3DWB,7K1V,4XBH


Conserved Protein Domain Family
Peptidase_M13_N

?
pfam05649: Peptidase_M13_N 
Peptidase family M13
M13 peptidases are well-studied proteases found in a wide range of organizms including mammals and bacteria. In mammals they participate in processes such as cardiovascular development, blood-pressure regulation, nervous control of respiration, and regulation of the function of neuropeptides in the central nervous system. In bacteria they may be used for digestion of milk.
Statistics
?
PSSM-Id: 461703
Aligned: 728 rows
Threshold Bit Score: 75.798
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
3DWB_A        21 PCHDFFSYACGGWIKANPVPDGHSRWGTFSNLWEHNQAiIKHLLeNSTAS--VSeAE-----------------R-KAQV 80 
XP_008078982 106 FCGDFEGTVCQGFREHHELRVDQSEAFAATLMKDRSQSlMRHVLdGEYPDieLEsKDpfsklvestreadrdnfS-KLKN 184
EEQ84240     138 PCTNFDELVCGGFYEN-DIPSDESSISTLAQVDDRVQTtLRHILeAppte--sndEn-----------------FiMLKT 197
EDN09517      10 PCTNFDQLVCGGFYE-EDIPYGQSSVSTLSQVEDRVQTaLRHILeNPRTNm-SE-NF-----------------I-TLET 68 
EAW09811     139 PCTDFEQYVCGGWRERHDLRPDQGSMFTGTLMAEAADMrLRHILe-STSVpeAAdEEn---------------fK-KLKA 201
Q4WYB2        19 PCEDFEQYVCGGWRERHDLRLDQGSMFTGTLMAEAAQMrLRHILe-STSVpeAAdEEn---------------lR-KLKS 81  Aspergillus fum...
EPS29887     122 PCTDFDQFVCGGWRERHDMRADQGSIFAGTIMAENSQTrLRHILe-RAEApeKQdVEn---------------fG-KLKA 184
XP_011114033 112 PCEDFRTFTCEGFDAVHEIREDQTNVASLQIMSEEGQLvLKRILeSPSPSteSLfWTasnpd--------kdifS-KMQD 182
XP_007588650 125 PCDDFATYVCGGWQDTHTYRPDQSSVTAFSLLSDENNAiMRAILeNPYPGnsSYsGAndtan--------renfA-KMQT 195
EKG13638     120 PCADFAEYVCGGFEAKNSPRPDQSAVNAFTQLDDQNKAiLRAILeSPYPDnsSYtGAndtan--------ranfA-KLQS 190
3DWB_A        81 YYRACMNETRIEELRAKPLMELI---ERLG--G--WnitgP---WA---KDNFQDTLqVV-TAHYRTSPF--FSVYVS-- 142
XP_008078982 185 AYNACLDTSAVEKVGLEPLILVL---TEL----------------E---QKPLSDAL-SY-LAELGAFPL--VAAGVG-- 236
EEQ84240     198 AYDACMNKTALEEIGAAPLQKLV---DRVNldG-------G----N---QNIFTDTV-LA-LIDIGv--NypISLYID-- 254
EDN09517      69 SYNACMNKTRLEEIGAAPLQKLV---DSVK--L--D----A---DN---QNSLADAI-IS-LIDIGTSYP--IDFGVD-- 125
EAW09811     202 AYSACLDEAAINKRGSQPLDALLarfEHIYtsG--Sg---Ss--AS---DVNVTDAV-LF-LKQSGVIAL--VDLDVG-- 265
Q4WYB2        82 AYNACLDEAVISKRGSEPLDALLaqlDDIY--S--A----Es--TAvgsDVNITDAV-LFlMN-SGVTAL--VEMGPGak 147 Aspergillus fum...
EPS29887     185 GYEACLDESAIRERGIKPLSDLL---AKLH--AvySlnnaKa-qTS---KDDLTDAI-IFlMK-SGTEAL--VSSGVS-- 249
XP_011114033 183 AYGACMNETLLGSLGARPLLDLL---SQLE--D--Iyp-vKkpkGI---DTSLTEAI-QF-LMGVGVGGP--IGLGVG-- 245
XP_007588650 196 TFNACMDLDAIKQAGVTPLKDLF---NDLP--G--Aa---Vt-yGH---TGDLTDSL-IW-LAQHGVSAL--VSAGTG-- 255
EKG13638     191 AYEACMDEDTIEQAGLEPIQNLL---NDLP--G--Ss---Va-yGH---TGDLTDAL-IW-LRRHQVSAI--VDADTD-- 250
3DWB_A       143 ADSKNS-NSN-VIQVD-QSG--LglpSRDYYlnktenekVLTGYLNYMVQLGK--LLgGg------------------dE 197
XP_008078982 237 PDFRDS-GDM-VVFVW-PANt-VglpAKEFYld----drIFNKYIDVVEKTFCn----Pvvrr------------vpqsS 292
EEQ84240     255 ADETNP-DAV-IIYLSfTTP--VglpSPTNYnn----tkIVNLYKEVMEQLFD--HFg---------------------- 302
EDN09517     126 ADSTNP-DAV-IVFVA-LTTh-VglpSPHLYna----tnVIELYAKVMELVLGd----Fg------------------gS 175
EAW09811     266 ADDRDPdSV--IISAA--PPyeIglpVREYYnss----etVTEYTKVMKHVLGkfVG-N--------------------K 316
Q4WYB2       148 PDDRDP-DKI-VISVG--PPdeIglpVREYYnss----qtVSEYTRVLKEVLGnfVg-Q--------------------D 198 Aspergillus fum...
EPS29887     250 PDDRDP-D-NvTIFVS--PPrrIglpAREYYnn----teMVADYTDVLKQVLKg----Fg------------------gD 299
XP_011114033 246 ADDKDP-DSN-VLQVV-PPRs-FglpSKEYYnn----taLVSLYKDTITSVLEa----LltkpsesvlstfrlkdkptvM 313
XP_007588650 256 PDDKTP-DVV-TLFVG--GGs-YglpSKEYYnrt----aiLANYTRTISEMFS--IV-N--------------------E 303
EKG13638     251 ADDKTP-DVV-TISVG-G-Gs-YglpSKEYYnr----taVVANYTSTITEMFAi----Inesn-------------dtaP 304
3DWB_A       198 -E-----AirP-QMQQILDFETALANITIPq-EKRrDEELIYhkvTAAELQ-TLaPAIN---WLPFLNTifY-PVeiN-- 262
XP_008078982 293 -C-----R--S-IAQDIVRFERSLAAVLPEr-EDYgNLTRTYnpmTLVEAD-ELaPLLQ---LPNFLQAl-S-DP--Ev- 353
EEQ84240     303 -------V--S-DAASVIDFEKKLAELQASs-ENT------LekyPLFDAQ-VLlPQVS---LQRIISA--KaPK--Gy- 356
EDN09517     176 ------------DAASVVDFEKKLAEIHINa-RG--STVKY----SLADAQ-ALlPQIS---LERIISAk-A-PI--Gy- 227
EAW09811     317 mD--------I-PVEDIVLFESKLANATPDt-QSMqDVEKYYnphTLKEAEsML-PQIS---LSDMISA--L-SP--Pdf 377
Q4WYB2       199 -------K--RvSVEDIVLFEWKLANAT-PdaQTLqDVEKYYnprNLDQVE-SMlPQISlstIVSMLSPagF-K------ 260 Aspergillus fum...
EPS29887     300 -------D--K-IAQEIVGLERKLADATPDtaTQE-DVTKYYnprSIEETE-SMlPEIS---FKSIINK--F-AP--Rdy 359
XP_011114033 314 -N-----K--T-VVDQVIEFEATMARASPDp-EDAnDVTKYYnprTLSEAA-ALiPEIA---IADIIQNf-T-SG--Y-- 373
XP_007588650 304 -NnatsyQ--T-IASQIVDLETKIARAQPDp-DQAsDVTYYYnpkPFSEVDeLV-EGIS---MSKLINAf-I-PA--Gy- 369
EKG13638     305 -Y-----Q--T-LAQQIADFEAKIARAQPDp-DQEdDVTYNYnpkPFSEVD-ELvPEIS---LSRLIKAf-L-PE--Gy- 365
3DWB_A       263 ESEPIVVYDKEYLEQISTLInT-TDrCLLNNYMIWNLVRKTSSFLDQRFQDADEKFMEVMYGTK--KtsL---PRWKFCV 336
XP_008078982 354 QIDRIILEIPESMKEINGVLsN-TTdPTVRAYLRWKAIQHFASTIESDALYSWKQLLNELLGKE--P--TsipERWRTCL 428
EEQ84240     357 KAKQIGVLGVDTVKALSKLLa-kTSnPVLESFLKWKVIQRYSSDIEDPIISLYRRFNRILAGRD--P--DsftERWEMCI 431
EDN09517     228 KAEQIVIYQPESFKQLSKLLaD-TPtPILNSFLKWKVIQNYASDIEDPIIKPYRRFHNALSGKD--P--DsvgERWRKCV 302
EAW09811     378 KTDRLIVGSPSYMKSLSTIL-NkTPrKTVELFFKWKIIQTYADEIEDAKITPLRQFSNKLAGKD--P--KatpERWRTCI 452
Q4WYB2       261 -PDRLIVSSPSYMESLSTIL-RdTPrKTVHHFFKWKIIQVYVDQIEDAKITALREFSNKLAGKD--P--KattERWRTCI 334 Aspergillus fum...
EPS29887     360 KGDRLIVGSPSYMKELSTIL-HdTSrETVSFFLQWKLIQAYSDSIEDKKITPLRRFNNKLAGKD--P--QsteERWRKCL 434
XP_011114033 374 KPPKVIVGSPDYLKSLSKILaS-QDrKTVQSYLAWKVISAWGGSVEDASVKPLLSFRNRLQGKApdV--Kq--ERWRTCV 448
XP_007588650 370 TPDQVIVQTPDYYPQLSAIL-KnTSsEVLQGYFQWQLIESWNGRLHPDYNRPLRVFTNQLNGQP--E--DasrERWRTCL 444
EKG13638     366 TPDQVIVRTPDYFPQLSPILkN-TSsEILHGYFQWQLISAWAVRLHRSYYRPLTKFNNQLNGRP--E--NataERWKTCL 440
3DWB_A       337 SDTENnLGFALGPMFVKATFAEDSKSIATEIILEIKKAFEESLSTLKWMDEETRKSAKEKADAIYNMIGYP 407
XP_008078982 429 QNVEDgLGWMLSKLFVSKSFSSESKQFAEDIVSDIQEQWIAKLKTIDWMDDKVKARAIQKTRNIVAKVGYP 499
EEQ84240     432 PTVNSgLGWILSKVFIEKAFSEESKKFGDQIILNIKDVFVETLKDTMWLSEKVRNVAIKKVENIVQKIGYS 502
EDN09517     303 SAVNtdLGWILSKFFIEKAFSEEAKKFGDQIISDIKEVFVETLEETTWLSDHVRKEAIEKVGNIVPKVGYS 373
EAW09811     453 KSLDRgLGWSLSRFYVLDSFSKEAKDLGDQVVSDIKERFVNILHQTTWMSPEVRKLSIQKVGNIVQKIGYP 523
Q4WYB2       335 RSLDRgLSWSLSRFYVLDAFSEASKELGDQIILDIKQRFVNILHQTSWMSPDVRKLSIEKVDNIVQKIGYP 405 Aspergillus fumigatus
EPS29887     435 RQLDQgLGWSLSRFYVLDSFSEASKKLGDQIISDIKERFAFTLNETPWMSPDVRKLGIQKVENIVQKIGYS 505
XP_011114033 449 RVVDSdLSWILSRSFIEAAFSKEAKDLGDQIIMDIKDEFSRKLQNSEWMSKKVRKLAIDKVHYIRQKIGYP 519
XP_007588650 445 GEVDSnMEWIESAFYVENQFGADDKQFGERIIDDIRSIFTERLDTYTWMADAVKDKAKQKVANIVKKIGYP 515
EKG13638     441 SEVDSnLAWIESAFWAQTQFGPDDRQFGERIIDDIIAIYTERLDTYTWMAEAVKVKAKQKVANIVKKIGYP 511
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap