Conserved Protein Domain Family
DUF4588

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pfam15251: DUF4588 
Domain of unknown function (DUF4588)
This family of proteins is found in eukaryotes. Proteins in this family are typically between 200 and 274 amino acids in length. There is a conserved LYK sequence motif. There is a single completely conserved residue A that may be functionally important.
Statistics
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PSSM-Id: 464591
Aligned: 10 rows
Threshold Bit Score: 169.684
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EDK45185      19 EDERRRNTslsgtgaaaasvtssqstsstsstsstadYTDLTTHFKDAAKAIASLYNTALGVQNltntndetpQKLTLKT 98 
XP_002616473  17 EQVSLVDL-----------------------------NRDLTNEFKNTAKAVASLYNATSQAEC---------EHRSAKT 58 
XP_011456911  21 EEECIEELhsetnmeea------------lekqqelaEQKLWLQFQNSATAIAQLYK----DRH---------QGLSLWV 75 
EFX87878      21 ERQCEIELenepdldqa------------vlserdlsTQKLWYLFQNSATSVAQLFK----DRN---------QPQVLWL 75 
XP_002595766  19 EQQCVEEVegegnmeer------------lageredvAQKLWLSFQNSATAVAQLYKGNTCNRG---------QGSHVWQ 77 
XP_780508     23 EAQCLEELdrelepnlde----------rlpqekqfaSEKLWYSFQNCASAVTTLYKERLNQSN---------IHIPLWL 83 
XP_003972349  25 ERQCLaeaeqsdp----------------keeeteqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGISLWV 78 
Q28HY5        25 ERQCLaeaeqedq----------------peeeaeqsQQKLWHLFQNSATAVAQLYK-DRVCQQ---------QGLSLWV 78  tropical clawed...
XP_006082091  38 pelqDdkddeddkgd-------------eealgpkseQQKLWHLFQISANSVAQLYK-GSECPQ---------SELSMWD 94  little brown bat
XP_023205108  25 ERQCLaeaetmdp----------------geeeadndQDKLWHLFQNSATAVAQLYK-DRVCHQ---------QGLSLWV 78  southern platyfish
EDK45185      99 DFAQAARSVAVLYKYAQ----MSHPASFDQGYLNCIDDLLqiitndedveNWALTRR-AEITKLQKTSNKDNERERkEKG 173
XP_002616473  59 EFSNAAKAVASLYRTGS----NSNVLSMHKGYLDCLDDMLrvitndedieSWVLTRR-AELTNSYNTNQNHGAGSPgRAS 133
XP_011456911  76 PFQNAASNVTSLYKDGVdslhNCVDFGIQKGKQYRNRDIV----------AWVKKKR-RNIRREDLLAFLCGKNPP-ARN 143
EFX87878      76 PFQTAAGTITSLYKESTealrRSSELGIQAGYQRRAREML----------AWAKKRRgRNIRREELIAFLTGKSVPgSGA 145
XP_002595766  78 VFQNAAQAVTLLYKDSIdankRSEDFGIQCGYQRRTRDVV----------AWAKKRR-RHIRREELLAFLCGKTVP---- 142
XP_780508     84 VFQNAAGSVTQLYKESTdaqkGSLDLGISIGHQRRTRDIV----------AWVKKRR-RHIRREDLLAFLCGKAPP--GR 150
XP_003972349  79 PFQNAATAVTNLYKESTearqRSYDLGIHLGNQRRNKDMI----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143
Q28HY5        79 PFQNAATAVTNLYKESVdahqRSFDLGIQIGYQRRNKDVL----------AWVKKRR-RTIRREDLISFLCGKVPP---- 143 tropical clawed...
XP_006082091  95 HFQSAAMALTSLYKESRdaqqRSFNLGVQVGYQRRIKDVL----------DWAKKGQ-STILREDLISFLCGKVPP-DPP 162 little brown bat
XP_023205108  79 PFQNAATAVTNLYKESVeahqRSCDRGIQIGHQRRNKDML----------AWVKKRR-RTIRREDLISFLCGKAPP---- 143 southern platyfish
EDK45185     174 ERERDRDRDREREREREKD--------------------IEsdsvLNFSQKSVVKNSLDSLQSKtafddgk--------l 225
XP_002616473 134 VSHNTHERLTDEAFPVRTN--------------------KDsshrLRDFDEASSENSKKNTTEKkfsnngtandlsssql 193
XP_011456911 144 RHASSMVRHSQSSRLSVERthsprlqgp---eslssgnePD----LQAFREAIALQGLNGAMSN---------------- 200
EFX87878     146 SQPRHQMRMGPRPRVSLSDgmsashhgasalqhpleasaGDfepaLQAFREALSLPLPSSASSN---------------- 209
XP_002595766 143 --SRTGSRSPPRS----TRdsprlgsqe---yapshqseID----LQPFKDAIALQGLNGAMAS---------------- 193
XP_780508    151 IRPSHGVPRSPSDRSSPRThsppreaqr----tglgepvdD----LQPFRDALALHGLNGAMAN---------------- 206
XP_003972349 144 ---PRAPRAPPRVASRSapqet------------gssveTD----LQPFREAIALQGLSGAMAS---------------- 188
Q28HY5       144 ---PRNSRAPPRLTVVSPNratpte--------tgssveTD----LQPFREAIALHGLSGAMAS---------------- 192 tropical clawed...
XP_006082091 163 PVPPHLPPVPPQLPPVPPHlpppyspkm--atessssldFI----LQPFQEAINLHELSGAMAS---------------- 220 little brown bat
XP_023205108 144 ---HRSSRTNSRLAMVAPSranspae-------tgssveTD----LQPFREAIALHGLSGAMAS---------------- 193 southern platyfish
EDK45185     226 psdfaFQfaLDLRPPTAFRPSipplSVLHNPSQRNLAIskknrfhqqilkkV------------------HSSEDSSESE 287
XP_002616473 194 htdyeFSlpQELMSHVVFRPSfpplSVSFKRSKKWCDIkdrk-----mpisL------------------QDASGSSDCD 250
XP_011456911 201 -----ITmgFSMSQGATASP-----QIGALPKSNG------------------------------------NMEELNRFI 234
EFX87878     210 -----NS------------------GSSAKSNGRRGSP-------------V------------------HNHSELSAFI 235
XP_002595766 194 -----FG----LRTPTSPSH-----NMHSTPSRRR------------------------------------NLGELHAFI 223
XP_780508    207 -----IG--------VSQSP-----SSHHSSSRRR------------------------------------HLSNHDLF- 231
XP_003972349 189 -----IS--VRSGPPGSPTHP------AQPHGRRRNGL-------------H------------------D--VDLNTFI 222
Q28HY5       193 -----IS--VRSSTPGSPTHV----SGSSNTGRRRNGL-------------H------------------D--VDLNTFI 228 tropical clawed...
XP_006082091 221 -----IS--VQSGPPSSPSQAgafsSNVATGDLQNSST-------------L------------------K--EDLSSCN 260 little brown bat
XP_023205108 194 -----IS--VRSGAPGSPTHV----SGSSSNTGSVSGG-------------GgassgsgpvcrsrrnglqD--VDLNTFI 247 southern platyfish
EDK45185     288 SDD------------------LKRVKifkdNT---SPSRKKKR 309
XP_002616473 251 SDDgitd----------adikKKRLA----HSlheVPKRQKRA 279
XP_011456911 235 LDEfsrn----------ydtaRKRTSsp-dNTlidSPSRKKSR 266
EFX87878     236 SHEsar-------------hkRPAPAspthDVimdSPTHKRSR 265
XP_002595766 224 SEEfanhmd------snspngRKRSSg--nDLlgdSPVHKRSR 258
XP_780508    232 PEDlvsh-----------pdsRKRSStniaPTvegSPSHKRSR 263
XP_003972349 223 AEEmarhm--------dstatRKRGPtpcsDVitdSPTHKRNR 257
Q28HY5       229 SEEmalhl--------dnggtRKRTSaqcgDVitdSPTHKRNR 263 tropical clawed frog
XP_006082091 261 SEDlalhl--------asggnLKRTSgqcdDVitnFPTHKRNR 295 little brown bat
XP_023205108 248 TEEmarhldstgagaaggggnRKRNStqcsDVitdSPTHKRNR 290 southern platyfish
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