1D0G,3ME2,2HEW,3QD6,2X29


Conserved Protein Domain Family
TNF

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smart00207: TNF 
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Tumour necrosis factor family.
Family of cytokines that form homotrimeric or heterotrimeric complexes. TNF mediates mature T-cell receptor-induced apoptosis through the p75 TNF receptor.
Statistics
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PSSM-Id: 214557
Aligned: 22 rows
Threshold Bit Score: 90.0989
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1D0G_A        39 NSWESSRSGH--Sf--lSNLHLRNG--E--LVIHEKGFYYIYSQTYFRfqeeikentknDKQMVQYIYKYTSYp---DPI 107 human
O02765        77 DSFILPLQKR--D----GTMEVQNN--S--VVIQCDGFYLLSLKGYFS-----------QEVSISLHYRKGEEp---FPI 132 rabbit
NP_000630    160 LEWEDTYGIV--Ll---SGVKYKKG--G--LVINETGLYFVYSKVYFRgqs-----cnnLPLSHKVYMRNSKYp---QDL 222 human
XP_002827026 195 SGWEEARINS--Ss--pLRYNRQIG--E--FIVTRAGLYYLYCQVHFDeg-------kaVYLKLDLLVDGV------LAL 253 Sumatran orangutan
ACA42558     382 LSWNKDGILH--------GVRYQDG--N--LVIQFPGLYFIICQLQFLvqcp----nnsVDLKLELLINKHIK-----KQ 440 synthetic const...
NP_033478     74 QLFISSYKNE--Y----QTMEVQNN--S--VVIKCDGLYIIYLKGSFF-----------QEVKIDLHFREDHNp---ISI 129 house mouse
AAV38445      73 kGFILTSQKE--D----EIMKVQNN--S--VIINCDGFYLISLKGYFs-----------QEVNISLHYQKDEEp---LFQ 128 synthetic const...
NP_003802    107 LSWYSDPGLAgvSl--tGGLSYKEDtkE--LVVAKAGVYYVFFQLELRrvva---gegsGSVSLALHLQPLRSa---AGA 176 human
AAA36175      73 LYWQGGPALG--Rsf-lHGPELDKG--Q--LRIHRDGIYMVHIQVTLa-----------ICSSTTASRHHPTT----LAV 130 human
ACT68289     317 LNWHSQDGAG--SsylsQGLRYEED--KkeLVVDSPGLYYVFLELKLSptftn--tghkVQGWVSLVLQAKPQvddfDNL 390 Cloning vector ...
1D0G_A       108 LLMK-S----ARNS--CWSKDAEYgLYSIY-QG-GIFELKENDRIFV------SVTNEHLIDMDh----eASFFGAF 165 human
O02765       133 LKKT-K----FANS--NVVLKLGY-KDKVY-LN-VTTDSASCKQLSV------NAGELIVILQN------PGGYCAP 187 rabbit
NP_000630    223 VMME-Gk---MMSY--CTTGQ-MW-ARSSY-LG-AVFNLTSADHLYV------NVSELSLVNFEe----sQTFFGLY 279 human
XP_002827026 254 RCLE-E----FSAT--AASSLGPQ-LRLCQ-VS-GLLALRPGSSLRI------RTLPWAHLKAAp----fLTYFGLF 310 Sumatran orangutan
ACA42558     441 ALVT-V----CESG--MQT---KH-VYQNLsQF-LLDYLQVNTTISV------NVDTFQYIDTStf--plENVLSIF 497 synthetic construct
NP_033478    130 PMLN-D----GRRIvfTVVASLAF-KDKVY-LT-VNAPDTLCEHLQI------NDGELIVVQLTp-------gYCAP 185 house mouse
AAV38445     129 LKKV-R----SVNS--LMVASLTY-KDKVY-LN-VTTDNTSLDDFHV------NGGELILIHQNp----gE--FCVL 183 synthetic construct
NP_003802    177 AALA-LtvdlPPAS--SEARNSAF----GF-QG-RLLHLSAGQRLGV------HLHTEARARHAwqltqgATVLGLF 238 human
AAA36175     131 GICSpA----SRSI--SLLRLSFH-QGCTI-VSqRLTPLARGDTLCT------NLTGTLLPSRNt----dETFFGVQ 189 human
ACT68289     391 ALTV-El---FPCS--MEN---KL-VDRSW--S-QLLLLKAGHRLSVglraylHGAQDAYRDWElsy-pnTTSFGLF 453 Cloning vector pRa...
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