Conserved Protein Domain Family
MYSc_Myo19

?
cd14880: MYSc_Myo19 
class XIX myosin, motor domain
Monomeric myosin-XIX (Myo19) functions as an actin-based motor for mitochondrial movement in vertebrate cells. It contains a variable number of IQ domains. Human myo19 contains a motor domain, three IQ motifs, and a short tail. The catalytic (head) domain has ATPase activity and belongs to the larger group of P-loop NTPases. Myosins are actin-dependent molecular motors that play important roles in muscle contraction, cell motility, and organelle transport. The head domain is a molecular motor, which utilizes ATP hydrolysis to generate directed movement toward the plus end along actin filaments. A cyclical interaction between myosin and actin provides the driving force. Rates of ATP hydrolysis and consequently the speed of movement along actin filaments vary widely, from about 0.04 micrometer per second for myosin I to 4.5 micrometer per second for myosin II in skeletal muscle. Myosin II moves in discrete steps about 5-10 nm long and generates 1-5 piconewtons of force. Upon ATP binding, the myosin head dissociates from an actin filament. ATP hydrolysis causes the head to pivot and associate with a new actin subunit. The release of Pi causes the head to pivot and move the filament (power stroke). Release of ADP completes the cycle. CyMoBase classifications were used to confirm and identify the myosins in this hierarchy.
Statistics
?
PSSM-Id: 276846
Aligned: 17 rows
Threshold Bit Score: 1299.05
Created: 7-Jan-2013
Updated: 2-Oct-2020
Structure
?
Aligned Rows:
  next features
Feature 1:ATP binding site [chemical binding site]
Evidence:

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1                                   ##########                                           
AFH34098      49 ETVLRCLQARymadrfYTNAGCTLVALNPFKPIPQLYSPELMREYhaapqpqklkphVFTVGEQTYRNVKsliepvnqsi 128  rhesus monkey
NP_079690     49 ETVLRCLQARytedifYTNAGCTLVALNPFKHVPQLYAPELMQEYhaapqpqklkphIFTVGEQTYRNVKsliepvnqsi 128  house mouse
EGV94928      49 ETVLRCLQARytedifYTNAGCTLVALNPFKPIPQLYAPELMQEYhaapqpqklkphIFTVGEQTYRNVKslikpinqsi 128  Chinese hamster
NP_001157208  49 ETVLRCLQARytedifYTNAGCTLVALNPFKHIPQLYAPELMQEYhaapqpqklkphIFTVGEQTYRNVKsliepinqsi 128  Norway rat
ELR58852      46 ETVLRCLQARymadtfYTNAGCTLVAMNPFKPVPQLYSPELMREYhaasqpqtlkphIFTVGEQTYRNVKsliepvnqsv 125  Bos grunniens ...
NP_001019672  49 ETVLRCLQARymadtfYTNAGCTLVAMNPFKPVPQLYSPELMREYhaasqpqtlkphIFTVGEQTYRNVKsliepvnqsv 128  cattle
EPY89280      63 ASVLRCLQARytadtfYTNAGCTLVALNPFKPVPQLYSPELMREYhaapqpqklkphIFTVGEQTYRNVRsliepvnqsi 142  Wild Bactrian ...
EMC88972      64 TTVLKCLQARyrvnlfYTNAGCSLVALNPFQPVSCLYSPELMREYhgalhpqdlkphIFAVAEQTYRNVQsqrepvnqsi 143  rock pigeon
EOB05137      47 TTVLKCLQARytvnlfYTNAGCSLVALNPFQPISCLYSPELMREYhvavrpqdlkphIFAVAEQTYRNVQsqidpinqsi 126  mallard
Q569U0        62 ATVLKCLQARysagvfYTNAGCTVVAVNPFQPVYKLYSSEVMKDYhstsnpqgckphIFTVAEQAYRNVQsqiqpvnqsi 141  African clawed...
Feature 1           ########                                             ###########             
AFH34098     129 vvsGESGAGKTWTSRCLMKFYAVVaaspaswethkiaeriEQRILnSNPVMEAFGNACTLRNNNSSRFGKFIQLQlnraq 208  rhesus monkey
NP_079690    129 vvsGESGAGKTWTSRCLMKFYAVVaasptscenhkiaeriEQRILnSNPVMEAFGNACTLRNSNSSRFGKFIQLQlnraq 208  house mouse
EGV94928     129 vvsGESGAGKTWTSRCLMKFYAVVasssascenhkmaeriEQRILnSNPVMEAFGNACTLRNNNSSRFGKFIQLQlnraq 208  Chinese hamster
NP_001157208 129 vvsGESGAGKTWTSRCLMKFYAVVaasptscenhkmaeriEERILnSNPVMEAFGNACTLRNNNSSRFGKFIQLQlnraq 208  Norway rat
ELR58852     126 vvsGESGAGKTWTSRCLMKFYAVVaasptsweshkvaeriEQRILnSNPVMEAFGNACTLRNSNSSRFGKFIQLQlngaq 205  Bos grunniens ...
NP_001019672 129 vvsGESGAGKTWTSRCLMKFYAVVaaspmsweshkvaeriEQRILnSNPVMEAFGNACTLRNSNSSRFGKFIQLQlngaq 208  cattle
EPY89280     143 vvsGESGAGKTWTSRCLMKFYAVVaasptsweshkiaeriEQRILnSNPVMEAFGNACTLRNNNSSRFGKFIQLQlnrdh 222  Wild Bactrian ...
EMC88972     144 ivsGESGAGKTWTSRCLMKFYASIaasvispkgnetveriEKRVLdSNPVMEAFGNACTLRNNNSSRFGKYIQLQldrsh 223  rock pigeon
EOB05137     127 ivsGESGAGKTWTSRCLMKFYASVaasvtspkdnetveriEKRVLdSNPVMEAFGNACTLRNNNSSRFGKYIQLQldrfh 206  mallard
Q569U0       142 ivsGESGAGKTWTSRCLMKFYATVsasrcyit-nemveriEGRVLdSNPVMEAFGNACTLRNNNSSRFGKYIQLQlnraq 220  African clawed...
Feature 1                                                                                        
AFH34098     209 qMTGAAVQTYllektrvacqasSERNFHIFYQICkgaseDERLQwhlpegaafswlpnpersleeDCFEVTREAMLHLGi 288  rhesus monkey
NP_079690    209 qMTGAAVQTYllektrvacqasSERNFHIFYQICkgatkDERLQwhlpegtafswlpnpessleeDCFEVTREAMLHLGi 288  house mouse
EGV94928     209 qMTGAAVQTYllektrvacqasNERNFHIFYQICkgatkDERLQwylpegaafswlpnpennleeDCFELTREAMLHLGi 288  Chinese hamster
NP_001157208 209 qMTGAAVQTYllektrvacqaaSERNFHIFYQICkgatkEERLQwclpegtafswlpnpessleeDCFEVTREAMLHLGi 288  Norway rat
ELR58852     206 qMTGAAVQTYllektrvacqapSERNFHIFYQIYkgahaEERVQwrlpegaafswlphpertleeDCFEVTREAMLHLGi 285  Bos grunniens ...
NP_001019672 209 qMTGAAVQTYllektrvacqapSERNFHIFYQIYkgahaEERVRwrlpegaafswlphpertleeDCFEVTREAMLHLGi 288  cattle
EPY89280     223 qMTGAAIQTYllektrvacqdsTERNFHIFYQICkgasaDERLQwhlpegaafswlpnpertleeDCFEVTREAMLHLGi 302  Wild Bactrian ...
EMC88972     224 hLSSASIQTFllektrvayqapNERNFHIFYQITkgataEERLEwnlpegaeyrwlpnsernldeDCFEVTRDAMFHLGi 303  rock pigeon
EOB05137     207 hLSSASIQTFllektrvayqapNERNFHIFYQITkgataEERLEwnlpegadyrwlpnsernldeDCFEVTRDAMFHLGi 286  mallard
Q569U0       221 qITGASIQTYllektrvahqapLERNFHIFYQMFkgasrLEREEwnlpekanfswlpnyennleeDDFEVTKKAMLHLGi 300  African clawed...
Feature 1                                                                                        
AFH34098     289 dtPTQNNIFKVLAGLLHLGNiqfaasedeaqpcqpmddakcsvRTASLLlglpeDVLLETVQIRTIragrqqqvfrkpcp 368  rhesus monkey
NP_079690    289 dtPTQNNIFKVLAGLLHLGNvhfvdsedealpcqvmddtkvsvRTSALLlqlpeKMLLESMQIRTIkagkqqqvfqkpcs 368  house mouse
EGV94928     289 dtPTQNNIFKVLAGLLHLGNvhftdsedeaqpcqlmdgtkvsvRTSASLlhlqeDLLLETMQIRTIkagkqqqvfrkpcs 368  Chinese hamster
NP_001157208 289 dtPTQNNIFKVLAGLLHLGNvhfvdsedeaqpcqlmdgtkgsvRTSALLlqlpdNMLLESMQIRTIkagkqqqvfqkpcs 368  Norway rat
ELR58852     286 daPTQNNIFQALAGLLHLGNtrfadsgneaqpcllvddaqcsvGTSALLlglpeDHLLETLQIRTIragrgqqvfqkpcs 365  Bos grunniens ...
NP_001019672 289 daPTQNNIFQALAGLLHLGNtrfadsgneaqpcplvddaqcsvGTSALLlglpeDHLLETLQIRTIragrgqqvfqkpcs 368  cattle
EPY89280     303 daPTQNNIFQALAGLLHLGNirfadsgdeaq--pcrpmddgavRTSALLlrlpeDPLLETLRIRTIragrqqqvfrkpcs 380  Wild Bactrian ...
EMC88972     304 drSTQNNIFKVLSGLLHLGNiqfsnpvdeaqpceledktkdfvKTSGDLlkipvEELLESLRIRTItagkqqqvfkkpcs 383  rock pigeon
EOB05137     287 drSTQNNIFKVLSGLLHLGNiqfsnpldesqpceledktkdfvKITGDLlkipvEELLESLRIRTItagkqqqvfkkpcs 366  mallard
Q569U0       301 dqPTQNNIFKILSGLLHLGNikfsdsvdesqpceplnytqefaSIAANLlkipvSHLLERLSIRTItagkqqv-fkkpcr 379  African clawed...
Feature 1                                                     ######                             
AFH34098     369 RAECDTRRDCLAKLIYARLFDWLVSVINSSIcadtdsWTTFIGLLDVYGFESFPdnSLEQLCINYANEKLQQHFVAHYLR 448  rhesus monkey
NP_079690    369 RAECDTRRDCLAKLIYARLFDWLVSVINSSIcadsksWTAFIGLLDVYGFESFPnnSLEQLCINYANEKLQQHFVAHYLR 448  house mouse
EGV94928     369 RAECDTRRDCLAKLIYARLFNWLVSVINSSIcadsssWTAFIGLLDVYGFESFPdnSLEQLCINYANEKLQQHFVAHYLK 448  Chinese hamster
NP_001157208 369 RAECDTRRDCLAKLIYARLFDWLVSVINSSIcadfssWTAFIGLLDVYGFESFPdnSLEQLCINYANEKLQQHFVAHYLR 448  Norway rat
ELR58852     366 QAECNTRRDCLAKLVYARLFDWLVSVINSSIcaapdsWTTFIGLLDVYGFESFPnnSLEQLCINYANEKLQQHFVAHYLR 445  Bos grunniens ...
NP_001019672 369 QAECNTRRDCLAKLVYARLFDWLVSVINSSIcaapdsWTTFIGLLDVYGFESFPnnSLEQLCINYANEKLQQHFVAHYLR 448  cattle
EPY89280     381 QAECDTRRDCLAKLVYARLFDWLVSVINSSVcadpasWTTFIGLLDVYGFESFPhnSLEQLCINYANEKLQQHFVAHYLR 460  Wild Bactrian ...
EMC88972     384 RAECETRRDCLAKAIYAKLFEWLVLVINESIyadpsaWTSFIGLLDVYGFEAFPenSLEQLCINYANEKLQQHFVAHYLK 463  rock pigeon
EOB05137     367 RAECETRRDCLAKVIYAKLFEWLVSVINESIfadtsaWTSFIGLLDVYGFEAFPenNLEQLCINYANEKLQQHFVAHYLK 446  mallard
Q569U0       380 KSECDTRRDCLAKTIYARLFEWLVTVINENIcaescrWNNFIGLLDVYGFESFPenNLEQLCINYANEKLQQHFVSHYLK 459  African clawed...
Feature 1                                                                                        
AFH34098     449 AQQEEYAVEGLEWSFVNYqdnQACLDLIegspiSICSLINEECrlnrpssAAQLQTRIetalagspclghnklsrepSFI 528  rhesus monkey
NP_079690    449 AQQEEYEVEGLEWSFVNYqdnQTCLDLLegspiSICSLINEECrlnrpssAAQLQTRIestlagrpclghnklsrepSFV 528  house mouse
EGV94928     449 AQQEEYAVEGLEWSFVNYqdnQTCLDLLegspiSICSLINEECrlnrpssAAQLQSRIesalagkpclghnklsrepSFV 528  Chinese hamster
NP_001157208 449 AQQEEYEVEGLEWSFVNYqdnQTCLDLLegspiSICSLINEECrlnrpssAAQLQTRIestlagrpclghnklsrepSFV 528  Norway rat
ELR58852     446 AQQEEYAVEGLEWSFVSYqdnQPCLDLIegspvSICSLMNEECrlnrpssAAQLQTRIesaltshprlgrdrlspepSFI 525  Bos grunniens ...
NP_001019672 449 AQQEEYAMEGLAWSFVSYqdnQPCLDLIegspvSICSLINEECrlnrpssAAQLQTRIesaltghprlgrdrlspepSFI 528  cattle
EPY89280     461 AQQEEYAVEGLEWSFVNYqdnQTCLDLIegspiSICSLINEECrlnrpssAAQLQTRIesalagspclghnklspepSFV 540  Wild Bactrian ...
EMC88972     464 AQQEEYAAEGLQWSFINYqdnQNCLELIeanplSIFSLLNEECrlnrpsnTHLFQTRIekalsnnqclsrnkfskepNFI 543  rock pigeon
EOB05137     447 AQQEEYAAEGLQWSFINYqdnQNCLDLIegnplSIFSLLNEECrlnrssnPDLFQTRIekalsdnqclsrdkfskkpNFI 526  mallard
Q569U0       460 SQQDEYAAEGLEWSFISYqdnQSCVDLLegspiSIFSLLNEECrlnrsldAGQLQSRLenalshnkcigrdkfskkpNFI 539  African clawed...
Feature 1                                                                                        
AFH34098     529 VVHYAGPVRYHtaGLVEKNkdPVPPELTRLLQQsqdpllmglfptnpkektqeepsgqsrnpvltvVSKFKASLEQLLQV 608  rhesus monkey
NP_079690    529 VVHFAGPVRYHtaGLVEKNkdPVPPELTELLQQsqdplltmlfpanpeektqeelsgqsrapaltvVSKFKASLEQLLQV 608  house mouse
EGV94928     529 VVHFAGPVRYHteGLVEKNkdPVPPELTGLLQQsqdpllmmlfpdnpeektqeelsgqsrvpaltvVSKFKASLEQLLQV 608  Chinese hamster
NP_001157208 529 VMHFAGPVRYCtaGLVEKNkdPVPPELTGLLQQsqdpllmmlfpanpeektqeelsgqsrapaltvVSKFKASLEQLLQV 608  Norway rat
ELR58852     526 VLHYAGPVRYRtaGLVEKNkdPVPPELTRLLQQsqdpllkvlfpadpedksqeepsgqnrapvltvVSKFKASLEQLLQV 605  Bos grunniens ...
NP_001019672 529 VLHYAGPVRYRtaGLVEKNkdPVPPELTSLLQQsqdpllkvlfpadpedkspeepsgqnrapvltvVSKFKASLEQLLQV 608  cattle
EPY89280     541 VLHYAGSVRYHtaGLVEKNkdPIPPELTRLLQQsqdtllkvlfpadpeeksqeepsgqsrapvltvVSKFKASLEQLLQV 620  Wild Bactrian ...
EMC88972     544 ISHYAGKVCYQlaAMVEKNkdPIPPELVNVLQNskdpllqklfpvaegn--qnniktqnraavvtvVSKFKGSLEHLMQL 621  rock pigeon
EOB05137     527 ISHYAGKVCYQleAMVEKNkdPIPPELIHVLQNskdpllqklfpatern--qnnvrtqnraavitvVSKFKGSLENLMQI 604  mallard
Q569U0       540 VSHYAGKVQYQieDMAEKNkdPVPPELIQLLQEsddhllqklfpvdnnk--lvygatnnravgvtvVSKFKGSLESLMQI 617  African clawed...
Feature 1                                                                                        
AFH34098     609 LHstTPHYIRCIKPNsqgqaqtfvQEEVLSQLEAcGLVETIHISAaGFPIRISHQNFVERYKLLRRLRPHTSSGPHSPYT 688  rhesus monkey
NP_079690    609 LHntTPHYIRCIKPNsqsqpqtflQEEVLNQLEAcGLVETIHISAaGFPIRVSHQNFIERYKLLRRLGPRMSSGLGGLEP 688  house mouse
EGV94928     609 LHstTPHYIRCIKPNsqskpqtflQKEVLSQLEAcGLVETIHISAaGFPIRVSHQNFVERYKLLRRLRPRTSSGLQGLCP 688  Chinese hamster
NP_001157208 609 LHktTPHYIRCIKPNsqsqpqtflQEEVLNQLEAcGLVETIHISAaGFPIRVSHQNFMERYKLLTRLRPRTSSGLRSLCP 688  Norway rat
ELR58852     606 LHgtTPHYIRCIKPNsqaqaqifhREEVLSQLEAcGLVETIHISAaGFPIRVSHRNFMERYQLLRRLRPAITPSPHDPCP 685  Bos grunniens ...
NP_001019672 609 LHgtTPHYIRCIKPNsqaqaqifhREEVLSQLEAcGLVETIHISAaGFPIRVSHRNFMERYQLLRRLRPAITPSPHGPCP 688  cattle
EPY89280     621 LQatTPHYIRCIKPNsqgraqalhREEVLNQLEAcGLVETIHISAaGFPIRVSHRTFVERYASLRRLHPRAPPDPHSPSP 700  Wild Bactrian ...
EMC88972     622 VNstTPHYIRCIKPNagckamtfqREEVLSQLQAcGIVEAITISAaGFPVRIPFQSFTERYEILRKSYPSNKNRVFFAGE 701  rock pigeon
EOB05137     605 LNstKPHYIRCIKPNadckaltfkKEEVLSQLQAcGIVEAITISAaGFPIRISFESFTERYEILRRSRGYNKKILQYLLF 684  mallard
Q569U0       618 LHstTPHYIRCIKPNvdcqalvfrQEEVLMQLEAcGIVETINISAaGFPIRISFENFVERYSVIAPRQSHMKTCFPLKKK 697  African clawed...
Feature 1                                                                  
AFH34098     689 AKGLPEwcphseeamlesliqdilhtlpvltqaaatpgdsaeampaPMHCGRTKVFIT 746  rhesus monkey
NP_079690    689 AEGSSEqplcakeatlqpllqdilhalpaliqtaatpsdpakntqiPLYCGRTKIFMT 746  house mouse
EGV94928     689 ARGPSEqplcakdatlqpplqdilhalpaliqtattpsdpaettqvPLYCGRTKIFMT 746  Chinese hamster
NP_001157208 689 AKGSSEqplcakeatlqpllqdilhalpaliqtattpsdpaktaqiPLYCGRTKIFMT 746  Norway rat
ELR58852     686 DGGRSEcppctepatlqg-----------------llqeilhalpaPLHCGRTKVFMT 726  Bos grunniens mutus
NP_001019672 689 DGGRSEcppctepatlqg-----------------llqeilhtlpaPLHCGRTKVFMT 729  cattle
EPY89280     701 DEGHSEgsphaeqatlrallqdilh--tlpaleaatpaapagatpaPVHCGRTKVFMT 756  Wild Bactrian camel
EMC88972     702 APLEGDaeasrsvifeilrnvv--------tgqtaaeqprnraentSVYCGKTKVFMA 751  rock pigeon
EOB05137     685 NAPFAGktavidddkasrsvifeilq-nvvtgqtaaeptgkrsdntSVYCGKTKVFMA 741  mallard
Q569U0       698 QGSIEKtdqlssklhtilqa------------vlpkqckdstlsnsLVHCGTTKVFLT 743  African clawed frog

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap