3DWL


Conserved Protein Domain Family
ARPC4

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pfam05856: ARPC4 
ARP2/3 complex 20 kDa subunit (ARPC4)
This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion.
Statistics
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PSSM-Id: 461760
Aligned: 37 rows
Threshold Bit Score: 164.693
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3DWL_K         2 SNTLRPYLNAVRSTLTASLALEEFSSEIVERQSQPEVEV-----------------------GR--SPEILLKPLVVSR- 55  fission yeast
CAM41457       2 AGEKQLYYDCVERTLLVALCLQSFASDVAEGCAVPEVELmsp------------------ytATdaSPFPFLVHPATADa 63 
XP_002141491  10 gsPLMPYLRRIFNALNKELCLYYSPLYFPSAFSIPSIEDn----------------------PS--NYSSLTKSLYIYR- 64 
Q5CUE1        14 NAPLLPYLRRLFNTLNREICLFYLPLNLPCMYSVPFIEQehliknlssadnidissskksfnRN--NKVELIKSLYVYR- 90  Cryptosporidium...
Q587H0         2 SEEELLYYTCIKNTLHAALCIGNYPSRTVERHNKPEVEVsgcae--------------gdneGK--SPELLLNRLHISR- 64  Trypanosoma brucei
Q4DTG5         2 ATAYLPYYDCIKCTLHAALCIGNYPSCTVERHNKPEVEVadhle--------------nngeRK--VQDFLLNPIRIVR- 64  Trypanosoma cruzi
Q23YX7        49 SSTLEGYTNALREVLDVSLSLQDFPSEIVEKHNKPEVELhg-------------------ynKT--TKNLVLHPIYLAR- 106 Tetrahymena the...
A0BUM1         2 AAANQVYSDAIRKTLEATLCLRSFPSEIIEKQSKPEIELng-------------------ysSK--TRQLVLSPIYLCR- 59  Paramecium tetr...
CBZ11950      30 TVAKQPYYDCVERTLLVALCLPSFAFDVTQGCTVPEVELvpp------------------dtGTgaPPSSFLVHCATAHa 91 
XP_002945817   2 ALSLRPYTNNIRTELNKALCIQSFACQNVERHDKPEVES-----------------------RD--NPELLLPPVTITR- 55 
3DWL_K        56 -----------NEQEQCLIESSVNSVRFSIRIKQV----DEIERILVRKFMQFLMGRAES---FFILRRKPVQ------- 110 fission yeast
CAM41457      64 slqsnklqlqwSSGDECLVEGSFNSTRVSFWFAAAhqpdDVLSTQLLSEYLAFFCSHGAAtgtLPVLRCAPVRqalmakp 143
XP_002141491  65 -----------HSKEYCLIESCLDSVRISLKFYLM----CKFEQCLFQQAIKFMTKNSDY---FKIIRKKEIL------- 119
Q5CUE1        91 -----------HSKEFCYIESCIDSVRVSLKFYFK----CEFERRLFNQLTIFMKKNSDY---LQLVRKKSIE------- 145 Cryptosporidium...
Q587H0        65 -----------SEQERCLIEASINSVRISFAFPKM----DPLAELIARKYVSFLAQRGQQ---FRILRKKPIA------- 119 Trypanosoma brucei
Q4DTG5        65 -----------SEQESCLIEPSINSTRISVSFLKS----DAIAEIIARKYVGFLAQRAKQ---FHILRKKPIP------- 119 Trypanosoma cruzi
Q23YX7       107 -----------SDKEKCLVEPSVNSCRISFLLKKN----DELDILIASRFSQYFMVRADQ---FQILRRKAVT------- 161 Tetrahymena the...
A0BUM1        60 -----------GEKEKCVIEPSINSTRISFSIKAL----DDVDRLIGEKFAKYLAVRADY---FEILRRKPIP------- 114 Paramecium tetr...
CBZ11950      92 alrchalrlqwSSGDECFIEASCDSTRVSFWFAAAhqpgDALSAQLLNEYMAFFCSHSAAtgaLPILRCIPVRrtsagkp 171
XP_002945817  56 -----------SEKERCLIEASINSVRVSLRLGQM----DMLEEELVKMYLRFLMQRAEL---LEVARRVPVE------- 110
3DWL_K       111 --------GYDISFLITNYHTEEM----------------LKHKLVDFIIEFMEEVDAEISEMKLFLNGRARLVAETYLS 166 fission yeast
CAM41457     144 aadaadqvIYDVSFLVLAAHVRQY----------------GRHSLARFIMTFVKEAEATVEMLKASLNSSGRAAAQSFFS 207
XP_002141491 120 --------GFDVSFLISYNMFENLhypl---------ispGKYDAINFVLKFIVSIDMQIQKERLQSTYFSRSFAYLLVs 182
Q5CUE1       146 --------GFDISFLITNHILNSYnnkicisnksnydgqmGKYDVIHFILKFVVDIDRQIQDKMLQSTYFSRYYIRKLLQ 217 Cryptosporidium...
Q587H0       120 --------GYDISFLITHEEVEVI----------------PRSKIIEFVITFLMEMDKDITLLKINANERARRAARQFFQ 175 Trypanosoma brucei
Q4DTG5       120 --------GYDISFLISHEEVETM----------------HRNKIIQFIITFLMDIDADIAAMKLNVNQRARRAAMEFFL 175 Trypanosoma cruzi
Q23YX7       162 --------GYDVSFLITNEHLEKY----------------QKKELIQYIIDFVGNVEKDLSDIKLNIISQARKSATFYAK 217 Tetrahymena the...
A0BUM1       115 --------GYDISFLILDSHLEKY----------------NVQGIINFIIDYVENIDKDLSDIKLNINTQARITAACFVg 170 Paramecium tetr...
CBZ11950     172 aadaagrtAYDVSFLVLAEHVCGY----------------GRQHLARSILAFAQEVEAAVASLKVSLNARRRAAAQAFFA 235
XP_002945817 111 --------GYDVSFLITDQHLRVY----------------GKQRLLDFMVAFIEEMDVETSSMKLAVNSRGRAVATEALR 166
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