1NEX,2E31,6O60,3L2O,6C16


Conserved Protein Domain Family
F-box

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pfam00646: F-box 
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F-box domain
This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.
Statistics
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PSSM-Id: 425796
Aligned: 426 rows
Threshold Bit Score: 27.8892
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

pfam00646 is a member of the superfamily cl46852.
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1NEX_B  15 ITSLPFEISLKIFNYLQFEDIINSLGVSQNWNKiIRKSTSLWK 57  baker's yeast
Q8L736 118 INEIGRDNSIDCLIRCSRSDYGSIASLNRNFRSlVKSGEIYRL 160 thale cress
Q9SIJ3  39 SLPIPEELILRCFLLVRRCHHPSLSLVCRSFHSlMSKLYDDRL 81  thale cress
O82370  20 PQELPEELIESIVAPIPRCYYPSLSLLSRAFRHvITSQQLFVT 62  thale cress
O82374  41 LLELPEELIERLIAHIPRCYYPYISLVSRDFRQvITSDKLFRT 83  thale cress
O82394  31 LLQLPEELIERIIAHFPQCYSPSPILVCETFRQvINSDHFYYV 73  thale cress
O82373  30 LLQLPEELIASIVALIPRCHYPSLSLVSRAFRHlITSQELYVA 72  thale cress
O82375  32 PKELPEELIVIIVALVRRYHYPKLSLISKAYRDlISSPELFQT 74  thale cress
Q9ZW38  58 PPQMPLELIVSTIATLRRCHYPTLSLLSDSFRQvISSVDLFQT 100 thale cress
O82378  45 PRQIPQALIRRTVALIKRCHYPSLSLLSKAFRIvISSPELHQT 87  thale cress
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