Conserved Protein Domain Family
Peptidase_M57

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pfam12388: Peptidase_M57 
Dual-action HEIGH metallo-peptidase
The catalytic triad for this family of proteases is HE-H-H, which in many members is in the sequence motif HEIGH.
Statistics
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PSSM-Id: 432518
Aligned: 7 rows
Threshold Bit Score: 275.547
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
MPITM:COCOR_04566  51 VYVGRDTVVTLDASREML-QTDSDTREQYRTTNVISRDVKWIKIRVPA-----SAPATIRTGLNEAMKNFNDL-KLSFEF 123
WP_014399603       51 VYVGRDAHVSLESSREML-QTDQQTAEQYRTTNLVGTSVTKICVVPTAq---fNSYSRLSAGLDLAIENYNSQ-GLRITF 125 Corallococ...
WP_014395908       51 VYVGGDAQVSVDASREML-QSGGDSAEQYRTTNVINK-SLVRKICINPts-tfSSYSRLSQGLDLAIQNYNAL-GLCFTM 126 Corallococ...
jgi:Krodi_0018     83 IYIGEDIVVTAKELDEMT---VNQDTRQFRTNNLVTGANRTIDIIGYTgndnfGLSTKGRTALEWAVANFNRIsGSALRF 159
EAP87052           76 IRIEGDIVMTKAELEELEfNGYSNENAQYSTNALV--SPQTITIIGYTgg-sqALTSSEQTALQWAVANYNRL-NLNINF 151
MPITM:COCOR_03090  51 VYVGRDAHVTLEASREMLqPATKETQEQYRTTNLV--ASTVTKICVNPts-gfNSYSRLSQGLDLAIQNYNQR-GL--SF 124
MPITM:COCOR_03188  49 VYVGRDAHVTLEASRELLqPLEEGSAEQYRTTNQVGTS--VTKICVNPta-afNSYSNLSQGLDLAIANYNEQ-GLRLTF 124
MPITM:COCOR_04566 124 mpePidpcdRVPppcpGTgIMStIDMVINPasPGGGGSSGGAP-SNGLPYPRFSISSSIASSPINTIEHVITHELGHVVG 202
WP_014399603      126 ---A-----RGS----AS-DCT-ATISAKT--TSGTGGSAGFP-KGGKPYGTINIGTGLQSYSVDVNEHVITHELGHTIG 188 Corallococ...
WP_014395908      127 vr-----gpSTG----CN-ANI----TAAT--AAGTVYNAGYP-SGGLPYGTITIGTGWNTAPLDTVEHIITHELGHTLG 189 Corallococ...
jgi:Krodi_0018    160 ---RltfgtNFN----NS-DMVvYDNTANN--PGQSGGVAGFPsAQGLPNKFVQI-YGLEGSSTNVNEHVITHEIGHSIG 228
EAP87052          152 ---SltfgtNYQ----NK-DMVvYNNTVNN--PSGAGGSAGFP-SGGNPHKFVQI-YGLSNYNTNVIEHVITHEIGHSVG 219
MPITM:COCOR_03090 125 ---TmargpTTG----CS-ANIt----ATT--MSGAGGSAGFP-SGGRPYGTINIGTGLQSYSVDVNEHVITHELGHAIG 189
MPITM:COCOR_03188 125 a--Rg---pTTG---------CtANISAET--TTGTGGQAGFP-SNGMPYGVFYIGTGLDSYSADVNEHVITHELGHAIG 187
MPITM:COCOR_04566 203 LRHSDFYNRSISCgGSAVNEGSAGVGAVLIPGTPNS-AtA-G-GSIMNSCIPTGSTGEFTSSDITALTYLY 270
WP_014399603      189 FRHSDYYDRSISC-GSGGNEGASNVGAIHIPGTPTT-A-TrG-GSVMNSCFGSNESGEWTSSDRTALDYLY 255 Corallococcus coral...
WP_014395908      190 MRHSDYYSQVISC-GTGGSEGTAGVGAILIPGTPSTsY-V-N-GSIFNACLPANPTGEFTSTDITALTYLY 256 Corallococcus coral...
jgi:Krodi_0018    229 FRHSDYYDRA-SC-GSGGGESAGSTGAIQLPGTPT--R-D-F-DSIMQACFSNNEDGEFSSNDVTALRAMY 292
EAP87052          220 FRHTDYFSRQ-SC-GQNTNEGTAGVGANHIPGTPTG-Y-D-S-TSIMLACFSSGEDGEFNSNDITALNYLY 284
MPITM:COCOR_03090 190 FRHSDYYNRAISCgGAASNEGTAGVGAILISGTPST-A-T-VgGSIMNSCFRSTETGEWTSSDITALNALY 257
MPITM:COCOR_03188 188 FRHSDYYNRSISC-GIGGDEGEAGVGAIHIPNTPTT-A-T-VgGSVMNSCFRSTETGEWTGSDITALAALY 254
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