                                                   
P76641    301 SNLYLGSGLFNLKKAWQKKVk--VGMGTDIGAGTTFNMLQTLNEAYKVLQLQgyrl------------------------ 354 Escherichia coli
CAB91408  307 SNMTVGGGFMAAPIREFLNRgikVGLGTDSGGGFSSSMLDAIRQAMIASHAReveskgr--------------------- 365 Neurospora crassa
NP_816079 301 SNAYFGNAVTPIAKLVHQHQv-eVGLGSDLSGGFSPSLFDNLKQAVISSRMLedgvdatkkpev---------------- 363 Enterococcus faeca...
NP_346923 291 SNFNLGSGMMPVRKYLNLGIn--VVLGSDISAGHTCSLFKVIAYAIQNSKIKwqesgkk--------------------- 347 Clostridium acetob...
AAO50910  309 SNFTLSSGNLDVRKVLEANIk--LGLGSDISGGYHPSILQVIRDSIKCSNSHffnngnh--------------------- 365 Dictyostelium disc...
EAA33231  323 SNSALTSGAARVRWLLERGIe--VGLGTDMSGGYSPSVLEMARQAALVSRHVamgcapakkenkgekenkgekeseaete 400 Neurospora crassa
Q9Y2T3    304 SNLSLSSGFLNVLEVLKHEVk--IGLGTDVAGGYSYSMLDAIRRAVMVSNILlinkvne--------------------- 360 human
AAF52167  293 SNTMLSSGLCDVQRLVSGGVs--VGLGTDVSGGNSVSIQDVLLRALDVSKHLdffkkqnirgtgvs-------------- 356 fruit fly
Q07729    322 SNSSLTSGECRVRWLLDQGIk--VGLGTDVSAGHSCSILTTGRQAFAVSRHLamretdh--------------------- 378 baker's yeast
O14057    303 SNSILASGLANVRKLLDSGIn--VGLGTDVSGGYAPSILIALRHAAMTSRSLsyvlgdp--------------------- 359 fission yeast

Feature 1                                                                                     
P76641    355 ------------------------------sayEAFYLATLGGAKSLglddlIGNFLPGKEADFVVMEptatplqqlr-- 402 Escherichia coli
CAB91408  366 --------------------------dkglkiaEAFYLATLGGAEVCcledkVGNFEVGKEFDALVVDwqrdgvmtiv-- 417 Neurospora crassa
NP_816079 364 ----------------------rgvktaritvnEAFYLATAGGGQALsl--pIGKLEKGYAWDVQIINtslsqaripk-- 417 Enterococcus faeca...
NP_346923 348 --------------------------dmflstsEAFYMATKKGGSFFg---kVGSFEEGYDFDALVINdsnlype----- 393 Clostridium acetob...
AAO50910  366 ---------------------------tpltfeEAFYLATVGGSKVVnldhrIGNFIVGKDFDAQIIDpfvqnspfdc-- 416 Dictyostelium disc...
EAA33231  401 gktnedgnsekeskanqankdgidrerakltveEVLYLATKGGAELVgmkgkVGGFEVGMEWDAQLIGlgrdvvdgeyed 480 Neurospora crassa
Q9Y2T3    361 ---------------------------ksltlkEVFRLATLGGSQALgldgeIGNFEVGKEFDAILINpkasdspidlfy 413 human
AAF52167  357 --------------------ktqdfnyhqlkykQALYLATLGGAKALsldhlTGNFALGKDFDALLVDvsvvdkpl---- 412 fruit fly
Q07729    379 ---------------------------aklsvsECLFLATMGGAQVLrmdetLGTFDVGKQFDAQMIDtnapgsnvdmfh 431 baker's yeast
O14057    360 --------------------------kvmldlsELLYLATQGGAEVVsrgdqVGSFAVGKYWDALIVDlsaethscvd-- 411 fission yeast

Feature 1                                                         
P76641    403 ----------------------ydnsvslvdkLFVMMTLGDDRsiyRTYVDG 432 Escherichia coli
CAB91408  418 -----------------------eeedeldtvFEKFVMTGDDRnivRVLVKG 446 Neurospora crassa
NP_816079 418 -----------------------npgeslldiFQKILYLARPEnirEVWVQG 446 Enterococcus faecalis V583
NP_346923 394 -------------------------dydlterLERFIYLGDDRnimKRYVCG 420 Clostridium acetobutylicum
AAO50910  417 -----------------------fdgetlkdiFQKFIYLGDDRnlsSLYIKG 445 Dictyostelium discoideum
EAA33231  481 eeke------------eegnvdvfgweswpnkVAKWLFNGDDRntrKVWVKG 520 Neurospora crassa
Q9Y2T3    414 ---------------------gdffgdiseavIQKFLYLGDDRnieEVYVGG 444 human
AAF52167  413 ------------------------rrlsvdelVEKFIYTGSDRnivEVFVAG 440 fruit fly
Q07729    432 wqlkekdqmqeqeqeqgqdpyknpplltnediIAKWFFNGDDRnttKVWVAG 483 baker's yeast
O14057    412 ----------------------iferdtwpvmLSKWVFTSDDRnlaQVWVNG 441 fission yeast

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