Conserved Protein Domain Family
SRP68

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pfam16969: SRP68 
RNA-binding signal recognition particle 68
SRP68 is a family that is part of the SRP or signal recognition particle complex. This complex, consisting of six proteins and a 7SL-RNA is necessary for guiding the emerging proteins designed for the membrane towards the translocation pore. SRP68 forms a stable heterodimer with SRP72, a protein with a TPR repeat. Specific RNA-binding of SRP68 is mediated by the N-terminal domain of approximately 200 residues of this family.
Statistics
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PSSM-Id: 465323
Aligned: 68 rows
Threshold Bit Score: 330.407
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003660447  15 LLYGDYSTYWSQLSGKLLNSRK--KLNIATKHRGKFNPKApV-----TPEQIAENHEYVYLHLLTAERTWAHAMTMKASH 87 
EMS51735      73 LRHGDYTRYRRYCTARLRRLYK--SLKFLHGRG-KYTRRN-I-----TESTV-TDVRFLHVVFYMAERAWSHAMEKKTA- 141
CCD82452      29 LRHGDYQRYHQYISRKLRRMRK--SLHFQQGNRSKVVPKK-L-----TPDIV-TDPRFIILAIFEIERSWAYAMQLKAES 99 
CDS37384      33 LRHGDYQRYRQYVTRKIRRMRK--SLRFQQGTRSRVVPKK-L-----TPEIV-TDARYLILSVFEIERCWAYAMQLRAEA 103
2_pfamImport   1 LRHGDYQRYHGYCNRRLKRIRK--VLKFKMGDKRKVTPKK-------VNEPIFTDPRYILMLLMTSERAWSRAMFLKQEA 71 
EDO32726      14 LRHGDYQRYRQYCARRLRRLYK--TLHFQHGSRHAFKPKK-L-----TKELV-KDVKFLHIPLMDTERAWSQAMELKLLA 84 
XP_006681695  24 LRQQDYQRYREYCARRIRRVRKntDM--IQGKK-RYEKKP-V-----TPTSL-VDPRSLQILLFEAERSWAYAMQLKADS 93 
XP_001027269  29 LKHSDFQRYRKYCGHKVHKLRK--LMKFSHEK--KYQKKQ-I-----HVERL-NDPKMLQVLLFKIENNWAYAMDLKQIM 97 
Q1ZXE8        35 LRLQDYKKYRQYCSKRIQRLRS--QLRKQYGKK-NYVNKI-VlnggeTEKQI-NDVRYLQISLLKTERAWSYAMDLKAQf 109 Dictyostelium d...
EFA86822      50 LRQDDFTAYRQYCTRRLGRIRS--SMKKQLGKK-NYIAKLn------DPKNI-VDARYLLIVLIKTERAWAYARALKQEy 119
XP_003660447  88 AAG--TKgmtSKTRSHIVSRLEKGARTAERLAEALASsA-SGASPTDVLDARAYAAMLRGAALFERQ-KWDACLKSYAVC 163
EMS51735     142 -GPn------APQRIYMLGRFRKAVKWAALFSQLCs----IKGDSRTSLEAEAYASYMKGTLLFEQEkNIEAAMLNFKNT 210
CCD82452     100 STE-------IRKRFQMCSRLRKAVARAELLCSMEDDl--SLLDAQTKLELRAYKQWIRGILFFELQ-NWAVAKEHLESA 169
CDS37384     104 NSE-------PRKRFHMLSRLSKAAKCAQGLNEIITSv--PMCGAQTKLELTAYIQWINGILHFEQQ-NWMKAKDLLESA 173
2_pfamImport  72 NSE-------PRKRHHMVEKMRKAVVLADELSLLCEGs--LRVDARTKLEAQAYSAYMSGILHFELK-NWISAMDLFRKS 141
EDO32726      85 NTE-------PRKRFHLIRRLQKASKHAQDLENLCDg---DMCDARTKLEAQAYSSYMKGSVSFELQ-NWKEALELFGRS 153
XP_006681695  94 QYE-------PRKKHHSIKRLCRAVSSANQLHELC---QlESIDHQTSLETQAYALRLAAYVHFERQ-EWQSALDVFASS 162
XP_001027269  98 QDSkdGA---ARKQHHVNKKMAKALKWANLLNNICr----ERTDERSYQESEAYLNFIKGIYHHERH-QWEDALESYIKS 169
Q1ZXE8       110 ek-----dndSRIGFHMNRRFGKASRNSTQLYELCk----LVADQYTIIEAHAYSSWMASSLSLTKQ-DFKKALEEINIS 179 Dictyostelium d...
EFA86822     120 eq-----sdqGRLKFHMNSRFAKAAVHADQLERFCr----EVADQYTQIEAAAYAAWIRSSHMIACS-RWLEALEAITKA 189
XP_003660447 164 RIIYSALATSAkGDVFRDLLSDTVD---PSIRYAAYQAKIPRTLPIATIARDAFd---HAA-GPELADRIR--------- 227
EMS51735     211 RTVYEELGKYG-GIENQLLCRQRIEevePMIGFCSRKLGGSALQEHDLLDM-EK----EGPaYDLFKAKIEdnrlkpesv 284
CCD82452     170 QAIYDVLLQMV-DEDSQAVYKSRIDdllPQIRYCAHSIGDETAATDLQRMRNQA----PDGlTLLSELQLD--------- 235
CDS37384     174 QQIYTGLASSV-DEDLRAVYAARTGeilPQIRYCAYSVGDTSAAKELREMRAG-------VeGTLVEEQLD--------- 236
2_pfamImport 142 QTIYGKLGDAM-SKEEQTIYKTMVEemsPNIRYCAYTIGDQSAMDDLVQMHGA------GRqDPLLSQKLD--------- 205
EDO32726     154 RTIYERLAGAF-SEEQRNMYLQRVEeitPNIRYCAYNLGESGTDINDLMQLRHCs--aGGVqDPVLAAKID--------- 221
XP_006681695 163 RSIYDKLAHVAvTASHATLCQAAMDeidPNIRYCAYNLKFKGNQTDDIESLLELrktsGGPgNDLLSAKID--------- 233
XP_001027269 170 RSIYLSLISVS-DSLQSVFFKEKVEfleQSIRYCHQQn------------------------NGFILDTIDviiskmgtk 224
Q1ZXE8       180 KTIYEKLSEQG-DHSQKELYQKRIEetePIIRFCLYNLKNEKNTSNKVSQNt----------LTIIEQSLE--------- 239 Dictyostelium d...
EFA86822     190 KTIYSSLATSG-TPSLKQLYVGRVEdaePIERFCLYNMRSLDTSSNSTVLADt---------TKILKKVTD--------- 250
XP_003660447 228 ---------DIN---PAVLEHGDADAA-Kga---ggTPAVLTWRGREVKIEDAAIAIAWAAVATARGRLAEKLa-----S 286
EMS51735     285 esrntpdilAVL---SETRSQQAAS------------MTEFNWLGRRFPITSAKTRVSILKAQQLERDLNG--------- 340
CCD82452     236 ---------QLL---GQARSKQASQ------------VSEVDWLGISIPVKSEKAKIAILTVEESKTELEKa-------- 283
CDS37384     237 ---------ELL---KQMQTLQAGS------------VTEVTWLGTTIPVKLEKARLAVLALQEADEQLAKl-------- 284
2_pfamImport 206 ---------SLI---AESREKKVAS------------MSEIVWRNRTIRIKNNKVRLFLIGVKEFEADLSSis------- 254
EDO32726     222 ---------EVL---AQTREKEAGA------------MTEVVWCNRTIPVRNEKVRGFILHAQQMARELDRa-------- 269
XP_006681695 234 ---------LLV---TERMHVKARA------------IHTMEWHGYSMDIHNEDLMAMIMEMQEISAKINGEVqgngivV 289
XP_001027269 225 mdiektptsKVA---QSEKKDQ---------------LIEVDYLGSKYPIKNQKAIYSYRQVEDCQKRIHE--------- 277
Q1ZXE8       240 ---------ELK---NQENKKKSSTSStTtt----tATTTIEWKSKSIKV-DEKLDEKLKIFNEFKKENENKLpk--niN 300 Dictyostelium d...
EFA86822     251 ---------DTEkktNQILSNSSSSSNtGskqqqeqPMSTVSWRQRQVRV-NEKVREKLVNYSNFVKEYDAa-------- 312
XP_003660447 287 AGA---LHPKETAAAYDEILIASQDAVDATKQAID-------------------ELRAEGVTQSDARMQSL--QITRTAV 342
EMS51735     341 -AAtepISADKKLAIFDKLFSAYHEARSCIRNDLA------------------------SAGSAENIRDEL--NGLDKAV 393
CCD82452     284 ------ETLQAKLSIYESILKLCVEAITSVRDELRtaiasepsvtgdkntaavvASSKFGQTLGSEKVSRL--QLLYTYL 355
CDS37384     285 ------PSSYTKAAICESTLKVIVDALVAIREEMRwlsnsegv---asagllpvQTSQKANATGIEKLPRL--QRLNIYM 353
2_pfamImport 255 -----eSDREARVEVYDRLLTECKDALQITRDDIR-------------------TDPHSKATEKTNQVSDL--QFLQSYL 308
EDO32726     270 ------EDLDGRMELYEDLLLECKDALQAIKDDLKgd----------------lVSEELKVHKTEAQVANL--QFLHTYV 325
XP_006681695 290 DGRvdeSQFAGIMAEYDKLLGLGWDAAKLSERDIKed---------------lvAVMKVKSSKSDMHSAML--KLIKEYV 352
XP_001027269 278 --LqrkTSKTNTQEEQDSILAIYNEAFNNFDECIK-------------------VIQKEKSDEKNSEAENLiyTNILSFL 336
Q1ZXE8       301 ASIdttSNISPIFNIYDKLVYNLINCETIVKNDLStl---------------vrVNLKNKSVKSEIEEQST--RILLAYI 363 Dictyostelium d...
EFA86822     313 ------TSDDAKFPLYEKIVKQLLDAEVMVRNELVni---------------vrVNIKNKTVKSEVEESDL--RALLAYI 369
XP_003660447 343 NYEMISWRIGRNRVLVGENDGVKMDFSGpVSQKKKkRKqqqqqeeeqegdrskdeAPGRQIARLKEKVVLYDGILQDLES 422
EMS51735     394 SAVLGLRTIERNQLLVSIAKSKFAKHRDeK---------------------------NEKITKPEELVRLYDLLIQNTTD 446
CCD82452     356 QYLKLSKTIDRTLLHIETTISSLAEGSHkRNQLA-----------------------TSAYPKPQELSRLYDTLVQNFQE 412
CDS37384     354 QYSKLSKTIWRTLYQLETLMSNVAPEHHhASWNLI----------------------TSGYQKPHEFARLYDSVVQNLQE 411
2_pfamImport 309 SYLRLTKTIERNLILVGGLQANNFPVEKaEGDS------------------------AHRGPKPSDFIRLYDGVLHNLTE 364
EDO32726     326 TYLKLTKTIERYLLLAESMKNQLPANLQdTANGSEpL-------------------PNKKLTKPEDMVRIYDIILQNLSD 386
XP_006681695 353 TYTRLEHTFDRDILLEQATSMRLKNLVHsSGSVE-----------------------KRPSQRREELIQLDITMLQVVNE 409
XP_001027269 337 NLNKQKFILDRNIILIKNAVQQFDKEDGvNNLEALtTKk----------------AFKLKLIRPTEIIKLCDNLLQVFKQ 400
Q1ZXE8       364 MYHKMKYLYERNSILITMMQRVLDGEKVdESAIKK----------------------KVKKVTWNDLVRLSTHQVKVYTI 421 Dictyostelium d...
EFA86822     370 SYHKYRYLYNRNETLINQYTQSADNSSSnKQQTTVvNS-----------------GGKKKKISTRDIIRILTNQIKVYSR 432
XP_003660447 423 IKELPG-----VANDQDLSERLDATSQYFTALKSLAIARSHAVAGNAVNSLALVKHALDQTNTAAPSLSSPEN-NdDddd 496
EMS51735     447 LTDLVSsgrdkNEEENAFVHEYELKDLAFRAERCFYLAKSYSSVSKRAEAYALFCYARSLADSALQELANSPHkVlKsn- 525
CCD82452     413 IISLPCl----VQDHIGLKDLLYAKMLSYRSYRCYYLALAYNCSKKYTECSALLTRAIQHAEKAVTSLEHSIStWtKaee 488
CDS37384     412 VLTLPGg----IQDNAEIRALIKAKIAAYKALRCYYLALAYLRNNRFLESSSLLQRCQKEVKEAEASLSKANLpEcTeae 487
2_pfamImport 365 VLSLPG-----IEVDSEISDAVGSQRAAFQAFRCFYVAQAYVNEKKWAEAMALYDRVLEHSRKAINMMMRSSEdIa---- 435
EDO32726     387 MSELHS-----VEDDLELTKEIAAQTLEYKAYRCFYIAHSYLLAKKWREAAVLYDRVTSHANSAVSHFREC--------- 452
XP_006681695 410 MKELDI-----IETDLALGHLVSSKGFFVVAQRLAHTADIYTADQKYAEALVLLNKAMEQVHLSRTSVVEFKRkIiKh-- 482
XP_001027269 401 IIEVER-----QNTNLENYRKLDVLEFHFKAIRCYYVSCVYLANSKYIETLSLLKVAENIVTNSSKKFVDMRD------- 468
Q1ZXE8       422 MSESRD-----TDSNKEIARDQDAQLILLKSIRLYYIAVCLAKSLKFSETMAVLDRVLTNIQNVRKTNTKNQQ------- 489 Dictyostelium d...
EFA86822     433 MIE--------NRNEQRQDAVLEAQLQLLKATRLYHIANGLALAKKWSETMATAERVSSMIATARK-------------- 490
XP_003660447 497 aaftPRNIQVTKRDLTLLHDTLTGELQRCLALAEI---FN--NNNknsssttiptdkaAEPFQqattttaaaaeaaaaTT 571
EMS51735     526 --snALTLQALIQDLEALSFNCRSNSCIEHATGIMed----eSAPerlskgvstislgDNRK-----------------K 582
CCD82452     489 ciapGPSPDALSKSLQSLILQAESEDFTCKAASMLdk----vEENepvsttplagttgVDA------------------- 545
CDS37384     488 -avpGHSRPFLLQLLRDLQDQMDAEMLACKAGYMLelsAGg-TSNefvddatasasvpRSV------------------- 546
2_pfamImport 436 -----EFKLVETGRLESLVETIAFNRYRVHASAILdsvAGkeGEKkdvd------------------------------- 479
EDO32726     453 -----QNFQSQASRLQDLASLSRGSKCSAHASSILd--------SeeitdklasatieD--------------------- 498
XP_006681695 483 ---dQQMAVNMTKLLDVLSQSICNRSLITKAKVYFendDK--VPYvslsktvqdmsigTHKIN----------------Q 541
XP_001027269 469 -----NFVEDYVEESDILMKKIKYLEIKAKLGLVEnt----tEEEtvitekladsnldGKVTNktiqsl---mkeqeqGN 536
Q1ZXE8       490 ----------ILNDTNELESNIKKQRSQIHANSFIqq----lSENqdlknqmsslsigGITTA---------------SG 540 Dictyostelium d...
EFA86822     491 -----NKNADVVKRADELDKLVASIRSQVHANAFIeq----mSNNedlkrqmselslsSGGDNns------------aAV 549
XP_003660447 572 KPPPLSSRLS-DYPA-GG-VDLDN----------IVTYPPRLEPFPVKPLFLDVAWNYI 617
EMS51735     583 DPKYLLDILG-SYESaLGeQSAKApc-------rISQFPPPFQPVPCNPIVLDMAYNAI 633
CCD82452     546 SRKVLIDRLD-IYADeKSvEKSFNnfv-----ypFVHLPPKFHPVPVKPIFFDLALNHI 598
CDS37384     547 LKEPLIRSLG-EFVPeKViLRKLTtqp-----apLVPFPPEFEAIPVKPTFFDLALNHI 599
2_pfamImport 480 tsipILERLD-VYHEdVAtSSLNIgkpnskvpqmTSAYPPKFEPVPCKPLFFDVALNH- 536
EDO32726     499 --KTLAERLD-VYHVdQSlVSKKPh---------VTTFPPDFQPVPCKPLFFDLALNHV 545
XP_006681695 542 MGVGRAEHMKvFFQPsEGvIPV------------VQSIPPAFEPVSFKPMFYDLAYlgm 588
XP_001027269 537 KLNVGINRLN-SIP--------------------IFALPPKPLLAGCKPIQFDLvdeyi 574
Q1ZXE8       541 KSNDLISGLD-SFDTsFLtEKK------------LVQLPPQLQPVQAKPIFFDLAFNSV 586 Dictyostelium discoideum
EFA86822     550 ASKDLLSGLD-NFDTsFLaEKR------------LVEFPPPLQPAPTKPLFFDLAFNQc 595
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