2YLF


Conserved Protein Domain Family
KIND

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pfam16474: KIND 
Kinase non-catalytic C-lobe domain
The KIND domain (kinase non-catalytic C-lobe domain) evolved from a catalytic protein kinase fold and functions as an interaction domain. In SPIRE1 (protein spire homolog 1) this domain interacts with FMN2 (formin-2).
Statistics
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PSSM-Id: 465129
Aligned: 18 rows
Threshold Bit Score: 251.842
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
2YLF_A        33 LSLEEILRLYNQPINEEQAWAVCYQCCGSLRAAARR-RQ--PR-HRVRSAAQIRVWRDGAVTLAPAADDAGepppvagkl 108 human
XP_014345822  31 LSLEEVLKSYEQPINEEQAWAVCYQCCRGLSQVLPG-EAq-RRtARVKDPGSIILHKDGAVTVFNDPEPNDsdr----kh 104
NP_001007343  21 LSLEKVLKSYEQPINEEQAWAVCFQCCGDLRAPRPQ-PHprHPeLQIRDPASIILHRDGRVTALLQSCDDSn-------a 92 
XP_002933730  20 LSLEEVLKSYEQPINEEQAWAVCYQCSRGLLGQPWP------PrGRIRDPSCLLLHRDGAITVLPETQGTAetv---prs 90 
XP_010812901  28 LSLEEVLKAYEQPINEEQAWAVCFQCCRGLRGAPGGr-------RRIRDTADILLRRDGSVSARRESGAAEpt-----tm 95 
XP_007477398  33 LSLEEVLKSYEQPINEEQAWAVCYQCCRGLLGAEPGg-------GRIRDTADILLHKDGTVSAQLEPGSADst-----mv 100
XP_002593964  18 FSLEEILRAFGAPINEEQAWAMCYQCAKSLQDDWRRcRK---EcFQFTGGESVALRKDGSVGAVRTESS-G--------- 84 
EFA04670      15 VCLEDILNSFNSSIREEHAWALCYQCAKYYSECVSS-RK--QNvHIVTEVRHVYLQTDGNVHENTIKARDTp-------- 83 
EGI70428      43 LNLQDVLLIFDSPLSQERAWALCYQIANGLLRLTEN------KfYEISELSQIILHKDGDIWLENLA---Gsk-----pp 108
XP_023811806  34 LSLEEVLKSYEQPINEEQAWAVCYQCCRGLRVPHPP-PG--Ra-DRVKDPSSLLLYRDGTVALRPNDVAdkppfp----- 104 Japanese medaka
2YLF_A       109 GYSQCMETEVIESLGIIIYKALDYGLKENEERELSPPLEQLIDHMANTVEA--Dg--------SNDEGYEAAEEGLGDE- 177 human
XP_014345822 105 PQPTCTEGQIVQSLGFAIYRALDWGLDENEERELSPQLEQLIDLMANGDLEgsNg--------TADEGYGQDEEE---E- 172
NP_001007343  93 GCESAADGKLVQSLGVAIYRALDWGLDDSEERELSPQLEQLIEFMVGGPDC--GqskhcgsnaAKDEGYSGQDEEEEEEe 170
XP_002933730  91 PLSGITETQMVQYLGFAIYRALDWGLDESEERELSPQLEKLIDLMADGDSEg-----------vTDEGYDGPEDE----- 154
XP_010812901  96 VSPASSEAQVVQSLGFAIYRALDWGLAEHEERELSPQLERLIDLMANSDCD--Ddgg----ggTADEGYGGPEEE---E- 165
XP_007477398 101 APPANTEAQMVQSLGFAIYRALDWGLDDSEERELSPQLEQLIDLMANSDSE--Dng-----caVADEGYGGQEEE-EET- 171
XP_002593964  85 --PARFESQLVYSLGLVVYRALDYGLSESEERELSHPLEDLIDRMTSNDND--Ds-------qNHDEGIEDSDEEITSE- 152
EFA04670      84 RKLLRCEKDVIAGLGVVIYIALDQGSQNDEERVISQDLEQLISDMISDELNssEqth----heTDDEGIERDSEEGEEE- 158
EGI70428     109 L---VSEEKVIFSLGMAIFKALDFGSNAGEEIALLPDLEALITSMTNCNRVy-EgdveerlqeTDDEGIERDSGDTDAE- 183
XP_023811806 105 ---ptaeceLVQSLGVVIYQALDWGLDDSEERELSPQLERLIEKMVAGVQE--EgvrsttknsTSDEGYSGQEEEEEEQ- 178 Japanese medaka
2YLF_A       178 D-----EKRKISAI----RSYRDVM--------KLCAAHLPT--ESDAPNHYQAVCRALFAETMELHTFLT 229 human
XP_014345822 173 E-----NEGLPRTM----RSFEQVM--------KACASHLTD--PTEAPSHYQAVCRALFLETKELMTFLV 224
NP_001007343 171 E-----EEGAGRGI----HTVQQVM--------TMCASRLAN--PVLAPEHYQAVCRALFLETLELQTFLS 222
XP_002933730 155 D-----EEGQPRLV----RSFSAVL--------RVCASRLPE--PHEAQTHYQAVCRALFAETVELKAFLS 206
XP_010812901 166 E-----AEGGPRTV----RTFAQAM--------RLCAARLTE--PRGAQTHYQAVCRALFVETLELRAFLA 217
XP_007477398 172 T-----ECSNLRAV----STFSQVM--------KLCASRLTD--YREAQSHYQAVCRALFVETVELKAFLT 223
XP_002593964 153 D-----TVKTLEQVvkisQGFHDLLgtlalkevKLCASHLQN--PSEAAGHYQAVCRALVAECQELTSFLA 216
EFA04670     159 P-----GTSRTQPH----MTLQEVI--------RRCESHLGTltKTQTEAHYKAVVRALVAEALELATFLE 212
EGI70428     184 DympkpTEYTDSPT----CTLKTIL--------QICARHAQSl-HENADNYYRNIIQAFVEEALNLSQFLE 241
XP_023811806 179 Q-----QEGTTRPV----CTFRQVM--------ALCASRLAN--PSVAPEHYQAVCRALFVETLELQTFLT 230 Japanese medaka
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