6QRQ


Conserved Protein Domain Family
ODP
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pfam19583: ODP 
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ODP family beta lactamase
The ODP (Oxygen-binding Di-iron Protein) domain is a distinct member of the metallo-beta-lactamase superfamily recruited to various bacterial and archaeal signal transduction pathways, including chemotaxis, to function as oxygen and iron sensors (1). ODP was shown to act as a sensor for chemotactic responses to both iron and oxygen in the human pathogen Treponema denticola (Td). The ODP di-iron site binds oxygen at high affinity to reversibly form an unusually stable peroxo adduct.
Links
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Statistics
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PSSM-Id: 437415
Aligned: 139 rows
Threshold Bit Score: 200.401
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6QRQ_A           28 VQTNQYLILDGNEGILLDPGGAHVFPRVMSNVAEVVDLSSIRHIFYTHQDPDVTSGILLWLSIc-EN-AKIYISSLWVRF 105 Thermotoga m...
WP_073335950     26 LHCNPYLIIDGDEAILIDPGSVIDFEIVYKNVTSLIDIEKLKYIVLSHQDPDICSSTPLFEKk--GVnAKIITHWRTGTI 103 Clostridium ...
WP_073341053     28 LHCNPYIIDDGEDVVFIEPGSVPHYPIVLNKVVSIIDIRRINYILESHQDPDLCASIPKFEEVinRKdLKVVTHSRAAIL 107 Caldanaerobi...
EHQ06102         40 FQCHPYFIRNGKNSVLIDPGSMLQLEKIIEKITMACDLSDVRYIILHHQDPDLCAAVPHLEKLikRPdLEIITHSRMSVL 119
jgi:Dester_0486  28 FQCHSYLIKNGKESILIDPGSLITFEETLKKLKYLINLDDIKYIVCHHQDPDLVSALPEIEKVfpDReRYIITHWRTYFL 107
SFP32835         25 FQCHVYLIKNGKESVLIDPGSMITFPVTMQKITSIMQLDDIKYIILHHQDPDIVGCVSTLETImsRNdKVFVTHWRTQTL 104
OCC15085         29 FQCHVYLINNGDESILIDPGSVITFSETIKKISEITQLKNIKYLICHHQDPDITSCISRLEKLinRNdKFIVTHWRAQAL 108
BAI79736         27 FQCHVYLILNGKGSILIDPGSKITFKYALEKIEQIIPFSYIKYFICQHQDPDITASLEIIRDLliRDdAVIVSHWRAIAL 106
SFP62509         31 FQCHVYLIDNGKESVLFDPGSKLTWPYTRKKILQLMPLENIKYIVCHHQDPDITSGITDMLDEigIEgRFLVTHWRVYEL 110
WP_013681306     25 FQCHVYLIRNGDESILIDPGSRITYDITKKKIEQLVKLKDIKYLICHHQDPDIIGCIDQLIKDtgKAeRYIITHWRAWAL 104 Hippea maritima

6QRQ_A          106 LPHfgiydQKRIVPISDKGTKIKLLSGnELEILPAHFLHSTGNFVLYDPVAKILFSGDIGAAvFEkgK-RYRYvDDfeRH 184 Thermotoga m...
WP_073335950    104 ADHyg--iKSKKYIVNENRYEITLKSGrKLKFIPTPYLHFPGAIVTYDAESKILFSSDLFGA-IS--TkWSLYaDE--SY 176 Clostridium ...
WP_073341053    108 MAHyg--fKAPFYYVDQNEWKLTLKSGrTLRFIFTPYCHFPGMFVTYDEKSKILFSGDIFGA-FS--YdWNLFaNK--YY 180 Caldanaerobi...
EHQ06102        120 IKHyg--iDAPYYNIDQHNFVIDA-GGrTLRFYTTPYCHSPGAFVTYDETSKVLFSSDIFGGlE---DsWHFYa-De-NY 191
jgi:Dester_0486 108 LRHyn--lLTPFYLVDQHEFKLELENGkELKFILTPYMHYAGNIVTYDPETKVLFSSDIFGGwIE--KnWSLFaKGe-EY 182
SFP32835        105 LKHyq--wKTPFWLVDENDWKLTLDGGrELEFVFTPYAHFAGAFCTFDKETKTMFSSDIFGG-LT--DeFALYaKDi-GY 178
OCC15085        109 LKHyq--wETPFWLIDQNDWQLNLKNGrRLRFIFTPYAHFPGAFCTFDETTKTLFSSDLFGG-FT--KtFSLFaQDe-NY 182
BAI79736        107 LKHyn--lNIPMICVEKENWKLNA-GGrELEFIFTPYCHFPGAFCTYDKKSKVLFSSDLFGG-FT--DrFKLFaEDi-NY 179
SFP62509        111 LEHyd--wGIDFYEIQDNGWKLKA-GDrTFNFIFTPYMHFPGAFCTYDPETKILFSSDIFGG-FT--KeFHLYaKDakSY 184
WP_013681306    105 LKHcd--wDAKLYEVEENGWKLKA-GDrLLKFIFTPYMHFPGAICTYDTETKVLFSSDIFGG-FT--PeFELFaKNseDY 178 Hippea maritima

6QRQ_A          185 LPLMEAFHKRYMSSNAACKKWVDMVSKKKIDMIAPQHG 222 Thermotoga maritima
WP_073335950    177 MEVMKTFHEHYMPGNQILRPVMEVFLKMDISMIASQHG 214 Clostridium grantii
WP_073341053    181 IEAMKAFHENYMPSKEILNRAMEKIEQLDIKMICPQHG 218 Caldanaerobius fijiensis
EHQ06102        192 FKSIEGFHMAYMPSRDILNYALRKIEALDLELIAPQHG 229
jgi:Dester_0486 183 IEAIKTFHETYMPCKKIILHSIEKLKKLDIEVIAPQHG 220
SFP32835        179 FESLKLFHIHYMPSKAILNHALLQIENKNPEMIAPQHG 216
OCC15085        183 FEEMKVFHEHYIPSKEILYNALVQIERYNPELIAPQHG 220
BAI79736        180 FDSIAAFHEPYMPSKEILVHSLKKIEQYDIDLIAPQHG 217
SFP62509        185 FESMVPFHTHYMPSKQIVNHGLDNIEKYEIDLIAPQHG 222
WP_013681306    179 FEKLKPFHEHYMPSNSILRNGLSNIEKFDIELIAPQHG 216 Hippea maritima
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