2ILR


Conserved Protein Domain Family
FA_FANCE
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pfam11510: FA_FANCE 
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Fanconi Anaemia group E protein FANCE
Fanconi Anaemia (FA) is a cancer predisposition disorder. In response to DNA damage, the FA core complex monoubiquitinates the downatream FANCD2 protein. The protein FANCE has an important role in DNA repair as it is the FANCD2-binding protein in the FA core complex so it represents the link between the FA core complex and FANCD2. The sequence shown is the C terminal domain of the protein which consists predominantly of helices and does not contain any beta-strand. The fold of the polypeptide is a continuous right-handed solenoidal pattern from the N terminal to the C terminal end.
Links
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Statistics
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PSSM-Id: 288377
Aligned: 2 rows
Threshold Bit Score: 403.638
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2ILR_A     2 LAESLELPKAIQDQLPRLQQLLKTLEEglegLEDAPPVELQLLHECSPSQMDLLCAQLQLPQLSDLGLLRLCTWLLALSP 81  human
AAI62341 245 LGSSKNLPDHMKAALPVIKELLDAESE----WDDSSVSALKVLHECDPNEVEVLCSVLCLSEVSEQRLPQFCSCLLKLTP 320

2ILR_A    82 DLSLSNATVLTRSLFLGRILSLTSSASRLLTTALTSFAAKYTYPVCSALLDPVLQAPGTGPAQTELLCCLVkMESLEPDA 161 human
AAI62341 321 DLSHSTASALITHLLLKKILSLAEPASRCLVTAVTSLCSRYPRPTCQALIEPLLQKGQLGSAQADLLCRLV-IDCLEPHH 399

2ILR_A   162 QVLMLGQILELPWKEETFLVLQSLLERQVEMTPEKFSVLMEKLCKKGLAATTSMAYAKLMLTVMTKYQANITETQRLGLA 241 human
AAI62341 400 RLLVFRTALGASWDEGVLSVIHALLDSKLELSQEDFCLFAEHLCSQSPHFSKSMKFAKMLLSVLTKYQSNVNPACHHTLS 479

2ILR_A   242 MALEPNTTFLRKSLKAALKHLG 263 human
AAI62341 480 SVLSFNETFLKKSLQAALKRIS 501
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