1NS5,1O6D,1TO0,1VH0,4FAK,5TWJ


Conserved Protein Domain Family
RlmH-like
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cd18081: RlmH-like 
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23S-rRNA-pseudouridine1915-N3-methyltransferase RlmH
23S rRNA (pseudouridine1915-N3)-methyltransferase RlmH catalyzes the addition of a methyl group at the N-3 position of pseudouridine Psi1915 in 23S rRNA to form m(3)Psi1915. This family of proteins belongs to the SPOUT methyltransferases. The SPOUT methyltransferase superfamily is a large class of S-adenosyl-L-methionine (AdoMet or SAM)-dependent RNA MTases which are structurally characterized by a deep trefoil knot.
Links
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Statistics
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PSSM-Id: 349954
Aligned: 364 rows
Threshold Bit Score: 104.831
Created: 8-Jan-2009
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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SAM bindingdimer interface
Conserved site includes 16 residues -Click on image for an interactive view with Cn3D
Feature 1:SAM binding site [chemical binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                ###  
1NS5_A      3 LQLVAVGTkxpDWVQTGFTEYLRRFPkdxPFELIEIpagkrgkna---dikrildkEGEQXLAAAgk---nRIVTLDIPG 76  Escherichia coli
4FAK_A      7 ITILAVGKlkeKYWKQAIAEYEKRLGpytKIDIIEVpdekapenmsdkeieqvkekEGQRILAKIkp--qsTVITLEIQG 84  Staphylococcus aureus
Q46L60      7 YKIIAIGKikkKWIQEGIEMYLKRLP---GLEVKEIkdst-------------qlkEEHTIKEIIsk--neFLVTLNENG 68  Prochlorococcus ma...
A2BQZ8      7 LTIYAIGKikkHWIRDGINQYKKRMP---ELIINESkt-----------------fNLDNLRSNNn-----IIICLSEEG 61  Prochlorococcus ma...
EDX87695    8 VKIIAVGKvkkSWLKEGIALYAKRLPeieMVEIKDSnk----------------enEADKLLSLIsa--qdRLVVMAEYG 69  Synechococcus sp. ...
A5GS43      9 IRILAIGKlkrAWVAEGVAFYRKRLP---GLEVVELkdst-------------pakEAEAIRAARkp--aeRLVLLSEEG 70  Synechococcus sp. ...
A2CA37     11 FRIIAVGKvrkGWIQDGLAMYQKRLPglmITEVRDAsl----------------prEAEAILAALns--neVLVPLSEEG 72  Prochlorococcus ma...
A9B9X8      7 YRILAIGKtrkAWIQNGLNLYIKRLP---GLTITELkdsd-------------lkkEAQSIRSSIkt--neLLIILTEEG 68  Prochlorococcus ma...
ADE54673    4 YTVIAVGKmknRNLAALCEDFTKRLKrsgTFELIELkdgd-------------vesEGERILETLakrsgaRVFAMGEEG 70  Coraliomargarita a...
AFY69326    6 ARIIAVGKikkKWIAAGVNEYLKRLPrmeIQEIKDTgk----------------ekEAEKILAMLkq--ydNLIVLSEDG 67  Pseudanabaena sp. ...

Feature 1                               #### #            #### ###    #                      
1NS5_A     77 KPWDTPQLAAELErwkl-dgrDVSLLIGGPEGLSPACkaaaeQSWSLSALTLPHPLVRVLVAESLYRAWSIttNHPYHR 154 Escherichia coli
4FAK_A     85 KMLSSEGLAQELNqrmtqgqsDFVFVIGGSNGLHKDVlqrsnYALSFSKMTFPHQMMRVVLIEQVYRAFKImrGEAYHK 163 Staphylococcus aureus
Q46L60     69 QSFTSKQLATKLLnsh---nqNITFVIGGASGLSSSLnnlasWQLSLSPLTFPHEIARLLLIEQLYRAKAItqGGPYHK 144 Prochlorococcus mar...
A2BQZ8     62 KQFNSVELCSLLLnfk---nkKINFLIGDTDGVSSDIkeksdLVLSLSPLTFPHELARLILIEQIYRAISIsnNSPYHR 137 Prochlorococcus mar...
EDX87695   70 KAYDSIAFANWLGrea---fgTLVLFIGGPEGIGDRLrs--hQSISLSAMTFPHEIARLVLLEQLYRAKTIlnNGSYHK 143 Synechococcus sp. P...
A5GS43     71 RQLSSVGLAELLGgwa---seRLALVIGGADGHDPTLkqqadVLLSLSELTFPHELARLMLVEQLYRASTIlqGGPYHR 146 Synechococcus sp. R...
A2CA37     73 EALTSVSFAKRLEkyg---sqRLAFVIGGADGLSAELknstqWQLSLSAMTLPHELARLLLVEQLYRAQTIlqGGKYHR 148 Prochlorococcus mar...
A9B9X8     69 ESLTSLGFANRLKslg---ssRLLFVIGSANGLDSEIkamanWSISLSPLTFPHEIARLLLIEQLYRAKNIceGGSYHR 144 Prochlorococcus mar...
ADE54673   71 KVRSSRALASQLLqlq---gqPAVFIIGGAYGLSDAVkqradELFALSPMTFTHEIARMLVCEQLYRAVSInsGSKYHH 146 Coraliomargarita ak...
AFY69326   68 EMFDSIELSQLLNqem---aqDVVFAIGGQDGVSETLkqsarRVLSLSRLTFPHELARLILVEQIYRAQTIinHQSYHR 143 Pseudanabaena sp. P...

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