Conserved Protein Domain Family
NADB_Rossmann

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cl21454: NADB_Rossmann Superfamily 
Rossmann-fold NAD(P)(+)-binding proteins
A large family of proteins that share a Rossmann-fold NAD(P)H/NAD(P)(+) binding (NADB) domain. The NADB domain is found in numerous dehydrogenases of metabolic pathways such as glycolysis, and many other redox enzymes. NAD binding involves numerous hydrogen-bonds and van der Waals contacts, in particular H-bonding of residues in a turn between the first strand and the subsequent helix of the Rossmann-fold topology. Characteristically, this turn exhibits a consensus binding pattern similar to GXGXXG, in which the first 2 glycines participate in NAD(P)-binding, and the third facilitates close packing of the helix to the beta-strand. Typically, proteins in this family contain a second domain in addition to the NADB domain, which is responsible for specifically binding a substrate and catalyzing a particular enzymatic reaction.
Links
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Taxonomy: root
PubMed: 612 links
Protein: Related Protein
Related Structure
Statistics
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Accession: cl21454
PSSM Id: 473865
Name: NADB_Rossmann
Created: 5-Sep-2014
Updated: 4-Oct-2023
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