3LH5,6UY7,2EYX,4Z88


Conserved Protein Domain Family
SH3_2

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pfam07653: SH3_2 
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Variant SH3 domain
SH3 (Src homology 3) domains are often indicative of a protein involved in signal transduction related to cytoskeletal organization. First described in the Src cytoplasmic tyrosine kinase. The structure is a partly opened beta barrel.
Statistics
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PSSM-Id: 429575
Aligned: 28 rows
Threshold Bit Score: 38.346
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3LH5_A    5 YIRTHFEYEKESPYG-------LSFNKGE---VFRVV---------DT--LYNgklGS-WLA-IRigkNHKev--erGII 59   human
Q8MQQ3  502 HIKTHFHCDNPSKGE-------MAFKAGD---VFRVIdtl--------hngVV---GS-WQV-LKigrGHQem--qrGVI 556  fruit fly
O62683  468 YIRTHFELEASPPSG-------LGFTRGD---VFHVLdtlcpgpgpSG--ARG---TH-WLA-VRm--GRDlreqerGII 528  dog
Q921G9  467 YIRTHFELEPSPPYG-------LGFTRGD---VFHVVdtlypgsgpGHghSSH---GGlWLA-ARm--GRDlreqerGVI 530  house mouse
O35601  503 HAKACCDVKG-GKNE-------LSFKQGEdieIIRIT-------------DNP---EGkWLG-RTa-rGSY------GYI 550  house mouse
Q91X43  418 HGIANEDIVSRNPTE-------LSCKRGD---VLVIL---------KQ--AEN---NY-LEC-QRg--EGT------GRV 463  house mouse
A1IGU4  510 LYQVSSNINGTGTLD-------LTLLRGQ---IVALLqn------kDT--KGN---NSrWLV-DTg--GHR------GYV 559  house mouse
Q81B28    2 KYIVIKSHVSNYPNP-------IRLEEGD---VVKMIesy----agPE--NWE---NW-MFChEEk-yNRK------GWV 54   Bacillus cereus ATC...
Q8A5A0    6 KYIVVCKWVESYKNP-------IILKKDE---KVVVNla-----ikET--DPEw-vNW-VWC-IAg-nGMT------GWV 58   Bacteroides thetaio...
Q8RBE1   35 VGKVTGNYVNVRTEGslsgsviTQVSKDE---VVTVL----------E--KQG---DW-YRI-RLs-dGRE------GWI 87   Caldanaerobacter su...
3LH5_A   60 PNKNRAEQ 67   human
Q8MQQ3  557 PNKSRAEE 564  fruit fly
O62683  529 PNQSRAEQ 536  dog
Q921G9  531 PNQSRAEQ 538  house mouse
O35601  551 KTTAVEID 558  house mouse
Q91X43  464 HPSQMKIV 471  house mouse
A1IGU4  560 PAGKLQLY 567  house mouse
Q81B28   55 PEQIIRKD 62   Bacillus cereus ATCC 14579
Q8A5A0   59 PIQILNVC 66   Bacteroides thetaiotaomicron
Q8RBE1   88 YGEYLSVR 95   Caldanaerobacter subterraneus subsp. tengcongensis
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