5T79,3ERP


Conserved Protein Domain Family
AKR_AKR14A2

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cd19151: AKR_AKR14A2 
Click on image for an interactive view with Cn3D
Salmonella enterica aldo-keto reductase (AKR) and similar protein
Salmonella enterica AKR is a founding member of aldo-keto reductase family 14 member A2 (AKR14A2).
Statistics
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PSSM-Id: 381377
Aligned: 14 rows
Threshold Bit Score: 627.123
Created: 14-May-2018
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
 
active sitecatalytic
Conserved site includes 28 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:5T79: Salmonella enterica aldo-keto reductase NADPH, contacts at 4A.

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                      ### #                         #    #                           
5T79_A     14 EYRRCGRSGVKLPAISLGLWHNFGdttrVENSRALLQRAFDLGITHFDLANNYGpppGSAECNFGRILQEdflpwRDELI 93  Salmonella enteric...
ONI40394   13 IYNRCGRSGLKLPAISLGLWHNFGnvdkFDNCRKMIYRAFDLGITHFDLANNYGppaGSAETTFGRILSEdlkpyRDEII 92  Epulopiscium sp. S...
3ERP_A     35 EYRRCGRSGVKLPAISLGLWHNFGdttrVENSRALLQRAFDLGITHFDLANNYGpppGSAECNFGRILQEdflpwRDELI 114 Salmonella enteric...
KGQ13839   14 EYRRCGRSGLKLPAISLGLWHNFGdetlLETSRQLLRKAFDLGITHFDLANNYGpppGSAEANFGRILREdfqawRDELI 93  Beauveria bassiana...
AIF52300   14 KYNYCGNSGLKLSAISLGLWHNFGdvniYENSRAMVRRGFDLGITHYDLANNYGpppGSAEETFGRILHDdfrrhRDEMV 93  Pelosinus sp. UFO1
KNC07150   14 QYRRSGRSGLKLPAISLGLWHNFGdstrVDNSRELLRHAFDRGITHFDLANNYGpppGSAESNFGRILREdfhglRDELV 93  snowberry fruit fly
ACZ07445   14 KYNRCGRSGLKLPAISLGLWHNFGtmdkYENMREMIRTAFDLGITHFDLANNYGpipGSAEENFGKMLADdlkpyRDELI 93  Sebaldella termitidis
SHE11220   14 IYNRCGQSGLKLPAISLGLWHNFGgtdvYENSRAMIRKAFDLGITHFDLANNYGpppGSAEETFGRVLKSdlrayRDEMI 93  Chlamydophila abortus
OGS20995    1 KYNRCGKSGLMLPAISLGLWHNFSgfddLKNSKQLLFRAFDLGITHFDLANNYGppaGHAESFFGKVMKSdlkkyRDELI 80  Elusimicrobia bact...
OLB18146   14 TYERCGKSGVQLPAISLGLWHNFGgvdrFSNSRAMVLRAFDLGITHFDLANNYGpppGSAETTFGRILRRdlasyRDELI 93  Gemmatimonadetes b...
Feature 1        #                                        #                             ##    
5T79_A     94 ISTKAGYTMWDGPygdwGSRKYLIASLDQSLKRMGLEYVDIFYHHRPDPeTPLKETMKALDHLVRHGKALYVGISNYpAD 173 Salmonella enteric...
ONI40394   93 ISTKAGYFMWDGPygdwGSKKYLVASLDQSLKRMGLDYVDIFYHHRPDPeTPIEETMRALDLIVRQGKALYIGLSNYgPL 172 Epulopiscium sp. S...
3ERP_A    115 ISTKAGYTMWDGPygdwGSRKYLIASLDQSLKRMGLEYVDIFYHHRPDPeTPLKETMKALDHLVRHGKALYVGISNYpAD 194 Salmonella enteric...
KGQ13839   94 ISTKAGYTMWDGPygdwGSRKYLISSLDQSLKRLGLEYVDIFYHHRPDPeTPLEETMRALDHVVRQGKALYVGISNYpAD 173 Beauveria bassiana...
AIF52300   94 ISTKAGYTMWSGPygdfGSKKYLVASLDQSLKRMGLDYVDIFYHHRPDAeTPLEETMGALDLLVRQGKALYVGLSNYkHE 173 Pelosinus sp. UFO1
KNC07150   94 ISTKAGYTMWDGPygdwGSRKYLISSLDQSLKRMGLEYVDIFYHHRPDPeTPLEETMRALDQVVRQGKALYAAISNYpAD 173 snowberry fruit fly
ACZ07445   94 ISSKAGYTMWPGPygdwGSKKYLISSLDQSLKRMGLDYVDIFYSHRFDPdTPLEETMEALAQIVRQGKALYVGISNYtAE 173 Sebaldella termitidis
SHE11220   94 ISTKAGFYMWPGPygewGSKKNMVASLDQSLKRMGLDYVDIYYHHRPDPdTPLEETMAALDLIVRQGKALYIGISNYrEE 173 Chlamydophila abortus
OGS20995   81 ISTKAGHYMWPGPygdhGSKKYLIASLNQSLKRMNLDYVDIFYSHRPDPdTPLEETMGALAQLVKQGKALYTGISNYkPE 160 Elusimicrobia bact...
OLB18146   94 VSTKAGWPMWPGPygdwGSRKYLIASLDQSLRRMGLEYVDIFYHHRPDPdTPLEETMGALDHAVRSGKALYAGISSYsPE 173 Gemmatimonadetes b...
Feature 1                        #                           #######  # #                     
5T79_A    174 LARQAIDILEDlgtPCLIHQPKYSLFERWVedgLLALLQEKGVGSIAFSPLAGGQLTDRYLNGIPEDSRaasgsrf-lkp 252 Salmonella enteric...
ONI40394  173 EAKRAFKILRDlgtPCLIHQPKYSMLDRTIengLLDTLEQEKVGAIVFSPLAGGLLSNRYLKGIPEDSRasrpdspflns 252 Epulopiscium sp. S...
3ERP_A    195 LARQAIDILEDlgtPCLIHQPKYSLFERWVedgLLALLQEKGVGSIAFSPLAGGQLTDRYLNGIPEDSRaasgsrf-lkp 273 Salmonella enteric...
KGQ13839  174 RAEQAINILNElgtPCLIHQPRYSLFERWVeggLLDLLQEKGVGSIAFSPLAGGQLTDRYLGGIPVDSRaasgsrf-lnp 252 Beauveria bassiana...
AIF52300  174 QAREAFAILKRlgtPCLIHQPRYSMLDRWIeegLLDVLEEAGVGCIAFSPLGKGVLTNRYLHGIPEDSRvasqsvf-lks 252 Pelosinus sp. UFO1
KNC07150  174 KAAEAIAILRDlgtPCLIHQPRYSMFERAPeqgLLDVLGDNGVGCIAFSPLAGGVLTDRYLQGIPEDSRiasgskf-lne 252 snowberry fruit fly
ACZ07445  174 QTREADRILKElgiKCLIHQPRYSMFERWIedgLQDVLTEKGIGSIAFCPLAQGLLTNKYINGVPEDSRagkaweislns 253 Sebaldella termitidis
SHE11220  174 RAREAIRILKQlgtPLLIHQASYSMFNRWIedgLQDILQDGGAGCIAFCPLAQGLLTNKYLKGIPADSRaakegsf-lke 252 Chlamydophila abortus
OGS20995  161 QVKASAKIVREkgeKILIHQPKYSMFDRWIeegLLDTLEQEGIGCIAFCPLAQGLLTNKYLNGIPSDSRvtkkgaf-lkk 239 Elusimicrobia bact...
OLB18146  174 ETRRAAHLLQTlgtACLIHQPNYSMFNRALeggLLAVLGDLGIGCIVFSPLAQGLLTDRYLSGIPADSRaakphgf-lkr 252 Gemmatimonadetes b...
Feature 1                              #                #####   #  #                
5T79_A    253 eqitADKLEKVRRLNELAARRGQkLSQMALAWVLRndNVTSVLIGASKPSQIEDAVGMlanRRFSAAECA 322 Salmonella enterica subsp. e...
ONI40394  253 sditSELLDKLMKLHVIANARDQkLSQMALSWILRksIITSVLIGASRISQIEECVEAvhnTEFTEEELS 322 Epulopiscium sp. SCG-B11WGA-...
3ERP_A    274 eqitADKLEKVRRLNELAARRGQkLSQMALAWVLRndNVTSVLIGASKPSQIEDAVGMlanRRFSAAECA 343 Salmonella enterica subsp. e...
KGQ13839  253 dqitEEKLAKVRRLNALAEKRGQkLSQMALAWVLRddKVTSVLIGASKTSQIEDAVGMlsqRHFSEQERA 322 Beauveria bassiana D1-5
AIF52300  253 editEELLFKVRSLHQIAEKRGQsMAQMALAWVLRkkQMTSVLIGASKVSQIDDCVGAlqyLDFSSEELA 322 Pelosinus sp. UFO1
KNC07150  253 nqltQEKMEKVRQLQAIAQQRGQkLAQMALSWVLRdaRVTSVLIGASKTAQIDDAVEMlsqPELSTDEIS 322 snowberry fruit fly
ACZ07445  254 dsitADKIEKVKKLDKIAKQRNQsLAQMSLAWTLRggKVTSALIGASKSSQIIENVHAldnLEFTVEELE 323 Sebaldella termitidis
SHE11220  253 kdvtEEKIAKVRLLAELAAERGQsLAQMSLAWVLRegKVTSALIGASRVSQIEENAAAiqnLDFSSEELT 322 Chlamydophila abortus
OGS20995  240 enitKEVIDKVSQLNKIAGKRGQkLAQMALAWVLKdkRVTSALIGASKISQLEENVRAldhPDFSQEELN 309 Elusimicrobia bacterium RIFO...
OLB18146  253 eqvtEEVLAQVRRLNECARARGQtLAQMALAWVLRhrEVTAALIGASRPGHIEDAVAAldkRAFSDDELR 322 Gemmatimonadetes bacterium 1...

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