1L3R,2JDS,1CDK,4DIN,3FHI


Conserved Protein Domain Family
STKc_PKA

?
cd14209: STKc_PKA 
Click on image for an interactive view with Cn3D
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase
STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.
Statistics
?
PSSM-Id: 271111
Aligned: 19 rows
Threshold Bit Score: 530.824
Created: 21-Jul-2011
Updated: 2-Oct-2020
Structure
?
Program:
Drawing:
Aligned Rows:
 
Conserved site includes 42 residues -Click on image for an interactive view with Cn3D
Feature 1:active site [active site]
Evidence:
  • Structure:1L3R; Mouse PKA binds 20-aa substrate peptide and ADP-Mg-AlF3; defined at 4A contacts.
  • Structure:1CDK: Sus scrofa PKA catalytic subunit binds MnAMP-PNP and peptide fragment; contacts at 4A.
  • Citation:PMID 8384554

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
Feature 1              ###### #              # #         #                     #              
1L3R_E     41 DQFDRIKTLGTGSFGRVMLVKHke--sgNHYAMKILDKqkvvkLKQIEHTLNEKRILQAVnFPFLVKLEFSFKDnsNLYM 118 house mouse
P12370     44 DDFERIKTLGTGSFGRVMIVQHkp--tkDYYAMKILDKqkvvkLKQVEHTLNEKRILQAIqFPFLVSLRYHFKDnsNLYM 121 fruit fly
AAD16003  112 DDFDRIKTLGTGSFGRVMLVQHkq--hkDYFAMKILDKqkvvkLKQVEHTLNEKRILQAVeFPFLVKLAYHFKDnsNLYM 189 lone star tick
CAA45014   42 DDFDRIKTLGTGSFGRVMLVQHkge-srNFYAMKILDKqkvvkLKQVEHTLNEKKILQSInFPFLVKLEYSFKDnsNLYM 120 California sea hare
BAE19914   43 DDFDRIKTLGTGSFGRVMLVQHka--nkDYYAMKILDKqkvvkLKQVEHTLNEKRILQAItFPLLVRLDFSFKDnsNLYM 120 calcareous tube worm
BAA18952   43 DDFDRIRTLGTGSFGRVMLVRHkp--tqKFYAMKILDKqkvvkLKQVEHTLNEKKILQAIsFPFIVSLAYHFKDnsNLYM 120 Hemicentrotus pulc...
P21137     79 DDFDRIKTLGTGSFGRVMLVKHkq--sgNYYAMKILDKqkvvkLKQVEHTLNEKRILQAIdFPFLVNMTFSFKDnsNLYM 156 nematode
AAC41690   51 DQFERLRTLGMGSFGRVMLVRHqe--tgGHYAMKILNKqkvvkMKQVEHILNEKRILQAIdFPFLVKLQFSFKDnsYLYL 128 human
125219     40 RNYTLIRTLGSGSFGRVMLSQHggdnpqKCYAIKILNKekvvkMKQVEHTMNEKRILLSIgSPFVVRCLNAFKDttNLYM 119 California sea hare
EAT46879   94 QDYDVLKTLGTGAFGVVKLIRRkn--teEYFALKILSKekivrHKQLQHTANEKRILQSVeFPFLVNMECCFKDnsYIYL 171 yellow fever mosquito
Feature 1      ## #   # #   #                                # #### #         ##  #          #
1L3R_E    119 VMEYVaGGEMFSHLRRigRFXEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDqqGYIQVTDFGFAKRVKGRTWXL 198 house mouse
P12370    122 VLEYVpGGEMFSHLRKvgRFSEPHSRFYAAQIVLAFEYLHYLDLIYRDLKPENLLIDsqGYLKVTDFGFAKRVKGRTWTL 201 fruit fly
AAD16003  190 VLEYVlGGEMFSHLRKsgRFSEPHARFYGAQIVLAFQYLHSLDLIYRDLKPENLLIDhtGYIKVTDFGFAKRVRGRTWTL 269 lone star tick
CAA45014  121 VLEFVtGGEMFSHLRRigRFSEPHSRFYAAQIVLVLEYLHHLDIMYRDLKPENLLIDsyGYLKVTDFGFAKRVKGRTWTL 200 California sea hare
BAE19914  121 VLEFVtGGEMFSHLRRigRFSEPHSRFYAAQIVLVLEYLHHLEIMYRDLKPENLLLDsaGFLKVTDFGFAKRVKGRTWTL 200 calcareous tube worm
BAA18952  121 VLDYIpGGEMFSHLRRigRFSEPHSRFYAAQIVLAFEYLHHLDLIYRDLKPENILIQenGYIAVTDFGFAKRVKGRTWTL 200 Hemicentrotus pulc...
P21137    157 VLEFIsGGEMFSHLRRigRFSEPHSRFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDstGYLKITDFGFAKRVKGRTWTL 236 nematode
AAC41690  129 VMEYVpGGEMFSRLQRvgRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDqqGYLQVTDFGFAKRVKGRTWTL 208 human
125219    120 VMEFVnGGELFHLLRKkgRLPEYWCTFYAAQVTMALQYLHNCSLLYRDLKPENILLDhlGYLKVTDFGFDRRVQGHTWTL 199 California sea hare
EAT46879  172 VMPFVcGGEMFALLRKskRFGEEQAKFYGAQVALAIEYLHHMNLIYRDLKPENILIDmkGYVKITDFGFCKLIRDRTWTL 251 yellow fever mosquito
Feature 1      ####                          #   ###  ###   #  #                              
1L3R_E    199 CGTPEYLAPEIILSKgYNKAVDWWALGVLIYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHfsSDLKDLLRNLLQVd 276 house mouse
P12370    202 CGTPEYLAPEIILSKgYNKAVDWWALGVLVYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHfgSDLKDLLRNLLQVd 279 fruit fly
AAD16003  270 CGTPEYLAPEIILSKgYNKAVDWWALGVLVYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHftSDLKDLLRNLLQVd 347 lone star tick
CAA45014  201 CGTPEYLAPEIILSKgYNKAVDWWALGVLIYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHfsSDLKDLLRNLLQVd 278 California sea hare
BAE19914  201 CGTPEYLAPEINPSKgYNKAVDWWALGVLVYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHfsSDLKDLLRNLLQVd 278 calcareous tube worm
BAA18952  201 CGTPEYLAPEIILSKgYNKAVDWWALGVLIYEMAAGYPPFFADq--PIQIYEKIVSGKVRFPSHfsADLKDILRSLLQVd 278 Hemicentrotus pulc...
P21137    237 CGTPEYLAPEIILSKgYNKAVDWWALGVLIYEMAAGYPPFFADq--PIQIYEKIVSGKVKFPSHfsNELKDLLKNLLQVd 314 nematode
AAC41690  209 CGTPEYLAPEIILSKgYNKAVDWWALGVLIYEMAVGFPPFYADq--PIQIYEKIVSGRVRFPSKlsSDLKDLLRSLLQVd 286 human
125219    200 CGTPQYLAPEMILNRsYASQWTTGGLGILIYELNAGFVPFDHKv--PLKLYELIVECRLTFPSFfkPTLRDLLTNIIQVd 277 California sea hare
EAT46879  252 CGTPEYLAPEIIQSKgYGKSVDWWSFGILLYEMAAGYTPFYTNssdHMVLFEKICKGKFRFPAGfgGDLKHLIQNILHAd 331 yellow fever mosquito
Feature 1                                                                     #  #
1L3R_E    277 LTKRFGNlknGVNDIKNHKWFATTDWIAIYQRkv--------------eAPFIPKFKGPGDTSNFDDY 330 house mouse
P12370    280 LTKRYGNlkaGVNDIKNQKWFASTDWIAIFQKki--------------eAPFIPRCKGPGDTSNFDDY 333 fruit fly
AAD16003  348 LTKRFGNlknGVNDIKNHRWFATTDWIAIYKKev--------------eAPFVPKCKGPGDTSNFDEY 401 lone star tick
CAA45014  279 LTKRFGNlknGVNDIKNHKWFSTTDWIAIYQRkv--------------eAPFVPKTKGAGDTANFDDY 332 California sea hare
BAE19914  279 LTKRYGNlknGVNDIKNHKWFSTTDWIAIYQRkv--------------dAPFIPKCKGPGDPSNFDDY 332 calcareous tube worm
BAA18952  279 LTKRFGNlkaGVADIKLHKWFQSTDWIAIYQQrv--------------dAPFVPRVKGPGDASQFDEY 332 Hemicentrotus pulcherrimus
P21137    315 LTKRYGNlknGVADIKNHKWFGSTDWIAIYQKkitppsfskgesngrlfEALYPRVDGPADTRHFVEE 382 nematode
AAC41690  287 LTKRFGNlrnGVGDIKNHKWFATTSWIAIYEKkv--------------eAPFIPKYTGPGDASNFDDY 340 human
125219    278 VTRRFGNlrnGALDIINHPWFKDTDFRKILMKae--------------kAPWVPNLKGQWIHQTFDKW 331 California sea hare
EAT46879  332 LTRRFGNlknGANDIKQHIWFRGTNWIGLMNMev--------------sAPFIPKISGPGDASQFDIY 385 yellow fever mosquito

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap