Conserved Protein Domain Family
CopB

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pfam05275: CopB 
Copper resistance protein B precursor (CopB)
This family consists of several bacterial copper resistance proteins. Copper is essential and serves as cofactor for more than 30 enzymes yet a surplus of copper is toxic and leads to radical formation and oxidation of biomolecules. Therefore, copper homeostasis is a key requisite for every organizm. CopB serves to extrude copper when it approaches toxic levels.
Statistics
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PSSM-Id: 428404
Aligned: 89 rows
Threshold Bit Score: 183.888
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CBV41747                   42 SRGSLLIDRLEYTTPdKGEEAL-AWDFRAWYGGDIKR-IYLKGEGENIQGdGKDAEFEnLDLLYSRLIAPFWELQGGIGY 119
BAM05386                   98 IYDLLLVEQLEWRIDdGGPDTL-GWDALYWVGGDYHK-LVVKAEGGAGFEgPDEGESE-TDVLYSYLVTPFWSAQAGLQY 174
WP_012992236               32 LYGKLLLDRLEYL---PSKKTF-RYDAEFWYGGDFHR-VYIETEGNHSLK-RGDGEIKrADIYIGKLVTPFWTMRLGAGA 105 Th...
WP_012676859               39 yYGQILFDRLEY----DDSKRL-NYEVTSWYGGDYQR-FWIEVEGENNFE-KEEGDLErLDVLYGKLFSPFWDIRAGVGY 111 Pe...
Q6FEA5                     70 IYQATQWDNLWALNR-HGEASI-SSELKSWIGTDENK-VFLKAELEKEQ--SSSPDRY-ISILYSRNIANFWDVQAGVRY 143 Ac...
Q5LKL2                     12 LIYGFQAEQLEYRQG-DSEDSF-VWDFDALIGTDELK-LVWRSEGERVQGaGGFETLE-NQLRLQFPVSTFFDAVVGVQA 87  Ru...
Q0VPT8                     39 TTWGVQFEEFEYRYS-DDDEELgVWNADAFYGTDEFK-VRLLTTGEYEIEeQAYETLE-NQLVGQIPISKFFDAKAGVRF 115 Al...
Academia_Sinica:M5M_13805  21 iefsgeFDQFELRSQ-----GLaLWDAELFIGNAADQaLVIKSTAEIPN--RYLGAHE-AQVLGQMAANDTWTLRAGVRS 92 
BAF69620                   22 fRYQMLVDQFE-----ASSQGKpSWDASFFIGYDANK-IYLYSEGDS-------KEQE-NEIVFSHAITPFFDLQIGMEH 87 
Q31DR9                     32 LLASLRVNQLEKST--QQGEPL-SWDASAWVGKNWHK-VYLTSEGESS---NGSTESE-NQLLYSTPVERFWDFQAGLGY 103 Hy...
CBV41747                  120 QGGIAtdtsPERYF-GVINLQGLAPYRFDTDISLRVSDDGDISGSLETEYDIRLTQRLLLQPRLEVAASANDVPEFGIGE 198
BAM05386                  175 ANAWApg-vYDDTYsLALAVQGLAPGLFEVDASAFLSEDADVSFRLTTSYDVRITQRLVLQPRAEVRLEAQDNRERGLGA 253
WP_012992236              106 EGEYRh---PFRKY-VVVGVEGLAPYWFEVDANMKVDTEGRTSLHMKTYVDLLITQKLVLQPRVEGAYYLRDIPKVSRPA 181 Th...
WP_012676859              112 RSSYGdg-tKDRKS-FVVGLKGLAPYWFEVDTNMRFTTEGELYGDVEAEYDLLFTQRLVFQPRIDTTFSFSDIPEIGVYN 189 Pe...
Q6FEA5                    144 RDQASqvesKEHLD-AVFALHGLAPYFFETDVSLYLGEQQYASLKLETERDILLTQKLILKPYLEADIVLSDQSRDAEKK 222 Ac...
Q5LKL2                     88 STPDGl---PDRYN-AVLGLKGLAPQWFEIDADLYLSDNS--FFRFEGEYEAMLTNRLTLTPSLELTLPLQDDPIYNQAA 161 Ru...
Q0VPT8                    116 DTPEG----PDRTY-AVLGVAGLAPQWFEIDANLYVSKDGDTSAELDAEYELLLTNYWILAATLDATVAFSEDREIGVGK 190 Al...
Academia_Sinica:M5M_13805  93 DHYPD----PKRHW-GVLSALAESDAGTAYEITGFVSPDNQ-GLLLGIEHFWEVAPQWKLIPKAELLFHTEDDIETATGE 166
BAF69620                   88 DMKD-----KGATF-GEITLMGLAPYFIETRTKLLFGEGG-VGIDFDFEYETLFTQRLILNSRIESRIFSKDIEKAGIFQ 160
Q31DR9                    104 DETPE----NSQTW-GIVGFQGLAPYFFEINSRLLVNDK-NAGFRLDAEYEALFTQRLILTPSLKLNAYTSDDKKMGIGS 177 Hy...
CBV41747                  199 GLNSVRTGLRLRYEIS-RKFAPYIGGYWQKSYGNTADIAQDDGEAAEDTGIVAGIRMWY 256
BAM05386                  254 GLSNTSLGLRLRYESR-REVAPYAGLRYSFASGNTADIIAAEGGSADRFEVVAGVRLSF 311
WP_012992236              182 GLSRLEAGLRLRYEFR-RELAPYIGLQYSMEKGKEGKK--------EGTHFLLGLRMWF 231 Thermocrinis albus
WP_012676859              190 GINNINLSFRLRYELK-REFAPYIGFSYNSFFGDIKDRNGKD----HDLTAFFGVRVWF 243 Persephonella marina
Q6FEA5                    223 GLSTLKSGLQTRYEIN-KKVMPFIDLAYHYKHGQDAQEKTSE----REWLYGAGMTFKF 276 Acinetobacter baylyi
Q5LKL2                    162 GGVTLEAGLRLSYDLIdRAVSPYIGVNYERSYGGTADMIRAAGDENGAFSVVFGTRLMF 220 Ruegeria pomeroyi
Q0VPT8                    191 GLVSTETGLRLSYDLIdRAFSPYVGVVHERKYGDSADFAEADGGSTADWFAVIGARIal 249 Alcanivorax borkumensis...
Academia_Sinica:M5M_13805 167 GLSYAEVGLRLRYVAS-PWFKPYVGINWITSHGNTRDFLEQEGARKQNFTYRAGFTWAF 224
BAF69620                  161 GLNDITVGFRLRYEIQ-REFAPYIGYSVTRNFGG---LKREEGK--VKDRFVTGIRFWF 213
Q31DR9                    178 GLSSTELGMRLRYEFS-RKFAPYIGVKWNQAYATTADYKKEEGAKTSETSLVAGLRFWF 235 Hydrogenovibrio crunoge...
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