2PTH,1RYB,1RYM,1RYN


Conserved Protein Domain Family
PTH

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cd00462: PTH 
Click on image for an interactive view with Cn3D
Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through abortion of translation and is essential for cell viability.This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts.
Statistics
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PSSM-Id: 238259
Aligned: 153 rows
Threshold Bit Score: 150.317
Created: 6-Mar-2002
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
Conserved site include 1 residue -Click on image for an interactive view with Cn3D
Feature 1:catalytic residue [active site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                     #                                                               
2PTH        4 LIVGLANPGaeyaaTRHNAGAWFVDLLAer-----lRAPLREEak---ffGYTSRVTlgg--edVRLLVPTTFMNLSGKA 73  Escherichia coli
EAA69724    7 LVVSLGNPLpk-yqSLHSAGHFALNGLA--------NVLRNPSfqektfgGQSCLVSqg---pkYTLVQSPTLMNISGRF 74  Gibberella zeae PH-1
CAG85334   11 MIASIGNPEpqyqgTRHNVGHWALDELItnhw-tsfNQFQNHKni---pdGVYSTSRvedlsdiFLFKSIYSFMNLQGAP 86  Debaryomyces hanse...
EAL04728   25 FIASIGNPEpqyanTRHNAGHRLMNQLIdv----ywKDHVYKKg------PYYLSTKys---nlVLFKSNDSLMNLQGLP 91  Candida albicans S...
AAS53816   18 CLTGLGNPEpqyrnTRHNAGLILLDLLKahy---apGKPWMPCtvp-rvaASYCHASrh---dlLLLRSDGAFMNRSGQN 90  Ashbya gossypii AT...
CAG62631   20 CLTGIGNPEpsykgTRHNVGLTVLDLLIkqlv-prdQHVFRRE-------GKVHVLRtp---tiTFIRSDIGFMNLSGRS 88  Candida glabrata C...
731759      8 VLTGIGNPEpqyagTRHNVGLYMLELLRkrl--glqGRTYSPVpn---tgGKVHYIEde---hcTILRSDGQYMNLSGEQ 79  baker's yeast
CAG85134   10 IIFSIGNPGs---tNRHSTGHIVMKALIeyf---gaKQLFKPLs-----nSMYSMTEvd----nIALVKSNNYMNDSNKL 74  Debaryomyces hanse...
EAL03659   10 IFFSIGNPGp---iTRHSVGHFMLKRLMesssttsiKQLSNYS-------SYSLSVDsf---nnIIYIKSNTYMNESSKA 76  Candida albicans S...
CAA21173   32 IIYGLGNPGsafvkSRHSLGKLMVSMYAd-------SMAFPKN-------WPSTKEN-------LTLVLSTSYMNDSGKQ 90  fission yeast
Feature 1                                                                                     
2PTH       74 VAAMASFfri-----------------npdEILVAHDELDLPPGVAKFKLGGGHG----GHNGLKDIISKLgnn------ 126 Escherichia coli
EAA69724   75 VARAWNDmikqq-------------dpsslSLIIVHDELEAKKGAVSLRAWDRSPr---GHNGIKDVKNKLsqdky---- 134 Gibberella zeae PH-1
CAG85334   87 VSKTWQKvsnyqk------------atrspALVVLHDELQVPFGKFQIRKQLSSAr---GHNGLRSIDSLMgg------- 144 Debaryomyces hanse...
EAL04728   92 ISKHFGKhdq-----------------gksALVVLHDELQVDLGKYQIRKPGTSSr---GHNGLKSIDKYLkn------- 144 Candida albicans S...
AAS53816   91 VVPLWQRig-------------------gaTRVVVHDELSLPLGKVQLRAPGRSPr---GHNGLKSIIAAGaq------- 141 Ashbya gossypii AT...
CAG62631   89 VVPMWQKlyt-----------------dhtDYAVIHDELSLRTGALQLRQPQASLr---GHNGLRDISAHWrh------- 141 Candida glabrata C...
731759     80 VCKVWARyak-----------------yqaRHVVIHDELSVACGKVQLRAPSTSIr---GHNGLRSLLKCSggr------ 133 baker's yeast
CAG85134   75 LKQYIEQekig---------------lrqaVLIVVYDEFDLDLGKVKISPFKKNE----SHNGIRSIKEYIsrqs----- 130 Debaryomyces hanse...
EAL03659   77 WNKFKLSkeyrsfikeqdqdqdqdhhdqivSVIILYDDFENNLGTIKLKQFKKKSnnneSHNGLKNLKLSMidgnsn--- 153 Candida albicans S...
CAA21173   91 LKKISNDfvrkvs------------pldkiVYVVVHDELELDLGKVKLRLPGGSHr---GHNGIRSCQEFLgkevrytfn 155 fission yeast
Feature 1                                                                  
2PTH      127 -----pnFHRLRIGIGHPgdk-----nkVVGFVLGKPPv-SEQKLIDEAIDEAARCTEMWF 176 Escherichia coli
EAA69724  135 ---ptspFVRIAVGIGRPsdger-drntVSDYVLNRISn-EERRIFEEDEVPRMVAQQLIQ 190 Gibberella zeae PH-1
CAG85334  145 ------gYTKISIGIGKPta------kdLSNYVLSPFTp-LEQEVLTYDVMPQIVNVLQEM 192 Debaryomyces hansenii CBS767
EAL04728  145 ------rYFKLGIGIGRPpas-----qsVVHYVLKNFSs-QELDVIDWEVLPKCVKDLENM 193 Candida albicans SC5314
AAS53816  142 -----gtYYSLAVGIDRPetrk---paaIADYVLSRFSr-AELSQLEQDALPAALGHLNGL 193 Ashbya gossypii ATCC 10895
CAG62631  142 ------qYYKLAIGIDRPesrd---pqaVADYVLSKVPq-RDATYIENTTTSKALELLQRQ 192 Candida glabrata CBS138
731759    134 -----vpFAKLAIGIGREpgsrsrdpasVSRWVLGALTp-QELQTLLTQSEPAAWRALTQY 188 baker's yeast
CAG85134  131 ---adltVYKLGIGIGPKpsna--ttstMSSWVLSNFKp-DERQIIDNLSIPLAIDYIDHV 185 Debaryomyces hansenii CBS767
EAL03659  154 -natgeaIYLLGIGIGPKpnnnp-sgeiMRQWILSPFNkqSEKYKLETESFKLLQLYIDTM 212 Candida albicans SC5314
CAA21173  156 fitnsksFYRIGLGIGRCesrn---redVSDYVLSKFNs-NEMKLIETDIFHKFCNILQQL 212 fission yeast

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