6G18,7MQ9


Conserved Protein Domain Family
RIBIOP_C

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pfam04950: RIBIOP_C 
40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins.
Statistics
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PSSM-Id: 461497
Aligned: 187 rows
Threshold Bit Score: 177.267
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6G18_u        488 VDTPRDVAARIRFQKYRGLKSFRTSPWDPKEN---LPQDYARIFQFQNFTNTRKSIFK-----EVEEkeve--------- 550 
XP_001867181  271 RIEEKNMSRTELMAKKMKLKAKFDSEYDNP-----EKDDQHIEGDH-KYYEKLKADALr---qSELNkkefsnlded--- 338 
Q9VVC9        685 RVEEENLTKAELMAKKLKLKAKFDAEYDNSGEgkgEEDNGRITGDH-SFYEDLKAEAQr---qSELNksefahldne--- 757  fruit fly
XP_002635477  582 ESEADKTRKQKRLEAKIKLKQRFNDDY----------------DETCKFYNKAKNELTe---qADLNrqvfegmdee--- 639 
XP_001470226  786 QGGSLTEEQERLLQKKMAKKRAFDQDYd-------TGNVDGGKNTTFSYYHRLNRQVEe---kKERInealddvgddm-- 853 
Q384C0        744 GGKPLTEEQERLLQKRMAKKKAFNELYd-------M----GGKNNTYSHYHEMTREVEa---kKERLdtalqevghdi-- 807  Trypanosoma b...
Q4CLA7        210 SGKTLTEEQERRLQKKMAKKKAFDESYd-------M----GDRSNTYAHYHQLTRVVEe---kKQRLdaalqemgedv-- 273  Trypanosoma c...
EFC48321      781 NDDILDELQKKRMEKKKSFDAQFDEKK-SSDKkegSAGVEEEEEDPITTIEKLKKKLReddpqMILNktefqnltre--- 856 
EEQ83069      342 IISESSDDEQDFESIKQQVKERFRKEA----------------FSENDFVEKFNEKYVe-----KINtadniylqekhli 400 
Q7RG00        765 EDEQNDEMDEKNEKMDDEMNEKVDDEMN----------DKSEAKGVRPIEENLKLAKEk----KEKEkakfleteeigi- 829  Plasmodium yo...
6G18_u        551 --------------gaevGWYVTLH--VSEVPVsvveCFRQgt----pLIAFSLLPHEQKMSVLNMVVRRDPGNTEPVKA 610 
XP_001867181  339 --------irlniegyraGLYVRMN--FTNVPY----EFVEhfdpafpVLIGGLNMAEENVGFVSCKVKKHRWYKKILKA 404 
Q9VVC9        758 --------friqiegyrpGLYVRLG--FKQLPA----EFIEnfdasypVLVGALNMTEENVGYVNCKVKKHRWYKKILKT 823  fruit fly
XP_002635477  640 --------erekiegfraGRYVRIE--IESVPC----EFVShfdatapYIIGGLLPGEQNMGVVQARVKRHRWFERTLKS 705 
XP_001470226  854 -------dkkiqlvgyfsGLYLRIV--IDSVPV----EFLKafdpavpLIAGGINAGEDEFRIVQARIKRHRWFPKILKA 920 
Q384C0        808 -------tnkiklvghfsGLYVRFV--LENVPV----EFVQlfdpsvpIIAGGVNAGEDQFQVVHAKLKRHRWFPKILKA 874  Trypanosoma b...
Q4CLA7        274 -------akkiqlvgyfsGLYVRFV--LENVPV----EFVRlfdptipLIAGGVNAGEDQFQIVHARLKRHRWYPKILKA 340  Trypanosoma c...
EFC48321      857 --------qreeiegispGSYVRLE--INSFPT----EFIEnvnfknpIIVGGMHPEECRMGLIKMRMKRHRWYPRTLKN 922 
EEQ83069      401 eenklkteqfkirdiaypGEYVKIY-----LDI----DFDKntdfskiIILGINLISETKQEILQGKIKTNKWYNKLLKT 471 
Q7RG00        830 -------isnaygtsvniGEYVKIEiiIKRSKL----EILKnn----iIICGGLQRYEEKNSIIHCRIKKHRWFPKVMRS 894  Plasmodium yo...
6G18_u        611 KEELIFHCGFRRFRASPLFSQHTa-ADKHKLQRFLtADMA-LVATVYAPITFPPASVLLFK-----Q--KsnGMHSLIAT 681 
XP_001867181  405 GDPLIISLGWRRFQTIPIFAKVEd-DLKHRYLKYT-PNHVtCSMTFWGPITPQNTGVLAIQsiaydPqeTkrLGFRVAAT 482 
Q9VVC9        824 GDPLIISMGWRRFQTVAIYAKVEd-NFRQRYLKYT-PNHVtCSMTFWGPITPQNTGFLALQtvrqdQeeMrrLGFRIAAT 901  fruit fly
XP_002635477  706 RDPLIISCGWRRFQTLAIYSVQDh-NMRLRFLKYT-PEHMhCHASFFGPICAQNTGLLAIQ-----SiaDktPGYRIVAT 778 
XP_001470226  921 QDPLLLSMGWRRFQTQPIFSTEDp-NGRCRYLKYT-PLHMhCMAAFYAPVAPPNTGFLAIP-----VrdPrvSSFRIPCT 993 
Q384C0        875 QDPLLLSMGWRRFQTQPILATEDp-NGRMRYLKYT-PMHMhCAAAFYAPVAPANTGFVAIP-----VreQrsPNFRISCT 947  Trypanosoma b...
Q4CLA7        341 QDPLLLSMGWRRFQTQPIFATEDp-NGRVRYLKYT-PQHMhCIAAFYAPVVPTNTGFIAIP-----VkeQrsPNFRVSCT 413  Trypanosoma c...
EFC48321      923 KDPLVFSIGWRRFQSIPTYCMQDd-NGRHRQIKYT-PEYMhCIAAIYGPFVPQNTGVIAFQ-----TlsEkvDTFRVSAT 995 
EEQ83069      472 NDPLLFSVGWRRFQSIPVYSSKT--SGENRMLKYS-FKHGfCLINFYGTIVPPGTSFSVFSe-------S--AKFRVLGY 539 
Q7RG00        895 NDPLIFSVGWRRYQSIPIYSINErnNVRIRFLKYT-TEHMhCNCTFYGPLAGVNSGILAIY-----NykKi-PFYRICIN 967  Plasmodium yo...
6G18_u        682 GHLMSVDPDRMVIKRVVLSGHPFKIFTKMAVVRYMFFNREDVLWFKPVELRTKWGRRGHIKEPL----GT-HGHMKCSFD 756 
XP_001867181  483 GAVSESDKSAQIMKKLKLIGTPYKIYNKTAFIQGMFNSTLEVAKFEGAKIKTVSGIRGQIKKAV-----PpDGSFRATFE 557 
Q9VVC9        902 GCVTEVDKSSQIMKKLKLVGHPFKIYKKTAFVKDMFNSSLEVAKFEGAKIKTVSGIRGQIKKAH----HTpEGSYRATFE 977  fruit fly
XP_002635477  779 GGVLDLDKSTQVVKKLKLIGTPEKIFKKTAFVKGMFNSPLEVAKFEGATIRTVAGIRGQIKKAI----KApAGAFRATFE 854 
XP_001470226  994 GYTIGNDVSTPIVKKLKLTGTPAKVEKTTAFIKGMFSSDVEAAKFIGAKLRTVSGIRGIIKSVM----KGkQGLVRATFE 1069
Q384C0        948 GYTVGNDLASNIVKKLKLIGTPQKIMKTTAFIKGMFNSDLEAAKYVGAKLKTVAGIRGIVKTVL----KGkNGLIRATFE 1023 Trypanosoma b...
Q4CLA7        414 GYTLGNDHATNIVKKLKLTGTPHKIMKTTVFVRGMFNSDMEATKFVGAKLKSVSGIRGIVKAAL----KGkDGLIRATFE 489  Trypanosoma c...
EFC48321      996 GYVMEMDQDFSIVKKLKLLGYPKIVHKNTCIVTKMFTSDLEVAKYEGASLRTVSGLRGSVKKPFrgdkASp-GDFRATFE 1074
EEQ83069      540 GNIMDVTGEHNLVKKLKLVGYPSKIMGNTAFIKDMFTSHLEVLKFKNAKVKSVSGLKGIVKNPV----GKf-GEFRGAFE 614 
Q7RG00        968 GIILETNNNINIMKKLKLIGEPYKIFKNTAFVKNMFNTDLEVCKFINCPVITPSGIKGLIKNKI----ND-KGDFRCTFS 1042 Plasmodium yo...
6G18_u        757 GKLKSQDTVLMNLYKRVFP 775 
XP_001867181  558 DRIVLSDIVFCRTWFKVTV 576 
Q9VVC9        978 DKILLSDIVFCRTWFRVEV 996  fruit fly
XP_002635477  855 DKILMRDIVFLRSWVTVPI 873 
XP_001470226 1070 DKLFPSDIVFISAWKSVEP 1088
Q384C0       1024 DKIFPSDIVFCRAWKMVEP 1042 Trypanosoma brucei
Q4CLA7        490 DKLLPSDIVFCRAWKTVHP 508  Trypanosoma cruzi
EFC48321     1075 DKLIRGDIIFLRCWYALEL 1093
EEQ83069      615 GEMLMSDIVILKCFVPFPV 633 
Q7RG00       1043 DQIKKSDIVILKLYVNVSI 1061 Plasmodium yoelii yoelii
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