2QX5


Conserved Protein Domain Family
Nic96

?
pfam04097: Nic96 
Nup93/Nic96
Nup93/Nic96 is a component of the nuclear pore complex. It is required for the correct assembly of the nuclear pore complex. In Saccharomyces cerevisiae, Nic96 has been shown to be involved in the distribution and cellular concentration of the GTPase Gsp1. The structure of Nic96 has revealed a mostly alpha helical structure.
Statistics
?
PSSM-Id: 461172
Aligned: 99 rows
Threshold Bit Score: 200.499
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
2QX5_B        73 AQLLESWKILESMKSKDi-----------------NIVEVGKQYLEQQFLQYTDNLYKKNMNE----GLA---TNVNKIK 128 baker's yeast
CAM44024     300 DDLTVLWASIvqiiepmqr--------rgsevdilSYVASSRRVMERKSLSRLLERMLR--------MDPirfEEVENLS 363
XP_004984390 259 VTMQKMWHLIQALVGEGsthrn--------vsrkmSLVIGARHHLEWGHEKYILETINSHPALaalgGSV---GNLQKIR 327
O22224       247 VNMQKIWQLVQAITGEDsavrqg-------vskrmALAIGARHHLQHGHEKFIMDTIQTHPTQaalgGSV---GNLQRIR 316 thale cress
XP_009384164 249 VTMQKIWHLIQALVGEYsnnrqk-------fsrkmSLVIGARRHLEWGHEKYILDMIKTHPSQaalgGAV---GNLEKIQ 318
XP_011436563 220 KPVMDLWEQVRYMVDVPmissnsvkesrtdyrtqaAFVQKGKEYLEQMYSKHIQNTIYSNLQQaqlgGIP---STYNQVK 296
XP_001633614 214 KSVRDFWPFIKDLGEIGhsresphki-rfspefqvQFLERARHFLEERYLRYVQETVYDNLQSaqlgGVP---GTFPLVK 289
XP_002108984 221 ANIVDIWDLIYEIADIEitevidplalryeaesqmLFINKARNCLERRYLDYVKKTIYGNLHQaklgGVP---STYHTVK 297
XP_008984160 218 KNISDMWTMVKQMTDVLltpatdplknrssvevrmEFVRQALAYLEQSYKNYTLVTVFGNLHQaqlgGVP---GTYQLVR 294
XP_005814359 219 KNVSDLWLMVKQMADVLlvpardalksrtavemqmAFVRQALGFLENRYKSFTMGTVFGNLHQaqlgGVP---GTYQLVR 295
2QX5_B       129 SFIDTK-----LKKAD-KSWKISNLTVING---VPIWALIFYLLRAGLIKEALQVLVENKANIKKVEQSFLTYFKAYASS 199 baker's yeast
CAM44024     364 ASHLLD-----IIARScGATNH--------------WMHAFVAMRVGRYDVAQ--LATDAIGIQSVRDAVA---KVAAAP 419
XP_004984390 328 AFMRVR-------LRDqGVLDFDATDLRRQppvDTTWQQIYFCLRTGYYDEARQVAQSSRAAH-----NFAPLLADWIST 395
O22224       317 AFLRIR-------LRDyGVLDFDSTDARRQppvDTTWQQIYFCLRTGYYEEAREIARSTRSSQ-----QFAPLLTEWITT 384 thale cress
XP_009384164 319 AFLRVR-------LRDhGMLDFDTTDIRRQppiDTTWQQIYYCLRTGYYDEAKKVAESSRAAH-----QFAPQLAEWIAS 386
XP_011436563 297 SYLNVRpp-hiKGLED-GHVD--------G---HPVWAMIYFCLRCGDLQAALQVTEKASHSL-G---DFPAFLREYVTD 359
XP_001633614 290 SFLKIKlphgaQGLED-GDLD--------G---TPIWPLIYYCMRCGDPDSALQAVGYIPQHL-S---DFKDFFREYINS 353
XP_002108984 298 SFLNITmpnsvLNLED-GLVD--------D---KPVWAMIYYCIRCGDLKAMLNAADL--QYL-G---EITNYLEEFANS 359
XP_008984160 295 SFLNIKlpaplPGLQD-GEVE--------G---HPVWALIYYCMRCGDLLAASQVVNRAQHQL-G---EFKTWFQEYMNS 358
XP_005814359 296 SFLNIKlpgplPGMQD-GEVE--------G---QPVWAVIYYCLRCGDMNAAMTVVSRAQHQL-G---DFKSWFQEYMSS 359
2QX5_B       200 KDHGLPVEYSTKLHTEYNQHIKSsl-----dGDPYRL-AVYKLI-----GR----CDLSRKNIP-AVTLSIEDWLWMHLM 263 baker's yeast
CAM44024     420 PAERNTMPPASDLQPVYAEAKTK--------EDPYRQ-AVLIVLlagrtGEnpavVLRTLLNLAqRVTDSLEDALWLRLS 490
XP_004984390 396 NGAV-SQDTALAASEECDKMLRMgdrpgrpgYDRKKL-LLYAII-----CGcrrqIDRLLKDLP-TLFNTIEDFLWFKLS 467
O22224       385 DGMV-AAESAAIASEECEKMLRMgdrlgrtaYDKKKL-LLYTII-----SGsrrqIERILRDLS-TLFNTIEDFLWFKLS 456 thale cress
XP_009384164 387 GGSV-SPETAAVASEECEKLLRMgdragrpgYDRKKL-LLYAII-----SGsrrqVERLLRDVP-SLFGTIEDFLWFKLS 458
XP_011436563 360 EDNRLSAASETKINLHYRRIIKNq-------NDPYKR-AVFCVV-----GR----CDPAEDHSE--IADKIDDYLWIKLS 420
XP_001633614 354 DRRRINPSTESKVRLQYRRSVRTs-------QDPFKR-AVYCLV-----GH----CDLADNHQE--LATKTEDYLWLKLS 414
XP_002108984 360 PNHSISAPSATKVQLMYKRSEGHs-------SDPFKRfELFTVL------------------WE--VVTRLIVTLKLQLK 412
XP_008984160 359 KDRRLSPATENKLRLHYRRALRNn-------TDPYKR-AVYCII-----GR----CDVTDNQSE--VADKTEDYLWLKLN 419
XP_005814359 360 PDKRLSPASENKLRLHYRRALRNs-------ADPYKR-AVYCLI-----GK----CDVNDSHGE--VADKTDDYLWLKLN 420
2QX5_B       264 L-----------IKEk------dAE-NDPVYER---YSLEDFQNIIIS-YGPSRF------SNYYLQTLL----LSGLYG 311 baker's yeast
CAM44024     491 C-----------IRGvdksaqvsPVqSLRTLQR---AVLDDMQELVSItQGNAYr-----lASFFIHALLpstgLRLLLE 551
XP_004984390 468 A-----------LREhn-----nASsSSVLNEGlvpYTLDDLQSYLNK-FEPSYYtksgkdPLIYPYVLF----LSIQLL 526
O22224       457 C-----------IRDvt-----gGSsSVVLNDGlapYSLDDLQAYLNK-FEPSYYtkngkdPLVYPYVLL----LSVQLL 515 thale cress
XP_009384164 459 A-----------IRDcp-----gGSsSIVLSEGlvpYNLDDLQGYLNK-FEPSYYtkngkdPLVYPYVLL----LSIQFL 517
XP_011436563 421 Q-----------IQGdsd---------ssRQDG---FTLQRLQSLLYEdFGESHFngy-qnPFLYFQILI----LTAQFE 472
XP_001633614 415 L-----------VSVdq----------sdAQDE---MTLDQLQILLLEqFGETHFgay-qqPFLYFMVLF----LTGQFE 465
XP_002108984 413 QkiifglrhgitISNtpne------dnsqSQEV---FTLPQLQTLLIDhYGESHFnay-qqPLLYFRVLL----LTMQFE 478
XP_008984160 420 Q-----------VCFdddg-------tssPQDR---LTLSQFQKQLLEdYGESHFtvn-qqPFLYFQVLF----LTAQFE 473
XP_005814359 421 Q-----------VCFddds-------sssPQDR---LTLPQLQKQLLEdYGESHFsas-qqPFLYFQVLF----LTAQFE 474
2QX5_B       312 LAIDYTYTfSE-----MDAVHLAIGLASLKLFKI---DS-STRLT------Kkp--kRDIRFANILANYT-KSFRYSDPR 373 baker's yeast
CAM44024     552 NSITH-----------VDGFHMTLCFNAQNLLQGrlhSAl----------------eAPIDIARHMSRYCsVVLLDVDRR 604
XP_004984390 527 PAILYLSKeIGedgyhVDAVHISIALADHGVLPDgvgSGq-----------KigvmdACAEAASIIRQYGsIYLRSGNID 595
O22224       516 PAIMHLSKeAGdggynIDAVHIAISLVDHSVLSEgsgTGh-----------KlsvmdSNAEASSMIRQYGsMFLHHGDLQ 584 thale cress
XP_009384164 518 PAVLYLFKeVGeegynVDAVHISIALADNGVLSDgigTDr-----------KigvmdACAEVASIIRQYGsVYLRQGNLE 586
XP_011436563 473 AAIEFMSRiDRl---lCHAVHVALVLYELKMLMLpp-sTqAQLLTkessdeGp---lRRLNFVRLITMYT-RKFEATDPR 544
XP_001633614 466 AAVEFLSRvEFf---rSHAVHIAISLYEMGLLAVse-sLqTQLLTtdpstpQp---fRQLNFARLIMSYT-RKFEMTDPR 537
XP_002108984 479 AAIEFLFRiARy---rTHSIHFAISLYEAHILSLsk-sSqSQLLeps--dpQp---sRRLNFCRLIMSYI-RKFEGTNTR 548
XP_008984160 474 AAIAFLFRmERl---rCHAVHVALVLFELKLLLKss-gQsAQLLShepgdpPc---mRRLNFVRLLMLYT-RKFESTDPR 545
XP_005814359 475 AAVAFLFRvERl---rSHAVHVALVLYELRLLLKss-gQsAQLLSqepgdpPm---vRRLNFIRLLMLYT-RKFESTDPR 546
2QX5_B       374 VAVEYLVLITLNEG--------------PTDV-ELCHEALRE-LVLETKEFTVLLGKIGR-DGARIP------GVIEERQ 430 baker's yeast
CAM44024     605 IRATVFAGTAMFAYf------------hKSGLtEAFVECCLKdLICA-----RLLGPRNTvGGHDSLllragtGALSEE- 666
XP_004984390 596 LALEYYAQAAAAMGggevswigqgnadqQRQRsLMLKQLLTE-ILLRDGGIQLLLGP----SGMGEE------GELKKYM 664
O22224       585 MTVEYYAQAAATVGggqlawsgrsnvdqQRQRnLMLKQLLTE-ILLRERGIYFLLGA----RGSGEE------GQLGRFF 653 thale cress
XP_009384164 587 LALEYYAQAAAAMGggevswigrgssdqQRQRnMMLRQLLTE-VLLQDGGISLLLGP----RGTGEE------GALSKYI 655
XP_011436563 545 EALQYFYFLNDLRT--------------SQGE-NLFMSCVSE-LVLETREFEMLLGKMEP-DGTRRL------GAIDK-- 599
XP_001633614 538 EALQYFYLLRNIKR--------------PHGG-DLFMECVSE-LVLETREFEMLLGKLEP-NGTRKP------GCIDK-- 592
XP_002108984 549 EALQYLYLLKGIKN--------------PQGE-DVFESSLSE-LALETREFDMLLGSLNS-DGSKKL------GCIDK-- 603
XP_008984160 546 EALQYFYFLRDEKD--------------SQGE-NMFLRCVSE-LVIESREFDMILGKLEN-DGSRKP------GVIDK-- 600
XP_005814359 547 EALQYFYFLRNEKD--------------SQGE-NMFMRCVSE-LVIESREFDMLLGKLEK-DGSRKP------GIIDK-- 601
2QX5_B       431 PLLHVRDEKefLHTITEQAARRADEDGRIYDSILLYQLAE--------------EYDIVITLVNSLLSDTLSAsdldqPL 496 baker's yeast
CAM44024     667 -----------LLKALIQVAEAASARSEVAKATHVLLAVAclanqlhrpelqqrALRRAVQIMSPALAQVLHlps----- 730
XP_004984390 665 MDWRS------RQQFLLEAAHRCQEAGLYDKAVEIHKRVG--------------DFAMALQIINKCLSDAVCamarnm-- 722
O22224       654 PDSRL------RQQFLVEAAHQCQEAGLYDKSIELQKRVG--------------AFSAALETINKCLSEAICslargr-- 711 thale cress
XP_009384164 656 MDWNS------RQQFLLEAARQCQEAGLYDKSVEIHKRVG--------------AFSVALETVNKCLSDVICamsrgr-- 713
XP_011436563 600 --FH---HD--TQRIIELVARDTENKGMFEEAVMLYDLGD--------------KHDKVLELLNRLISQVVSQ-----PN 653
XP_001633614 593 --FQRDRQD--TQAIIERVAKDTEEKGLFEEAIRLYDLAK--------------NHDKTIELMNKLISQVVST-----CG 649
XP_002108984 604 --FYISG----AKAVIEKVAVESEKKGLFEEAIKLYDLAK--------------NHEKVLEILNRLLSQVVPK-----SN 658
XP_008984160 601 --FT---SD--TKPIINKVASVAENKGLFEEAAKLYDLAK--------------NADKVLELMNKLLSPVVPQ-----IS 654
XP_005814359 602 --FA---GD--TRTIISKVALEAENKGLFEEAVRLYELAK--------------NPDKVLELMNRLLSPVIAQ-----VS 655
2QX5_B       497 VGPDDNSETNPVLLARRMAS--IYFDNAGISR-QIHVKNKEICMLLLNISSIRELYFNKQWQETLSQMELLDLLPF---S 570 baker's yeast
CAM44024     731 ---rssVVSDVLSQAAQLQQavNAVPH-HLHDeAVGAQDYQTFAQLCRMADVYAFNVNGNVSDAVDTFLQLPFVPPpntA 806
XP_004984390 723 -ldgesRATALIHSGNEIMEtaRYSSETSVQDkDLISEQQTVLRQLEAILHIYRLARAGQTVDALRETIRLPFLHL---D 798
O22224       712 -ldgesRTSGLILAGNDILEtyKYYPEVSLQErERVMEQETILRELEAILSIHKLGRLGNHLDALREIAKLPFLHL---D 787 thale cress
XP_009384164 714 -ldgesRAASLIQSGNDILEnfKYSSGVSLQEkEPVSEQQTVLRQLEAILHISKLARAGQHVDALREIIKIPFLPL---N 789
XP_011436563 654 TPQSAR--DRLRAMALSIAK--RYRER-NN---EGSRSNTSTFYLLLDLLTFFDSYHEGNVDEAFEVMKQLKLLPL---T 722
XP_001633614 650 APQSPR--DRLHNMAVEIAD--RYRAQ-GH---NASQSRMSTFFLLLDLMQFFDLYHGNQTDTALDVIQKLKLVPL---S 718
XP_002108984 659 DSDNTR--SRLQDLAVSIAQ--RFKSL-GH---FASRVRLKALYILLDVMLFFDLFHGHNYEQALDVVKKIGILPL---E 727
XP_008984160 655 APQSNK--ERLKNMALSIAE--RYRAQ-GI---SANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLVPL---N 723
XP_005814359 656 APQSNK--ERLKNTAVVIAE--RYRSQ-GT---AAEKSISSTFYLLLDLMTFFDEYHAGHVDRAYDVMERLKLLPL---S 724
2QX5_B       571 DeLSARKKAQDFSNLDDNIVKNIPNLLIITLSCISNMIHIL-NE---------SKYQ-SSTKGQ-----------QIDSL 628 baker's yeast
CAM44024     807 VtGGVDAYVEAYCNAPGSVQLGASAALRVAISAAGQLLQYYaRNs--------------TGDSAdvddkrlrllhRMQTV 872
XP_004984390 799 P-QSPNVTVDIFRNLSPHVQACIPDLLKVALNCIDNVRDTDg---------------------------------TLRAV 844
O22224       788 P-RMPDATADVFQSASPYFQTCVPDLLKVALTCLDNVPDTDg---------------------------------SIRAM 833 thale cress
XP_009384164 790 P-RVPDVHYDVFQKLSPHVQACVPHLLKITLNCLDNVKDTDg---------------------------------TLRAL 835
XP_011436563 723 A-DAVEHKVNAFRHYTDEVRRCLPDILIATMNILHNQYKNA-KNsaprggysgQGRS-EDGGREt----------yLNYL 789
XP_001633614 719 S-ETVEERVAAFRQYNDEIRRVLPDVLLATMNILYTKYRGT-KSsgq---splLDRRrDDGGMEq----------lRMIL 783
XP_002108984 728 IdDTVEQKVASFKQIADEIKRNIPQVLLATMNILYAQYESI-RPgsiq--nplLTSRaNDGGRDm----------hVKEI 794
XP_008984160 724 Q-ESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRL-KGtsps-sssrPQRViEDRDSQ---------------L 785
XP_005814359 725 Q-DSVEERVAAFRNFSDEVRHNLSEVLLATMNILFTQYKRL-KGapag-tpgrSPRStEDRGTQ---------------L 786
2QX5_B       629 KNVARQCMIYAGMIQYRMPRETYST 653 baker's yeast
CAM44024     873 LEWARQCCARTSV--------AYPA 889
XP_004984390 845 KSKIANLV--ANNMSRNWPQDLYQK 867
O22224       834 RSKIAGFL--ASNTHRNWPRDLYEK 856 thale cress
XP_009384164 836 KSKIANLV--ANNMNRNWPQDLIEK 858
XP_011436563 790 RSQARALIMFAGMLPYRLPGDTNAR 814
XP_001633614 784 RRQARSLLTFAGLIPYRMPGDTNAR 808
XP_002108984 795 RRQARTLITFAGMISYRIPGDTNSR 819
XP_008984160 786 RSQARTLITFAGMIPYRTSGDTNAR 810
XP_005814359 787 RLQARALITFAGTIPYNMAGDTNAR 811
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap