Conserved Protein Domain Family
bHLH_TS_TCF24

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cd19710: bHLH_TS_TCF24 
basic helix-loop-helix (bHLH) domain found in transcription factor 24 (TCF-24) and similar proteins
TCF-24 is an uncharacterized bHLH transcription factor that shows high sequence similarity with TCF-23.
Statistics
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PSSM-Id: 381553
Aligned: 12 rows
Threshold Bit Score: 89.9968
Created: 28-Jun-2018
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   # ### #    #                 ####                  
Q7RTU0        50 PAAANAARERSRVQTLRHAFLELQRTLPSVPPDTKLSKLDVLLLATTYIAHLTRSL 105 human
XP_002740066  94 PTGANAARERSRVKTLRSAFLELQKTLPAVPPDTKLSKLDVLVLATTYIAHLMQTL 149 Saccoglossus kowalevskii
CDQ79625      63 PAAANAARERSRVQTLRSAFLELQRTLPSVPPDTKLSKLDVLILATTYIAHLTRTL 118 rainbow trout
XP_780938    135 NDPVNAARERSRVKTLRDAFLELQRSLPSVPPDTKLSKLDVLVLATTYISHLMRTL 190 purple urchin
KQK76330      49 PAAANAARERSRVQTLRHAFLELQKTLPSVPPDTKLSKLDVLLLATTYIAHLTRSL 104 blue-fronted amazon
EKC39936      32 IIAGNAARERSRVKTLRSAFLDLQRTLPAVPPDTKLSKLDVLVLATTYIAHLMRTL 87  Pacific oyster
XP_002609825   2 PTGSNAARERSRVKTLRSAFLELQKTLPSVPPDTKLSKLDVLVLATTYIAHLMRTL 57  Florida lancelet
OCT74790      53 PAAANAARERNRVQTLRHAFLELQRTLPSVPPDTKLSKLDVLILATTYIAHLTRSL 108 African clawed frog
XP_006006859  71 PAAANAARERSRVQTLRHAFLELQRTLPSVPPDTKLSKLDVLILATTYIAHLTRTL 126 coelacanth
XP_013396669  31 PCGANAARERSRVQTLRGAFLDLQKTLPSVPPDTKLSKLDILVLATTYIAHLMKTL 86  Lingula anatina
XP_007885518  56 PAAANAARERSRVQTLRNAFLELQRTLPSVPPDTKLSKLDVLILATTYIAHLTRTL 111 elephant shark
XP_023244579  42 AVSRNAARERTRVKSLRNAFLNLQRTLPYVPPNTKLSKLDVLILATTYISHLMKLL 97  bark scorpion

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