Conserved Protein Domain Family
TMEM144

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pfam07857: TMEM144 
Transmembrane family, TMEM144 of transporters
Members of this family fall in to the drug/metabolite transporter (dmt) superfamily. They carry 10xTM domains arranged as 5+5. Although these two sets may originally have arisen by gene-duplication the divergence now is such that the two halves are no longer homologous.
Statistics
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PSSM-Id: 285141
Aligned: 6 rows
Threshold Bit Score: 469.991
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
O01810   4 VIGLAACAVSSVFFGSMFVPIKSYDSRDGIFAQWMMSIAILLVGFIVFATTGFPGFYPLAMLGGASWCIGNATAIPIISR 83  Caenorhabditis elegans
Q10000   4 AVGLSACALSSVLFGSMFVPVKKCHSGNGIFVQWIMSTAILLVGIVVYSTQGFPEFEPLAMLGGMFWALGNATAVPIMNT 83  Caenorhabditis elegans
Q9U3C0  15 IVGYVALLLSCCAFGTMFVPLRRRNCKDGFFVQWIECGVVFIVGCIFYAARGFPKFEPIACIGGFLYATGNVFSVPIVEG 94  Caenorhabditis elegans
Q7Z5S9   9 TFGYISCFVAILLFGSNFVPLKKFDTGDGMFLQWVLCAAIWLVALVVNLILHCPKFWPFAMLGGCIWATGNIAVVPIIKT 88  human
Q20583   6 TLGIVCAVVSAITFGSTYVPLKWFHKGDGLYFQWVQSLGQLLVGVAVAMTTAPAPIHPIAMLSGMFYSVGNSLTVFIMDG 85  Caenorhabditis elegans
Q95QA2   2 IVGILACLTATFTLGSVFAPIKRFPSSDGFMVQFFMSLGGFITSLAIHALLGFPPIYPLAMLGGALWCAANAFAFLIMNR 81  Caenorhabditis elegans
O01810  84 LGLAVSILVWNTSNCLVGWAGGRFGLFG-MKAQVPASPFLNYLGLVFVVIGGSIFAQVR-SEPlpiakktsRTSFDLENL 161 Caenorhabditis elegans
Q10000  84 IGIGMGMLVWGTTNCVAGWAAGRFGLFG-INSTVPEYPFLNYFGLVLVVFGGFLFSQIRpNEP--------QTASERSPL 154 Caenorhabditis elegans
Q9U3C0  95 IGMGVGFLIWTSLQIIVGWGVARFGLFQwIAPQNVKNDVLNYIGIALTIVSGVLLIFVK-HVEte-----pENEYDVTSK 168 Caenorhabditis elegans
Q7Z5S9  89 IGLGLGILIWGSFNALTGWASSRFGWFG-LDAEEVSNPLLNYIGAGLSVVSAFIFLFIKsEIPn------nTCSMDTTPL 161 human
Q20583  86 IGLAIGYLLWNTVTCVVGWAVTRFGLFA-NPQQYPKSDWLNILGVVTVCVGGAIYAPIK-HIP---------------AR 148 Caenorhabditis elegans
Q95QA2  82 LGLAVPILIWSTVSCLTGWATTRYGLFG-VPKGIPSSVILNYIGIIVLVVGSSFFLFIKsHVYipk--krnNSESLTSGG 158 Caenorhabditis elegans
O01810 162 NSEEKKALNTTESSDD--------GGLEtevlrpdKnlnsgtqRFFAFITAIVAGFFYGMTFVPVIRMIDNPQ----LYP 229 Caenorhabditis elegans
Q10000 155 MVAPDDDLTDDVAPDDsdivvprgGAVPtrahrnqK-------RLLAIITSLVAGVFYGFTFVPVIYIQDHPE----IYP 223 Caenorhabditis elegans
Q9U3C0 169 EMEHQEEIEQRLSNSErdssfdmaGLAK---------------KLPYILMAMVLACLHGLMMSPIEYLKQQNP------P 227 Caenorhabditis elegans
Q7Z5S9 162 ITEHVINTTQDPCSWVdkls-------------------tvhhRIVGCSLAVISGVLYGSTFVPIIYIKDHSKrndsIYA 222 human
Q20583 149 VRPAPWSLEEDNYKDDplvvke----------------vsctrRILCLFLTIFVGFLYGNFLTPINYIIANE-------P 205 Caenorhabditis elegans
Q95QA2 159 EIPSKKSMATQSSEEDdivqhph--------------hvspivRIVCFLAAIFSGLFYGSMCTPVTFIQNRPD----LYP 220 Caenorhabditis elegans
O01810 230 FYPQDGISYVFSHYFGIFITSTIIFVIYSIFRRNQPYAPPNLFLPGMAAGCLWAVAQTSFFVANQHLSQTVTFPIISQMP 309 Caenorhabditis elegans
Q10000 224 TAPKTGLGYVFSHYIGIFCTASALMIGYVIYSRNNPFASSRLVGPSMTAGSMWGIAQASWFVANDNLSQAVSFPIISMVP 303 Caenorhabditis elegans
Q9U3C0 228 TDSFQVFDYIFPFYTSVFLFSTLYFFAYCVILRRKAYVERNLIIPSIGYGILWTTGMTLWFVSSDKLSQVVAYPCTARLP 307 Caenorhabditis elegans
Q7Z5S9 223 GASQYDLDYVFAHFSGIFLTSTVYFLAYCIAMKNSPKLYPEAVLPGFLSGVLWAIATCCWFIANHSLSAVVSFPIITAGP 302 human
Q20583 206 GSHQDVRAYILSYCLGSFVTSTVIFFVYSIVKKNVPLVNAELSMPSIISGILYGIAVTTFFMANQHLDQVIAYPILSKAP 285 Caenorhabditis elegans
Q95QA2 221 GAPTEGLPYLFSFFCGIMPMSTFVLVIYSAVKKNNPSLPSYLVLPSLFGGLLFAIGMGGFFIGNQKLSQTISYPICSFAP 300 Caenorhabditis elegans
O01810 310 GCIAAAWSIFYYREIRGKKNFILLGAAMSITITGATLVGLSK 351 Caenorhabditis elegans
Q10000 304 GVIAALWSVFYFRDISGSRNLRLLSIAVAITLIGAICVGVSK 345 Caenorhabditis elegans
Q9U3C0 308 PLISGALDVFVFKSIQGTRSYATLAISSVIGVISVIMIALSN 349 Caenorhabditis elegans
Q7Z5S9 303 GFIAAMWGIFMFKEIKGLQNYLLMILAFCIILTGALCTAFSK 344 human
Q20583 286 GIIVSLWAIFLFKEIQGKKDIIQLYIGIFVTLLGIAFISLSK 327 Caenorhabditis elegans
Q95QA2 301 GLIVSAWSVLYFKEITGKRNLILLGIAYAFTLVGVIMVTVSK 342 Caenorhabditis elegans
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