1LSH_A    2 FQPGKVYRYSYDAFSISGLPEPGVNRAGLSGEMKIEIHGHTHNQATLKITQVNLKYFL----GP--WPS--DSFYPLTGG 73  
Q9U572   15 LQPGLEYQYRYSARVASGIPSINRQFAAAGIQADVTVQMAADYSVVVQFSNIEVGDLN----KV--LDCdlRAPLPIEYH 88   black tiger shrimp
Q9UAR3   16 LHSNLEYQYRYSGRVASGIPFIKSQYSGAGFQADVFLQITSTKVPFFKISNTMVGEYH----DE--LECdtRAPLPIEYH 89   signal crayfish
Q9N4J2   24 FSPKSEYVYKFDGLLLSGLPTTFSDASQTLISCRTRLQAVDDRYIHLQLIDIQYSASHipqsEQ--WPK--IKSLEQREL 99   Caenorhabditis elegans
P55155   24 FEPKIDYHYKFDGLVLSGLPTASSELSQSRFSARVRIQAVDDRHIHLQLVNIHMAASHlpesEQ--IPS--LNSMEQREL 99   Caenorhabditis elegans
Q94637   26 YRSGREYRYQFNGHLSAGLPIPGEENSATRIQSLIRIQPENGDFMRLQMTKTRFATSE----EDrvLSF---ENMNEVPV 98   Oscheius tipulae
Q25490   39 FAAGQKYNYGVEGTVSVYLTGADNQETSLKMLGQASVSAISNCELELSVHNMVLSGPD----GK---------------- 98   tobacco hornworm
Q9GSG2   42 YQPGKTYTYEYSGKSRIQLKGVEGGLTETDWSAQVELSWITPCDMVITMKDSKTDGAT--------VPG----------- 102  Cherax quadricarinatus
Q9NDS1   42 YQPEKTYTYQYSGKSRVQLKGVDDGVSETEWAARVDLTWISPCDVAISFNNMKMDGAR----GP---------------- 101  Penaeus japonicus
P04114   46 FKHLRKYTYNYEAESSSGVPGTADSRSATRINCKVELEVPQLCSFILKTSQCTLKEVY----GF--NPEg-KALLKKTKN 118  human

1LSH_A   74 YDHFIQQLEV-PVRFDYSAGRIG-DIYAPPQVTDTAVNIVRGILNLFQLSLK-------------------KNQQTFELQ 132 
Q9U572   89 PLEDYVDLLEkPFRVIMNESHVP-SYMEGPEEPIWISNVRKGFVNIFRVPLFwst-------------elhSTKLNYGAV 154  black tiger shrimp
Q9UAR3   90 PLVEGKELLEkPFQAIPGEQRGE-EHLVGPAEPAWITNIKKAIVRAFSIPPImanag---------rqvdaFKRTTYSHN 159  signal crayfish
Q9N4J2  100 SDELKELLEL-PFRAQIRNGLVS-EIQFSSEDAEWSKNAKRSILNLFSLRKSapvdemsq---dqkdmesdKDSLFFNVH 174  Caenorhabditis elegans
P55155  100 SEEYKQMLKL-PLRAQLRNGLIA-ELQFDKEDAEWSKNMKRAVVNMISFNPIaprneiekiessydkeeqsEENTSFFTN 177  Caenorhabditis elegans
Q94637   99 SEKVEKVLSL-PIRFSYRHGMVG-EIEFSTEEQTWSSNIKKAVVNMLQVNLVkkgmsek------neyeteHDNDFFLSN 170  Oscheius tipulae
Q25490   99 KYPCPQGIEK-PVRFSYQDGRVGpEICAAEDDSRRSLNIKRAIISLLQAEQK-------------------------PSV 152  tobacco hornworm
Q9GSG2  103 ---ASRFLERyPLVVAVTDGKVH-HVCSHPDDDTWSINLKKGVASAFQNSLPsn----------------sTINSGQNIT 162  Cherax quadricarinatus
Q9NDS1  102 --IAARTLERhPLVVAVVDGRVQ-HVCAHPDDEPWAINLKKGVASAFQNSIPsl----------------sTVSSGMTVT 162  Penaeus japonicus
P04114  119 SEEFAAAMSRyELKLAIPEGKQV-FLYPEKDEPTYILNIKRGIISALLVPPE-------------------TEEAKQVLF 178  human

1LSH_A  133 ETGVEGICQTTYVVQ----------------------------------------------------------------- 147 
Q9U572  155 EETLVGRCQNWYTSMklpvnlaeevnvqrehfmeediqrdaysssyttkt------------ksktssktssktssktss 222  black tiger shrimp
Q9UAR3  160 GTFIHGDCMCWYSMIhlnkeeaarenrqreaameediqreeqdesdrftsskvpsktsktqtskttkttgtkttgtkttg 239  signal crayfish
Q9N4J2  175 EKTMEGDCEVAYTIV----------------------------------------------------------------- 189  Caenorhabditis elegans
P55155  178 EKTLEGDCQVAYTVI----------------------------------------------------------------- 192  Caenorhabditis elegans
Q94637  171 ERTLEGECEVAYTKI----------------------------------------------------------------- 185  Oscheius tipulae
Q25490  153 QVDVFGVCPTEVSSS----------------------------------------------------------------- 167  tobacco hornworm
Q9GSG2  163 ETDVVGKCPTRYEVQ----------------------------------------------------------------- 177  Cherax quadricarinatus
Q9NDS1  163 ETDVVGKCPTTYQIE----------------------------------------------------------------- 177  Penaeus japonicus
P04114  179 LDTVYGNCSTHFTVK----------------------------------------------------------------- 193  human

1LSH_A  148 ----------------EGYRTNEMAVVKTKDLNNCDHKVYKTMGTA-YAERCPTCQKMNKNLRSTAVYNYAIFDEPS--G 208 
Q9U572  223 ktsktgktspgqlanvPHIEDTLWSVRRTTDFDMCENLVSLQI---------HSSKYTEDIIQRSSVASYLIRGDTH--- 290  black tiger shrimp
Q9UAR3  240 tkntgfkgapaklttpERIDNTLWSMSRTVDFDSCEDLVKWRI---------HGNKKIDKKIQRTSIGTYLLRGNAR--D 308  signal crayfish
Q9N4J2  190 ------------------QEGEKTIYTKSVNFDKCITRPETAYGLR-FGSECKECEKEGQFVKPQTVYTYTFKNEK---- 246  Caenorhabditis elegans
P55155  193 ------------------REQKKTIITKSINFDKCTERSEIAYGLR-YSSECPECEKDTVLIRPQTVYTYILENEE---- 249  Caenorhabditis elegans
Q94637  186 -----------------EKSEKEQQWTKSINFEKCSLRPEIVYGRR-YAEECNECRERDEKFS-STVFFYNITGTPE--E 244  Oscheius tipulae
Q25490  168 ------------------QEGGAVLLHRSRDLSRCAHREQGRNDFV------NSIANPDAGIKDLQVLQSMLNVESKvnN 223  tobacco hornworm
Q9GSG2  178 ------------------DHGDTVIMIKEKNHRQCKERYHTPAENP--APWL-----RGPFIT--DESTCMCKQETR--N 228  Cherax quadricarinatus
Q9NDS1  178 ------------------TEGEKVIVVKEKNHRHCQQRYPTPAETP--APW-----LKAPLPIEESKSEC----KQEitN 228  Penaeus japonicus
P04114  194 ----------------TRKGNVATEISTERDLGQCDRFKPIRTGISpLALIKGMTRPLSTLISSSQSCQYTLDAKRK--H 255  human

1LSH_A  209 YIIKSAHSEEIQQLSVFDIKEGN-VVIESRQKLILEGI-QSA-PAASQAASLQNRGGLMYKFPS---------------- 269 
Q9U572  291 RRIEQVVVEGTITVLTNKEQHEH-VDTFTNQTLELKAVrEVG-EPITVTYDVHPHYDWQYDIERpqgdq-------fipl 361  black tiger shrimp
Q9UAR3  309 TRVEYAVIEGSITVFTGTQSHEH-ISTFTNQTLELKRVrRIQ-NLFSFDYETVTHQSFHFEVDKfdvseqepghdihpsl 386  signal crayfish
Q9N4J2  247 --LQESEVHS--IYTLNVNGQEV-VKSETRSKVTFVEEsKIN-REIKKVSG--PKEEIVYSMENeklie------qfyqq 312  Caenorhabditis elegans
P55155  250 --LKESEVRS--LYTVNVNGQEV-MKTETRSKLVLEENhSIK-SHIEKVNG--EKESIIYSSRWeqlve------dffkn 315  Caenorhabditis elegans
Q94637  245 FLINSVELQSKHMFAPVTEQKQL-ITARITNRLELVYSgEQK-EQIEAVRNSDKKENLLYNPEHeiaee------kfaqt 316  Oscheius tipulae
Q25490  224 GVPEKVSAIEEYLYKPFSVGENG-ARAKVHTKLTLSGKgGAG----GGNAHCTESRSIIFD------------------- 279  tobacco hornworm
Q9GSG2  229 GIYSAITCEDKNVVKPSYGAYKY-VEAKMMSTLKYLSEsSEH--SSDILEGNMVRKSLLYDYHT---------------- 289  Cherax quadricarinatus
Q9NDS1  229 GIYTSIMCHDKNIVRPAIGIYKY-VEANQESTLHFISEtTDTsAITAIPRGEMHIESLLYNHET---------------- 291  Penaeus japonicus
P04114  256 --VAEAICKEQHLFLPFSYKNKYgMVAQVTQTLKLEDTpKIN-SRFFGEGT--KKMGLAFESTK---------------- 314  human

1LSH_A  270 SAITKMSSLFVTKGKNLESEIHTVLKHLvENNQL-SVHEDAPAKFL-RLTAFLRNVDAGVLQSIWHKLHQ-----QK-DY 341 
Q9U572  362 EQVLTGRPVTDQIVNSIMEYIKKTVDDLsHRMEHyPAKPENLAYIIgRLVEAVANLDYPYIQTLYTHFDG------KgTM 435  black tiger shrimp
Q9UAR3  387 EQLVTGIRITTQGVTEIKTLIIRLLKMLvKRTTThPYSTDPLVKDMsTLVDAASILSRPEIEALCSQIEH-----EElHA 461  signal crayfish
Q9N4J2  313 GDQAEVNPFKAIEMEQKVEQLDEIFRQIqEHEQN---TPETVHLIA-RAVRMFRMCTIEELKKVHTTIYT------KaEK 382  Caenorhabditis elegans
P55155  316 GDKAEFAPFEKFPLDKKMHLIKTITEQIqEVENN---IPETSHFLA-RLVRIFRTTSTSQLKEIHETLYV------KaDK 385  Caenorhabditis elegans
Q94637  317 GDEKYLRRIPNY-VDQG-EIIRQQLNRLsKQTEQ--IELESNHVHA-RLVKSLRFATEDNLSSIRSLVSQk-----SeVV 386  Oscheius tipulae
Q25490  280 ------VPHGTSSASGNLNSVISAVKETaRTVAN-DASSKSAGQFA-QLVRIMRTSSKDDLMRIYSQVKA------HqLE 345  tobacco hornworm
Q9GSG2  290 ----------PKKDPSMVTQLDRIMSQIcRKTRD-NVERDVAALVA-RAIQFLRMVPEEAVEQTLNKIRSgqycqDYkKL 357  Cherax quadricarinatus
Q9NDS1  292 -----------MKDPELAPELDQLMKEIcEKTKD-TVEAEAAALVA-KALHLLRRVPETVVVEIAQKVRQghycsDSaKL 358  Penaeus japonicus
P04114  315 ----------STSPPKQAEAVLKTLQELkKLTIS-EQNIQRANLFN-KLVTELRGLSDEAVTSLLPQLIE---------- 372  human

1LSH_A  342 RRW--ILDAVPAMATSEALLFLKRTLASEQLTSAEATQIVASTLS--NQQATRESLSYARELLNT-SFIRNRPILRKTAV 416 
Q9U572  436 QKYi-FVQLVIHAGTEPAVNFAVDNLSDI-LFYVTFYESIGVSLR--TPAPIPKIMHSLINGEEG--------LHHSLGL 503  black tiger shrimp
Q9UAR3  462 KKLeiFYELLVTAGTEPAIRYLLDKIKDPEFRKTNVASVKTILENfhTSVKNPLLIPDIIDLEQTlTWDEENQQFKMTLL 541  signal crayfish
Q9N4J2  383 KVQlvIETTLAVAGTKNTIQHLIHHFEKKSITPLRAAELLKSVQE--TLYPSEHIADLLIQLAQS-PLSEKYEPLRQSAW 459  Caenorhabditis elegans
P55155  386 KIQslMEHALAIAGTKNTIQHILVHIENEDIVPLEAAQLLKSIQE--TPFPSQTIAEALIKFAES-RVSKNNQVVRQSAW 462  Caenorhabditis elegans
Q94637  387 QSL--YWDALAIAGTKVTVSHLLEKINNKEISPMKASQLMKILAE--VRIPSEQIAQELHRFCES-DIVSRSAVLRQSCW 461  Oscheius tipulae
Q25490  346 KRV--YLDALLRAGTGESIEASIQILKSKDLSQLEQHLVFLSLGN--ARHVNNPALKAAAGLLD-------MPNLPKEVY 414  tobacco hornworm
Q9GSG2  358 EEL--FLDFVSFVDEPGAVKVMVKELLNSRFTRGRYSLYTAAFYL--IPRPCIHAMKALKPLFES-TRPMPYPT------ 426  Cherax quadricarinatus
Q9NDS1  359 ESI--FLDAVAFLHESGAVKVMVQEILNGRATGGRLALYTAALYL--TPRPNIEAVKALTPLFES-------PRPMPSLL 427  Penaeus japonicus
P04114  373 VSSpiTLQALVQCGQPQCSTHILQWLKRVHANPLLIDVVTYLVAL--IPEPSAQQLREIFNMARD--------QRSRATL 442  human

1LSH_A  417 LGYGSLVFRYCANTVS--------------CPD-----ELLQPLHDLLSQSSDR------AKEE-EIVL-ALKALGNAGQ 469 
Q9U572  504 MNFATLAHDACLSEDRkhfyfdyscgpkttCDPeliitNFIPYLVRELGNQ---------GKDVwQRLI-YLQALSNLGT 573  black tiger shrimp
Q9UAR3  542 LNLASLAKQLCLSSDKwesygyntcdpqhtCTPdfiieNFLPTLIQGVQDD---------ESSLwIRLV-YIQALANLGI 611  signal crayfish
Q9N4J2  460 LAAGSVVRGFASKTQDlpli-------rpaSRQtk--eKYVRVFMQHFRN----------ADSTyEKVL-ALKTLGNAGI 519  Caenorhabditis elegans
P55155  463 LAAGSVVRGIVDYKNIrpl---------vrEDKrelkeKFLRVFMQQYKD----------AETTyEKIL-ALKSIGNAGL 522  Caenorhabditis elegans
Q94637  462 LSYGSVLNGVCGQTKNvygsei--tetrkqCTR-----QMKEKYIRELIEKMNQ------AESRyEKVL-FVKAIANAGI 527  Oscheius tipulae
Q25490  415 LGAGALGGAYCREHD---------------CHNvk--pEGIVALSNKLGSKLQNcrpknkPDED-VVVA-ILKGIRNIRH 475  tobacco hornworm
Q9GSG2  427 LAASSMVNNYCNHNRN--------------CHEe----EPVKSLAETLGNKLQRqcsaseDEQTvQAALtTLKALGNMGV 488  Cherax quadricarinatus
Q9NDS1  428 LAAASMVNHYCRHTPH--------------CHQeapveRIAEILAAKVEGHCSPsi---gVEEKeEALA-IFKALGNMGV 489  Penaeus japonicus
P04114  443 YALSHAVNNYHKTNPT--------------GTQ-----ELLD-IANYLMEQIQDdc---tGDED-YTYL-ILRVIGNMGQ 497  human

1LSH_A  470 ------PNSIKKIQRFL--PGQgkslDEYSTRVQAEAIMALR--NIAKRDPRKVQEIVLPIFLNVAIKSELRIRSCIVFF 539 
Q9U572  574 ------PQTINVLKPII--LGV----TETNIFMRTNAIWSLSayNMHKTALSQIYEILMPIIENKGEQFEIRNIAFLTLA 641  black tiger shrimp
Q9UAR3  612 ------PQTIDVLKHFAlgDKP----STNIHVLRTNAILGLSgvYLPETAQSSVFGILMPVFENTGEHNEVRAVAFLAMM 681  signal crayfish
Q9N4J2  520 ------DLSVYELVQLI---QD----PRQPLSIRTEAVDALR--LLKDVMPRKIQKVLLPVYKNRQNKPELRMAALWRMM 584  Caenorhabditis elegans
P55155  523 ------DISVNQLNEII---VD----KRQLLPVRKEAIDALR--LLKDTMPRKIQKVLLPIYKNRQYEPEIRMLALWRMM 587  Caenorhabditis elegans
Q94637  528 ------DTSVVELEKII---RN----QEVEKTVRMQAIDALR--RLRLSMPKKIQNVLMPVYRNHKETPGIRISALHMIM 592  Oscheius tipulae
Q25490  476 l----eDSLIDKLVHCA---VD----NNVKARVRAVALEAFH----ADPCSAKIHKTAMDIMKNRQLDSEIRIKAYLAVI 540  tobacco hornworm
Q9GSG2  489 m----tPAVATSVLRCM---GT----EGADNRIRVAAAQAFR----KAKCHRASTGRLVGYALDSRKTTEVRIASYIAAV 553  Cherax quadricarinatus
Q9NDS1  490 v----tPAVTRAAAQCI---EK----EGLETSIRVAAAQAFR----QANCDRPAVQKLVDIATRPTFETEVRIASYLAAI 554  Penaeus japonicus
P04114  498 tmeqltPELKSSILKCV---QS----TKPSLMIQKAAIQALR--KMEPKDKD--QEVLLQTFLDDASPGDKRLAAYLMLM 566  human

1LSH_A  540 ESKPSVALVSMVAVRLRREPNLQVASFVYSQMR 572 
Q9U572  642 TWGPGHAWWQQLAVSTWHDPSPQFANFVTTTIY 674  black tiger shrimp
Q9UAR3  682 TFKPSLAWWERIAISTWRDPSSQVANYVSTTIT 714  signal crayfish
Q9N4J2  585 HTIPEEPVLAHIVSQMENESNQHVAAFTYNVLR 617  Caenorhabditis elegans
P55155  588 HTRPEESLLVQVVSQMEKETNQQVAALTHQMIR 620  Caenorhabditis elegans
Q94637  593 QTQPTSGVLDMIVRGLEKERSQQVRVYTWSTLK 625  Oscheius tipulae
Q25490  541 EC-PCSHSASEIKNLLDSEPVHQVGNFITSSLR 572  tobacco hornworm
Q9GSG2  554 RCAEKWD-FEKIVEKISVGQNTQVRGFILSHLR 585  Cherax quadricarinatus
Q9NDS1  555 RC-AEKEHLEQIIEKISEEENTQVRGFVLGHLI 586  Penaeus japonicus
P04114  567 RS-PSQADINKIVQILPWEQNEQVKNFVASHIA 598  human