5H3A,7CCA,3NRR,3KGB,2AAZ,3UWL,1TIS


Conserved Protein Domain Family
Thymidylat_synt

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pfam00303: Thymidylat_synt 
Thymidylate synthase
This is a family of proteins that are flavin-dependent thymidylate synthases.
Statistics
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PSSM-Id: 459753
Aligned: 432 rows
Threshold Bit Score: 212.28
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5H3A_A         5 LQYLRQLREILCRG--SDRLD-R-----TGIG--TLSLFGMQARYSLR-DhFPLLTTKRVFWRGVVQELLWFLKGSTD-S 72  Human gammaherp...
CCX65185       6 DNFIRMCNDILEHGttTEGQKvRphw-pdGTPayTIKTFGVVTRYDLQk-eFPVLTLRKTPVKSALDELLWIWQQKSNkI 83 
CDC47241       6 nLFIHMCQDILENGtdTKGEKvRpkwedTGEFayTIKRFGVVNRYDLRk-eFPALTLRKTALKSCMDEILWIYQKKSNnI 84 
WP_012808719   6 RIFIDMCSDIIENGttTEGEKvRptw-edGTSayTIKKFGVCNRYDLRe-eFPALTLRRTALKSAMDEVLWIYQKKSNnV 83  Lancefieldella ...
WP_013251670   6 DIFVRMCTDIIERGttTEGQRvRphw-edGTPayTIKQFGVCNRYDLRe-eFPALTLRRTALRSAMDEVLWIYQKKSNnI 83  Olsenella uli
WP_021919930   6 QIFLANCQEILSRGtwDTHLPvRprw-edGTPahTVKCFGLVNRYDLRe-eFPIQTIRRMYLKSAVEELLWIWQKKSNnV 83  Evtepia gabavorous
CDB86654       6 EIYIQTCRDILDHGvwDTDREvRphw-edGTPahTVKKFCVVNRYDLRe-eFPIMTLRRTYYRSCIQELLWIWQKKSNrI 83 
CCX93405       6 ELYKKTCRDILENGfsDENLEvRphw-adGTPahTIKKFGVVNRYNLAe-eFPIMTLRRTYWKSAVDELLWIWQKKSNrV 83 
Q65J44         6 QQYNAIIQKIIESGisDEEYQvRtkwdsDGTPahTLSIMSEKMRFDNSe--VPILTTKKVAWKTAIKELLWIWQLKSNdV 83  Bacillus lichen...
Q8RGP6         7 KIYKDIVDTIAEKGi-WSEGNvRtky-adGTAahYKSYIGYQFRLDNSdDeAHLITSRFAPSKAPIRELYWIWILQSNnV 84  Fusobacterium n...
5H3A_A        73 RELSRTGVKIWDkngsrEF-L-AGRglahrreGDLGPVYGFQWRHfGAAyvda--------------------------- 123 Human gammaherp...
CCX65185      84 SELHS---GVWD-----EW-A-DEE-------GTIGKAYGYQMAV-KNRyydvteeglrrafgaafadavpetelvtdvl 145
CDC47241      85 KDLKP---HIWD-----AW-A-DEH-------GSIGTCYGDVVGR-KFLy------------------------------ 116
WP_012808719  84 NDLNS---HIWD-----SW-A-DES-------GSIGKAYGYQVGQ-VSHy------------------------------ 115 Lancefieldella ...
WP_013251670  84 HDLSS---HIWD-----EW-A-DES-------GSIGKAYGYQIAQ-KSHy------------------------------ 115 Olsenella uli
WP_021919930  84 RALST---GIWD-----AW-A-DET-------GSIGKAYGYQMGV-KHRy------------------------------ 115 Evtepia gabavorous
CDB86654      84 SELGS---HIWD-----SW-A-QPD-------GTIGKAYGYQLGV-KHIy------------------------------ 115
CCX93405      84 ADLGS---HVWD-----EW-V-GED-------GTIGKAYGYQLGI-KHQy------------------------------ 115
Q65J44        84 QVLNDMGVHIWD-----QW-Rl-ED-------GTIGAAYGYQLGKknrtv------------------------------ 119 Bacillus lichen...
Q8RGP6        85 DVLNELGCKFWD-----EWkMqD---------GTIGKAYGYQIAQe---------------------------------- 116 Fusobacterium n...
5H3A_A       124 ---dadyTGQG----------FDQLSY---IVDLIKNNPHDRRIIMCAWNPAD-LsL-MALPPCHLLCQFYV----Ad-- 179 Human gammaherp...
CCX65185     146 vpeteemKRAHalkgpdgcwyMDQVDR---VIYDLKNNPFSRRILTSIYTFSD-L-HaMNLHPCAYSMTFNViqkpGhek 220
CDC47241     117 -------KGEQ----------IDQMDY---VLKQLKENPYSRRIMTNLYQFEY-L-HsGALDPCCYSMTYNVtkerNsek 174
WP_012808719 116 -------ADGD----------YDQMDR---VLKDLKENPFSRRIMTNLYTFAD-L-SeMNLYPCAFNAIYNVtqgaGknr 173 Lancefieldella ...
WP_013251670 116 -------PEGD----------MDQMDR---VLFDLRSNPYSRRIMTSTYTFAD-L-SeMNLYPCAFNVIYNVtqtpGeer 173 Olsenella uli
WP_021919930 116 -------PEGE----------MDQVDR---VLYDLKHNPSSRRILTNLYNHHD-L-SeMALYPCAYSMTFNVtg------ 167 Evtepia gabavorous
CDB86654     116 -------PEGA----------FDQVDR---VLYDLRHNPASRRILTNLYNHHD-L-HeMALAPCAYSMTFNVsg------ 167
CCX93405     116 -------KEGM----------FDQVDR---VIYDLKHNPASRRILTNIYNFED-L-HeMNLYPCAYSMTFNVtg------ 167
Q65J44       120 -----------------ngqkVDQVDY---LLHQLKHNPSSRRHLTMLWN-PDdL-DgMALTPCVYETQWYVke------ 171 Bacillus lichen...
Q8RGP6       117 --------------------tFGQKSQlhyVINELKKNPNSRRIMTEIWI-PNeL-SeMALTPCVHLTQWSVig------ 168 Fusobacterium n...
5H3A_A       180 -GeLSCQLYQRSGDMGLGVPFNIASYSLLTYMLAHVTGLRPGEFIHTLGDAHIYKTHIEPLRLQLTRTPR-PfPRLEIl- 256 Human gammaherp...
CCX65185     221 lT-LNGILNQRSQDILAAFAWNEWQYACLLAMLAQVCDMEAGEFVHVVADAHIYDRHVDAVKELMSRTPQpA-PKVWInp 298
CDC47241     175 lA-LNGVLNQRSQDVLAANNWNVCQYALLLMMVAQVNDMIPGELVHVIADAHIYDRHVDAVKELIARETYpA-PKVSLnp 252
WP_012808719 174 pT-LNLLLVQRSQDILAANNWNVCQYAILLMMVAQVSGMEAGELVHMIADAHIYDRHVDIVKELISRPTFdA-PKVSLnp 251 Lancefieldella ...
WP_013251670 174 pS-LNMLLVQRSQDILAANNWNVCQYAILLMMVAQTNDMVAGELVHMISDAHIYDRHVDIVRELIARPTYpA-PKVSLrp 251 Olsenella uli
WP_021919930 168 -ntLNAILHQRSQDMLTANGWNVMQYAVLVHMLAQVSGLEAGELVHVIADAHIYDRHVPLVEELLGRTPYpA-PRLRLdp 245 Evtepia gabavorous
CDB86654     168 -ntLNAILNQRSQDMLTANNWNVVQYAALVHMLAQVSGLEAGELVHVIADCHIYDRHVPLVEKMLQNPSYpA-PEFVIdr 245
CCX93405     168 -dtLNAILNQRSQDMLTANNWNVVQYAVLTHMMAQVAGLKVGELVHVIADCHIYDRHIPAVKAMLELDGYpT-PTFRMde 245
Q65J44       172 -gkLSLEVRARSNDMALGNPFNVFQYNVLQRMIAQVLGYELGEYIFNIGDCHIYTRHIDNLNIQMKREQYeA-PKLWInp 249 Bacillus lichen...
Q8RGP6       169 -nkLYLEVRQRSCDVALGLVANVFQYSVLHKLVALECGLEPAEIIWNIHNMHIYDRHYDKLIEQVNRETFeP-AKIKIn- 245 Fusobacterium n...
5H3A_A       257 -RSvSsMEEFtPDDFRLVDYCPHPTIRM 283 Human gammaherpesvirus 8
CCX65185     299 dIH-D-FYQFtREDVKLENYQVAGDQIr 324
CDC47241     253 eIK-D-FYDFtTEDLVVENYEAGPQIKn 278
WP_012808719 252 nIT-N-FYDFtTDDLIVEDYQHGPQVKn 277 Lancefieldella parvula
WP_013251670 252 dVH-D-FYDFtTDDLIVCDYNHGPQVKd 277 Olsenella uli
WP_021919930 246 aVT-D-FYAFtPDSVQLENYRYHPLKEK 271 Evtepia gabavorous
CDB86654     246 sIT-D-FYRFtADSFRMENYQYAPFDAK 271
CCX93405     246 sIT-D-FYAFtKDSFSMENYQFHPFNFE 271
Q65J44       250 dIK-N-FYDFtIDDFKLIDYKHGDKLTF 275 Bacillus licheniformis DSM 13 = ATCC 14580
Q8RGP6       246 nFK-S-IFDFkPDDIEIIDYKYGEKVSY 271 Fusobacterium nucleatum subsp. nucleatum ATCC 25586
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