Conserved Protein Domain Family
PRK05755

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PRK05755: PRK05755 
DNA polymerase I; Provisional
Statistics
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PSSM-Id: 235591
Aligned: 742 rows
Threshold Bit Score: 935.279
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
257125590    1 MKRAVILDTSAIMYRSHFAlmGmRNSSGMSTGATFGFINTLESVIREFRPDYLVACLDVKRDELERTgELETYKAHRESM 80  
222475578   15 MANFVVVDAYGFLFRAYYAlpQlHTSQGAPIGGVYGFINILLKHLLTHNADYIAVVFDTGSKNFRHT-LYPQYKMNRPRL 93  
269958395    1 MASFVVVDAYGFLFRAYYAlpQlHTSQGAPIGGVYGFINILLKHLMEHDADYLAVVFDTGSKNFRHA-MYPQYKMNRPRL 79  
56417214    15 MANFVVVDAYGFLFRAYYAlpQlHTSQGAPIGGVYGFINILLKHLLTHNADYIAVVFDTGSKNFRHT-LYPQYKMNRPRL 93  
57238779     6 MSIFTIIDAYGLLFRAYYAlpHlSTSNGVPIGGVYGFINMLLKYIEVHTANYLVVAFDTGGKNFRHD-IYPQYKSNRIKL 84  
58616765     1 MSTFTIIDAYGLLFRAYYAlpNlSTSNGVPIGGVYGFINMLLKYIEVHTANYLVVVFDTGGKNFRHD-IYPQYKSNRIKL 79  
58578703     6 MSIFTIIDAYGLLFRAYYAlpHlSTSNGVPIGGVYGFINMLLKYIEVHTANYLVVAFDTGGKNFRHD-IYPQYKSNRIKL 84  
73666681     1 MRIFTVIDAYGLLFRAYYAlpNlSTSYGLPIGGVYGFINIFLKYIEKHSTDYLVVVFDTGSKNFRHD-IYPEYKSNRPKL 79  
88607943     4 KKSFVIVDAYGFLFRAYYAlpGlSTSYNFPVGGVYGFINILLKHLSFHDADYLVVVFDSGSKNFRHT-MYSEYKTNRPKA 82  
254797027    2 SETLMIIDAYNFLFSAYFAlp-nLTHNELPVGAVYGFLNILLKHL-RTKPEYLVVALDNGKSTFRET-IYNNYKANRPPV 78  
257125590   81 PEELVMQIDTIMKVLDGYRIPKYKKAGQEADDVIATFATKFSnDADeqIEVFVITGDKDLTQLVDGKINIAL-Lgkgdkn 159 
222475578   94 PEDLLRQFSPLREAVSALGIASEEVHNFEADDVIATLSTKYA-SED--VQVRVITADKDLLQLMGEHVQIFDpI------ 164 
269958395   80 PEDLLRQFSPLREAVSALGIASEEVQNFEADDVIATLSTKYA-SQD--VQVRIVTADKDLLQLIGEHVQVFDpI------ 150 
56417214    94 PEDLLRQFSPLREAVSALGIASEEVHNFEADDVIATLSTKYA-SED--VQVRVITADKDLLQLMGEHVQIFDpI------ 164 
57238779    85 PEDLISQFPLLREAVNALNISYEEVAGYEADDVIATLSKNYSkFDG--IKVTVVTSDKDLLQLLEHNIHIFDpV------ 156 
58616765    80 PEDLISQFPLLREAVNALNISYEEVAGYEADDVIATLSKNYSkFDD--IKVTVVTSDKDLLQLLEHNIHIFDpV------ 151 
58578703    85 PEDLISQFPLLREAVNALNISYEEVAGYEADDVIATLSKNYSkFDG--IKVTVVTSDKDLLQLLEHNIHIFDpV------ 156 
73666681    80 PNDLISQFSLLREAVSAFNIASEEVIGYEADDVIATLTKKYSqLQD--VEVTVVTSDKDLLQLLNYGIRIFDpI------ 151 
88607943    83 PEDLSLQCAPLREAVEAFNIVSEEVLNYEADDVIATLCTKYA-SSN--VGVRILSADKDLLQLLNDNVQVYDpI------ 153 
254797027   79 PGNLTPQFALLRECVDVLNLNPLEIEGFEADDIIATLVRKFS-KSD--LKIKILSTDKDLMQLVSENVHVINpI------ 149 
257125590  160 sAFKHIKTDeDVVEYLGVTPDKIPDLFGLMGDKSDGIPGVAGIGPKNGVKLITTYGNLEGIYENIDEIKGkq-kEKLLTD 238 
222475578  165 -KNKYLTDE-YVVDKFGVTPDKLLDVLALTGDASDNIPGVPSIGVKTAARLINQFGSLDNVLSCAEKVEQkkcrEMLIQH 242 
269958395  151 -RNRYLTNE-YVVDKFGVTPDRLLDVLALTGDTSDNIPGVPSIGVKTAAKLVNQFGSLDNVLNCAEQVEQkkcrEMLIQH 228 
56417214   165 -KNKYLTDE-YVVDKFGVTPDKLLDVLALTGDASDNIPGVPSIGVKTAARLINQFGSLDNVLSCAEKVEQkkcrEMLIQH 242 
57238779   157 -KNKYIVED-DVQDKFGISSSKLLDFLSLTGDTSDNIPGVPGIGIKTAAKLLNNFGSLDNLLSQPHAIEKnkcrESIIKY 234 
58616765   152 -KNKYIVED-DVQDKFGISSSKLLDFLSLTGDTSDNIPGVPSIGIKTAAKLLNNFGSLDNLLSQPHAIEKnkcrESIIKY 229 
58578703   157 -KNKYIVED-DVQDKFGISSSKLLDFLSLTGDTSDNIPGVPGIGIKTAAKLLNNFGSLDNLLSQPHAIEKnkcrESIIKY 234 
73666681   152 -KNRYIEEE-DVHNKFGISSNQLLDFLSLTGDASDNIPGVPGIGVKTAAKLLNDFGSLNDLLLRAQEIKTnrcrESIVQY 229 
88607943   154 -KSRYLTNE-YVLEKFGVSSDKLLDAMALTGDASDNIPGVPSIGVKTAAKLINEFGSLDNVLNSVEQVAQkkcrDMLTEY 231 
254797027  150 -KNRIIGVN-EVKEKFGVFPTQMTDFLSLVGDTSDNIPGVPGIGVKTAAKLLNTFGAIDNF--RLNEVSParikESLLRH 225 
257125590  239 KENAFISRELATVKRELDVEYDKNKLKFEEKDFDSLLKLYEELNFKRFSKAveeekerflqngnqkelteeeklvleknk 318 
222475578  243 ADQALLSRDLVSLQRAVEFDGDLNKYAKKLPDSEQLLAFLEKYELNSLRGK----------------------------- 293 
269958395  229 ADQATLSRDLVSLQRTVEFDGDLDKYAKRPPDTERLLAFLEKYELGSLRGKieqc------------------------- 283 
56417214   243 ADQALLSRDLVSLQRAVEFDGDLNKYAKKLPDSEQLLAFLEKYELNSLRGK----------------------------- 293 
57238779   235 QDQAILSRQLLTLCDTVNLDNNIEKYRSRIPDTQKLVKFLKKYELQSLINKigki------------------------- 289 
58616765   230 QDQAILSRQLLTLCDTVNLDNNIEKYISRIPDTQKLVKFLKKYELQSLINKigki------------------------- 284 
58578703   235 QDQAILSRQLLTLCDTVNLDNNIEKYRSRIPDTQKLVKFLKKYELQSLINKigkifk----------------------- 291 
73666681   230 SDQAILSRQLVTLCDTVDICGGIEKYIFQNSEIHELTAFLKKYELQSLINKvnki------------------------- 284 
88607943   232 ADRAILSRDLISLCHDVEVEGDLEKYAKRVPDPVKLMAFLEKYELTSLEGKvakyc------------------------ 287 
254797027  226 HGQLTLSRKLVSLVDDINIQCSLDCIRYQQQDGTKLLAFLEKYGFKNLIPK----------------------------- 276 
257125590  319 kiteeklekerferekiekqeleydkenpifdgishfyehveyehnseiD----------KKIDEIQVLKEEL------- 381 
222475578  294 --------------------------------------------------------------------IEQCYqislesp 305 
269958395  284 ----------------------------------------------yqvS----------FKSSERQDAGELP------- 300 
56417214   294 --------------------------------------------------------------------IEQCYqislesp 305 
57238779   290 ----------------------------------------------fktDaftvyqksgyNNENSIKTNVIPY------- 316 
58616765   285 ----------------------------------------------fktDaftvyqksgyNNENSIKTNVIPY------- 311 
58578703   292 -------------------------------------------tdaftvY----------QKSGYNNENSIKT------- 311 
73666681   285 ----------------------------------------------fkqNvpstnrnlnnSSDIVTSDKAIQY------- 311 
88607943   288 --------------------------------------------------------kmvaAPIQSSEVVKKEN------- 304 
254797027      --------------------------------------------------------------------------------     
257125590  382 ----------AIeyeaqkkkqeeialenqktektkkikdekvyfeknygkV-----------V-SWNDAYSVIEKMDKKV 439 
222475578  306 drqggagempES----------------------------------------------------HTEDPVAFLRKCENVG 333 
269958395  301 ----------ES----------------------------------------------------QTEDPVAFLHKCESIG 318 
56417214   306 drqggagempES----------------------------------------------------HTEDPVAFLRKCENVG 333 
57238779   317 ----------------------------------------------------------------SSEELKTFIENCKNEG 332 
58616765   312 ----------------------------------------------------------------SSEELKTFIENCKNEG 327 
58578703   312 ----------NV--------------------------------------I-----------PySSEELKTFIENCKNEG 332 
73666681   312 ----------------------------------------------------------------SAEGLSVFIENCKSEG 327 
88607943   305 ----------EK----------------------------------------------------CIDKLEEFLEQCQRSG 322 
254797027  277 --------------------------------------------------LvkstpkqslhvTkSTNKINDFSLSAKY-- 304 
257125590  440 Ai-------FENMLGLSICDEKM-NIVLLDSElknILQnknyeksgaevqinlfslgentaekednkKNIENIYKLLSEK 511 
222475578  334 LlafhakiaDGTINELSVAYDREhALTVRGDEv---------------------------------rNFMDAARQILASD 380 
269958395  319 VlafyakiaDETINELSVAYDREhALTIRKEE---VQN------------------------------FMEVAKQILASD 365 
56417214   334 LlafhakiaDGTINELSVAYDREhALTVRGDEv---------------------------------rNFMDAARQILASD 380 
57238779   333 TialyiditDNTINSMSLSYKEGtILYINKEH---ITH------------------------------ALDLIKPLFSLD 379 
58616765   328 IialyiditDNTINSMSLSYKEGtILYINKEHi---------------------------------iHALDLIKPLFSLD 374 
58578703   333 TialyiditDNTINSMSLSYKEGtILYINKEH---ITH------------------------------ALDLIKPLFSLD 379 
73666681   328 IialhieivDNSIGSISLSYRKEvFFYIDKDH---VD------------------------------DALEFIKPIFSLG 374 
88607943   323 LlglyieveQGFISTIFAACDETrSFTVSSPE---KVQ-----------------------------KFVAAVTPILHSD 370 
254797027  305 ---------EGQI----TIYKNGkEIIFSTREtsiVGD-------------------------------LNTVQDLLTDQ 340 
257125590  512 EI--IAYNVKEYMKSgeseyfgysvggktyginEE--RFGIkcteYFDILLARYVLGTE-SL-QEIEEIILDEFGVE-IA 584 
222475578  381 SVlkIVHDAKLIMRH------------------FP--Dlg----aFDDVMLMSYSLDAGsh-dHSLAGMAYRYL------ 429 
269958395  366 SVlkVVHDAKLIMQH------------------FP--DLGV----FDDVMLMSYSLDAS-SHdHSLTGMTYRYLHQK--- 417 
56417214   381 SVlkIVHDAKLIMRH------------------FP--Dlg----aFDDVMLMSYSLDAGsh-dHSLAGMAYRYL------ 429 
57238779   380 HIlkVMYDVKTLFKI------------------IQe-Dtni--taFDDILIMSYSLDAG-LhdHTLKNIIIRNIDKH-DI 436 
58616765   375 HIlkVMYDVKTLFKI------------------IQ--EDtni-taFDDILIMSYSLDVG-LhdHTLKNIIIRNTDKH-DI 431 
58578703   380 HIlkVMYDVKTLFKI------------------IQ--EDtni-taFDDILIMSYSLDAG-LHdHTLKNIIIRNIDKH-DI 436 
73666681   375 YIlkVIYDVKTLLKI------------------IP--Nldi--vaFNDIMVMSYVLNPG-VhdHSLQN----------II 421 
88607943   371 SVlkVVYDAKSMMQF------------------FPelRa------FDDIMIMSYSLDTGhHd-HGFDSMSQRHLGQI--- 422 
254797027  341 SIkkIFHSDNIPHPD------------------PA--NEs-----FEDLKVIAYPLNTL-N--TDLEYLFSHYLGETsPE 392 
257125590  585 TFEEQfkkerrkkdfsdvsddVVCEFLSKRTFFIYKLE----IIFRNR-LQNE-QFLNIFDKLESRLIPVLAQMEETGIK 658 
222475578  430 ----------------------HQKFPARLACTLVQLHgvmrNKLLLD------RLFTVYYQLERPLVRVLYEMQEIGVE 481 
269958395  418 -------------------------FPAKMACALVQLH----SVMREKlL--SdRLFTVYYQLERPLVRVLYEMQEVGIE 466 
56417214   430 ----------------------HQKFPARMACTLVQLHgvmrNKLLLD------RLFTVYYQLERPLVRVLYEMQEIGVE 481 
57238779   437 TNENI------------------------TASTLLSLH----TALRRNlF--TnQLCTIYYRIEKPLINVLHNMEKIGIM 486 
58616765   432 TNENI------------------------TASTLLSLH----TALRRNlF--TnQLCTIYYRIEKPLINVLHNMEKIGIM 481 
58578703   437 TNENI------------------------TASTLLSLH----TALRRNlFTN--QLCTIYYRIEKPLINVLHNMEKIGIM 486 
73666681   422 SYN------------------VEQSITNMNAANLLLLH----ELLRKSlF--VdRLYTVYERVEKPLIRVLDNMEKIGVL 477 
88607943   423 -------------------------FGITNGCILIRLH----RVIMRKlF--SaKLYTVYYTLERPLVPVIYELEKTGIK 471 
254797027  393 AFH----------------------------KRLNELY----DKLRNAmF--TeKVLTLYYKVDKPLINVIKHMEKNGIS 438 
257125590  659 IDKKYFSEFQNELEEKINMLQSDIYKLADGEFNIDSPQQLGEVLFEKLQI-PS-GKKTKTG-YSTNVEVLEMIANnrelt 735 
222475578  482 VDTEILKQLSQDFHGSIRSLEKEIYDLAGCKFNVASARQLGKLLFERMGL-SSsAKKMPSGsYSTNAEVLTELAA----- 555 
269958395  467 VDTEILKQLSRDFHGSIRSLEREIYGLAGCKFNVASARQLGKLLFERMGLsSS-TKKMPSGsYSTNAEVLTELAA----- 540 
56417214   482 VDTEILKQLSQDFHGSIRSLEKEIYDLAGCTFNVASARQLGKLLFERMGL-SSsAKKMPSGsYSTNAEVLTELAA----- 555 
57238779   487 IDGSILDKLSSTFSDKISVLEEKIYKLSGEEFNIASSRQLSTILFDKMGI-KK-GKKLSSGtYSTDAEVLHELAF----- 559 
58616765   482 IDGSILDKLSSTFSDKISVLEEKIYKLSGEEFNIASSRQLSTILFDKMGI-KK-GKKLSSGtYSTDAEVLHELAF----- 554 
58578703   487 IDGSILDKLSSTFSDKISVLEEKIYKLSGEEFNIASSRQLSTILFDKMGI-KK-GKKLSSGtYSTDAEVLHELAF----- 559 
73666681   478 VNVDVLKTLSATFSEKINMLESEIYKLSGAEFNIASSKQLGNILFDKMGI-KK-GKKLSSGnYSTDAEVLSDLAF----- 550 
88607943   472 IDTELLKQLSDEFSLSISNLEEEIFGLAGCKFNIASSQQLGKVLFEHMRI-GG-AKKMPSGsYCTNAEVLTALAL----- 544 
254797027  439 LDVEQLLSLSTQISGKLEEIENKIFDTAGKTFSLQSPKQLGKVLFEEMQI-PV-QKKLKTGlSSTDNEVLTSLSS----- 511 
257125590  736 EdkRMIGKKLLEYRAYKKLLSTYIEPIPKLADKEE---RIHTTFNQNGTSTGRLSSANPNLQNIPVRTDDGIRIRTGFVS 812 
222475578  556 Eg-VEIADKVLKWRHFSKLKSTYVDALLRQVETGTk--RVHTSYSMISTATGRISSSNPNLQNIPIRSKEGTEIRKAFVA 632 
269958395  541 Eg-VEIADKVLKWRHFSKLKSTYVDALLRQVETGTe--RVHTSYSMVATATGRISSSNPNLQNIPIRSKEGTEIRKAFVA 617 
56417214   556 Eg-VEIADKVLKWRHFSKLKSTYVDALLRQVETGTk--RVHTSYSMISTATGRISSSNPNLQNIPIRSKEGTEIRKAFVA 632 
57238779   560 Ng-VEIADEILKWRHFTKLKNTYTDVLAKQIDNNTs--RVHTFYSMTSTVTGRLSSSNPNLQNIPIRSEEGNAIRNAFIA 636 
58616765   555 Ng-VEIADEILKWRHFTKLKNTYTDVLAKQIDNNTs--RVHTFYSMTSTVTGRLSSSNPNLQNIPIRSEEGNAIRNAFIA 631 
58578703   560 Ng-VEIADEILKWRHFTKLKNTYTDVLAKQIDNNTs--RVHTFYSMTSTVTGRLSSSNPNLQNIPIRSEEGNAIRNAFIA 636 
73666681   551 Nd-VEIADKILKWRHLTKLKTTYTDVLEKQKNSNSg--RVHTFYSMVSTATGRLSSSNPNLQNIPVRSEEGNSIRRAFIA 627 
88607943   545 Dg-VEVADKILKWRHFTKLKSTYTDALVRQVDANTg--RVHTKYSMTATATGRLSSSNPNLQNIPIRSKDGEKIRSAFIA 621 
254797027  512 Qg-YEIADYLLSWRHYIKLKTAYIDPLLLKVNPSEkkhRISTTYSTTLTLTGRLSSSNPNLQNIP----REKNIRKIFTA 586 
257125590  813 KEGHSLISFDYSQIELRVLAELSKDRHLVQAYQDNQDLHNLTARKIFFKTeEDEI-SRHERSIAKVINFSILYGKTPFGL 891 
222475578  633 REGHKLVSADYSQMELKIMAHIAGVQAFRDAFSEGKDIHMVTAQQIFG----DGVtDPELRRRAKSINFGIIYGMSPFGL 708 
269958395  618 REGHKLVSADYSQMELKIMAHIAGVQAFRDAFAEGKDIHQVTAQQIFG----DDVtDPELRRRAKSINFGIIYGMSPFGL 693 
56417214   633 REGHKLVSADYSQMELKIMAHIAGVQAFRDAFSEGKDIHMVTAQQIFG----DGVtDPELRRRAKSINFGIIYGMSPFGL 708 
57238779   637 KSGYKLISADYSQIELRIMAHIASVQAFRDAFSLDQDIHLITAQQIFN---TQNI-DKKLRRKAKSINFGIIYGISPFGL 712 
58616765   632 KSGYKLISADYSQIELRIMAHIASVQAFRDAFSLDQDIHLITAQQIFN---TQNI-DKKLRRKAKSINFGIIYGISPFGL 707 
58578703   637 KSGYKLISADYSQIELRIMAHIASVQAFRDAFSLDQDIHLITAQQIFNTQ---NI-DKKLRRKAKSINFGIIYGISPFGL 712 
73666681   628 KKGYKLISADYSQIELRIMAHIADVQAFKNAFFLNQDIHSITAKQIFN---TEKL-DKNLRRRAKSINFGIIYGMSAFGL 703 
88607943   622 EKGHKLIAADYSQMELKILAHIADVKAFRQAFAEGLDIHVVTAQQIFGE--YYEI-DYELRRRAKSINFGIIYGMGSYGL 698 
254797027  587 KEGHYFLCADYSQIELRILAYIANVERLKCALASGTDLHTLTASQIFK---TDKI-TPNLRNKAKAVNFGIVYGITNFGL 662 
257125590  892 SKELGITVQEASQYITTYFEEYPRVRKFLDIVTETAKLHGFVETFYGTRRYISGINATNKNVQAQAVRMAVNTVVQGTAA 971 
222475578  709 AKNVGITRQEASQYVAQYFRSYPEIKNYMEAIKAYARKYGYTRTAFGRKCYISGINSEQHTVRGFAERAAINAPIQGTAA 788 
269958395  694 AKNVGITRQEATQYVEQYFRSYPEIKNYMEAIKAYARKYGYTRTAFGRKCYVPGINSAQHAIRGFAERAAINAPIQGTAA 773 
56417214   709 AKNVGITRQEASQYVAQYFRSYPEIKNYMEAIKAYARKYGYTRTAFGRKCYISGINSEQHTVRGFAERAAINAPIQGTAA 788 
57238779   713 AKQLGITRSEASKHIENYFKSYPEIKSYIEDIKVYARTHGYTRTVFGRKCFIKDINSNNHALRNFSERAAVNAPLQGTSA 792 
58616765   708 AKQLGITRSEASKHIENYFKSYPEIKSYIEDIKVYARTHGYTRTVFGRKCFIKDINSNNHALRNFSERAAVNAPLQGTSA 787 
58578703   713 AKQLGITRSEASKHIENYFKSYPEIKSYIEDIKVYARTHGYTRTVFGRKCFIKDINSNNHALRNFSERAAVNAPLQGTSA 792 
73666681   704 AKQLSISRSEASTYINNYFRSYPEIQSYMENIKAYAKTHGYTRTIFGRKCFVKDINSDNVTARNFSERAAINAPLQGTSA 783 
88607943   699 ARNIGISRREASEYVEQYFQYYPEIKRYMETTKAYAKKHGYTITAFGRKCFIEGINSPKRALSSVAERAAINAPIQGTAA 778 
254797027  663 SKQLAISKEEAASYIQKYFDEYPEIKSYMNHIRNQAKKDTYVKTIMNRKCPIQNINSDNRAISLIAERSAINAPIQGTAA 742 
257125590  972 NIIKKVMIELHEEFKNDEnIKMLLQVHDELIFEVRDEFAKEYMEKIEKIMENTVKFkKVPLKANGSVAKNWGLLK 1046
222475578  789 DVVKKAMINLRNKLEVG---AIILQVHDELLVEVPESHVDRVAKLMKEVMEGVANF-SVPLKVDIGVGSSWGSMA 859 
269958395  774 DVVKKAMINLRDKLe---vGTIILQVHDELLVEVPESHVDNVAQLMKEVMEGVASF-SVPLRVDIGVGNSWGSMA 844 
56417214   789 DVVKKAMINLRNKLEVG---AIILQVHDELLVEVPESHVDRVAKLMKEVMEGVANF-SVPLKVDIGVGSSWGSMA 859 
57238779   793 DIIKMSMIHLFDRLKTG---YMILQVHDELLFEVPEDHVDNTVKLIKEVMEGIVKL-SVPLKVDITIGDNWGNLV 863 
58616765   788 DIIKMSMIHLFDRLKTG---YMILQVHDELLFEVPEDHVDNTVKLIKEVMEGIVKL-SVPLKVDITIGDNWSNLV 858 
58578703   793 DIIKMSMIHLFDRLk---tGYMILQVHDELLFEVPEDHVDNTVKLIKEVMEGIVKL-SVPLKVDITIGDNWGNLV 863 
73666681   784 DIIKMSMIHLFDKLKNG---SLILQVHDELLFEILEEQVDDAVKIIREVMENIVKL-SVPLKVDFNIGDNWADLV 854 
88607943   779 DIVKKAMVRLQDRLt---qGTMLLQVHDELLVEVPEEHVLSVARLMKEVMESAVVF-SLPLDVNISVGDNWGDMV 849 
254797027  743 DIIRAAMVRMAQ--EKELlSHMVMQVHDELVFELETDAIQQLAKKIKQIMEEP-H--GIPLLVELKHGPNLGELE 812 
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