Conserved Protein Domain Family
FGAM_synt

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TIGR01735: FGAM_synt 
phosphoribosylformylglycinamidine synthase, single chain form
This model represents a single-molecule form of phosphoribosylformylglycinamidine synthase, also called FGAM synthase, an enzyme of purine de novo biosynthesis. This form is found mostly in eukaryotes and Proteobacteria. In Bacillus subtilis PurL (FGAM synthase II) and PurQ (FGAM synthase I), homologous to different parts of this model, perform the equivalent function; the unrelated small protein PurS is also required and may be a third subunit. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]
Statistics
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PSSM-Id: 188163
Aligned: 6 rows
Threshold Bit Score: 2185.72
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
BAA20816   40 FYVRPSGHEGAASGHTRRKlQGKLPELQGVE-TELCYNVNWTAEALPsaEETKKLMWLFGCPLLLDdvarESWLLP---- 114  human
Q9M8D3     90 FYRVPLIQESANAELLKAV-QTKISNQIVSLtTEQSFNIGLESKLKD--EKLSVLKWILQETYEPEnlgtDSFLERkkqe 166  thale cress
Q9PDF6      3 VLKGASALSPFRLARFESRlQTTVPELHIVG-AWHCYLIQIKSGHTLd-MSALHRILQAESVSEPp----QEHVVS---- 72   Xylella fastidios...
P43847      5 TFRGSPALSEFRLTQLQQKcQQYQLPITSVY-AEYLHFVEQKTSLVEdeIVKLQALLHYGSMFSE-----LKPAGY---- 74   Haemophilus influ...
Q9HXN2      3 ILRGAPALSAFRHGKLLEQlTQHVPAVTGLY-AEFAHFADVTGALTAdeEQVLARLLKYGPSVPV-----QEPSGR---- 72   Pseudomonas aerug...
Q9JWC5      6 PLRGVTALSDFRVEKLLQKaAALGLPEVKLS-SEFWYFVGSEKALDAatVEKLQALLAAQSVEQTp----KAREGLh--- 77   Neisseria meningi...
BAA20816  115 GsndlLLEVGPRLNFSTPTSTNIVSVCRATGLGPVDRVETTRRYRLSFAHPPSAEVEAIALATLHDRMTEQHFPHPIQSF 194  human
Q9M8D3    167 GlhavIVEVGPRLSFTTAWSTNAVSICRACGLDEVTRLERSRRYLLFSKEPLLENQIKEFAAMVHDRMTECVYTQKLVSF 246  thale cress
Q9PDF6     73 ------RYVMPRLGTHSPWSSKTTELLHGAGQP-IARIERGTRIDLLG-WSANAATCPAIAKQLYDPMTQSLLESEDEVK 144  Xylella fastidios...
P43847     75 -----CLIVTPRVGTISSWSSKATDIAHNCGLSKVNRIERGIAYYFNIERDLTEAELATLKDLLHDRMLETVLNHETEAA 149  Haemophilus influ...
Q9HXN2     73 -----LFLVVPRFGTISPWSSKASDIARNCGLAKIDRLERGIAYYVQG--ELSESDAQQVAARLHDRMTQLVLDRLEGAA 145  Pseudomonas aerug...
Q9JWC5     78 -----LFLVTPRLGTISPWASKATNIAENCGLAGIERIERGMAVWLEG--ALTDEQQQQWAALLHDRMTESVLPDFQTAS 150  Neisseria meningi...
BAA20816  195 SPESMPEPLNg-PINILGEGRLALEKANQELGLALDSWDLDFYTKRF-QELQRNPSTVEAFDLAQSNSEHSRHWFFKGQL 272  human
Q9M8D3    247 ETNVVPEEVK--YVPVMEKGRKALEEINQEMGLAFDEQDLQYYTRLFrEDIKRDPTNVELFDIAQSNSEHSRHWFFAGNM 324  thale cress
Q9PDF6    145 TLFNVPEPLSleRIALID-----LEHANTRWGLALTADEIDYLRTRY-TELNRVPSDVELMMFAQANSEHCRHKIFNATW 218  Xylella fastidios...
P43847    150 LLFTQQEPKAltTIDILNGGRQALEQANIALGLALADDEMDYLVESF-TALKRNPQDVELYMFAQANSEHCRHKIFNADW 228  Haemophilus influ...
Q9HXN2    146 ELFSHAQPRPltAVDVLGGGRAALEKANVELGLALAEDEIDYLLKSF-GELGRNPHDVELMMFAQANSEHCRHKIFNASW 224  Pseudomonas aerug...
Q9JWC5    151 KLFHHLESETfsTVDVLGGGKEALVKANTEMGLALSADEIDYLVENY-QALQRNPSDVELMMFAQANSEHCRHKIFNADF 229  Neisseria meningi...
BAA20816  273 HVDGQKLVHSLFESIMSTQESSNPNNVLKFCDNSSAIQGKEVRFLRPEDPTRPSRFQQQQGLRHVVFTAETHNFPTGVCP 352  human
Q9M8D3    325 VIDGKPMDKSLMQIVKSTWEANRNNSVIGFKDNSSAIRGFLVNQLRPLLPGSVCLLDVSARDLDILFTAETHNFPCAVAP 404  thale cress
Q9PDF6    219 TINDKEQQHSLFQMIKHTHQHTPQYTLSAYADNAAVIEGHPTARYRPDPITG-EYRHEAVLPGAFQIKVETHNHPTAIAP 297  Xylella fastidios...
P43847    229 IIDGKKQDKSLFKMIKNTFEQTPDFVLSAYKDNAAVMEGSKVGRWFPDPD-G-QYRVHQED-VHILMKVETHNHPTAISP 305  Haemophilus influ...
Q9HXN2    225 DIDGQAQDKSLFGMIKNTYEMNREGVLSAYKDNAAVIVGHVAGRFFPDPQTR-EYAASREP-VQILMKVETHNHPTAIAP 302  Pseudomonas aerug...
Q9JWC5    230 ILNGEKQPKSLFGMIRDTHNAHPEGTVVAYKDNSSVIEGAKVERFYPNAAENQGYRFHEED-THIIMKVETHNHPTAIAP 308  Neisseria meningi...
BAA20816  353 FSGATTGTGGRIRDVQCTGRGAHVVAGTAGYCFGNLHIPGYNLPWEDLsFQYPGNFARPLEVAIEASNGASDYGNKFGEP 432  human
Q9M8D3    405 YPGAETGAGGRIRDTHATGRGSFVVASTSGYCVGNLNMEGSYAPWEDSsFQYPSNLASPLQILIDASNGASDYGNKFGEP 484  thale cress
Q9PDF6    298 FPGASTGAGGEIRDEGATGRGGKPKAGLSGFSVSHLRIPTLPHPWETP-RALNPRMASALDIMLEGPLGSAAFNNEFGRP 376  Xylella fastidios...
P43847    306 FPGAATGSGGEIRDEGATGRGAKPKAGLTGFSVSNLVIPNFEQPWENP-LSKPNRIASALDIMIDAPLGSAAFNNEFGRP 384  Haemophilus influ...
Q9HXN2    303 FPGASTGSGGEIRDEGATGRGAKPKAGLTGFTVSNLQIPGFEQPWEVP-YGKPERIVTALDIMVEGPLGGAAFNNEFGRP 381  Pseudomonas aerug...
Q9JWC5    309 FAGAATGAGGEIRDEGATGKGSRPKAGLTGFTVSNLNIPGLKQPWEQD-YGKPEHISSPLDIMIEGPIGGAAFNNEFGRP 387  Neisseria meningi...
BAA20816  433 VLAGFARSLGLQ--LP-DGQRREWIKPIMFSGGIGSMEADHISKEAPEPGMEVVKVGGPVYRIGVGGGAASSvQVQGDNT 509  human
Q9M8D3    485 MIQGYTRTFGMR--LP-SGDRREWLKPIMFSAGIGQIDHTHITKGEPEVGMLVVKIGGPAYRIGMGGGAASS-MVSGQND 560  thale cress
Q9PDF6    377 NLLGYFRSFELSasK---TLTRAYDKPIMLAGGLGAIDRIHIKKLRLQPGDVIIVLGGPAMLIGLGGGAASS-VTSGTST 452  Xylella fastidios...
P43847    385 ALLGYFRTYEEKvnSFaGKEVRGYHKPIMLAGGIGNIRGEQVQKGEIPIGAKLIVLGGAAMNIGLGGGAASS-MDSGKSK 463  Haemophilus influ...
Q9HXN2    382 ALTGYFRTFEQKiaTPhGEEVRGYHKPIMLAGGMGNIRDEHVQKGEISVGAKLIVLGGPAMLIGLGGGAASS-MATGASS 460  Pseudomonas aerug...
Q9JWC5    388 NLLGYFRTFEEKfdG----QVRGYHKPIMIAGGLGSIQAQQTHKDEIPEGALLIQLGGPGMLIGLGGGAASS-MDTGTND 462  Neisseria meningi...
BAA20816  510 SDLDFGAVQRGDPEMEQKMNRVIRACVEAPKGNPICSLHDQGAGGNGNVLKELSDP--AGAIIYTSRFQLGDPTLNALEI 587  human
Q9M8D3    561 AELDFNAVQRGDAEMSQKLYRVVRACIEMGEKNPIISIHDQGAGGNCNVVKEIIYP--QGAEIDIRAVVVGDHTMSVLEI 638  thale cress
Q9PDF6    453 EALDFASVQRDNPEMQRRCQEVIDHCVALGTNNPIRSFHDVGAGGLSNAIPELLHDseVGGVIDLAKIPSDDPSLSPLEL 532  Xylella fastidios...
P43847    464 EDLDFASVQRENPEMERRCQEVIDRCWQLGEENPILFIHDVGAGGLSNAMPELVHDgkRGGKFDLRSILCDEKGMSPLEI 543  Haemophilus influ...
Q9HXN2    461 ADLDFASVQRDNPEMERRCQEVIDRCWQLGERNPISFIHDVGAGGLSNALPELINDggRGGRFELRAVPNDEPGMSPLEI 540  Pseudomonas aerug...
Q9JWC5    463 ASLDFNSVQRGNPEIERRAQEVIDRCWQLGDKNPIISIHDVGAGGLSNAFPELVNDagRGAVFKLREVPLEEHGLNPLQI 542  Neisseria meningi...
BAA20816  588 WGAEYQESNALLLRSPNRDFLTHVSARERCPACFVGTITGDRRIVLVDDr------------------eCPVRRNGQGDA 649  human
Q9M8D3    639 WGAEYQEQDAILVKAESREILQSICKRERLSMAVIGTINGGGRCTLIDS--------------------TAAAKCSKEGL 698  thale cress
Q9PDF6    533 WCNESQERYVLGISAAHLQAFAAICTRERCPFAAVGVATATEQLIVGYGvtlpaalhvteqqtpqranhTETSPTPNTLP 612  Xylella fastidios...
P43847    544 WCNESQERYVLAVAPENLELFTALCERERAPFAVIGEATQAEHLILHD-------------------------------- 591  Haemophilus influ...
Q9HXN2    541 WCNESQERYVLSVDAADFETFKAICERERCPFAVVGEAIEQRQLTVAD-------------------------------- 588  Pseudomonas aerug...
Q9JWC5    543 WCNESQERYVLSILEKDLDIFRSICERERCPFAVVGTATDDGHLKVRD-------------------------------- 590  Neisseria meningi...
BAA20816  650 PPTPPptPVDLELEWVLGKMPRKEFFLQRKPPMLQPLALPPGLSVHQALERVLRLPAVASKRYLTNKVDRSVGGLVAQQQ 729  human
Q9M8D3    699 PPPPP--AVDLELEKVLGDMPKKTFKFNRIAYAREPLDIAPGITLMDALKRVLRLPSVSSKRFLTTKVDRCVTGLVAQQQ 776  thale cress
Q9PDF6    613 PSVREafAIDLPMDVLFGKAPKMHRNTAHPPPPHWPTLDSTQLDLHHAGLRVLAHPTVAAKNFLVTIGDRSIGGLTAREQ 692  Xylella fastidios...
P43847    592 -SHFDnnPIDLPMNVLLGKTPKMTREVLSKTVENQSLKI-ESIQLKEAFHRVLRLPVVAEKTFLITIGDRSVTGMVARDQ 669  Haemophilus influ...
Q9HXN2    589 -SHFDnkPVDMPLEVLLGKAPRMHRAVTREAELGDDFDA-AGLELQESVERVLRHPAVASKSFLITIGDRTITGLVARDQ 666  Pseudomonas aerug...
Q9JWC5    591 -DLFSnnPVDLPLNVLLGKPPKTTRTDKTVAPSKKPFHA-GDIDITEAAYRVLRLPAVAAKNFLITIGDRSVGGMTHRDQ 668  Neisseria meningi...
BAA20816  730 CVGPLQTPLADVAVVALSHEELIGAATALGEQPVKSLLDPKVAARLAVAEALTNLVFALVTDLRDVKCSGNWMWAAKLPG 809  human
Q9M8D3    777 TVGPLQITLADVAVIAQTFTDLTGGACAIGEQPIKGLLDPKAMARLAVGEALTNLVWAKVTALSDVKASGNWMYAAKLEG 856  thale cress
Q9PDF6    693 MIGPWQLPLADCAITLAGFGTYAGEAFAIGERAPLALLNSAAAARMAVGEAITNLCAAPVESLSMVKLSANWMAAAEHPG 772  Xylella fastidios...
P43847    670 MVGPWQIPVSDVAVTTASLDSYHGEAMAIGERSPVALLDFSASARLAVAEAITNIAGTLIGEMKRIKLSANWMSAAGHTG 749  Haemophilus influ...
Q9HXN2    667 MVGPWQVPVADCAVTATSFDVYTGEAMAMGERTPLALLDAPASGRMAIGETVTNLAAARVGKLSDIKLSANWMAAAGHPG 746  Pseudomonas aerug...
Q9JWC5    669 MVGKYQTPVADCAVTMMGFNTYRGEAMSMGEKPTVALFDAPASGRMCVGEAITNIAAANIGDIGNIKLSANWMAACGNEG 748  Neisseria meningi...
BAA20816  810 EGAALADACEAM-VAVMAALGVAVDGGKDSLSMAARVGT----ETVRAPGSLVISAYAVCPDITATVTPDLKHPEGRGHL 884  human
Q9M8D3    857 EGSAMYDAAIAL-SEAMIELGIAIDGGKDSLSMAAHADG----EVVKAPGNLVISAYVTCPDITKTVTPDLKLGGDDGIL 931  thale cress
Q9PDF6    773 EDALLYDAVKAIgIELCPALDISIPVGKDSLSMQSRWQAdgatHTCISPVSLVISAFTPVADARRQLTPLLHHQt-NSEL 851  Xylella fastidios...
P43847    750 EDAGLYEAVKAVgEELCPALGLTIPVGKDSMSMKTTWIDngeqKSVTAPLSLVISAFARVEDVRKTLTPQLRTDKgFSSL 829  Haemophilus influ...
Q9HXN2    747 EDARLYDTVKAVgMELCPELGITIPVGKDSMSMKTRWQDngedKSVTSPVSLIVTGFAPVADVRQSLTPQLRLDKgETDL 826  Pseudomonas aerug...
Q9JWC5    749 EDEKLYRTVEAV-SKACQALDLSIPVGKDSLSMKTVWQDgeekKSVVSPLSLIISAFAPVQDVRKTVTPELKNv-eDSVL 826  Neisseria meningi...
BAA20816  885 LYVALSPGQHRLGGTALAQCFS------QLGEHPPDLDLPENLVRAFSITQGLLKDRLLCSGHDVSDGGLVTCLLEMAFA 958  human
Q9M8D3    932 LHVDLAKGKRRLGGSALAQVFG------QIGNDCPDLDDVPYLKNVFDGVQALIAENLVSAGHDISDGGLVVTALEMAFA 1005 thale cress
Q9PDF6    852 WLIALDGGKQRLGGSVLAQVHAdsaalpTFGGECPDLDTPETLRAFFALMNDARNAGLLLAYHDRSDGGAFAALCEMAFA 931  Xylella fastidios...
P43847    830 LLIDLGEGHNRLGATALAQVYK------QLGDKPADVVKVQRLKDFYNAMQTLVAEDKLLAYHDRSDGGLITTLAEMAFA 903  Haemophilus influ...
Q9HXN2    827 ILIDLGRGKNRLGGSILAQVHG------KLGRAVPDVDDAEDLKAFFAVIQGLNADGHILAYHDRSDGGLITSVLEMAFA 900  Pseudomonas aerug...
Q9JWC5    827 LFVDLGFGKARMGGSAFGQVYN------NMSGDAPDLDDTSRLKAFYNVIQQLVAEDKLLAYHDRSDGGLFAVLVEMAFA 900  Neisseria meningi...
BAA20816  959 GNCGLQVDVPVPRVDV---------------------------LSVLFAEEPGLVLEVQEPDLAQVLKRYRDAGLHCLEL 1011 human
Q9M8D3   1006 GNKGINLDLASNGISL---------------------------FETLFSEELGLVLEISKTNLDAVMEKLRAFDVTAEII 1058 thale cress
Q9PDF6    932 SHLGLDITCDNRTEHL---------------------------FPHLFNEELGAIVQVADEHRTAFTDLVEQHGLTAYTQ 984  Xylella fastidios...
P43847    904 GHCGVEVDISALGDND---------------------------LAVLFNEELGAVIQVADSQLESVREVLKAHNLLGIIH 956  Haemophilus influ...
Q9HXN2    901 GHCGVELNLDALADSRee------------------------lAAVLFSEELGAVIQVREGATPEVLAQFSAAGLDDCVA 956  Pseudomonas aerug...
Q9JWC5    901 GRCGLDIDLNLLLAQTfitnhtalsqslrteevkalaewqetiARTLFNEELGAVIQVRKQDVADIINLFYQQQLHHNVF 980  Neisseria meningi...
BAA20816 1012 GHTGEAgphAMVRVSVNGAVVLEEPVGELRALWEETSFQLDRLQAEPRCVAEEERGLRERMGPSYCLPPTFPKASVPREP 1091 human
Q9M8D3   1059 GNVTDS---PLIEVKVDGITHLSEKTSFLRDMWEDTSFQLEKLQRLASCVEMEKEGLKFRHEPNWKLSFIPSSTNNNYMS 1135 thale cress
Q9PDF6    985 RIAHPTt-aPSIRIMHNDQCLAQWTWETLFDAWWSVTHAMQRLRDNPECADEEREIARTFTAPGLKPTLSFDPAVDVAMP 1063 Xylella fastidios...
P43847    957 QLGTVTa-dDRFEISRGSHKLFSEKRSELRSIWAELTYQMQRLRDNPECAEQEFEAKKNPDDKGLSAFLTYDVNEDITAP 1035 Haemophilus influ...
Q9HXN2    957 VIGQPVn-gYEINLNYNGETVYSAQRRILQRIWSETSYQIQRLRDNADCAEQEFDALLDEDNPGLSIKLSYDVNDDIAAP 1035 Pseudomonas aerug...
Q9JWC5    981 EIGTLTd-eNTLIIRDGQTHLISDNLIKLQQTWQETSHQIQRLRDNPACADSEFALIGDNGRSALFANLKFDVNEDIAAP 1059 Neisseria meningi...
BAA20816 1092 G---GPSPRVAILREEGSNGDREMADAFHLAGFEVWDVTMQDLCSGAIGLDTFRGVAFVGGFSYADVLGSAKGWAAAVTF 1168 human
Q9M8D3   1136 Q---DVKPKVAVIREEGSNGDREMSAAFYAAGFEPWDVTVSDLLAGDITLDQFRGIVFVGGFSYADVLDSAKGWAASIRF 1212 thale cress
Q9PDF6   1064 FiatGIRPTVAILREQGINGHIEMALCFERAGFHCVDIHMNDLITGRVHLDEFVGLAACGGFSYGDVLGAGRGWATSILE 1143 Xylella fastidios...
P43847   1036 FinkGVKPTIAILREQGVNSHYEMAAAFDRAGFNAIDVHMSDLMIGRRNLAEFNAMVACGGFSYGDVLGAGGGWAKSILF 1115 Haemophilus influ...
Q9HXN2   1036 YikkGVRPKVAILREQGVNGQVEMAAAFDRAGFAAIDVHMSDILAGRVDLDAFKGLVACGGFSYGDVLGAGEGWAKSILF 1115 Pseudomonas aerug...
Q9JWC5   1060 FinsGAKPKIAILREQGVNGQIEMAAAFTRAGFDAYDVHMSDLMAGRVHLADFKMLAACGGFSYGDVLGAGKGWAKSILF 1139 Neisseria meningi...
BAA20816 1169 HPRAGAELRRFRKRPDTFSLGVCNGCQLLA-LLGWVGGDPNEDAaemgpdsqparpglLLRHNlSGRYESRWASVRVGPG 1247 human
Q9M8D3   1213 NEPVLSQFQEFYKRPDTFSLGICNGCQLMA-LLGWVPGPQVGGSldts-------qprFVHNE-SGRFECRFTSVTIKDS 1283 thale cress
Q9PDF6   1144 RTALRDQFAAFFTRTDRFALGVCNGCQMLSqLKSMIPGAEHWPR--------------FVRNR-SEQFEARTALLEVIQS 1208 Xylella fastidios...
P43847   1116 NPKLHEQFSQFFINPNTLTLGVCNGCQMISnLAEIIPGTENWPH--------------FVRNK-SERFEARVSLVKINEV 1180 Haemophilus influ...
Q9HXN2   1116 NARARDGFQAFFARKDSFALGVCNGCQMMSnLHELIPGTEFWPH--------------FVRNR-SEQFEARVAMVQVQES 1180 Pseudomonas aerug...
Q9JWC5   1140 HPALRDQFAAFFTDPNTLTLGVCNGCQMVSnLAEIIPGTAGWPK--------------F-KRNlSEQFEARLSMVHVPKS 1204 Neisseria meningi...
BAA20816 1248 PALMLRGMEGAVLPVWSAHGEGYVAFSSPELQAQIEARGLAPLHWADDDGNPTEQYPLNPNGSPGGVAGICSCDGRHLAV 1327 human
Q9M8D3   1284 PSIMLKGMEGSTLGVWAAHGEGRAYFPDEGVLDHMLHSDLAPLRYCDDDGNVTEAYPFNLNGSPLGIAAICSPDGRHLAM 1363 thale cress
Q9PDF6   1209 PSIFLSGMAGSRLPVAVAHGEGYAMFDTPADQAAAH----VALRYINGHGQAATHYPLNPNGSPNGITGLTTTDGRITIL 1284 Xylella fastidios...
P43847   1181 DSVWFAGMAGSHMPIAVSHGEGQVKFKSVEQFAGLKAQGIIAAQYIDNNGSPTELYPANPNGSSEGITAITNLDGRVAIM 1260 Haemophilus influ...
Q9HXN2   1181 SSIFLQGMAGSRLPIAIAHGEGHAEFESEEALLEADLSGCVSLRFVDNHGKVTEAYPANPNGSPRGITGLSSRDGRVTIM 1260 Pseudomonas aerug...
Q9JWC5   1205 ASLILNEMQGSSLPVVVSHGEGRADFALHGGNISADLG--IALQYVDGQNQITQTYPLNPNGSPQGIAGVTNADGRVTIM 1282 Neisseria meningi...
BAA20816 1328 MPHPERAVRPWQWAWRPPPFDTlTTs--PWLQLSINARNWT 1366 human
Q9M8D3   1364 MPHPERCFLMWQFPWYPTSWDVeKAgpsPWLKMFQNARDWL 1404 thale cress
Q9PDF6   1285 MPHPERTPRTINLSWSPNEWGE-DT---PWLRLFRNARAWV 1321 Xylella fastidiosa 9a5c
P43847   1261 MPHPERVFRAVSNSWHPENWTE-DG---AWMRLFRNARMVF 1297 Haemophilus influenzae Rd KW20
Q9HXN2   1261 MPHPERVFRAVQNSWRPDDWQE-DG---GWLRMFRNARVWV 1297 Pseudomonas aeruginosa PAO1
Q9JWC5   1283 MPHPERVYRAAQMSWKPEDWTE-LS---GWYRLFAGARKAL 1319 Neisseria meningitidis Z2491
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