Conserved Protein Domain Family
Ilm1

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pfam10311: Ilm1 
Increased loss of mitochondrial DNA protein 1
This is a family of proteins of approximately 200 residues that are conserved in fungi. Ilm1 is part of the peroxisome, a complex that is the sole site of beta-oxidation in Saccharomyces cerevisiae and known to be required for optimal growth in the presence of fatty acid. Ilm1 may participate in the control of the C16/C18 ratio since it interacts strongly with Mga2p, a transcription factor that controls expression of Ole1, the sole fatty acyl desaturase in S. cerevisiae responsible for conversion of the saturated fatty acids stearate (C18) and palmitate (C16) to oleate and palmitoleate, respectively.
Statistics
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PSSM-Id: 431212
Aligned: 49 rows
Threshold Bit Score: 126.155
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003236905   4 ISSKTYIRLHALFQVVLAVYLTFARESVGGPELVYKVRDKLRIDILQPFNLPR-SPFAYCGILLLSFAIFDLTLAik--- 79 
XP_002560159   4 ISSKTLIQAHAVFLVVIAGYLVKNPEVITDSDLVFMMGEALKIDF-PSLSSPQqSPFTFCAILIFIESLVDLVLLsnipf 82 
EPS27594       4 LSSKTLIQAHAVFTVVIAGYLLKNPAVITDSDIVFMMGEALQIDF-PAPTTPTsSPYVICSVLLFVAAAVDIVLLtslpf 82 
EEA22762       4 LSSKTLIQAHALFTFILSVYLVISPNAITDSDIIFIIGEAMQIDLDPAMTTFQ-YPLAICAILLTGEALVDLIIVrk--- 79 
EED15299       4 LSSKTLIQLHALFMFILAVYLITSPSSITESDLIFIIGEAMQIDLDPAMSTSQ-FPFSICAILLVSEALIDLIVVgk--- 79 
GAD96368       4 FSSKTLIKAHAFFLFVLAVYLTKSPEVITDSDLVFILGEAMKIDVSPTFARPQ-SPFALCGILLVADALVDLIVVtk--- 79 
GAA90082       4 LSSKTLIQAHALFLFVLAVYLTRSPEVVTESDLVFMLGEFLNLEATPSISRPQ-SPFALCGVLLVVDALVDLILVtk--- 79 
EED56482       4 LSSKTLIQAHALFLFILAVYLTRSPEVITDSDVVFMLGETLQIDAAPSLSRPQ-SPFALCGILLVADALVDLILVtk--- 79 
XP_001272585   4 LSSKTLIRAHALFLFVLAVYLTKSPEAVTESDFIFMVGEMVQIDAAPTLSRPQ-SPFAMCGILLIADALVDLIILsk--- 79 
EEQ88659       4 LSSKGYIKLHALFQFALAIYLTRYKEVISDCDLVYNVNDVIRIDATPTFARPR-SPFAYCGVILLVFALFDLILTir--- 79 
XP_003236905  80 lpTLNHVLAVAEFIHRQqlrqqqerqqrefllqsrassssssstalpppvisrsrlpytrppasrssstsstastdsdss 159
XP_002560159  83 heALDEALPYIRPLRNGnlpaedlqvlqslpey----------------------------------------------- 115
EPS27594      83 hdALNDALPYIRPLRNSnlpaedlqalarlpey----------------------------------------------- 115
EEA22762      80 lpQIDDILSTVQHEQRRtedtgfsritlqkpkqni--------------------------------------------- 114
EED15299      80 lpQLDSILTNLQREQRQtedrgfsritlqkpkqti--------------------------------------------- 114
GAD96368      80 vpQINEVLARADVARSRsngstavisnnpfa------------------------------------------------- 110
GAA90082      80 ipQINEILAMAQAARVQspipvagavrtnpfm------------------------------------------------ 111
EED56482      80 vpRINEIIAMAEIARSAaptsiagamrtnpfl------------------------------------------------ 111
XP_001272585  80 vpWINEIIAMAQAARSEsavpvpgamrhnpfl------------------------------------------------ 111
EEQ88659      80 lpLINQLISITRRLFDSrlanssgrsrtsrtsrtspsspss--------------------------------------- 120
XP_003236905 160 tstelneaalkitaefsslyrqlcillITLRSWIFMIVSLQIYLSSDMEWGAastalpstatvagmpatstlaantmatp 239
XP_002560159 116 ------------itksltiywsvwiavAACRFAVYAAIAFFIYQ------------------------------------ 147
EPS27594     116 ------------itksltmywniwvavSAVRFALYGALSFYIYQ------------------------------------ 147
EEA22762     115 ---------naltiqlatlyneiwtfiACVRFCFFFAVSLFIYTSGGNA------------------------------- 154
EED15299     115 ---------nswtiqlatiyneiwtfiAGARFVFFFAVSLFIYTGDS--------------------------------- 152
GAD96368     111 -------------irmaalyseiwtllAASRFCLFFAVSIFIYQSKPVAWGVg--------------------------- 150
GAA90082     112 -------------arltslyseiwtllSAARFCIFFAVSFFIYQSQPSAWGM---------------------------- 150
EED56482     112 -------------arlaslytdiwtllSASRFCLFFAVSFFIYQSKPSDWGV---------------------------- 150
XP_001272585 112 -------------arlaslyseiwtllSAVRFCLFFAVSFFIYQSKPDAWGV---------------------------- 150
EEQ88659     121 ---palstakkmlriynsifthmcillAVTRCLVFSIISIRIYASATDIWVPaa-------------------------- 171
XP_003236905 240 fqsaagktilwldqnmhftRDGPSTAAAlsgsalGYDVIDLKRKIVLGYGVLELMFSCWILFALRHEKKQA 310
XP_002560159 148 -------------------GKGDHLASSytsaaaIGGLDRLKNRVVFSFAFFEMMFWFWTFSTLREERQER 199
EPS27594     148 -------------------ARGSYMVASyaaktaPTGLAQLKSRVVFTFAFMEMMVWFWVFFTCREERQQR 199
EEA22762     155 -------------------GKASLEWSDddagqiKLGLEQVKSRVVFTYAFVEMMFWLWTLSNVREERREV 206
EED15299     153 -------------------SGATGKKSWvgqgqvRNGLDQVRNRIVFTFAFVEMMFWLWALSNVREERREV 204
GAD96368     151 ------------------aSEA------------MSGLDQLKNRVVFTYGFMEMMFWLWILLTLREERQET 191
GAA90082     151 -------------------DAATGMGNYgtagaaTSGLDQLKNRVVFTYGFMEMMFWLWIFITLREERQEA 202
EED56482     151 -------------------DVRHTVDGYgqe--saSGLNQLKNRVVFTYGFMEMMFWLWIFLTLREERHEI 200
XP_001272585 151 -------------------NVTARGTEYsst-eaLSGLDQLKNRVVFTYGFMEMMFWLWIFITLREERQEI 201
EEQ88659     172 ------------------aAS-----GMqdtaalDAKAIHMKNKVVLGYAVIEMMISSSTLLSLKDERRQv 219
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