Conserved Protein Domain Family
NanH

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COG4409: NanH 
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis]
Statistics
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PSSM-Id: 443531
Aligned: 98 rows
Threshold Bit Score: 199.777
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_231419       5 Mtsqrrrasihketdsnikgvdmrfknvkktalmlamfgmatssnaalfdynatgdtefd-------------------- 64  
WP_000739360    1 Mkknikqyvtlgtvvvlsafvansvaaqetetsevstpklvqpvapttpisevqptsdnssevtvqprtvettvkdpsst 80  
WP_001042179    1 Mnkrglysklgisvvgisllmgvptlihanelnygqlsispifqggsyqlnnksidissllldklsgesqtvvmkfkadk 80  
WP_011590241  145 Vktvtfdspidaeeikitaiqgvggfasiaelnvyeikgevdeianygnlkitkeeervnitgdlekfssleegtivtrf 224 
WP_011590331    1 ------------------------------------mnykgitliltaamvisggnyvlvkgstldsgknnsgyeikvnn 44  
WP_058118625  158 sdpevktaktvtsfdgsattqfpnyaswfnqnadvndiqflniggtsgalansnnnanfvgriafvaflpevftqaeaaa 237 
WP_003021729    6 Mkkrnkkimavfmaltltstivpaysynvwagekennanisvipqglilekenidieegntydltnetggdmiqsleegt 85  
WP_103082430    1 M------------------------------------------------------------------------------- 1   
WP_024364345    1 Mfkvgtfkimiivlffvfstlgsapvyakdssnpaklvyqtdnlelknqgkditndvkdvldsesttiiikfktdnqnal 80  
WP_121614569    1 Mknvyaiiisvvffifigadqklveastsksepivsveneqiengyftnlnseidklkgleegtivvrfrytgssimslf 80  
NP_231419         --------------------------------------------------------------------------------     
WP_000739360   81 aeetpvleknnvtltgggenvtkelkdkftsgdftvvikynqssekglqalfgisnskpgqqnsyvdvflrdngelgmea 160 
WP_001042179   81 pnslqalfglsnskagfknnyfsif--------------------------------------------mrdsgeigvei 116 
WP_011590241  225 nmndtsiqsliglsdgnkannyf-------------------------------------------------slyvsggk 255 
WP_011590331   45 senlsslgeykdinlessnasnitydlekyknldegtivvrfnskdskiqsllgisnsktkngyfnfyvtnsrvgfelrn 124 
WP_058118625  238 lssetwppsavpvysaqnitinsaadavelssalvdtlkglhnasiivkyqntntgvgsffsisdptkvnahfhvyesgn 317 
WP_003021729   86 iivsftstgtqayqslisagnstkgnrnry-----------------------------------fhlyitdtgalgmel 130 
WP_103082430      --------------------------------------------------------------------------------     
WP_024364345   81 qalfsssnnnpyfrnnyfdifmr------------------------------------------------nngelgiev 112 
WP_121614569   81 slsnsnlanghfhlyisps---------------------------------------------------------sigs 103 
NP_231419      65 ----------------------------------spakqgwmqdntnngsgvltnadgmpawlvqgiggraqwtyslstn 110 
WP_000739360  161 rdtssnknnlvsrpasvwgkykqeavtntvavvadsvkktyslyangtkvvekkvdnflnikdikgidyymlggvkragk 240 
WP_001042179  117 rdaqkginylfsrpaslwgkhkgqaventlvfvsdskdktytmyvngievfsetvdtflpisningidkatlgavnregk 196 
WP_011590241  256 vgyelrrqegngdfnvhhsadvtfnrgintlalkiekgigakiflngslvktvsdpnikflnainlnsgfigktdrangy 335 
WP_011590331  125 qknegntqngtenlvhmykdvalndgdntvalkieknkgyklflngkmikevkdtntkflnnienldsafigktnrygqs 204 
WP_058118625  318 tfgfelrnsdnpkysgtcrvyggelntvafkaeagvgyklfangalgstvsktgtdylfldgmsglttafvgklkrsndq 397 
WP_003021729  131 rntdevfkytlsrpaalrgsykgeiaentvafkadkekkeykifangellatlkqedfkfikdisgvnnvqlggtirdga 210 
WP_103082430      --------------------------------------------------------------------------------     
WP_024364345  113 rdatehinylfarpaslwgksknktalnaiafvanaeeksyklfangdkileenvsnyksltdiygvntfliggvnregk 192 
WP_121614569  104 enrfqkpgepqenvhtsvaanlkeghvytlamvvdkeagykyfldgelikkdtttprkflnniykpnsaqlgrteraagg 183 
NP_231419     111 qhaqassfgwrmtTEMKVLSGGMITNYYANGtqrvlpiisldssgnlvvefegqtgrtvlatgtaATEyhkfelVFlpgs 190 
WP_000739360  241 tafgfngtlenikFFNSALDEETVKKMTTNAvtg--------------------------------------hlIY---- 278 
WP_001042179  197 ehylakgsideisLFNKAISDQEVSTIPLSNpf---------------------------------------qlIF---- 233 
WP_011590241  336 neylfrgnidfmnIYDKPVSDNYLLRKTGETkapleds--------------------llpddvyKTQpv---eLF---- 388 
WP_011590331  205 neynfkgnigfmnIYNEPLGDDYLLSKTGETkakeev----------------------lvegavKTEpv---dLF---- 255 
WP_058118625  398 nsypftgtiesieIYATALTDEELIDRTKDTa---------------------------------RESn----aIFf--- 437 
WP_003021729  211 vgypfegtiknvkVYSNPLSDEELLESTGKTtyg--------------------------------------knIF---- 248 
WP_103082430    2 -------------MYNSIITDYLIHFLRLHDwfgamqk--------------------qkedcnmDTRpv---tVF---- 41  
WP_024364345  193 lefgfdgeiytlaIYNGVLTNDVLLHETSNAln---------------------------------------kmIF---- 229 
WP_121614569  184 nnypfegdidfakIYNKPLSDEVITAVTGVTaaaplvt--------------------pmpdeayVTDpe---sIF---- 236 
NP_231419     191 npSaSfyfdGklirdniqptaskqnmivwgngssNtDGVAAYrdikfeiqgdvifrgpdRIPSIVASSvtPGVVTAFAEK 270 
WP_000739360  279 --T-A----N------------------------DtTGSNYF-----------------RIPVLYTFS--NGRVFSSIDA 308 
WP_001042179  234 --Q-S----G------------------------DsTQANYF-----------------RIPTLYTLS--SGRVLSSIDA 263 
WP_011590241  389 --Y-P----G------------------------Y-LESRGY-----------------RIPALETTK--KGTVLASIDV 417 
WP_011590331  256 --H-P----G------------------------F-LNSSNY-----------------RIPALFKTK--EGTLIASIDA 284 
WP_058118625  438 --N------G------------------------DaTGSTFF-----------------RIPFLLAAS--DGTLIAGTDA 466 
WP_003021729  249 --Y-A----G------------------------DeTSSNYF-----------------RIPTLLTLS--SGTVVATADA 278 
WP_103082430   42 --E-P----G------------------------L-GGSANY-----------------RIPSLISTK--KGTLIAAIDA 70  
WP_024364345  230 --T-S----G------------------------DaSKANYF-----------------RIPALYTLN--SGRVLASADA 259 
WP_121614569  237 --Y-P----G------------------------F-MDSNNY-----------------RIPALFYTE--KGTLIAGIDR 265 
NP_231419     271 RV-GGGD-PGalsnTNDIITRTSRDGGI-----TWDTELN--LT---EQinvSDEf------------------DFSDPR 320 
WP_000739360  309 RYgGTHDfLN----KINIATSYSDDNGK-----TWTKPKL--TLafdDF---APVplewprevggrdlqisggaTYIDSV 374 
WP_001042179  264 RYgGTHDsKS----KINIATSYSDDNGK-----TWSEPIF--AMkfnDY---EEQlvywprdnklknsqisgsaSFIDSS 329 
WP_011590241  418 RNnGDHDaPNn---NIDVGIRRKEVNGE------WEEGKV--IL---DY---PGKs------------------AAIDTS 462 
WP_011590331  285 RRqGGADaPNn---DIDTAVRRSEDGGK-----TWDEGQI--IM---DY---PDKs------------------SVIDTT 330 
WP_058118625  467 NFgSTGDsAE----NIDAAIRIKPNAAAhdimeGWLDASVpdVLhmrDY---ADEygyk-----------qksaSFIDGV 528 
WP_003021729  279 RYgGTHDaKS----NIDIAFAKSKDSGE-----TWSTPTL--PLvfdDY---AAQaidwprdsvgknvqingsaSFIDSV 344 
WP_103082430   71 RRdEPGDnPN----NIDKVIRRSTDNGE-----TWGDIQL--LV---DY---PGRgrk-------------egsAAIDPA 120 
WP_024364345  260 RYgGTHDsRS----KINIVTSYSDDNGR-----TWTPPKF--ALkfdDY---EEQtiewprdnvrkniqisgsaSFIDSA 325 
WP_121614569  266 RVeNGADsPN----NIDAVIRRSFDDGD-----TWEENGV--MVn--DY---PDQa------------------SNIDLA 311 
NP_231419     321 PIYDP------SSNTVLVSYARWptdaaqngdrik--pwmpngifysvYdVASgnwqapidvtdqvkersfqiagwggse 392 
WP_000739360  375 IVE-K------KNKQVLMFADVMpagvs----------------freaTrKDSgykqidgny------------------ 413 
WP_001042179  330 IVEDK------KSGKTILLADVMpagig----------------nnnaNkADSgfkeinghy------------------ 369 
WP_011590241  463 LMSATieengiEKERIFLIVTHFpegy-----------------gfpnTeGGSgyreidgk------------------- 506 
WP_011590331  331 LIQDD------ETGRIFLLVTHFpsky-----------------gfwnAgLGSgfknidgk------------------- 368 
WP_058118625  529 IVEDTv-----HTDRVLLLIDAFawngggfqwlnvdqygqahggtarsVaLGDgfctiggqky----------------- 586 
WP_003021729  345 TVEDS------TTGRLFLFADAMpagi-----------------gfsnTaAGSgfktvdgeky----------------- 384 
WP_103082430  121 MLEDK------ETGTIWMIYCHTpggi-----------------glwnSsPGTgfdsngy-------------------- 157 
WP_024364345  326 LVQDK------QTNKVILMADFMpagig----------------nhnaLkNDSgykeingay------------------ 365 
WP_121614569  312 FLQDK------SNERIFALVDGFphgaglm------------ggfgvnSyKGTgfktidgk------------------- 354 
NP_231419     393 lyrrntslnsqqdwqSNakirivdgaanqiqvadgsrkyvvtlsidES-------------------------------- 440 
WP_000739360  414 ------ylklrkqgdTDyny------------------------tiRE-------------------------------- 431 
WP_001042179  370 ------ylklkkngdNDfry------------------------tvRE-------------------------------- 387 
WP_011590241  507 -------yyfilkdaQNney------------------------tvRE-------------------------------- 523 
WP_011590331  369 -------eylclydsSGkef------------------------tvRE-------------------------------- 385 
WP_058118625  587 ------lllsdqnikSGninm----------------------nvdRSkfnyaadiygaknadgrynvyhltgtplpyts 638 
WP_003021729  385 -----vklhwhkdpaNTyny------------------------tiRE-------------------------------- 403 
WP_103082430  158 ---------rllydeSGniy------------------------tlRE-------------------------------- 172 
WP_024364345  366 ------ylklrksneSTyhy------------------------siRE-------------------------------- 383 
WP_121614569  355 -------kymfltdeSGkey------------------------tvRD-------------------------------- 371 
NP_231419     441 GGlvanlngvsapiilqsehakvhsfhdyelqysalnhtttlfvdgqqittwagevsqenniqfgnadaqiDGRLHVQKI 520 
WP_000739360  432 NGtvyddrtnrptefsvdknfgikqngnyltveq-----ysvsfennkkteyrngtkvhmnifykdalfkvVPTNYIAYI 506 
WP_001042179  388 NGvvynettnkptnytindkyevleggksltveq-----ysvdfdsgslrerhngkqvpmnvfykdslfkvTPTNYIAMT 462 
WP_011590241  524 DGivynsegnqtdyvmkndktl------------------------------iqngeevgnallsnsplkaVGTAHIEMI 573 
WP_011590331  386 -Nvvydkdgnkteyttnalgdl------------------------------frngtkidninsstaplkaKGTSYINLV 434 
WP_058118625  639 SGtpvddsglslgalseyslgenyelykdgta---------ltvtqkssdatapsvsvpmkifyedselqvYNTNYIMQL 709 
WP_003021729  404 DGiiyddrtgmpteysvdgdydllkngeyltqkq-----ydvhfegtklieekndvdvnmnifykdsyfkvLPTNFIVMK 478 
WP_103082430  173 EGevfdasgkktdmvvdrggnv------------------------------yigndkigniyldrgplleARTSFLQAI 222 
WP_024364345  384 NGvifndtvnqpteykvdgyynlmknddylyvpq-----ysvrfdndrlieyqngknvkmnifykdslfkiTPTNYLGFT 458 
WP_121614569  372 GGqvydnegnqteykvddrrnl------------------------------ylngekidnifskttplkpYKTSYLELY 421 
NP_231419     521 VLTQQGHNLVEFdafylAQQTPEVeKDlEklGWTkiktgntmslygnaSVNPGPGHGITLTRqqnisGSQNGRLIYPAIV 600 
WP_000739360  507 SSNDHGESWSAP-----TLLPPIM-GL----NRN--------------APYLGPGRGIIESS--------TGRILIPSYT 554 
WP_001042179  463 TSQNRGESWEQF-----KLLPPFL-GE----KHN--------------GTYLCPGQGLALKS--------SNRLIFATYT 510 
WP_011590241  574 YSDDDGKTWSEP-----EDLNPGL-KK-E--WMK--------------FFGTAPGKGIQIKN-----GEHKDRLIFPIYY 625 
WP_011590331  435 YSDDDGKTWSEP-----QNINFQV-KK-D--WMK--------------FLGIAPGRGIQIKN-----GEHKGRIVVPVYY 486 
WP_058118625  710 YSTDSGRTWHTD-----KLITGMV-KR-E--ESH--------------YYLTGPGHGIQLQH-----GEHAGRLVVPIYF 761 
WP_003021729  479 YSDNEGETWSD------MQILGRF-KE-D--NQR--------------VPLYGPGVGTQIKN-----GEHAGRIILTMYN 529 
WP_103082430  223 YSKDDGLSWSEP-----IELNPQV-KE-P--WMR--------------FIGAGPGIGIQLTS-----PRYKGRIVFPIYY 274 
WP_024364345  459 ISDDLGETWGAP-----KLLPPFN-GL----NKN--------------ATYLSPGQGIVLSN--------MNRIIFATYT 506 
WP_121614569  422 YSDDEGETWEGT-----IDLNDEV-KE-E--WMA--------------FLGTGPGNGIQLTE-----GEHKGRLVFPVYF 473 
NP_231419     601 LDR------FFLNVMSIYSDDGGSNWQTGSTLPIpfrwks-------ssiletLEPSEADMVELQNGDLLLTARLDFnqi 667 
WP_000739360  555 G----------KESAFIYSDDNGASWKVKVVPLPs------------------SWSAEAQFVELSPGVIQAYMRTNN--- 603 
WP_001042179  511 S----------GELTYLISDDSGQTWKKSSASIPf-----------------kNATAEAQMVELRDGVIRTFFRTTT--- 560 
WP_011590241  626 TNQnn-----fQSSAVIYSDDFGETWKLGESPIDtasvss-------etvssgTQLTECQVVEMPNGQLKLFMRNTGs-- 691 
WP_011590331  487 TNEkg-----kQSSAVIYSDDSGKNWTIGESPNDnrklengkiinsktlsddaPQLTECQVVEMPNGQLKLFMRNLSg-- 559 
WP_058118625  762 QGEggggltGSAHTEVIYSDDGGVTWAHGEPLPn-------------------TLGHESVIVELPNGNLQIFMRNTA--- 819 
WP_003021729  530 SiS--------AEFGFLYSDDHAANWNYVTTDLGg-----------------sGTFAEAQIVELPDGTLQTYMRTSV--- 581 
WP_103082430  275 SNNpdn-gePRMSCCLIYSDDHGTTWKRGKSPNDgrvwegsil-dsrtlsireAELTESQVVELDNGDLLYFMRNHS--- 349 
WP_024364345  507 N----------GQMVYLISDDHGNSWSHRTASLPf-----------------aNATAEAQMVELSPGVIQTYLRTST--- 556 
WP_121614569  474 LNDnf-----kQASAVVYSDDNGKTWHRGESPNEgrvvgngevihektfnnsaYEVTESQVVEMPDGQLKLFMRNHSg-- 546 
NP_231419     668 VNGvnysPRQQFLSKDGGITWSL-LEAnnanvFSNISTGT--VDASITRFe-----qSDGS--HFLLFTNPQGNpagtNG 737 
WP_000739360  604 G------KIAYLTSKDAGTTWSA-PEY-----LKFVSNPSygTQLSIINYsq----lIDGK--KAVILSTPNST----NG 661 
WP_001042179  561 G------KIAYMTSRDSGETWSK-VSY-----IDGIQQTSygTQVSAIKYsq----lIDGK--EAVILSTPNSR----SG 618 
WP_011590241  692 -------YTRIATSFDGGATWHDeVPE-----DTSLREPY--CQLSVINYsg----kINGK--DAIIFSNPDAS-----S 746 
WP_011590331  560 -------YLNIATSFDGGATWDEtVEK-----DTNVLEPY--CQLSVINYsq----kIDGK--DAVIFSNPNAR-----S 614 
WP_058118625  820 SSGg---KCKTATSLDGGLTWVE-VHSt---fGDN--SAGtnSQLSAIAYsqdvvsaKDGQsyPAVLLSMAYNR-----S 885 
WP_003021729  582 G------KIGVITSIDGGTTWTE-QEF-----VPGMTAASygTQLSVISTsq----lVDGK--PAILLSEPAAT----NG 639 
WP_103082430  350 SKR----RTAFAYSRDGGETWGE-VDF-----FDDFADPI--CQSTVIKYpd----iGDGK--ERLIFANPCHE----TQ 407 
WP_024364345  557 G------KIGYMTSTDYGDTWSA-VQY-----LEHVQNPFygTQLSIIKYsq----kVNGH--DILLMSTPNSK----NG 614 
WP_121614569  547 -------YAQIATSFDGGETWEEeVVT-----EKDLVAPY--SQMSVIRYdg----kVDDK--EALIFSSANNS----AS 602 
NP_231419     738 RQNLGLWF-------SFDEGV--------TWKGPIQLV--N-GA--SAYSDIYQLDSENAIVIVETDNS---------NM 788 
WP_000739360  662 RKHGQIWIgl----iNDDNTI--------DWRYHHDVDysNyG---YSYSTLTELPNHEIGLMFEKFDSwsrnelhmkNV 726 
WP_001042179  619 RKGGQLVVgl---vnKEDDSI--------DWKYHYDIDlpSyG---YAYSAITELPNHHIGVLFEKYDSwsrnelhlsNV 684 
WP_011590241  747 RVNGSVKVglinengTYDNGEpry---efDWIYNKTVK--P-GS--FAYSCLTELPDGNLGLFYEGEGAg--------RM 810 
WP_011590331  615 RSNGTVRIglinqvgTYENGEpky---efDWKYNKLVK--P-GY--YAYSCLTELSNGNIGLLYEGTPSe--------EM 678 
WP_058118625  886 RTDGRIYVgllkengTYDNGStky---eiDWEYKYQVT--A-ADelFAYSSMVELSNGKVGMIYEASPTnswa-dglqYM 958 
WP_003021729  640 RRGGKIWVg-----lVNDTGAegydkydiEWKYCYSIDndKyG---FAYSCMSELPDGNIGIYYEKYDSwsrdelhlkNI 711 
WP_103082430  408 RINGTVRL-------SEDGGK--------TWPYSKVID--E-GN--YMYSCLTVLPTYEIGLLYEGRDD---------KI 458 
WP_024364345  615 RRSGQIWVgi---vnETNPSV--------NWQKKYDVDfsNyG---YSYSAITELPNQEIGLLYEKYDSwsrnelhlkNV 680 
WP_121614569  603 RVDGTVRIglieesgTYGNGHtky---siDWKYDQLVK--E-GH--YGYSSLTNLSDGNIGLFYEGTPNt--------VM 666 
NP_231419     789 -RILRMPITLLKQ 800 
WP_000739360  727 vPYITFKIEDLKK 739 
WP_001042179  685 vQYIDLEINDLTK 697 
WP_011590241  811 -AYTEFDLNYLKF 822 
WP_011590331  679 -SYIEMNLKYLES 690 
WP_058118625  959 -YYGEYDIDSLTS 970 
WP_003021729  712 mKFEKYSLDELTG 724 
WP_103082430  459 -RFVKFTLDWIKS 470 
WP_024364345  681 lKFEILTLEDIYQ 693 
WP_121614569  667 -DFRKFNTDFVKW 678 
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