Conserved Protein Domain Family
Phospholipase_B_like

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cd01824: Phospholipase_B_like 
Phospholipase-B_like. This subgroup of the SGNH-family of lipolytic enzymes may have both esterase and phospholipase-A/lysophospholipase activity. It's members may be involved in the conversion of phosphatidylcholine to fatty acids and glycerophosphocholine, perhaps in the context of dietary lipid uptake. Members may be membrane proteins. The tertiary fold of the SGNH-hydrolases is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; Its active site closely resembles two of the three components of typical Ser-His-Asp(Glu) triad from other serine hydrolases.
Statistics
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PSSM-Id: 238862
Aligned: 21 rows
Threshold Bit Score: 227.225
Created: 16-Aug-2004
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:active site [active site]
Evidence:
  • Comment:the active site resembles the typical Ser-His-Asp(Glu) triad from other serine hydrolases
  • Comment:by similarity to other SGNH-hydrolases
  • Citation:PMID 7773790

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                        #                                                             
Q05017     382 SVHRLKPADIKVIGAMGDSLTAGngags-----------------qpgniLDVltq---yrGLSWSVGGdqnistvTTLA 441  rabbit
XP_316429    8 SVDRLRPGDIDIIGAIGDSLTAGngam-------------------atniLEVlie---nkGLSWSIGGqgtwrqfLTLP 65   Anopheles gambia...
AAL39319    95 SVHRLRPGDIDVIGAMGDSLTAGngif-------------------atnlLHVtve---nrGVVWSIGGqydwrkyLTLP 152  fruit fly
NP_496440   41 SAHSVRFADIKVIGALGDSLTAAngag--------------------aqpGDPlavilqyrGLAFQIGGdksldehITVA 100  nematode
NP_608955  123 SIEHLRPGDIDIIAAFGDSLSAGngil-------------------snnaIDMine---frGLTFSGGGlanwrrfVTLP 180  fruit fly
T16060      66 SVHQLHPSQIGVIAALGDSVSVAqaak-------------------sssiLDLfdq---fpGVSFVTGDdvklneqATFI 123  nematode
AAW41038    59 VAKDVRPDDFRVVMALGDSITAGllargsrsssassapsqvdpqrpllpfLDIqe----yrGLSYPIGSdp---gaITIP 131  Cryptococcus neo...
NP_871868  142 NVGNISPEDITIIAAMGDALATGigl---------------------wpnADIef-----rGASFPIGGdstidglITIP 195  nematode
NP_508140   93 SVAQLSPEDIQIVGAMGDSLASGrgl---------------------wpfTDVef-----rGAAFPIGGdanmdglVTIP 146  nematode
NP_694566   61 SVHSLKPSDIKFVAAIGNLEIPPdp-----------------------gtGDLekqdwterPQQVCMGVm------TVLS 111  human
Feature 1                 #                                                                    
Q05017     442 NILREFNPSLQGFSvgtgre-----------------ttsqaFFNQAVAGARADGlipqaqrlvalmkndtrinfqeDWK 504  rabbit
XP_316429   66 NILKEYNPKLYGYPtkdgls-----------------trkasLFNAAEGGAMSQDipyqarnlvkrmlsdrkvdinnHWK 128  Anopheles gambia...
AAL39319   153 NILKEFNPNLYGYAikdgis-----------------tdrssRFDVAELAAMSRDmphmakvlvrrmqrdprvnmtsDWK 215  fruit fly
NP_496440  101 NVLRKFNPTLVGASkgigse----------------nvwevsHLNMGVPGAESKDiigqaralvntmhahseinvkeDWK 164  nematode
NP_608955  181 NILKIFNPKLYGFAvsnslv----------------inhrssRLNIAEPMIMSRDlpfqarvlidllrrdrhvdmkrHWK 244  fruit fly
T16060     124 NIFRKFAPRIKGGSsdfv--------------------qkfyDFNMAIPGSFSSElpeqalklastlkkklgretsdTWK 183  nematode
AAW41038   132 EILRHFSPSAKEIPgsskgkhppvtclngwgikgcaerpeedGLNAAVSGSVSSGllrqvedfilp-rlkdmeirkeDWK 210  Cryptococcus neo...
NP_871868  196 NILREFSPKLVGVShgmga------------------dlpnhQLNVAVTGATTEDlpdqarrltrrlkklseldyhnEWI 257  nematode
NP_508140  147 NILSQFGSNLEGIShgmgsk----------------ralpdyQFNVAEIGAETEDlpqqalelvhriqryigrslknKWA 210  nematode
NP_694566  112 DIIRYFSPSVPMPVch-------------------------tGKRVIPHDGAEDLwiqaqelvrnm-kenlqldfqfDWK 165  human
Feature 1              #                                                                       
Q05017     505 IITVFIGGNDLCd-FCndpvr------yspqNFTDNIGTALDILHAEIPRAFVNL-----VKVLEISKLrelyqetkvSC 572  rabbit
XP_316429  129 MITLMIGGNDFCaeICymatp-----ekilqYHEKNIVSALRTFRDYLPRTFVNLaaspnVTVLRTFSPrp------aSC 197  Anopheles gambia...
AAL39319   216 LVTLFIGNNDFCtdICyypep-----ektvdWHERNMLKTYRYLRDNVPRLMLNI-----VPAPNLRFLtnlt-glppIC 284  fruit fly
NP_496440  165 LVNIFIGANDICv-YCedpyfns-talhgnaTFEKNIIAAVQILQDNLPRTIVSL-----TGMFNMRMLrkid-kkkyFC 236  nematode
NP_608955  245 LLTVYVGNNDICsdLChwdtp-----qsfldQHARDLRQAFRLLRDHVPRLLINL-----IVVPNIPLVlstmtkvplQC 314  fruit fly
T16060     184 FVNIFIGHNDLCn-ICnnett------fgpeTFGKSLHSALTIIQTNVPKVFVNI-----MPPINVKIHsqah-klskFC 250  nematode
AAW41038   211 FVNLGIGANDICs-FClysnmtdidfngspkRFAKDIKRAVNALRKNVPNIIINI-----IGLFRVSAIyklt-lkdpYC 283  Cryptococcus neo...
NP_871868  258 MIIITIGTEELCs-RCe-------------gPSYDNIRKAIEHLQIEIPKALVVL-----LGPVHVSSFh-------eQK 311  nematode
NP_508140  211 LITIVTGSEEFCe-KCe-------------pPSRTSIRRALGVLRRGLPRALIVL-----LGPVHVASTy-------rQN 264  nematode
NP_694566  166 LINVFFSNASQCy-LCpsaqq-----nglaaGGVDELMGVLDYLQQEVPRAFVNL-----VDLSEVAEVsr------qYH 228  human
Feature 1                                                                                      
Q05017     573 PRMILRSl-------CPCVLkfddnste-iaslietIKEYQERTQQLIDsgrydtrddFTVVLQPFFEKvnmpktqdg-l 643  rabbit
XP_316429  198 VTTHAFE--------CPCVFgtryasf--qprleyiIHQWNRIQQSVAEreefnnatdFVVNFQPFPEQltlptlqng-d 266  Anopheles gambia...
AAL39319   285 YSTLRFE--------CPCLMgkgkgql---dylegiMKRWIAKDFEIANreef-ntetFTINVQPFSQFqdfprtrsg-q 351  fruit fly
NP_496440  237 EGLHTFE--------CDCESnkqftdd--diqgvcfGYMNAEKDIQNTGlfdn--kddFTFVVQPFFNGildppyaspgv 304  nematode
NP_608955  315 FVVHRVG--------CHCLIndrlnrte-fnermdtLTRWQQLDMEIARlpef-rrqdFAIVAHPMLTKltaptlpdg-s 383  fruit fly
T16060     251 EFSHRKT--------CSCIFelnekey---qnikkqFDEQLNEVVEQFNqkyg-nsstFAVVIAPAMDLksipllknq-- 316  nematode
AAW41038   284 QPPLFPYpiphfplgCSCALlpgptgdwtrqkmdelGEAYDEAVLEIVRewekeddehFGAIWQPGTAIdlpnypi---- 359  Cryptococcus neo...
NP_871868  312 SNLLKAR--------CACSRdqtegfm---ydvsrkWSKVWRDVQKFVEngvt-arptFGMISYPMVTItsryps----- 374  nematode
NP_508140  265 INLMRPR--------CKCLEkmtgsny---rklfdvWKRYFVEFETEFNvdn----gtFGVLSIPSLAIhsrnpq----- 324  nematode
NP_694566  229 GTWLSPApe-----pCNCSEettrlak---vvmqwsYQEAWNSLLASSRyse---qesFTVVFQPFFYEttp-------- 289  human
Feature 1              #  #                      
Q05017     644 pdnsffapDCFHFSSKAHAHAASALWNNMLEPVG 677  rabbit
XP_316429  267 tdagiasvDCFHFSQRGHAIAANSYWNNLIDMEG 300  Anopheles gambiae str. PEST
AAL39319   352 tdtrffseDCFHLSQRGHAAAANSIWNNMLELPG 385  fruit fly
NP_496440  305 vdmtffapDCFHFSAYGHGNIGMHLWNTIVQPVG 338  nematode
NP_608955  384 tdwrffshDCFHFSQRGHAIISNLLWNSMLLPDD 417  fruit fly
T16060     317 pnigllalDCFHLSPIAHDIAAKQIWKGLFEPID 350  nematode
AAW41038   360 --talspiDCFHPSEASHQRMAAGIWNRLTLSLE 391  Cryptococcus neoformans var. neoformans JEC21
NP_871868  375 ---glfirDKPLLNRRGHNYATKWLWNRLIGGDL 405  nematode
NP_508140  325 ---tllvpGKPLLNRKGHSYAAKWLWNRLIAGPN 355  nematode
NP_694566  290 ------slHSEDPRLQDSTTLAWHLWNRMMEPAG 317  human

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