1RTG,1FBL,1PEX,1QJS,1HXN


Conserved Protein Domain Family
HX
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cd00094: HX 
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Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of metalloproteinases (TIMPs). This CD contains 4 instances of the repeat.
Links
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Statistics
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PSSM-Id: 238046
Aligned: 42 rows
Threshold Bit Score: 111.249
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Metal binding
Conserved site includes 8 residues -Click on image for an interactive view with Cn3D
Feature 1:Metal binding sites [ion binding site]
Evidence:
  • Comment:bound metal ions link the 4-bladed propeller
  • Citation:PMID 7583664
  • Citation:PMID 8969305
  • Structure:1RTG
  • Structure:1PEX
  • Structure:1QJS
  • Structure:1HXN
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1               # #                                                        # #        
1RTG       16 PEICkqdivFDGIAQIR---GEIFFFKDRFIWRTvtp-----rdkPMGPLLVATFWPe------LPEKIDAVYEApq--- 78  human
1QJS_A     49 IEQCsdgwsFDATTLDDn--GTMLFFKDEFVWKSh----------RGIRELISERWKn------FIGPVDAAFRHgh--- 107 Oryctolagus cuniculus
1HXN       11 STRCdpdlvLSAMVSDNh--GATYVFSGSHYWRLdtn------rdGWHSWPIAHQWPq------GPSTVDAAFSWe---- 72  Oryctolagus cuniculus
102769     33 LQSIfp--sIDAVFKWSn--GVTYIFKGSCYFRYedk------tnEISNCRRLSAWGg------LTGPVDAVFRWrn--- 93  Atlantic horseshoe...
1708182    47 TERCsdgwsFDATTLDDn--GTMLFFKGEFVWKSh----------KWDRELISERWKn------FPSPVDAAFRQgh--- 105 human
123090    377 RRACsg--sFDAVVRDSs--NRIYALTGPYFWQLdq--------pSPSWGLVSNRFGf-----gLPQNIDASFQRg---- 435 common urchin
1848139    47 LDRCqg-ieMDAVAVTEe--GIPYFFKGGHVFKGfhg------kaELSNESFAELDDh-----hHLGHVDAAFLMhfpdk 112 rainbow trout
3183022   380 RQACtg--sFDAVIKDNs--DRIYALAGRYYWRLdq--------aSPSWGVVRNRFGf-----dLPENVDASFQNg---- 438 Hemicentrotus pulc...
113570      1 MTKTg---yINAAFRSSq-nNEAYLFINDKYVLLdyapgtsndkvLYGPTPVRDGFKslnqtvfGSYGVDCSFDTd---- 72  pea
2129908     1 MSNLp---yINAAFRFSsrdYEVYFFAKNKYVRLqytpgktedkiLTNLRLISSGFPslagtpfAEPGIDSAFHTea--- 74  mung bean

Feature 1                                                         # #                         
1RTG       79 --eeKAVFFAGNEYWIYSast------leRGYPKPLTS-LGLppd---vqRVDAAFNWsk----nKKTYIFAGDKFWRYN 142 human
1QJS_A    108 ---tSVYLIKGDKVWVYTsek------neKVYPKSLQDeFPGip-----fPLDAAVEChrgecqdEGILFFQGNRKWFWD 173 Oryctolagus cuniculus
1HXN       73 ---dKLYLIQDTKVYVFLtkgg---ytlvNGYPKRLEKeLGSppvi-sleAVDAAFVCpg----sSRLHIMAGRRLWWLD 141 Oryctolagus cuniculus
102769     94 ---gVTYFFQGDCYYRYEdk--------tDEISKCSPV-TAWggm---tgPVDAVFRWs-----nGITYFFKEDCYYRYE 153 Atlantic horseshoe...
1708182   106 ---nSVFLIKGDKVWVYPpek------keKGYPKLLQDeFPGip-----sPLDAAVEChrgecqaEGVLFFQGDREWFWD 171 human
123090    436 ---vVTYFFSECYYYYQTst--------qRNFPRIPVN-RKWvgl---pcNIDAVYRSs-----rGPTYFFKDSFVYKFN 495 common urchin
1848139   113 ptehDHIFFMLDTKVFSYykh-----qleTGFPKDISEvFPGip-----dHLDAAVVCpapdceeDAVIFFKGDEIYHYN 182 rainbow trout
3183022   439 ---iFSYFFSGCYYYYQTst--------rRRFPRTPFN-RRWvgl---pcDIDAVYKSgd----sGTTYFFKGRFVYKFS 499 Hemicentrotus pulc...
113570     73 ---nDEAFIFYEKFCALIdyaphsnkdkiILGPKKIADmFPFfegtvfenGIDAAYRStr----gKEVYLFKGDQYARID 145 pea
2129908    75 ---sEAYVFSANNRAYIDyapgt-tndkiLAGPTTIAEmFPVlrntvfadSIDSAFRStk----gKEVYLFKGNKYVRID 146 mung bean

Feature 1                                   # #                                               
1RTG      143 Evkkkmdpgf-----pkliadawnAIPDnLDAVVDLqg----------ggHSYFFKGAYYLKLEnqsl--------ksvk 199 human
1QJS_A    174 Lttgtkk------------erswpAVGN-CTSALRWl------------gRYYCFQGNQFLRFNpvsge------vppgy 222 Oryctolagus cuniculus
1HXN      142 Lksgaqa-----------twtelpWPHEkVDGALCMekplgpnscstsgpNLYLIHGPNLYCYRhvdklna---aknlpq 207 Oryctolagus cuniculus
102769    154 Dkdnkiskc--------tpitawgKMTGpIDAVFRWsn-----------gVTYFFKRDCYFRYEdkpnei----skcrai 210 Atlantic horseshoe...
1708182   172 Latgtmk------------erswpAVGN-CSSALRWl------------gRYYCFQGNQFLRFDpvrge------vppry 220 human
123090    496 Snnrlqrrtri----sslfndvpsALHDgVEAVVRAdr-----------nYIHFYRDGRYYRMTdygrqfvn-fpnglpy 559 common urchin
1848139   183 Vktkkve------------ekkfeGMPN-CTSAFRFm------------eHYYCFHGHQFSKFDpktge------vhgry 231 rainbow trout
3183022   500 Ssnqlqrrspi----ssyfrntpyALRDgVEAVVRVdd-----------vYLHFYRDGRYYRMIestkqfvn-fpnglsy 563 Hemicentrotus pulc...
113570    146 YetnsmvnkeiksirngfpcfrntIFESgTDAAFAShk----------tnEVYFFKGDYYARVTvtpgatddqimdgvrk 215 pea
2129908   147 Ydskqlvgsirn-isdgfpvlngtGFESgIDASFAShk----------epEAYLFKGDKYVRIHftpgktddtlvgdvrp 215 mung bean

Feature 1                
1RTG      200 FGSIKSdWLGC 210 human
1QJS_A    223 PLDVRDyFLSC 233 Oryctolagus cuniculus
1HXN      208 PQRVSR-LLGC 217 Oryctolagus cuniculus
102769    211 ALWGASsYQPL 221 Atlantic horseshoe crab
1708182   221 PRDVRDyFMPC 231 human
123090    560 SDVIESvIPQC 570 common urchin
1848139   232 PKEARDyFMKC 242 rainbow trout
3183022   564 RDVIDTlIPQC 574 Hemicentrotus pulcherrimus
113570    216 TLDYWPsLRGI 226 pea
2129908   216 ILDGWPvLKAF 226 mung bean

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