6SNH


Conserved Protein Domain Family
Alg6_Alg8

?
pfam03155: Alg6_Alg8 
ALG6, ALG8 glycosyltransferase family
N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147.
Statistics
?
PSSM-Id: 460831
Aligned: 203 rows
Threshold Bit Score: 355.645
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
6SNH_X                         64 AVILRCTIglgpysgkgsPPLYGDFEAQRHWMEITQHLPLSKWyw----yDLQYWGLDYPPLTAFHSYLLGLIG-SFF-N 137 baker's yeast...
CDS35857                       19 GLCLRSLGilypysgmssPPMFGDYEAQRHWMEITVNLPISEWyvntssnDLQYWGLDYPPVTAYHSYILGQVS-KLI-D 96 
CCD77290                       19 GIALRSSTslhsysgenkPPMYGDYEAQRHWMEITVNLPFTEWymnsthnDLNYWGLDYPPLTAYHSWLMGKLA-SKI-D 96 
EFX68452                       14 TVIIKLGVslfpysgknnPPMFGDYEAQRHWMEITVNLPIQDWyrnttdnDLLYWGLDYPPLTAYHSYLTGLMA-KKI-N 91 
XP_002060109                   12 GLALRSIIsmnsysgfnqAPMFGDYEAQRHWQEVTTNLDVKNWytngthnDLQYWGLDYPPLTAYHSYLTGRVA-KLL-N 89 
Q176C2                         15 GILLRAAIslhsysgenrPPMFGDFEAQRHWQEVTVNLPVRDWyenttdnDLQYWGLDYPPLTAYHSFLVGKWA-QLK-D 92  yellow fever mosquito...
EDS42995                       17 GILLRATVslysysghgkRPMFGDFEAQRHWQEVTVNLPIADWyrnttdnDLLYWGLDYPPLTAYHSFLVGKWA-QLQ-D 94 
WGS:AAGF:cds.TTHERM_00500810A 163 ASFIRILAgigpysgykdAPTYGDYEAQRHWMELTLHTPPSQWyvetlnnDLTYWRIDYPPLSAYVSYIFGYIShQF--D 240
A0DD77                         10 SISLRIYVafggysgmndPPQYGDFEAQRHWMELTSHLNITQWyeksefnDPKWWPLDYPPLSGYFAYALGKVAeKF--D 87  Paramecium tetraurelia...
XP_552840                      16 GLFLRAAIslhsysgqnqPPKYGDYEAQRHWQEVTVNLPVSDWyrnttdnDPLYWGLDYPPLSAYHSYLVGLWA-RRWhN 94  Anopheles gambiae str. PEST...
6SNH_X                        138 PSWFALeKSRGFESPdnGLKTYMRSTVIISDILFYFPaVIYF-TKWL-------GRYRnqspIGQSIAASAILFQPSLML 209 baker's yeast...
CDS35857                       97 PAWTELfISRGLETP--EHKRFMRLTVIVSDCLSYMLaALSYcAITLkrl--kkDAEL-----SGFSVALSMMSFPGLIL 167
CCD77290                       97 RDWVQLyTSRGFESK--EHKLFMRYTVLVADLLFFIPsILLYfYYVLpsimnkgNKSQq---IGGFYSACLTLTYPGLIL 171
EFX68452                       92 PDYVNLlASRGFESP--NHQFFMRMSVLVSDCLFFISaLYFY-IK----------NLKm--dNKYKWVFFALCSHPGLTL 156
XP_002060109                   90 YSYVELhTSRGIETK--EHKSFMRLTVLAADILIYMPaIIAIsVCMDlt----fEKNL------KHHLLVLLAIYPGQIL 157
Q176C2                         93 PAFVKLhESRGITKD--EHKEFMRNTVLLVDLLVYIPaILLGcYTIRkti-lggHVAG-----SDVLSMAFAVLYPGQIL 164 yellow fever mosquito...
EDS42995                       95 PKFVELhKSRGITNQ--GHKRFMRNTVLLADLLIYIPaVLLAcHAVRkti-hreSATG-----VDLLFMATAILYPGQLL 166
WGS:AAGF:cds.TTHERM_00500810A 241 PKSVELyHSRGYEEP--NHKIYMRMTVLISDILFFFTsLYYVtKIEFn-----kYSFT-----LRSLFYLLALLCPPFIL 308
A0DD77                         88 PEIIAPySSRGIETF--NTKLFMRLSVFISEIIFLYPpLIYF-I------------LK-----QQSKQQLIALCCPLLVL 147 Paramecium tetraurelia...
XP_552840                      95 ESYVALyESRGISTD--QHKQFMRNTVLLLDVLLYLPaILYAtYTVRkrl-andRSEV-----AEWASLTLAVLFPGQIL 166 Anopheles gambiae str. PEST...
6SNH_X                        210 IDHGHFQYNSVMLGLTAYAINNLLDEYYAmAAVCFVLSICFKQMALYYAPIFFAYLLSRS-L---LF----------PKF 275 baker's yeast...
CDS35857                      168 LDHGHFQYNCVSLGLFMMSLVFFSEDLDViGSVVFCLAFLYKQMELYHALPIFFFLLSKC-Fsh-------------sFT 233
CCD77290                      172 IDHGHFQYNCISLGLYLSGINFLLLEWDMlGSILFCLAIGYKQMELYHALPIFFYLLGRCiYkk-------------sVY 238
EFX68452                      157 IDYGHFQYNSVSLGLALWAIIFVSKGRNLwAAVAFSAALNFKQMELYHAIPMFFYLLASChRkgsT------------LI 224
XP_002060109                  158 IDNGHFQYNNISLGFLALAVAALLCNRNNiAALTFTLALNYKQMELYHALPFFAYLLSVC-FsqnS------------LR 224
Q176C2                        165 IDNGHFQYNNASLGLMAAAIAAILLERQLfGAFIFVLALNYKQMELYHALPVFFYLLQWC-FrssKGf---------DFA 234 yellow fever mosquito...
EDS42995                      167 VDNGHFQYNNISLGLAAAAIAAILRNRNLlGAFFFVLALNYKQMELYHALPFFFYLLASC-FkstKGf---------SLG 236
WGS:AAGF:cds.TTHERM_00500810A 309 IDHAHFQYNSFMHGLVLWSVYFCSQGSVViGGILFTLALNFKQMGLYYSLGFFFYILGYLaVdsgFRsiktnkynfgASL 388
A0DD77                        148 VDHGHFQYNCIMLGLTLYAIISLEKGKLVlGSIFYVMALHFKVMSLYYSLPFFIYILSKT-------------------Y 208 Paramecium tetraurelia...
XP_552840                     167 IDNGHFQYNNASLGLCALAVVALLERKTLaGAVLFCLALNYKQMELYHALPFFFYLLRDC-FtgsDKsst----vleRLT 241 Anopheles gambiae str. PEST...
6SNH_X                        276 -NIARLTVIAFATLATFAIIFAPLYflGgglkNIHQCIHRIFPFARGIFEDKVANFWCVTNVFVKYKE-------RFTIQ 347 baker's yeast...
CDS35857                      234 vGFKRVAILAATVCTTFLLVFLPFL--Tsl-dQLKHVGLRVFPVDRGLFEDKVANFWCISSVLIKWKQ-------IFATN 303
CCD77290                      239 rGLTHLAKLSFVVFLTIFLIFAPFVltTdl-sLLFQVVRRLFPFDRGIYEDKVSNFWCATSPLVKWRSplfmsslTLSST 317
EFX68452                      225 sQLVNLIKIGVVTLATFALIWYPFLqlHd--gLLQQVLSRVFPFNRGIFEDYVANFWCTLNVLVKIRR-------ILEPT 295
XP_002060109                  225 lFVTKLLMIATTVLATFFILWYPWL--Ssi-dATAQVLYRLFPLGRGVFEDKVANFWCSINVIYKLKK-------HIVNH 294
Q176C2                        235 gGIWKLVKLGSVVAVSFALIWSPWI--Gsi-gALKQVVHRVFPVARGVFEDKVSNVWCIVNVFIKLRN--------YPNS 303 yellow fever mosquito...
EDS42995                      237 sGLWKLIKLGALVVATFAVLWSPWL--Gsv-dSALQVLHRVFPVARGVFEDKVSNVWCIVNVFVKLRN--------FDNA 305
WGS:AAGF:cds.TTHERM_00500810A 389 fFILRIALVGFGVIATFVLMILPWItdKy---LLTSLVSAIFPVHRGLYQLKVANFWCFSNIFIKWTQ-------IFDQK 458
A0DD77                        209 kEPKKVAVVGITVILTTLIIWLPWLsd---lkLIQEAIATIFPIHRGLYQLHVATFWCISHIVIKWNL-------VFNNQ 278 Paramecium tetraurelia...
XP_552840                     242 aGVSRLAVLGVTVLATFLVLWLPWL--Ssl-eAAGQLVHRIFPVARGVFEDKVSNVWCMVNVLVKLRN--------FPNT 310 Anopheles gambiae str. PEST...
6SNH_X                        348 QLQLYSLIATVIGFLPAMIMTL-LH--PKKHLLPYVLIACSMSFFLFSFQVHEKTILIPLLPITLLYS--STdwnvLSLV 422 baker's yeast...
CDS35857                      304 VALYICCLVTLLTSLPACLSLF-RR--PSISRFILTEAIVSLSFFLFSYQVHEKSVLLVAIPVLCLLPi-FP-----LSS 374
CCD77290                      318 KLVWVSAQLVLITCLPSCLVLL-KK--SKKQKFLVSLALCALNFYLFSFQVHEKSILLVSIPALCLLPf-YP-----ISS 388
EFX68452                      296 SIASYCLLLTALFSFPCGLHLY-FK--NSLRNFHLCLINVSLAFFLFSYHVHEKSILLVTLPVSIASPy-FP-----FTA 366
XP_002060109                  295 EMALICIGTTLLAVLPTNVQLFcRR---SKYTFILTLFNTAAAFFLFSFQVHEKSILLILLPSICLFAw-WP-----NEM 365
Q176C2                        304 FMAIVCLVCTLLTVIPSGVHLL-FR--TSKRNFLLALLNSSLGFFLFSFQVHEKSILLATLPALLLFQl-YP-----LEC 374 yellow fever mosquito...
EDS42995                      306 HMAIVCLTCTLFAVLPSCVHLL-FHstS-KRNFLLALANSALGFFLFSFQVHEKSILLAALPITLLFPl-YP-----AQC 377
WGS:AAGF:cds.TTHERM_00500810A 459 VIILMSIAFTLVACLPSIYVVF-LR--PKYKYLKLALFNISMSFFFFSYHVHEKTILIPLVLYVLCIRy-MNi---YYL- 530
A0DD77                        279 LLFRLAAILTLLFSIPSLIRLF-KQ--PN--LFRHTLFIVSQTFFLFSFHVHEKTILLPII-LLLISQkdYG-----YLV 347 Paramecium tetraurelia...
XP_552840                     311 TMALVCLLCTLLAVLPSGLHLL-LQkaSTIRSFLYSLAVTALGFFLFSFHVHEKSILLVALPVTLLLPl-EP-----LAA 383 Anopheles gambiae str. PEST...
6SNH_X                        423 SWINNVALFTLWPLLKKDGLHLQYAVSFLLSNWLIGn----------fSFITPRFlPKsltpgpsiss-----insdyrr 487 baker's yeast...
CDS35857                      375 YYFLFVSTLSMWPLFYKDRLCYVCVALLIIFYAVASiclssdstaknrVSLARFW------------------------- 429
CCD77290                      389 FLFSLCSTLSMWPLLKKDGLQLASLCLTCIHTILGCfiilksnngdkhVAERKKLqNSatsn------------------ 450
EFX68452                      367 FWFLSISHFSMLPLYAKDDLILPAVAVLALYCLLANs----------sLklemgr------------------------- 411
XP_002060109                  366 LWFLKMSVFSMTPLLKKDNLVVPTLALMIIFQLIFMcsyfetnqnimiRKNWIGL------------------------- 420
Q176C2                        375 FWLLQISTFSMIPLLHKDGLLLPYLALTLFTLTLLKlsisalnnfkpvGKICTIDlFTigtflqsdgs-----akshrin 449 yellow fever mosquito...
EDS42995                      378 FWFLQIATFSMVPLLAKDGLVGPYLGLTVLTLAFLKislgfltnftlkPSFCTLDaFGveslfkgkra------ipsrwd 451
WGS:AAGF:cds.TTHERM_00500810A 531 -DFVTISCLTLYPLLREDKQTLCWFVLTIVHHFFVRk----------tLKYLEIQgVIkknltdqctlisdskvtdqttq 599
A0DD77                        348 YDYTIIATITHHPLMIEDKLFIEYCVLLVLFFIFTRnnqppqfqdswiLRFYSKIrNVi--------------------- 406 Paramecium tetraurelia...
XP_552840                     384 CWFLQIATFSMFPLLHKDGLTVPFVGLSLISLALLRtargaqsgnkarDSSYDLLhLRgllpesva---------nnvtg 454 Anopheles gambiae str. PEST...
6SNH_X                        488 rslLPYNVVWKS---------------------FIIGTYIaMGFYHFLDQFVaPPSKYPDLWVLLNCAVGFICFSIFWLW 546 baker's yeast...
CDS35857                      430 ---------------------------------PLSISLIgYAFIFALQFFVqPPVKYPFLFQLFINAYSFFHFSGFYVF 476
CCD77290                      451 nvtIS----------------------------IILLILIgYSSLIIGDLLItPPVAYPDLFPLLSSIYSFTLFSLFMLY 502
EFX68452                      412 ---------------------------smqfkcLAGISAIgSAVLALLFLICpNPPAYPYLWTLLVSVWSFAHFSVFFAY 464
XP_002060109                  421 ---------------------------------IIKISEIlMISILFASLIIePPARYPDIWPLIISIISCAHIFMFLVW 467
Q176C2                        450 ralVS----------------------------SFYGSLVgQLLLLFAFVCVdPPAQLPFLWPLLISAYSCGHFVLFFIY 501 yellow fever mosquito...
EDS42995                      452 islVH----------------------------LYYASLVaQAMLLLAFQYVpPPPQLPFLWPLLISAFSCGHFVLFFVY 503
WGS:AAGF:cds.TTHERM_00500810A 600 kkiLEQEKDIPLivklisltdlfyksifrkaiyIL------SIIAIIAEKYVkPPTNYPYLFSLIYAVLGFGLFAYVFIQ 673
A0DD77                        407 --iQF----------------------------QVQIPVLlYVILFFCQQLIqPPQRFPFLYELSMQVLGFSMYTFMYII 456 Paramecium tetraurelia...
XP_552840                     455 svlVT----------------------------LFYLSLLgQVLLLVAFLCLpAPAHLPFLHSLAISAYSCGHFVLFYMY 506 Anopheles gambiae str. PEST...
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap