Conserved Protein Domain Family
RCS1

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pfam07326: RCS1 
Regulator of chromosome segregation 1
This family consists of several mammalian proteins of around 240 residues in length. Family members include regulator of chromosome segregation 1 (RCS1), also known as FAM64A, CATS or PIMREG (PICALM-interacting mitotic regulator). It is a substrate of APC/C. It may control the metaphase to anaphase transition. It is also a substrate of the Kinase Interacting Stathmin (KIS). RCS1 is highly expressed in cancer cell lines in a cell cycle dependent manner and is induced by mitogens.
Statistics
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PSSM-Id: 462146
Aligned: 14 rows
Threshold Bit Score: 298.655
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_415930      1 MASMLQNVKATMGWQRRLLLADFDENESPVPDKFKRKASFSSLHTICMSLRKRIPLKQVELNFHETPLWENMEARNKSQV 80 
XP_006100736   1 MASRWPGVSTSMRRRSLQDHQQLEESDELPPAAGHLEASGGALGSLCRQFQRRLPLRAVSLNLGAGPSWKRLETPEPEQQ 80 
XP_013968962   1 MASKWPGVGASGR----QDQEQLQEPEVVLRAAGHPDISCGALGSLCRQFQRRLPLRAVSLNLGAGPSWKRLESPEPGQQ 76 
XP_023099528   1 MASKWPGVGVSLRRGPLQEREQLAEKEAEQTAGGHPEPSSGALGSLCRHFQRRLPLRAVSRNLGAGPSWKRLENPEPSQQ 80 
XP_003416906   1 MASRWQGVGASRRRRSLQDQEQLQENVVPQPAVGHLESSTSALGSLCRHFQRRLPLRAVNLNLGAGPSWKRLENPEPGQQ 80 
EHB13573       1 MASQWHGMRSSVRRRSLLKEEQMEE-EVVWSAAGHVEPSTGALGSLCRQFQRRLPLRAVSLNLGAGPSWKRLQTPEPQQQ 79 
Q8BFY7         1 MASQWQGMRTSVRRRSLLKEEQLEKKEVTRSAGGHPET--GPLGSLCRQFQRRLPLRAVSLNLGNGPSWKRLESPEPEQQ 78  house mouse
Q9BSJ6         1 MASRWQNMGTSVRRRSLQHQEQLEDSKELQPVVSHQETSVGALGSLCRQFQRRLPLRAVNLNLRAGPSWKRLETPEPGQQ 80  human
XP_005056615   1 MASVLQNVKATVTWRKHQLLADLNENESPVPDKFKRRASQSSLSTICMSLRKRAPLKRVELNFHKTPTRESLEPRQRGQT 80 
XP_010720254   1 MASMLQNVRATMDWQRHLLLADF-ENERPVPDKFKRKTAFSSLNTICMSLRKRIPLKQVELNFHETPLWENMEARKKSQV 79 
XP_415930     81 -FQSITKTARNAFGTVSQKIQKTCQSPVHSTVTFPAEDIGSSSATCFSKkrr-tvQTPclsvnsvtPAARSKCTLRSSRR 158
XP_006100736  81 gLQAAARSAKNALGAVSQRIQESCQSGTKWLVETQVKARRRKRETQKGG------SPP--------ARSLSQRSTRLSGT 146
XP_013968962  77 gLQAAARSAKNALGAVSQRIQESCQSGTRWLVETQVKARR-RRGPQKGS------SPP--------AHSLSQKGGRLPGT 141
XP_023099528  81 gLQAAARSAKNALGSVSQRIQESCQSGTKWLVGTQVKARKRRRGAQTGS------RPP--------AHTPGQKSPRLCGA 146
XP_003416906  81 gLQAAARSAKNALGAMSQRIQESCQNGTKWLVETQVKARRRKRGAQKGG------SPP--------PRSLSQKNTRLSGA 146
EHB13573      80 gLQAAARSAKNALGVVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGS------GSP--------PPTLSQKSTRLCGA 145
Q8BFY7        79 gLQAAARSAKSALGAMSQRIQESCQSGTKWLMETQVKVRR-KRGAQKDR------GSP--------PPSLSQKNTRLCRA 143 house mouse
Q9BSJ6        81 gLQAAARSAKSALGAVSQRIQESCQSGTKWLVETQVKARRRKRGAQKGS------GSP--------THSLSQKSTRLSGA 146 human
XP_005056615  81 -LHAIKRRAKYAFGTMSQKIQKSCQSPVCSVVTLPAEPISSSCVISSTKkrsttpRTPcck--svtPAASSKGTPRSSRR 157
XP_010720254  80 -LQSITRTARNAFGTVSQKIQKTCQSPGHSTVTFPAEDIGSSFATSFSKkr--tvQTPclsmnsitPAASSKCTPRSSRR 156
XP_415930    159 SLLGPTTASEHKELRGFPSWHGEDAVPLLKSRTAsAALKSLYSSPTPTCRRIe--EFDCELELVSSGIHQLKHLFWAPDD 236
XP_006100736 147 GPACSTLGPWGWERHRRSTQMGPRAHPLRRSRRE-AAFRSPYSSTEPLCSPS---ESDSDLEPVGAGIQHLQKLSQELDE 222
XP_013968962 142 VPAYLSLGPWE-DCHRPSAHGGPRAYPGRRFRRD-AALRSPYSSTEPLCSPS---ESDSDLEPVGAGLQHLRKLSQELDE 216
XP_023099528 147 APASSALGPRERPCRRLSGHVGPRAHPQWRSRRE-PTFRSPYSSTEPLCSPS---ESDSDPEPVGAGLQHLQKLSRQLDE 222
XP_003416906 147 TPAYSALDSWKKEQHSLSAQRSPQTHPLRRSRRE-AAFRSPYSSTEPLCSPS---ESDSDLEPVGMGIQRLQKLSHKLDE 222
EHB13573     146 -----TLDPGKREYHRLSAQKDPRSHPRRRPRRN-AAFQNPYSLTEPLCSPRqvvESESDLEPVGAGIQHLQKPSQKLDK 219
Q8BFY7       144 -----NRDARVGGHLRLSGQMGPHAHRRQRLRRE-SALRSPCSSTEPLCSPS---ESDSDLEPVGAGIQHLQKLSQRLDR 214 house mouse
Q9BSJ6       147 APAHSAADPWEKEHHRLSVRMGSHAHPLRRSRRE-AAFRSPYSSTEPLCSPS---ESDSDLEPVGAGIQHLQKLSQELDE 222 human
XP_005056615 158 ALLGPTRVSEHREWREFSSWLDKNAVSLRRSRRA-AALKSPYSSPAPSSRRI---EFDCELDLVSSGICQLKCISQAFDD 233
XP_010720254 157 CLLWPTRLSEHTKLRGFPSWRGEDAVPLLRSRRAsAALKSLYSSPTPASRRIe--EFDSELELVSSGIHQLEHLFWASDD 234
XP_415930    237 AIVHGDRQHA 246
XP_006100736 223 AIAAEESADM 232
XP_013968962 217 AIVAAEGSDM 226
XP_023099528 223 AIVAEESGDM 232
XP_003416906 223 AIVAEDSGDM 232
EHB13573     220 AIMAED---K 226
Q8BFY7       215 AIKAEESGDM 224 house mouse
Q9BSJ6       223 AIMAEERKQA 232 human
XP_005056615 234 AIVKEERKEA 243
XP_010720254 235 DTVQGERQHA 244
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