Conserved Protein Domain Family
Scs3p

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pfam10261: Scs3p 
Inositol phospholipid synthesis and fat-storage-inducing TM
This is a family of transmembrane proteins which are variously annotated as possibly being inositol phospholipid synthesis protein and fat-storage-inducing. The members are conserved from yeasts to humans and are localized to the endoplasmic reticulum where they are involved in triglyceride lipid droplet formation.
Statistics
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PSSM-Id: 402051
Aligned: 74 rows
Threshold Bit Score: 180.995
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCE65002      33 KTWDINRDSIINSVFVKRGWFWNSLVLWYVILFtnitivdEPkrnnSIEGRktkt------------------------- 87 
XP_004194678  63 YNYYNDKRNILNQFFVKKGWAWTTVVIVVFYILilrs----------khpKvqsq------------------------- 107
EMG45163      57 YNYYNNKGNIFNQYFVKKGWGWTTLVILLFYSNll--------------yKtpa-------------------------- 96 
EER30745      56 YNYYSNKKNIFNKLFVKQGWGWTTLVILIFYSNli--------------yKtsny------------------------- 96 
CCE44412      70 YNYYNNKHNFFNTVFVKRGWGWTTLIIIVFYAVivmpklyS---------Nkndtts----------------------i 118
XP_001524468  63 YNYYNDKRNVLNQWFVKRGWGWTTLVVVLFYSLfavpqilNStlttATAARttttarrvdeneddsvlvsgkkekklytt 142
XP_001386227  60 YNYYTNKKNVLNQVFVKNGWFWTTANIVLFYGIvl--------------yKekss------------------------- 100
Q6BUP0       109 YNYYNNKRNVFNQVFVKRGWGWTTLIIVVFYSFlm--------------yGnshari----------------------r 152 Debaryomyces ha...
EGV62536      93 YNYYNDKNNVFNQLFVKRGWFWTTVVMAAFYGSvfygkhpQLgtnrF--------------------------------- 139
EGW35656      56 YNYYTDKRNILNQLFVKNGWAWTTIVIVVFYVSiltqsrpRKs------------------------------------- 98 
CCE65002      88 --rihTLNIKKFIkRYVIVTMWWILFTQGipFFKiPPIMDLCFVFTGGSCN--------------------FEIfde--- 142
XP_004194678 108 --qekIRLLRNGLiKYSIMTFWWVLFTQW--CFG-LPIMDKVFVWTGGKCQkvaekell----rhfpgalkDKFfspssd 178
EMG45163      97 --adrIRVLRRAVtNYIIATVWWILFTQW--CFG-LPIMDKIFVWTGGKCKiditnh--------dvnhvhSSFihsl-- 161
EER30745      97 --sirQKLIYKGIlNYLLSTLWWILFTQW--CFG-LPIMDKIFIWTGGKCKiegieik-------ninhlhNSFiqtl-- 162
CCE44412     119 qqqqkIEFLIKAVvRYAIATFWWILFTQW--CFG-LPIMDKIFVLTGGVCVlephpttqttppstianhalGQSflqdle 195
XP_001524468 143 kserlSKYFLGAIvRYLLLTIWWVLFTQW--CFG-LPIMDKIFVVSGGACVieppqfaasqqkisnsqhlfGKfiqdl-e 218
XP_001386227 101 --airINIAKGAViRYVLATVWWIFFTQW--FFG-LPIMDKVFVYTGGSCViekethpgqsrflhlfeaagEEVgnk--- 172
Q6BUP0       153 tkqqrISVLKKAIfNYVVATLWWVLFTQW--CFG-LPLMDKVFVWTGGKCTgiaqekla----lhipsygtSSIfteies 225 Debaryomyces ha...
EGV62536     140 ------PVAKNAIiSYTIATAWWILFTQW--CFG-VPIMDKIFLWTGGRCVsvaed----------rlahhSEFfnkv-- 198
EGW35656      99 ------KVIREAViRYAVITMWWILFTQW--CFG-LPIMDRIFVLTGGKCVvedpgrhvkl--------------fanlg 155
CCE65002     143 -snaINIKFQdseyrklkslkriykilkdykesyiessylhhlrcaidenaegcmdfvpskdtnelikkiqdldpmvqfi 221
XP_004194678 179 gesfEASSIT---------------------------------------------------------------------- 188
EMG45163     162 eniwESTGIT---------------------------------------------------------------------- 171
EER30745     163 eniwESTGIT---------------------------------------------------------------------- 172
CCE44412     196 tlvwKSKDVS---------------------------------------------------------------------- 205
XP_001524468 219 tlvwRSSSVS---------------------------------------------------------------------- 228
XP_001386227 173 ---lsSTSIT---------------------------------------------------------------------- 179
Q6BUP0       226 dlsyESKAIT---------------------------------------------------------------------- 235 Debaryomyces ha...
EGV62536     199 edlyESTVVG---------------------------------------------------------------------- 208
EGW35656     156 ngksVSSTIS---------------------------------------------------------------------- 165
CCE65002     222 SSKCKRNGG-HWVGGHDPSGHIFLLTLMMMMIIAELP--------KINRirKQnmiyqkdskiRRVNivEKISKIIGEii 292
XP_004194678 189 SYTCRKLKG-AWTGGHDPSGHVFLLVHSSLYLFLETSqfwgswpsFFGSarNLcgklrrvpadQSAEpkSKLAQVVDF-- 265
EMG45163     172 SYYCRKMKG-NWIGGHDPSGHVFLMIHSSLYLFFETSssfpsltvLKQNfnHFk---------RTTTlkEKLNVVWNTp- 240
EER30745     173 SYTCRKFKG-NWIGGHDPSGHVFLMIHSSLYLYLETIdyfpgfsnIKNNlkRLv---------RVNSfkEKLIILWNTp- 241
CCE44412     206 SYHCRKFKG-SWLGGYDPSGHVFLMIHSSIYLYFETAawfn-wtdVRGAlySIkqslrdrrylESHIwqLVYGIVq---- 279
XP_001524468 229 SYHCRKLRG-NWEGGHDPLGHVFLMIHSSLYLYLECAawfd-wksLVRCvvYVyrklqnyggkSLVRgfEHNEKLFVG-- 304
XP_001386227 180 SYHCRRIKG-SWEGGHDPSGHVFLLIHSSLYLFLEVSpywvsyshFKASlsKLrke-----vvKPVSlgEKFSSFIKY-- 251
Q6BUP0       236 SYMCRKLKG-SWEGGHDPSGHVFLLIHSSLYLFLEALpfwiswatLKHHlcQFvks-------wrLTsgSKPKLLFGL-- 305 Debaryomyces ha...
EGV62536     209 SKVCRQLRG-NWEGGHDPSGHVFLLIHSSLYMFFETVpfwrnwthVRTTlgKLk---------QDLSvsDNRTITVGR-- 276
EGW35656     166 SYNCKRIKGsSWEGGHDPSGHVFLLIHSSLYLFLETAeywpgwgaLINSisSVvhn-----heKTIIekLKQLAILGV-- 238
CCE65002     293 gtipsrsilsngllstyeklyqflilpimqnvkliiqlisytihfALFQEpaVLLISLLGMWCYSFLITIIVFHTFYEQV 372
XP_004194678 266 ----------------------------------------------FHGTphFIVFLLLSLWWFMLLMTNIYFHSLAEKL 299
EMG45163     241 ---------------------------------------------------qVLVGLLLALWWFMLLMTNIYFHSILEKF 269
EER30745     242 ---------------------------------------------------sIFISLLIGLWWFMLLITNMYFHSILEKL 270
CCE44412     280 ----------------------------------------------------LSLVGLVALWWFMLLMTNVYFHSIVEKL 307
XP_001524468 305 ------------------------------------------------ELaqLSVVLLISLWWFMLLMTNMYFHSIAEKL 336
XP_001386227 252 ----------------------------------------------SVANppIVVAKLITLWWFMLLMTNIYFHSLGEKL 285
Q6BUP0       306 ----------------------------------------------FAQDphTIIIPLISLWWFMLFMTNIYFHSIGEKL 339 Debaryomyces ha...
EGV62536     277 ---------------------------------------------FFLHNpwIPVGMLILLWWFMLLMTNVYFHSILEKL 311
EGW35656     239 -----------------------------------------------KIHpqLLVIGMISFWWFMLLTTNIYFHSIAEKL 271
CCE65002     373 TGFLSAYIVAVIIY 386
XP_004194678 300 VGLLFAYAGALLVY 313
EMG45163     270 AGLLFGYIGVLIMY 283
EER30745     271 VGLIFGYLGIAVIY 284
CCE44412     308 SGLVFGYFGVIVVY 321
XP_001524468 337 VGLVFRYVGVFAIY 350
XP_001386227 286 VGLVFGYIGVVGIY 299
Q6BUP0       340 VGLVFGYVGLAVVY 353 Debaryomyces hansenii
EGV62536     312 VGLLFGY--AISLV 323
EGW35656     272 VGMVYGYLGIVVVY 285
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