3DOU,5KYG


Conserved Protein Domain Family
FtsJ
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pfam01728: FtsJ 
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FtsJ-like methyltransferase
This family consists of FtsJ from various bacterial and archaeal sources FtsJ is a methyltransferase, but actually has no effect on cell division. FtsJ's substrate is the 23S rRNA. The 1.5 A crystal structure of FtsJ in complex with its cofactor S-adenosylmethionine revealed that FtsJ has a methyltransferase fold. This family also includes the N terminus of flaviviral NS5 protein. It has been hypothesized that the N-terminal domain of NS5 is a methyltransferase involved in viral RNA capping.
Links
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Statistics
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PSSM-Id: 426399
Aligned: 226 rows
Threshold Bit Score: 70.6955
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
3DOU_A          5 LRSRAafKLEFLLDRYR-------VV--R--KG---------DA----VIEIGSSPGGWTQVL-----NSL--------A 47   Thermoplasma ...
Q0N437         47 VRNRCyhKLREIDQQFN-----------VcqNV---------NL----FLDLCGGPGQFAKYV-----IDNnp------- 90   Clanis biline...
AXR98050       43 RHRRCwhKMKELDERFN--------L--C--RNv--------RL----YVDLCGGPGQFANYI-----SNNst------- 86  
P41469         35 RRPRCwrKLSEIDKKFH-----------VcrHV---------DT----FLDLCGGPGEFANYT-----MSLnp------- 78   Autographa ca...
Q7Q7A5        108 FVTQAfaKLYECVSAYE--------LidGqqQE---------LY----SVHLCEAPGAFVTGL-----NHYirlhcaprT 161  Anopheles gam...
Q174Y1        120 FVTQAfaKLYECVATYE--------LvpPfsVG---------KHrefySVHLCEAPGAFITGLnhylkLNRgde--vkwR 180  yellow fever ...
Q9UAS6        110 FVTVAwcKLFECLHRYP-------LV--Tk-PA---------VN----SMHLCEAPGAFIASL-----NHYlhs--kyeK 159  fruit fly
Q65148        105 IVTNAwlKMYELLNTMN--------F--N--NTs-------------qAFCNCELPGGFISAI-----NHFnyt--mmhY 152  African swine...
XP_001608975  127 LVTNAwvKLYEILEFYK--------V--V--ETliprlaedgGTi--nSFHLSECPGGFIAAL-----NHAikq--rnsT 185 
Q4UCQ7        148 LVTNAwlKFYEILEVYKlveylkpNF--Kt-EG---------GTl--tSFHISECPGAFIASL-----NHNlkskn---- 204  Theileria ann...

3DOU_A         48 ----RKIISIDL-QEX------------E----EI--AGVRFI-------------RCDIFKETIFD--------DIDRA 83   Thermoplasma ...
Q0N437         91 ---gCKGFGTTLrNSCdy--------qyK----HEdfKKIYGKh-----------nSGNIFEESLRY--------EIN-M 135  Clanis biline...
AXR98050       87 --lnSQGYGVTLrNHLd-----------Y----NVfvPNFCAVygd--------anTGDIFEEDIQN--------KLN-M 132 
P41469         79 ---lCKAYGVTLtNNSvc--------vyK----PTvrKRKNFTtitg------pdkSGDVFDKNVVF--------EIS-I 128  Autographa ca...
Q7Q7A5        162 k---WAWFACTLnPHYeg--------ncP----GNmiPDDRFIlhtlgswcfgadgTGDIMVRENRD--------AIIKR 218  Anopheles gam...
Q174Y1        181 ----WFANTLNPyYEGnc--------lgN----MIadDRFILHtmdswc--fgadyTGDIMRKENLGeivrrskdFPM-- 240  yellow fever ...
Q9UAS6        160 deikWRWRSTTL-NPYyegn-----ainQ----MI--SDDRFIvhtldnwffhkdlTGNLLDVANID--------HLVE- 218  fruit fly
Q65148        153 p--tFNWVASSL-YPSsetda--ledhyGly-qCNpdNWLMQSpllkk---nvdynDGDVTIASNVK--------NLALR 215  African swine...
XP_001608975  186 a--nLSWQATSL-NPYhegnshmeclaeDilyrDTvtNWLTGSd-----------eSGNINKTANIE--------YIWDR 243 
Q4UCQ7        205 yngeLKWYATSL-NPY-----------------YEgnNHNVVL-------------AEDILLKETYQ--------NWL-L 244  Theileria ann...

3DOU_A         84 LrEeg-------ieK-----VDDVVSDAX-AKVSGI-PSRDHAVS---Y-QIGQRVXEIAVRYLRNGGNVLLKQFQ--GD 143  Thermoplasma ...
Q0N437        136 WcGg----------L-----CDLVMADGA-VDVSGReNEQEQIML-----PLLKREIEICLENVRPGGACVLKIFDtyQE 194  Clanis biline...
AXR98050      133 LcGh----------R-----CDLVVADGG-IDVYG--KENDQELI---MlPLIAKQCEIILDCLRVGGNSVLKIFD--TF 189 
P41469        129 KcGn----------A-----CDLVLADGS-VDVNG--RENEQERLnfdL-IMCETQLIL--ICLRPGGNCVLKVFD--AF 185  Autographa ca...
Q7Q7A5        219 SqRf---------pT-----VHLVTADGSiDCLNVPeEQEERVAK---L-HLAETVLAL--SVLSPGQHFVLKMFTl-FE 277  Anopheles gam...
Q174Y1        241 --------------------INLVTADGSiDCLDVPeAQEEHVSK---L-HLAEAVTAL--KILTTDGCFILKMFTf-FE 293  yellow fever ...
Q9UAS6        219 --Rc---------eVefqgqVDLVTADGS-IDCAAQ-PDCQEEIV---V-RLFFAEVLSALRILSSGGNFLVKMFTl-FE 280  fruit fly
Q65148        216 AtQrl--------tP-----IHLYTADGG-INVGHD-YNKQEELN---L-KLHFGQALTGLLSLSKGGNMILKHYTl-NH 275  African swine...
XP_001608975  244 VsRaskfnkgrapvL-----VDIVTADGS-FCCQAD-PNNQETLT---A-PLKLSEVVCALGLMRVGAIFILKMFTl-FE 311 
Q4UCQ7        245 GyDns-------gnI-----TKSSTADGS-FNCQFD-PNNQELLT---S-PLKFAEVVCALgLLRVGGCFIIKMFNl-FE 305  Theileria ann...

3DOU_A        144 XTN-DFIAI-WR-KNFSSYKISKPPASRGSSSEIYIXFFGF 181  Thermoplasma volcanium
Q0N437        195 DTV-ALLEYfVS--HFSEHTVFKPKSSRAANSEKYLVCQRR 232  Clanis bilineata nucleopolyhedrovirus
AXR98050      190 ARN-TFVVLeSFiSNFSEFYVFKPVSSRPANAERYLVCLNR 229 
P41469        186 EHE-TIQMLnKFvNHFEKWVLYKPPSSRPANSERYLICFNK 225  Autographa californica nucleopolyhedrovirus
Q7Q7A5        278 HSSvSLLFL-LN-HCFDELHVFKPCTSKPGNSEVYIVAKHY 316  Anopheles gambiae str. PEST
Q174Y1        294 HSSvDLLYL-LY-VCFRELHVFKPATSKPGNSEVYVIAKYF 332  yellow fever mosquito
Q9UAS6        281 ACSvSLLYT-LN-CIFEEVHIFKPATSKRGNSEVYVICLNY 319  fruit fly
Q65148        276 AFTlSLICV-FS-HFFEELYITKPTSSRPTNSETYIVGKNR 314  African swine fever virus BA71V
XP_001608975  312 ESSlSIFTI-LK-MCFKTVEVYKPHLSKSNGSEVYVVCIGF 350 
Q4UCQ7        306 EPSmSIIAL-LS-LCFKRLEVYKPFLSREANSEVYVICLDF 344  Theileria annulata
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