Conserved Protein Domain Family
7tmA_NPSR
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cd15197: 7tmA_NPSR 
neuropeptide S receptor, member of the class A family of seven-transmembrane G protein-coupled receptors
Neuropeptide S (NPS) promotes arousal and anxiolytic-like effects by activating its cognate receptor NPSR. NPSR is widely expressed in the brain, and its activation induces an elevation of intracellular calcium and cAMP concentrations, presumably by coupling to G(s) and G(q) proteins. Mutations in NPSR have been associated with an increased susceptibility to asthma. NPSR was originally identified as an orphan receptor GPR154 and is also known as G protein receptor for asthma susceptibility (GPRA) or vasopressin receptor-related receptor 1 (VRR1).
Links
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Statistics
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PSSM-Id: 320325
Aligned: 7 rows
Threshold Bit Score: 405.655
Created: 16-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Feature 1:putative peptide ligand binding pocket [polypeptide binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                              #  ##          ###### #
Q6W5P4     50 TEQLITLWVLFVFTIVGNSVVLFSTWRRKKks-rMTFFVTQLAITDSFTGLVNILTDINWRFtgdFTAPdlvCRVVRYLQ 128 human
ELU12393    3 TPQLAFLCVIFVFIVTGNISVIIAIFMSKArksrMHFFILHLAAADLLTGMITVVTDLSWKItveWHAGlfgCKVIRFLQ 82  Capitella sp. I Gr...
Q868T3    124 TEQFAVLWILFTVIVLGNSAVLFVMFINKNrksrMNYFIKQLALADLCVGLLNVLTDIIWRItisWRAGnlaCKAIRFSQ 203 fruit fly
EFX81678   44 TEQLAFLWILLILIVVGNMAVLVALSMSSArksrMNYFIKHLAIADLSVGVISVLTDIVWKItvaWHAGniaCKVIRFSQ 123 common water flea
GAA50255   27 DIGFGISLVLLVIIVTGNVSVLVALLYRNVkn-qMRWFIVNLAATDLCVAIAGVLPECILDYtsqFRAPvaiCKLVKYMA 105 Clonorchis sinensis
XP_426022  50 TEQLVTLWILFIVTIAGNAIVLFSTWRRKRks-rMTFFVTQLAITDSFTGLINIMTDIIWRYtgdFMAPdivCRVVRYLQ 128 chicken
EEN61441    1 TEQLVTLWVLFAFIVVGNSLVLLVMWMERHkktrMNFFITNLAIADLGAGLFNVLPDLVHRFtveWIAGdfmCKLIKYIQ 80  Florida lancelet

Feature 1     #  #                                              # #####                       
Q6W5P4    129 VVLLYASTYVLVSLSIDRYHAIVYPMKFLQGEk----QARVLIVIAWSLSFLFSIPTLIIFgkrtlsnGEVQCWALWpdd 204 human
ELU12393   83 SVVVFAANYILVALSIDRLDAIARPMNFSSSGr----RAKMLVSTAWILAFLFSAPMGIIPelt-vrrGLVQCFISLpep 157 Capitella sp. I Gr...
Q868T3    204 VCVTYSSTYVLVAMSIDRYDAITHPMNFSKSWk----RARHLVAGAWLISALFSLPILVLYeek-liqGHPQCWIELgsp 278 fruit fly
EFX81678  124 VLVTYSSTYVLVALSIDRYDAICHPMNFSRGWr----RARILVSVAWILSAIFSSPMLVLYeqg-lvqGQVQCWIDFtap 198 common water flea
GAA50255  106 SASTYASSFALIVLSIDRAEAVCRPLRVATSGvssktQARLLICGAWFVASLCGLPGLILAqktgegtDREACYLNFrt- 184 Clonorchis sinensis
XP_426022 129 VVLLYASTYVLVSLSIDRYHAIVYPMKFMQGEr----QAKVLIGVAWSLSFLFSIPTLIIFgkrqlsnGEVQCWALWpdd 204 chicken
EEN61441   81 GGVLYGSTYVLVALSVDRYDAIIHPMRFAHDR-----KSKAMICVAWGLAALFSIPSPVIFaqtkldnGEWQCWATWped 155 Florida lancelet

Feature 1       #  ### ### ##                                                                 
Q6W5P4    205 syWTPYMTIVAFLVYFIPLTIISIMYGIVIRTIWiksktyetvisn---------------------------------- 250 human
ELU12393  158 whWKVYITILAFALFILPAIIISTCYIIIVIVIWskgnvsttsnkrq--------------------------------- 204 Capitella sp. I Gr...
Q868T3    279 iaWQVYMSLVSATLFAIPALIISACYAIIVKTIWakgsifvpterag--------------------------------- 325 fruit fly
EFX81678  199 wqWQLYLTLVAVSLLVLPALLIFACYIVIVRTIWvqsaiflginraggsag----------------------------- 249 common water flea
GAA50255  185 vdTKVYMTCIAVSVFMIPATIIAICHIIMVTTIWkasklqpalfdhgekrgrneceptcrtpeypphvkdhrrlrlaipk 264 Clonorchis sinensis
XP_426022 205 syWIPYMTVVAFLVYFIPLIIISVIYSIVIRTIWmkskaqavivssc--------------------------------- 251 chicken
EEN61441  156 wyWIPYMTIVTTLVFFIPLVIISTCYIFIVVKIWrrskelvqerk----------------------------------- 200 Florida lancelet

Feature 1                                                     #  ## ##  #           ## ###  # 
Q6W5P4    251 ------------csdgklcssynrGLISKAKIKAIKYSIIIILAFICCWSPYFLFDILDNFNLLpdt-qeRFYASVIIQN 317 human
ELU12393  205 -----------lskrgresttssrGMIPKARIKTIKMTFAIVTVFIICWVPFFVFDLADVYGLIprt-khKRAIAIFIQS 272 Capitella sp. I Gr...
Q868T3    326 ------------fgaaparrassrGIIPRAKVKTVKMTLTIVFVFIICWSPYIIFDLLQVFGQIphs-qtNIAIATFIQS 392 fruit fly
EFX81678  250 --------tamldedqesrrassrGIIPRAKIKTVKMTFVIVFVFILCWAPYIVFDLLQVYGHIpks-ktMIAVATFIQS 320 common water flea
GAA50255  265 yvrhkrsstdgflhkpsqsasiaaGCIPRARIKTVKMTFVIVSVYIICWCPFMVWNLLVTFEVLdrkarmLLIYTPLIQK 344 Clonorchis sinensis
XP_426022 252 ------------tdgktsagytsrGFISRAKVKAIKYSIVIVLAFALCWSPYFLFDILDNFNILpet-keRFYASVIIQN 318 chicken
EEN61441  201 -------------figgkrlslsqGIIPKAKIKTIKLSLAIITAFIACWSPYFVFDMITNFSDLpes-etKKRASLIIQN 266 Florida lancelet

Feature 1      ##                     
Q6W5P4    318 LPALNSAINPLIYCVFSssISFPC 341 human
ELU12393  273 LATLNSATNPVIYFIFSktQCSPL 296 Capitella sp. I Grassle & Grassle, 1976
Q868T3    393 LAPLNSAANPLIYCLFSsqVFRTL 416 fruit fly
EFX81678  321 LAPLNSAANPLIYCLFSthLCRNL 344 common water flea
GAA50255  345 LVPLNSATNPLIFWIFNarSIRSQ 368 Clonorchis sinensis
XP_426022 319 LPALNSAINPLIYCLFSnhLCTPF 342 chicken
EEN61441  267 LPALNSAINPIIYGFFStkNCGKF 290 Florida lancelet

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