Conserved Protein Domain Family
Elong_Iki1

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pfam10483: Elong_Iki1 
Elongator subunit Iki1
This family is a component of the RNA polymerase II elongator complex. This complex is involved in elongation of RNA polymerase II transcription and in modification of wobble nucleosides in tRNA.
Statistics
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PSSM-Id: 431307
Aligned: 87 rows
Threshold Bit Score: 140.805
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EPE02265      15 LLQKLLNLRDGvSPLTLVLDTPREPGTPLLEEMMLRAK-TGaggaaR-TKVVYVCSN------LAPRr------------ 74 
EGD72432       2 MLADLLALRQTtTSL-IVQDELECRGDVILAQLARQLR-SR-----G-GKCVVVCGErg--adVFDG------------- 58 
XP_006627641   1 MLLEIIDGTEG-GGLVVIKDSVNCPGRCLLKSCVNAAL-RR-----K-ESVHVLGFD------VSEEelragldgeaaks 66 
EPB89703       5 aLDQLLNNKKS-SSFIFINDTIRLSALPILADIGKRAL-VD-----D-KSLVVLLTE------TSPRawrerfpvdkqnn 70 
CCF56456      11 LLKRVLSLTEP-SSFILCLDSVSQSSSYLIEELVFNANkSA-----G-TNIIFVSFE------TNDK------------- 64 
EJT41876      11 LFKRVLSLTES-SPLILCLDSMAQTSHRLIQEFIHQSKsKG-----NeCPVVYISFE------TVNV------------- 65 
XP_003669258  11 LLKRILSLSEA-TPLLLCLDSIPQTANYLINEIVHHSRnTL-----N-LETIFVAFE------TLNK------------- 64 
XP_003677064  11 LLKRVLCLTES-SPLILCLDSVAQTSNHLIDEIIHNTKtNS-----S-LKVIYVAFE------TLNK------------- 64 
CCG82820       9 LISRILQFKDI-SPLLILTDSIFQSAAPLLDHLASSAR-SA-----K-FRVITINWRresdvcTMTS------------- 67 
EPY49617       5 LLDRCL--REL-SPLTVLKDDIQQTAKPLLHFMIQSAA-SR-----N-IKVLFVSYE------TLEAn------------ 56 
EPE02265      75 --------qSPHVD----VYIER--RDE-PsLEAFQARILKEVPPPPAPtsSssspssssggTRCLIIIDSLG-PIaqsd 138
EGD72432      59 ---------PVTSV----PWLDAtaSA--DfVTRIAEEAEA---------------------QQACVFVDSFG-SLa--- 98 
XP_006627641  67 lvfhngytdPLCWTgmgtGQLTAlhFS----AQEIRARISQSRGP-----------------EPVTLAVDSLSwVLr--- 122
EPB89703      71 iyiidcysdPHGWDnhveKRMDSntVQVnD-IKDMEKLILSPILKKVMDt------------PNCTILVDSIT-PLam-- 134
CCF56456      65 ---------PEYAS----NFIDAenMD----LAKIGQLVKSYL-PSSSE--Trr--------sKNLVIVDSLN------- 109
EJT41876      66 ---------PSYCT----QFIDAaqMD----FVHVVRQITSYL-PAATA--Tqa-------kKH-MVIIDSLN------- 110
XP_003669258  65 ---------PSYAT----HFIDIneVS--GgLPKLIETLQSYL-PSPQQ--Khs-------nKR-LVIIDSLN------- 111
XP_003677064  65 ---------PDYAS----HFIEVtnTSS---LTKTMEIIQSHL-PSPSSttThn-------nKKILLIIDSLN------- 113
CCG82820      68 ---------PAARD----TLPQV------KdLDGILQEIGLLAGQAS---------------SKVLMVIPDLNdFL---- 109
EPY49617      57 --------cPSEIN----QFIYAtsWNKmKsLKELYDEIVQWWKPE----------------DQHLIVIDAINpIL---- 104
EPE02265     139 plF-----VAAFVSSLV-SP--TTSVVGLYRTDNyassiqlplspelQGKPHPYKVLTHLATAVLRVN----------PL 200
EGD72432      99 -aFageraALKFVQRLLqRK--GCSVYMCLHSNT--------------VSAFCARELEHLCRTHVRIQahsaalshagTA 161
XP_006627641 123 --HnptasVCQSLQELRrDGl-LKRILVLLHSDL--------------HQHGMVDSVCHLASTVVTVA----------PF 175
EPB89703     135 isQhrayqLVKALESLTtDA---IRLAVGYHSDVkl---------isKTGLALQDSLNRLGSVIIKLE----------AL 192
CCF56456     110 --CisrshLTQFVSSIAs-P--HATIVATYHKDVpevde-----hgleNYPSAVELLKFISTTIMNINp---------IL 170
EJT41876     111 --YiptdlITRFLSEIAs-P--HCTIIATYHKDItdddhav-ipggnnNYPDKLTLLQFMATTILDIEv---------AL 175
XP_003669258 112 --YipndkLAQFISAVAs-P--HCTLVGVYHKDTpevdi-----paldNYPSSLELLQFMATTILNITp---------AL 172
XP_003677064 114 --YipndkLAQFVSSIAs-P--NATLVATYHKDFpeven-----paldNYPSSLELIQFMATSVINIYp---------KL 174
CCG82820     110 --AqnaahLSTFLSSLIqISpdTVSVCAIHHRDVpvp-------gyaSHLPSPETLLQYLATTIIDVD----------SL 170
EPY49617     105 --NnsvssFSMFFGSILaLG--STAFLTAYHKDVsle-------nypSYLPACETFLDYTSTCTVSFT----------GM 163
EPE02265     201 DEE--VARKRARDRAEELPQFGWAEG-EG-FPFAynnwrysktdlmataatpgtgafasdidrrgILVDMELRRRSGRAV 276
EGD72432     162 PH---VGRQLQQQHVVVADTIHMRTGgSKpTTSR-------------------------------ALVTINTLRNGQRAV 207
XP_006627641 176 SGLggVVGETAPQ----------------------------------------------------GIAMTTQRIKSGKVL 203
EPB89703     193 KERtaFETQAALTGFVPQDTFSYLTItSNcLTKG-------------------------------GIAHIEWRKKSGKVQ 241
CCF56456     171 PRS--LDRE-ELNISLNRFRMP--RGlNN-PTFK---------------------------------LEFTNRRRSGRAL 211
EJT41876     176 AGN--LDTE-EVGELLNEFRIP--VGxNN-EIYQ---------------------------------LRFVNKRKSGRSL 216
XP_003669258 173 PSR--IDEE-SLKYELEKYSIP--RGlNN-PIFN---------------------------------LKLINRRRSGRSL 213
XP_003677064 175 SKS--LDDE-TLKYELDKFNIP--RGlNN-QTFN---------------------------------VNLINRRKSGRSI 215
CCG82820     171 EHV--LLQRDAERRSRTSRVTLDLEGrDIfVPVGsnc--------------------------drLYLDLEHRRKSGRGN 222
EPY49617     164 QHL--MVEHDARMRSQPNPLTEELQDcSIvNLLGsnc-------------------------engIVCYVDFRKKSGRVI 216
EPE02265     277 VER------YVMVLGGAGGAGAkkepsssagtrgkmpwqkgatpctdITVMSDHPLFavpdlsegfkrpgd------gng 344
EGD72432     208 SVQpltaapTLLDALEHTPAPItatatspast--------attttatteAVSTRGQGatasvsmpsttrtataaappqpq 279
XP_006627641 204 QEE------ECFTVGQDLSVQVygrpsqpglt------------------------------------------------ 229
EPB89703     242 YES------N-------------------------------------GFLLSDNGLLqvvaanqltlekee-------ep 271
CCF56456     212 SYE------FNVDTVNHNYSIVmeagted------------gvvetpEML---QDLA----------------------- 247
EJT41876     217 EYD------FTIDSKNHEYELSlstrqeead--------ggneletpDML---QGLT----------------------- 256
XP_003669258 214 SYD------FQIDTNKHLYEHVinnpeeq-----------eneietpEML---QGLT----------------------- 250
XP_003677064 216 TYS------FQIDSTKHTYDLIksalqqde---------eqqvnetpEML---QDLT----------------------- 254
CCG82820     223 TES------SVFDVRTGRILATgevdgleh----------rlerpaeVGIPEEHEL------------------------ 262
EPY49617     217 KET------CTLKNGALEVFTPfvgaqkeael------------------------------------------------ 242
EPE02265     345 ndddsdedlptS-----TFNLGLTDKQRRDREGIVLPYF------------DAQTDIGa---G---EGGRILYD 395
EGD72432     280 qvsagggggddDpltnlTFSLKLTEEEKAMRARTALPYAkt--------reEKQRALA--------GTGAIYYE 337
XP_006627641 230 --epepedsqaDpaanlTFNLRLSEHERQAKDNLALPFA------------FSQEKKSallrPr-aGGGQILYE 288
EPB89703     272 epeamqvdtksDptanlSFNLSLTDEQRKTKENLVLPFM------------KAQ-QLEvsveEekkSSGLIYYD 332
CCF56456     248 -----------------TFNLSTSAKQKEAKDQVALPFL------------EAQ-SF-----S---AGGAIVYE 283
EJT41876     257 -----------------TFNLGTSNKQKLAKDQVALPFL------------EAQ-SF-----G---QGGAIVYE 292
XP_003669258 251 -----------------TFNLSTSTKQKMAKDQVALPFL------------EAQ-GLE----S---HGGAIVYE 287
XP_003677064 255 -----------------TFNLSTSAKQKKAKDQVSLPFL------------EAQ-SLS----S---HASAIVYE 291
CCG82820     263 -----------------GFKIGLSEKQQRDRDGVMLPHYvqiengrggvveETKQDVAgtaaA---GGGNIYYE 316
EPY49617     243 ---------eapadldvpFNLTLSEKERNEREEVFLPHF------------GAQ-DIRksaePgfvDGGAIIYH 294
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