Conserved Protein Domain Family
Stk19

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pfam10494: Stk19 
Serine-threonine protein kinase 19
This serine-threonine protein kinase number 19 is expressed from the MHC and predominantly in the nucleus. Protein kinases are involved in signal transduction pathways and play fundamental roles in the regulation of cell functions. This is a novel Ser/Thr protein kinase, that has Mn2+-dependent protein kinase activity that phosphorylates alpha -casein at Ser/Thr residues and histone at Ser residues. It can be covalently modified by the reactive ATP analogue 5'-p-fluorosulfonylbenzoyladenosine in the absence of ATP, and this modification is prevented in the presence of 1 mM ATP, indicating that the kinase domain of is capable of binding ATP.
Statistics
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PSSM-Id: 431315
Aligned: 47 rows
Threshold Bit Score: 121.255
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EON64937      78 RDRMFSDVPErGSGMNSTRTAEVLNYRLN-LP--------PIVTVAHIHSFT-N-SPTSIDREIAELIRSGKIRKLVIPG 146
XP_006685681 121 EHLVFQ-----LKGLAMSTKAEIMKYRTThIPq-------GLVTTNQLYSIFdKeGNTFVDRNIELSIRKGQIRKFVITN 188
XP_002614347 101 QDLLFS-----LRGLSMEVKAEILKYRNHqLPr------gGMVTVNQLYTVFeHrGNTFVDRSLEKCIRDGLVMKFVITN 169
EER34893     117 EERILS-----LKGISQQVKIEILRFRRN-LPn-------GLITTTQLYSIFlNqNNTFVDKSLELNIRQGKLRRFVISN 183
EMG47184     110 EERIFS-----LKRLSSDAKVAILKFRKG-FPs-------GLVTVTQLYSIFlNqNNTFVDKSVELGVRQGKLRKFVINN 176
CCE44862     116 EEKVFQ-----IKGLSSTLKAELIRYRHS-LPq-------GLVAITQLYAIFhNeGPTFVDKSLELNIRKGILRKFIITN 182
XP_001525879 139 EEVIFQ-----IKGLSLTSKAELVKFRLS-FPs-------GIVTINQLYSIFsAqGNTFVDKQVELNVRQGLLRKFVLNN 205
XP_002277335  22 esedydealsleqslTFSDTLVALRIMRAqFPqiekvsvqPFILRSQLYSSVk--DRTQVDRELESLRRDKVLRIFKLNT 99 
Q5XVE4        36 gavsedqclpledDLTFSDTSVALRMMRAqFPridqasipPFILQSQLYSSVn--DRTQVDRELECLRREKVVRVFKLNT 113 thale cress
XP_006005728  32 kramfQDVPDtKAALKYLASLFPRKLFNDsLP--------PVVLKHQLYSIVk--DKTTVDRQLNELKDQGEIRIFQLGF 101
EON64937     147 RNAGRAagrdAVG-----------DCLVLFSDWERLV----RSHPDLTDGLK--------------------EKYVTLLR 191
XP_006685681 189 AAPIIQtsndQARngkitygyenvEVLVKTGVFYSKI----QETLSKLTDSFqik---------------vlQKFEKFTK 249
XP_002614347 170 ASPVISrsgkSGTyhkvtygyensEVVVKKEQYLRLI----DESMGKEKPEss------------------lVKFKEYVM 227
EER34893     184 ASPVISrslnRFEsgkvtygfenvDLIVKSKEYFKLI----MELKTKLEEELederlptslrnkkvtglsslVKFLNYLQ 259
EMG47184     177 ASPVISrssnKFQsgkvtygfenvDILVETETYFEMI----KSAINASQEDltatpeqr------klalsslTNFQNYLN 246
CCE44862     183 ASPVISrshnKFQvnkvtygfediEVIAKVDYFHKLI----KKVMSGLDDKSssk--------------qalVKFNELIS 244
XP_001525879 206 ASPVILrsinRLQmrkvtygyenvELLVKTEDYYKNL----INIVESTDKENeklr-------------ltmSKFLNLAK 268
XP_002277335 100 GQDD--------------------HAIMFMDDYLNQIerviKRMAAKKQDELav-----------------fEWFKTHVI 142
Q5XVE4       114 GQDD--------------------HAIIFLDDYLNQVdrivKRMEEKKQSDLei-----------------fKLFKMHVL 156 thale cress
XP_006005728 102 ATDV--------------------FGIVFTDEYKNKV----LAATAGKEHSVv------------------tQKFLETVL 139
EON64937     192 ATQTSSIA------SSA----L----TH-SEAATLTSAGFLISTtasahsstadfflrpsvassgtlsslasagsraaag 256
XP_006685681 250 ENPTTLFI--------StedsF----LE-SELTTLVELGFITLTsn---------------------------------- 282
XP_002614347 228 SHPEALFVtt---------edF----SV-EEITKLVKLGFLTLTsn---------------------------------- 259
EER34893     260 ESPSATSI-------TSmnsgL----AK-EELSHLMNLGFVTLSsn---------------------------------- 293
EMG47184     247 KSPSALYVtg---------dtF----ANqDEVSYLVKSGFLTLSsn---------------------------------- 279
CCE44862     245 LHPTEMFIst---------ldF----TN-EEVSNLVQLGFITLTsn---------------------------------- 276
XP_001525879 269 SSPLQMFIst---------slF----DD-YEVSMLIQMGYLTLTt----------------------------------- 299
XP_002277335 143 TSKLEPSIehqelcSLLs---FggnvKD-EHISLLINAGLLTRQ------------------------------------ 182
Q5XVE4       157 DSKLEPSIghhellSLLs---LggkvKD-AHITLLINAGLLTRQ------------------------------------ 196 thale cress
XP_006005728 140 MSCSDISFnkekmlKEFl---F----RD-KEITQLMNAGVITVR------------------------------------ 175
EON64937     257 tleavggvnalhnvggsgggtaisggarAAAASGAQYNFSLPNTGPYLRLLTTARSHLVTLLGKSsRYREAPVSLLRDRW 336
XP_006685681 283 ---------------------------hKNEIESQQYALSFPNCGTYLKLVNNGRSWLVKTLNKC-KFHELLESELFNRW 334
XP_002614347 260 ---------------------------hHNEIDIHDYALAYPKCGTFLKIVNSGRAWLVRILSKM-TYKEMLEDTIYEKW 311
EER34893     294 ---------------------------hLNEIESNEYAISYPSCGTYLKLVNAGRSWLVKVLNKL-KFKELLEDQLITKW 345
EMG47184     280 ---------------------------hLNEIEVSQYAISYPSCGTYLKMINAGRTWLVKLLNKG-KFKELLEDQIQSKW 331
CCE44862     277 ---------------------------hFNEIE-HKYSISYPGCGTYLKLVNEGRTWLVKSLNRN-KHKEALEEELFRKW 327
XP_001525879 300 ---------------------------nFSSSEEAQLEISYPGCGRFLRLINEGRMWLVGTLNRN-THKEMLEDELFRKW 351
XP_002277335 183 ------------------------------LIDPNMYWFAIPNIGSLLKGLSQGRKELLSFLNRR-RYKEMMLAPLEKK- 230
Q5XVE4       197 ------------------------------LIDPDMYWFAIPSTGKLWKGLSQGRNELLSLIKRK-RHKEMFLAELEKK- 244 thale cress
XP_006005728 176 --------------------------------DAGSWWLAIPGAGRFVKYFIKGRKHVLGMIKKT-KYKEVLQSDLETR- 221
EON64937     337 DGgvadd-statqAKKvrgefvgvlpgrtkKWRTFWGLRFEWVLEEAVGMGLVEAFQTgSVGLGVRV 402
XP_006685681 335 EGidlndnskmsnFRK-----------------PFYGFDLNWILADALGAGIIEVFNT-PVGRGWKL 383
XP_002614347 312 EGkim------anFRR-----------------PFYGYDLTWILADSWGSGVVEPFNT-PVGRGWRL 354
EER34893     346 QGinpqgnskmnnFRA-----------------PFYGYDLNWVLADALGAGVVEVFNT-PVGRGWRL 394
EMG47184     332 EGftpqgnskmnnFRA-----------------PFFGYDLNWVLADALGAGVIEVFNT-PVGRGWRL 380
CCE44862     328 SGmnpegdpklnnFRK-----------------PFYGYDLHWVLADGLGSGIVEVFNT-PVGRGWRL 376
XP_001525879 352 MGvslegdlklnnFKK-----------------PFYGYDLHWVLADAFGGGIVEVFNT-PVGRGWRL 400
XP_002277335 231 -------------------------------RLRLSPLDMRFHLRDLIGSGHVKTVHT-PTGLVVRV 265
Q5XVE4       245 -------------------------------RLRFSPLDVRFHVRDLIGSGHLKTVQT-TSGLIVRI 279 thale cress
XP_006005728 222 ------------------------------KMVSAVKLGIQYHVHDIIGAELVTCIPT-TSGTLLRL 257
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