6PNS


Conserved Protein Domain Family
Orbi_VP1

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pfam05788: Orbi_VP1 
Orbivirus RNA-dependent RNA polymerase (VP1)
This family consists of the RNA-dependent RNA polymerase protein VP1 from the Orbiviruses. VP1 may have both enzymatic and structural roles in the virus life cycle.
Statistics
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PSSM-Id: 461740
Aligned: 3 rows
Threshold Bit Score: 2127.86
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6PNS_A    1 MVAITVQGAQLIKRVVERFYPGIAFNINEGACYIYKFSDHIRRIRMKHGTKYRRQAEEIIRNISLRKERLYGIPVLDEVE 80  
P13840    1 MVAITVQGAQLIKRVVERFYPGIAFDINEGACYIYKFSDHIRRIRMKHGTKYRRQAEEIMRSISLRKERLYGIPVLDEVE 80   Bluetongue virus (s...
P13840    6 VQGAQLIKRVVERFYPGIAFDINEGACYIYKFSDHIRRIRMKHGTKYRRQAEEIMRSISLRKERLYGIPVLDEVEWKYVF 85   Bluetongue virus (s...
6PNS_A   81 WKYVFDGQTFQSYAFEVYVNSILPWSELDPEEEFLRNYRVSREMTEVEKFIEFRAKNEMQIYGDIPIKVWCCFINELSAE 160 
P13840   81 WKYVFDGQTFQSYAFEVYVNSILPWSELDPEEEFLRNYRVSRETTEVEKFIEFRAKNEMQIYGDIPIKVWCCFINELSIE 160  Bluetongue virus (s...
P13840   86 DGQTFQSYAFEVYVNSILPWSELDPEEEFLRNYRVSRETTEVEKFIEFRAKNEMQIYGDIPIKVWCCFINELSIELNPIP 165  Bluetongue virus (s...
6PNS_A  161 LKHVPLGMQVMADFVNRFDSPFHQGNRDLSNLEDFQVAYTTPLLFEMCCMESILEFNIKMRMREEEISALEFGDMKVDPV 240 
P13840  161 LNPIPLGMQVMADFVNRFNSPFHQGNRDLSNLEDFQVAYTTPLLFEMCCMESILEFNIKMRMREEDISALEFGDIKIDPV 240  Bluetongue virus (s...
P13840  166 LGMQVMADFVNRFNSPFHQGNRDLSNLEDFQVAYTTPLLFEMCCMESILEFNIKMRMREEDISALEFGDIKIDPVGLLRE 245  Bluetongue virus (s...
6PNS_A  241 GLLREFFILCLPHPKKINNVLRAPYSWFVKMWGVGADPIVVLQSTAGDDRNSKDVFYDKFRTEPNRYKALFRSSFYNESR 320 
P13840  241 GLLREFFILCLPHPKKINNVLRAPYSWFVKMWGVGADPIVVLQSTAGDDRNSKDVFYDKFRTEPNRYKALFRSSFYNESR 320  Bluetongue virus (s...
P13840  246 FFILCLPHPKKINNVLRAPYSWFVKMWGVGADPIVVLQSTAGDDRNSKDVFYDKFRTEPNRYKALFRSSFYNESRRMNEE 325  Bluetongue virus (s...
6PNS_A  321 RMNEEKILEAVKYSQKLGSHDRRLPLFEKMLKTVYTTPFYPHKSSNMILASFLLSIQTITGYGRAWVKNVSTEFDKQLKP 400 
P13840  321 RMNEEKILEAVKYSQNLGSHDRRLPLFEKMLKMVYTTPFYPHKSSNMILASFLLSIQTITGYGRAWVKNVSTEFDKQLKP 400  Bluetongue virus (s...
P13840  326 KILEAVKYSQNLGSHDRRLPLFEKMLKMVYTTPFYPHKSSNMILASFLLSIQTITGYGRAWVKNVSTEFDKQLKPNPSNL 405  Bluetongue virus (s...
6PNS_A  401 NPSNLVQDVSDLTREFFKQAYVEAKERREEIVKPEDLYTSMLRLARNTSSGFSTEIYVKKRFGPRLRDKDLIKINSRIKA 480 
P13840  401 NPSNLVRDVSDLTREFFKQAYVEAKERREEMVKPEDLYTSMLRLARNTSSGFSTEIYVKKRFGPRLRDKDLVKINSRIKA 480  Bluetongue virus (s...
P13840  406 VRDVSDLTREFFKQAYVEAKERREEMVKPEDLYTSMLRLARNTSSGFSTEIYVKKRFGPRLRDKDLVKINSRIKALVIFT 485  Bluetongue virus (s...
6PNS_A  481 LVIFTKGHTVFTDEELHKKYNSVELYQTKGSRDVPIKATRTIYSINLSVLVPQLIVTLPLNEYFSRVGGITSPDYKKIGG 560 
P13840  481 LVIFTKGHTVFTDEELHKKYNSVELYQTKGSRDVPIKATRTIYSINLSVLVPQLIVTLPLNEYFSRVGGITRPDYKKIGG 560  Bluetongue virus (s...
P13840  486 KGHTVFTDEELHKKYNSVELYQTKGSRDVPIKATRTIYSINLSVLVPQLIVTLPLNEYFSRVGGITRPDYKKIGGKVIVG 565  Bluetongue virus (s...
6PNS_A  561 KVIVGDLEATGSRVMDAADCFRNSADRDIFTIAIDYSEYDTHLTRHNFRTGMLQGIREAMAPYRDLRYEGYTLEQIIDFG 640 
P13840  561 KVIVGDLEATGSRVMDAADCFRNSADRDIFTIAIDYSEYDTHLTRHNFRTGMLQGIREAMAPYRALRYEGYTLEQIIDFG 640  Bluetongue virus (s...
P13840  566 DLEATGSRVMDAADCFRNSADRDIFTIAIDYSEYDTHLTRHNFRTGMLQGIREAMAPYRALRYEGYTLEQIIDFGYGEGR 645  Bluetongue virus (s...
6PNS_A  641 YGEGRVANTLWNGKRRLFKTTFDAYIRLDESERDKGSFKVPKGVLPVSSVDVANRIAVDKGFDTLIAATDGSDLALIDTH 720 
P13840  641 YGEGRVANTLWNGKRRLFKTTFDAYIRLDESERDKGSFKVPKGVLPVSSVDVANRIAVDKGFDTLIAATDGSDLALIDTH 720  Bluetongue virus (s...
P13840  646 VANTLWNGKRRLFKTTFDAYIRLDESERDKGSFKVPKGVLPVSSVDVANRIAVDKGFDTLIAATDGSDLALIDTHLSGEN 725  Bluetongue virus (s...
6PNS_A  721 LSGENSTLIANSMHNMAIGTLMQREVGREQPGVLTFLSEQYVGDDTLFYTKLHTTDTKVFDKVAASIFDTVAKCGHEASP 800 
P13840  721 LSGENSTLIANSMHNMAIGTLIQRAVGREQPGILTFLSEQYVGDDTLFYTKLHTTDITVFDKVAASIFDTVAKCGHEASP 800  Bluetongue virus (s...
P13840  726 STLIANSMHNMAIGTLIQRAVGREQPGILTFLSEQYVGDDTLFYTKLHTTDITVFDKVAASIFDTVAKCGHEASPSKTMM 805  Bluetongue virus (s...
6PNS_A  801 SKTMMTPYSVEKTQTHAKQGCYVPQDRMMIISSERRKDIEDVQGYVRSQVQTMITKVSRGFCHDLAQLILMLKTTFIGAW 880 
P13840  801 SKTMMTPYSVEKTQTHAKQGCYVPQDRMMIISSERRKDIEDVQGYVRSQVQTMITKVSRGFCHDLAQLILMLKTTFIGAW 880  Bluetongue virus (s...
P13840  806 TPYSVEKTQTHAKQGCYVPQDRMMIISSERRKDIEDVQGYVRSQVQTMITKVSRGFCHDLAQLILMLKTTFIGAWKMKRT 885  Bluetongue virus (s...
6PNS_A  881 KMKRTIKEDAMYRDRKFDSNDEDGFTLIQIRNPLALYVPIGWNGYGAHPAALNIVMTEEMYVDSIMISKLDEIMAPIRRI 960 
P13840  881 KMKRTIKENAMYRDRKFDSNDEDGFTLIQIRNPLALYVPIGWNGYGAHPAALNIVMTEEMYVDSIMISKLDEIMAPIRRI 960  Bluetongue virus (s...
P13840  886 IKENAMYRDRKFDSNDEDGFTLIQIRNPLALYVPIGWNGYGAHPAALNIVMTEEMYVDSIMISKLDEIMAPIRRIVHDIP 965  Bluetongue virus (s...
6PNS_A  961 VHDIPPCWNETQGDKRGLISATKMSFFSKMARPAVQAALSDPQIINLVEELPLGEFSPGRISRTMMHSALLKESSARTLL 1040
P13840  961 VHDIPPCWNETQGDKRGLISATKLSFFSKMARPAVQAALSDPQIMNLVEELPLGEFSPGRISRTMMHSALLKESSAKALL 1040 Bluetongue virus (s...
P13840  966 PCWNETQGDKRGLISATKLSFFSKMARPAVQAALSDPQIMNLVEELPLGEFSPGRISRTMMHSALLKESSAKALLSSGYR 1045 Bluetongue virus (s...
6PNS_A 1041 SSGYELEYQKALNSWITQVSMRLGEESGVISTSYAKLFDVYFEGELDGAPHMFPDQNLSPQFYIQKMMIGPRVSSRVRNS 1120
P13840 1041 SSGYRLEYQKALNGWIAQVSMRLGEESGVISTSYAKLFDVYFEGELDGAPYMFPDQNLSPQFYIQKMMIGPRVSSRVRNS 1120 Bluetongue virus (s...
P13840 1046 LEYQKALNGWIAQVSMRLGEESGVISTSYAKLFDVYFEGELDGAPYMFPDQNLSPQFYIQKMMIGPRVSSRVRNSYVDRI 1125 Bluetongue virus (s...
6PNS_A 1121 YVDRIDVILRKDVVMRGFITANTILNVIEKLGTNHSVGDLVTVFTLMNIETRVAEELAEYMTSEKIRFDALKLLKKGIAG 1200
P13840 1121 YVDRIDVILRKDVVMRGFITANTILNVIEKLGTNHSVGDLVTVFTLMNIETRVAEELAEYMTSEKIRFDALKLLKKGIAG 1200 Bluetongue virus (s...
P13840 1126 DVILRKDVVMRGFITANTILNVIEKLGTNHSVGDLVTVFTLMNIETRVAEELAEYMTSEKIRFDALKLLKKGIAGDEFTM 1205 Bluetongue virus (s...
6PNS_A 1201 DEFTMSLNVATQDFIDTYLAYPYQLTKTEVDAISLYCTQMIMLRAALGLPKKKMKIVVTDDAKKRYKIRLQRFRTHVPKI 1280
P13840 1201 DEFTMSLNVATQDFIDTYLAYPYQLTKTEVDAISLYCTQMVMLRAALGLPKKKMKIVVTDDAKKRYKIRLQRFRTHVPKI 1280 Bluetongue virus (s...
P13840 1206 SLNVATQDFIDTYLAYPYQLTKTEVDAISLYCTQMVMLRAALGLPKKKMKIVVTDDAKKRYKIRLQRFRTHVPKIKVLKK 1285 Bluetongue virus (s...
6PNS_A 1281 KVLKKLIDPNRMTVRNL 1297
P13840 1281 KVLKKLIDPNRMTVRNL 1297 Bluetongue virus (serotype 10 / American isolate)
P13840 1286 LIDPNRMTVRNLENQFV 1302 Bluetongue virus (serotype 10 / American isolate)
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