Conserved Protein Domain Family
ODR4-like

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pfam14778: ODR4-like 
Odorant response abnormal 4-like
In C.elegans, odr-4 and odr-8 are required for localising a subset of odorant GPCRs to the cilia of olfactory neurons. Olfactory receptors (ORs) are synthesized in endoplasmic reticulum of the olfactory neurons, trafficked to the cell surface membrane and transported to the tip of the olfactory cilium, where they bind with odorants. Various accessory proteins are required for proper targetting of different ORs to the cell membrane. ODR-4 was the first accessory protein to be described.
Statistics
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PSSM-Id: 464311
Aligned: 51 rows
Threshold Bit Score: 226.086
Created: 25-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEH51996      30 GLLLGK-LeVG-SRDVVLALVPTPAkeeddddaGGGPGPGRdaSSSsa------------aaASasalEIDEDWIVEHAT 95 
KJE97509      27 GLLIGQ-MtAG-QRDHIVAIVPTPKdetasattATTTATEQgaGASkkaaagktpassnatsMQaqieGIDQEWVVAHAR 104
XP_003288942  25 GLLIGQqSnIN-DEAYVLGFFPSPPqlseysdtNTEKKQEQqeKIT----------------TNdlkkLIDKEWILEFCF 87 
Q54QH3        26 GLLIGQeSeISeQQTFVLGLFPTPLnisntdddNNNKPINIdsISS-----------------------IDKEWILEYCH 82  Dictyostelium d...
XP_004355872  30 GLIIGQ-------NQVFIGSVPTPPlygddnqiTKYKTIK----------------------------DFDQIWISEHAR 74 
EFA79156      30 GLLIGQq--QNeTKATFLSMISTPKpfdnqnveYKTTK------------------------------DIDDVWVAEHSR 77 
XP_004231486  29 GLVIGN-IsGKlDRGFIFDLIPTPVndngepacSIIGEAKDdrKKApkg----------kslPNsstlFIDKDWLAEHAR 97 
XP_005844179  28 GTLVGR---SSpGKDLLLQALRTPNsdgvaplsVTAGSTAKkgGKGgkp-----------ssSAggglLLDEELVVEHAT 93 
XP_008187864  27 GVIIGQ---VIgNNYHVVHLSAMTIwnediqnnKIDVLSYKtlSDL----------------------LANSDTIFQKSL 81 
EFP09578      44 YFLLGSf--CSdNDIHVAYASKCPVhssa-----------------------------levnAPekakMLEEDWMADHAE 92 
EEH51996      96 QATRMLPGGIHVVGVYV---FASDVAMKR-----AssAALRAAIEvgiaeraldvyAPPPPASSSSSsssSSSVLtRHQA 167
KJE97509     105 QVRQALPGGIDVVGVYIy--APSDLSLKTs----StaAKLRQLVTavgans--------------------lnagePHAI 158
XP_003288942  88 QVYRMLYGGISIVGFYIitpDNEILNDDD--------EFFIKLLKfldanmtepikSIQFI------------------- 140
Q54QH3        83 QVNIMLYGGIDIVGIYMiipDSDTLNEKNn------eSFIMKLLK-----------SIHTIINSKSLqf----------- 134 Dictyostelium d...
XP_004355872  75 QVSKLMYGGVSVVGIYLsvpSIATLTTDS-----KndSLLWKILK-----------SIRDSLISDRKcmrQREEVvVYSQ 138
EFA79156      78 LVSKMLYGGINITGICLsvpSINVVNDAN----------LAQILK-----------SIRTTLIQERSyltNII------- 129
XP_004231486  98 QVGRMLVGGVKVVGIYV---WTNESSFK------NstITLCQAAKsvaeaapllevHWD--------------------- 147
XP_005844179  94 IVERLLPGGLDVMGFYVl--CPATAFA-------GttALLSALVGqaarel--------------------------sgr 138
XP_008187864  82 EVATLLPGGSHVLGLFFi--VPQDLKSIQ---------------------------PIDIDFYEFNNelnENLLYkKTNE 132
EFP09578      93 RLLRMLPGGIHVVGVAWf--SDKKTFTERkphihKtlGRIQKMNNqit------taNVDESISD---------------- 148
EEH51996     168 spERLVVHLSaDARGKVVVKRCALADP--GGDlRHVEHRLGKV---AAS--LIRIDATYDVRC--ELELEREGGKtkTM- 237
KJE97509     159 tsERYLVHVC-SATKKRIVRTLDVADH--RASlATAEWKAQNT---FAK--FRTISATYHLDS--LVPLAGATGDtgMV- 227
XP_003288942 141 -----------SYSLKTNLINGKLTNSslNYRlKSTEIKIINS---LENe-FLKFSCNFPIDI--VLHSKKKIEDi---- 199
Q54QH3       135 ----------iSYSKKTGLINGKATNStqLYRlKSTEIKVINN---LENe-FLSLHCILPIDI--KLKSKNGMIS----- 193 Dictyostelium d...
XP_004355872 139 tlENMHVLIYlRSTKQYILKSHDMTTVkyEKFkQQSDNIVFPSpniSKTlsCFKLVTSLSIQL--DIDLNNTAVD---Le 213
EFA79156     130 --KTLYVLIYiRSTKQYILKSISSASTd-NKFkQITDIKFTQP---TQDflYLSLNTTLNIKM--KLNSSKQ------Fn 195
XP_004231486 148 --ERLLVHIG-YSPLRWTCRNCSLASNitSGNiRPCDFKMGKI---LST--RQAFRCTYDFDW--RLPIYQGSSNkkL-- 215
XP_005844179 139 lpTMLVLHID-SISGALSLREVAa-----GGSlRPCEFKLAGL---LDQ--MVQLQCRYEIRL--QVPVTRGKQEl---- 201
XP_008187864 133 twNYLMLNYS-TVNKKSYCYSVDFNr---VNGpEKTTYKTVDAvfgSFNndWVTLIGTFNFGAleRLNVGGGPKA----- 203
EFP09578     149 --NMITVFFE-TPSTTPIGAIIDVTNRg-NDSaQKVQFQKLE---------WISLVTNASARVvhNVPVESGKPTd---- 211
EEH51996     238 ---RDAAGAAIER-EATRVMASRV-L-LDGTFARPEEDVv----------GvvgadVRAAPVRAELLCpPR------ASS 295
KJE97509     228 ---VSQVIKAFKP-VLAQLASAET-V-FDSTLASTALDTplp-----------esaKGQSSVTVTIVTaLPsfasfnDLK 290
XP_003288942 200 --nVVDLKKQVKE-TFNNLFKDSLfL-IDNEVVKENIISstl------------knSNNNNFSIDILIkQLdsnftiESS 263
Q54QH3       194 ---FENLKKDIIEiFENQLFKESTlL-IENEFVSGNEIIsq-------------qfKSKSKLNIDLLInQLdsistsSLE 256 Dictyostelium d...
XP_004355872 214 ivlKKQIESMY---YSSELKDSMYlVnGDDSLILPPTTLvknikknnsnsDgtsssSSSSCHQIDLLLnQPilklsnQPT 290
EFA79156     196 vemFNEMKQLIEKnLYSQLKKSIVfT-VDNQYCPMDSTGst-------vkLsefanGKSPIVVVDALMsGTdivlgrDSA 267
XP_004231486 216 ---VDILHHGISI-HAQELKGAKA-L-IDGKLANEDEq-----------------fDLGGVRVVEFLL-PF--------M 263
XP_005844179 202 ---HAVLQSAADS-AVDQVHGALG-L-VSGQLATDDCQVad-------laDdgsgsGGGGPIPVDLLLqPSsslvfcTAG 268
XP_008187864 204 ---LFSIRDSLLDkFESVLNKSVY-T-FNGCVCDENKTLkd-------veCdeidnLLKNVVKIEFYRe-------vDLG 264
EFP09578     212 --fYSDLMVATKN-FVNNIFHCEFtL-LDGEIRDEKEPLikd-----------ikkNKKTTIEATLFLnPLhnrepgATD 276
EEH51996     296 SSSAAAAAsgGGRGGG-----------VTL-RGTITSRCYAYGRESIARACEDVKGDVVNSLRSRLGVLCDLAdsADDAA 363
KJE97509     291 LTSTSIATttS----------------VSV-SGDVYVTAVVHPKATMAEAQQALLSDLVRTTSIRLAYLAEDLadSLAAQ 353
XP_003288942 264 NTPFH----------------------FQF-NSNTNCIAFAHKSEQVSTIYQYIKQDIIKSFESRLDIINDELlnNPSVV 320
Q54QH3       257 FNFNN--------------------------NNNTHCIAYIHQLEQIKTAFKFIKKDIIKSVESRFDLLFNEIssNNNNN 310 Dictyostelium d...
XP_004355872 291 TISTTPITiaSATLADysdiqqpqpfkLMIqSGIFECKAYINEKETLETAINYLYQDLVGQFISRLETLFDQIitNNRSI 370
EFA79156     268 VT-------------------------LHFgNGVQQYRAYALKSESITNTLEYLLHDIINSLESRVELLIDNNdvDQSNM 322
XP_004231486 264 EDTYLEVCsqKEITGL-----------LVF-SGSVCSYAYSNSKEPSSQALADIKEDIIKSLRSRLDIMCDEAdrKSDSK 331
XP_005844179 269 GGKAGSGLqhGSAEGPtl-------glILL-AACLDCRACVHRREAATAAVNAIRADLKRSLQARMDALLDAAeqQQEAS 340
XP_008187864 265 NECKNASLkvKRGKGK-----------ILM-SGLCSIAVPFNRNGTIKDAIKAIHEDAMQTFATRLKMHLESMveEESLE 332
EFP09578     277 ELASNMHE-------------------ILF---DIEVRAAVPIRTSVKDAIRAIKHHLVRNLFARVELHYESMevVEEER 334
EEH51996     364 AAAAdEKEdsdaaaaaahplse-kgdpfpggdwgpkRRASIALPRRAWARWTvggeaegdarHRGVQLCDYLTADEGAAE 442
KJE97509     354 ADSS--------------------------------AMLVQPSPVRSLFSLPh---------LPSFPLSDYAYEDDSAEI 392
XP_003288942 321 SNQSnSILti-------------------------sNDLPILLPRRVNIQWIgn----------sITICDYLSNHDEIND 365
Q54QH3       311 DNDQdNIKls-------------------------kESPILELPRRVNIQWLsn----------kISICDYLSSNGTIDD 355 Dictyostelium d...
XP_004355872 371 SKYFtCFVn--------------------------sPTLQVPLPKRVSIGWVd-----------hIDICDYLNEDEPLQD 413
EFA79156     323 S-----------------------------------KSTEITLPRRASVQWInn----------nIELCDYLYDAEGYYD 357
XP_004231486 332 EDRTeESNnqilsgsav----------lqldlqlqrKHCSMSFPRRVFLPWLa-----------dTFLCDYIQPSESVEV 390
XP_005844179 341 AAEAeQRQqggnsssseaaaafppvhpllsavahcsKPLVVSLPRRAFVAAVppa--------rgVSFCDYLFEGESTQA 412
XP_008187864 333 EEDGd-------------------------------ANIVHETPRRILIIKTe---------GSRFAFSDYVFPGETSQE 372
EFP09578     335 SPKT--------------------------------GITVHQLPRPATTVLYt---------HPAILINDFLFEADNVED 373
EEH51996     443 VVARAKEVLGCDVVGGVDGV 462
KJE97509     393 LEQRLSDLFGLKVTALAAAS 412
XP_003288942 366 CIERLSDLLQFDSPSSKIIS 385
Q54QH3       356 CYKIINDLL--QITSPKINS 373 Dictyostelium discoideum
XP_004355872 414 CKNRLLELLGLNLEEVITSS 433
EFA79156     358 FQQRIQELTNLEFSHQS-ES 376
XP_004231486 391 LVDHFADLMSLEFPSISSII 410
XP_005844179 413 LLARLQMLLLMPGLATAAVE 432
XP_008187864 373 ALYVAGEIL--NLPEDKIEL 390
EFP09578     374 AQKNFDDMMDLQTSIEHVDE 393
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