Conserved Protein Domain Family
STKc_Nek11

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cd08222: STKc_Nek11 
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
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PSSM-Id: 270861
Aligned: 8 rows
Threshold Bit Score: 495.405
Created: 11-Apr-2007
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:ATP binding site [chemical binding site]
Evidence:
  • Comment:based on the binding of MgADP to human Nek2

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                ## ##   #                   # #                              #           
NP_001072436   27 RYLLQQrLGKGSFGTVYLVIDkka---kdeQESLKVLKEIPVGELnpNETVQANVEAQLLSKLdHPAIVKFHASFLenes 103  western clawe...
EEN68416       30 RYVVEKkLGSGNFGTAYLVRDmkt---ktaDGEWKVLKEISVGDLapDETVGAMHEAKLLSKLeHPGIVKFHDSFLeken 106  Florida lancelet
EMC86752       28 RYAIQRkLGNGSFGSVYLVSDrka----khGEELKVLKEISVGDLkpNETVEANMEAQLLSKLdHPAIVKFYASFVerds 103  domestic pigeon
EKC31506       19 RYEIVKkLGKGNFGTAYLCKDlrsknpetdEYDLKVLKEISVGELqpDETVDAVREARVLSKLdHPSIVKFHDSFIdges 98   Pacific oyster
Q8NG66         28 RYVLQQkLGSGSFGTVYLVSDkka----krGEELKVLKEISVGELnpNETVQANLEAQLLSKLdHPAIVKFHASFVeqdn 103  human
EDO37069        5 RYRVVRrLGSGSFGTVFLVEDlk------aNGERKVLKEIYVGELqpDETVDAMREAKLLSKLnHPNIVKFMDSFMdrey 78   starlet sea a...
EDV21183       20 RYRVVRkIGSGNFGVVFLVNDl-------nTEELKVLKEIDIGNLqpDETIDAAKEANLLSSLnHPHIVRFYESFVsdgs 92   Trichoplax ad...
EGD74633        9 RYREVRkLGHGNFGAAWLVQDlq------cDRDWKVLKRVYIGTLkeSDSAGALREAKLLSQLeHPNILRFHDSFIdkdf 82   Salpingoeca s...
Feature 1              ###   #                                               # #              #   
NP_001072436  104 FCIITEYCEGRDLDFKVREckkneeKIAENQVVEWFIQLLLGVNYMHVRRILHRDLKAKNIFLKnNLLKIGDFGVSRLLM 183  western clawe...
EEN68416      107 FCIVTEFCEGGDLDNVSSEyrkrntTPAPEQVMEWFIQLLLAVQHMHERKVLHRDLKAKNIFMKnNVIKVGDFGISRILM 186  Florida lancelet
EMC86752      104 FCIITEYCEGGDLDFKIQEykesgrIFTQRQILDWFIQLLLGVDYMHERRILHRDLKAKNIFLKnNLLKIGDFGVSCLLM 183  domestic pigeon
EKC31506       99 FCIVTEFCEGGDLDCKINEcvknkqEIDSKLIMDWFVQLLLAVHYMHQRRVLHRDLKTRNIFLRqNMIKVGDFGISRILM 178  Pacific oyster
Q8NG66        104 FCIITEYCEGRDLDDKIQEykqagkIFPENQIIEWFIQLLLGVDYMHERRILHRDLKSKNVFLKnNLLKIGDFGVSRLLM 183  human
EDO37069       79 FCIVTEYCEGGDLDDKISAwrksgkKFDESLILAWFIQIVLAVQHMHEMRILHRDLKTRNIFLKnNIVKLGDFGISRILM 158  starlet sea a...
EDV21183       93 FCIVTEYCEGGDLDEKIKSirksstTLDETLIVTWFIQLLSAVQYIHKRRILHRDLKARNIFLRnNVIKVGDFGISRVLS 172  Trichoplax ad...
EGD74633       83 VCIVTEYCEGGDLADKIEAvkqeggVIQQQQVLDWFVQLTMALKYLHERGVLHRDLKSKNVFLKrGVIKLGDFGIARVLM 162  Salpingoeca s...
Feature 1                                                                                         
NP_001072436  184 GSCDLATTFTGTPYYMSPEALKHQgYDSKSDIWSLGCILHEMccLEHAFIGynfLSVVISIVEGETPSLPdcYSSSLNLI 263  western clawe...
EEN68416      187 GTSDMATTFTGTPYYMSPEVLKHEgYNSKSDIWSIGCILYELccLKHAFEGqslMAVMYKIVEGKTPSLPdtYPKELNDI 266  Florida lancelet
EMC86752      184 GSCDLATTFTGTPYYMSPEALKHQgYNTKSDIWSLGCILYEMccMNHAFTGhnfLSVVLKIVEGDTPSLP--DRYPSRLN 261  domestic pigeon
EKC31506      179 GTTDLASTFTGTPYYMSPEVLKHEgYNSKSDIWSIGCILYEMctLTHAFDGkslMAVMYKIVEGEVPKLPekFSSELNNV 258  Pacific oyster
Q8NG66        184 GSCDLATTLTGTPHYMSPEALKHQgYDTKSDIWSLACILYEMccMNHAFAGsnfLSIVLKIVEGDTPSLPerYPKELNAI 263  human
EDO37069      159 GTSDMATTFTGTPYYMSPEVLKHEgYNHKSDIWSLGVVLYELcnLQHAFQGqslMGVMYKIVEGELPALSdkYSSQLQAF 238  starlet sea a...
EDV21183      173 GTSDFATTFAGTPYYMSPEVLDHNaYNSKSDVWALACILYELccLRHAFEGqnlLNVMRAILEGEIPELPsiYHTELRRV 252  Trichoplax ad...
EGD74633      163 GTTDEATTFAGTPYYMSPEALQGVgYNDKSDIWALGCILYEMctLKHAFDGaglLSLLYQICEGDVPQIPdhYDKELKQL 242  Salpingoeca s...
Feature 1                                 
NP_001072436  264 MNRMLNKdPALRPSaGEILQDPFI 287  western clawed frog
EEN68416      267 LARILMKdPAKRPSaADLLTTPYI 290  Florida lancelet
EMC86752      262 AVLMLNKdPSLRPAaAEILRIPYI 285  domestic pigeon
EKC31506      259 LKLMLSKdPDKRPSaTDLLKIPLI 282  Pacific oyster
Q8NG66        264 MESMLNKnPSLRPSaIEILKIPYL 287  human
EDO37069      239 YSRLMDKdPKLRPSaNEILKHHFI 262  starlet sea anemone
EDV21183      253 YLGMLQRdPKQRFSiSEVLQNPFI 276  Trichoplax adhaerens
EGD74633      243 SSWLWQRdPAKRPSaVAILNTALV 266  Salpingoeca sp. ATCC50818

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