5H6O


Conserved Protein Domain Family
HemC

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COG0181: HemC 
Porphobilinogen deaminase [Coenzyme transport and metabolism]
Porphobilinogen deaminase is part of the Pathway/BioSystem: Heme biosynthesis
Statistics
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PSSM-Id: 439951
Aligned: 810 rows
Threshold Bit Score: 232.217
Created: 9-Feb-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5H6O_A        12 IRIATRQSPLALWQANYVKDALMAAhpGLQVELVTMVTRGDVILDTPLAKVGGKGLFVKELEIAMLEGRADLAVHSMKDV 91 
WP_036674229   6 LIIGTRGSDLALWQANFIKDKLAAI--GVEAELKIIKTQGDKILNLRLDKLEGKGFFTKELEEELLGGTIDIAVHSHKDL 83 
WP_013631311   5 FKIGTRGSDLALWQANHVASKLNEA--GYQTEIKIIKTQGDNILNLRLDKLEGKGFFTKELEEHLLAGDIDLAVHSHKDL 82 
WP_013668383   5 LIIGTRGSDLALWQANHVKDRLATI--GVQAELKVIKTQGDNIQHLRLDKLEGKGFFTKELEEELLAEKIDIAVHSHKDL 82 
WP_014937556   8 IKIGTRNSPLALWQAKEVAAALEQK--NYATEIVPIVSSGDKNLTQPLYSLGITGVFTKDLDIALLNKQIDIAVHSLKDV 85 
WP_024563901   4 IKIGTRNSPLAMWQAERVASQLQTL--RHKTELVPVVSTGDKNLQQPLYALGITGVFTKDLDIALLNKEIDIAVHSLKDV 81 
WP_079240030   4 IRIGTRNSALALWQAREVARHLQNN--NYLTEIVPIVSSGDKNLNQPLYSLGITGVFTRDLDIALLNDEIDIAVHSLKDV 81 
WP_114985194   6 IRIGTRDSILATWQAEHVAAGLKQH--GFKTELVFIKTEGDQVLDTPLPLLGGKGVFTKALDDALLRDEVDIAVHSFKDI 83 
WP_069797422   2 IRIGTRNSPLAMWQAKEVEQKLQNL--GYETVLVPVLSSGDKNLNQPLYSLGITGVFTKDLDIALLNNEIDIAVHSLKDV 79 
WP_128150180   4 IRIGTRNSPLAMWQALEVEQQLNKL--GHTTQIIPIASLGDKNLTQPLYQMNVVGVFTRDLDIALLNNEIDIAVHSLKDV 81 
5H6O_A        92 PVDFPDGLGLVTICEREDPRDAFVSNTYA----K-IEDLP-SGAIVGTCSLRRQCQLKAARPDLVIKELRGNVGTRLSKL 165
WP_036674229  84 PTVHPAGLTIAAVTEREDPSELLLILKDCvsinH-KLSLK-KGAMVGTSSNRRKAQLLALRPDLNIEDLRGNVPTRIQKL 161
WP_013631311  83 PTENPPGLFISAVSEREDPSEVLLILKDCvdtsK-KLSVK-HNGLVGTSSNRRQSQISSVRPDLEFEDLRGNVNTRIQKL 160
WP_013668383  83 PTANPPGLRIAAVSEREDPSELLIILKDCvdlkK-RLSVK-HNAIVGTSSNRRKAQLLAFRPDLEIEDLRGNVNTRLQKL 160
WP_014937556  86 PTQLPQNIALIAYLERDYPQDVLVRSSNA----K-DQPL--EKLTIATSSLRRRAFWLKQFPNTKFSDIRGNVQTRLQKL 158
WP_024563901  82 PTALPTGVIISAVLERDFPEDVLIRNPKA----K-DKDI--SELSVATSSLRRKAFWLNQYPNTHFSDIRGNVQTRLKKL 154
WP_079240030  82 PTQLPQNIEMIAYLERDYPQDILIRKESS----R-NKEF--HELKLATSSLRRRAFWLRNYPTTDFSDIRGNIQTRLQKL 154
WP_114985194  84 PTQTPEGLAVIAILEREDPRDVLVARKDA----DfLTDPE-YTATIATSSHRRGGQWLGQYPKHRLTDIRGNVHTRLRKL 158
WP_069797422  80 PTILPQNIEVSAVLERDFPQDVLVRKSSS----K-NKDL--AELKIATSSLRRRAFWSEKFPNTQFSDIRGNVQTRLKKL 152
WP_128150180  82 PTLLPEGIILSSVLKRDYESDILIRNPKK----N-LQAGNfENLYIGTGSLRRRAFWKAAYPQVKFSNIRGNVQTRLLKL 156
5H6O_A       166 DAGEYDAIILAAAGLKRLELE--SRIrSFIEP-EQSLPAVGQGAVGIECRVNdQRVRALLAP-LNHADTADRVRCERAMN 241
WP_036674229 162 RDEDYDAILLARAGVNRLNIDlsEFHvEVVDT-TELVPAPAQGALAIQIRENeNELFDILQQ-INHSETAEEIAIERKVL 239
WP_013631311 161 RDENYDAIVLAKAGVSRLNLDlsEFYiETIEPvAEMIPAPAQGVLAVQIREGdSELDAVLKEvIHNQEVANCISVERKVL 240
WP_013668383 161 RDEKYDAIMLAKAGVERLKLDlsEFHvEIIPP-TEIIPAPAQGVLAIQIRESdHTLYEVLQK-LHQKDVAETIGVERKVL 238
WP_014937556 159 EDGIADATLFSLAGLKRMALD--IP---YEHL-PFMISAPSQGVVTVAGHTDnTEINEIVKT-INHHQTQVCVEIERQFL 231
WP_024563901 155 EDGLADATLLSLAGIKRMEMD--IE---YEYL-PFLLQAPSQGVVCCASLVEnEELTSILAQ-INHEETYKCTKVERDFL 227
WP_079240030 155 EDGDFDATILSLAGIKRMKME--ID---YEML-PLMICAPSQGVISVAGHTDkPEINEIVSQ-INHQQTQICVEIERNFL 227
WP_114985194 159 NENNWDGAIFAAAGLKRVGLD--GNIs--AYL-DWMIPAPAQGAVAVMARDNrPDLNRAIGL-LHHATTALCTRVERRFL 232
WP_069797422 153 EEGDFDATLFSLAGIKRMEME--LE---YEML-DFMISAPSQGVVAISSRVDdVETKAILQK-INHKTTQICVEIERNFL 225
WP_128150180 157 ETENFDGTIFSLAGIKRLDLQ--MD---YEVL-DFIIPAPAQGVVGITSLENnVPVNEILKK-INHKETQQCVTAEREFL 229
5H6O_A       242 LTLQGGCQVPIGSYALLEGDTIWLRALVGEPDGSQIV--RGEIRGPRTQAEQLGITLAEQLL--SQG-AKE-ILERLY 313
WP_036674229 240 NLFEGGCHMPLGCYCKKEDGQYEVWTSKAETD-ED-FpdRLFYRV--EKLDGLAEKIVAKFSa-DRKfPAKvFISRev 312
WP_013631311 241 NLFNGGCHMPLGSYCKKEDDIYKVWTSKAN-EAEE-FvdRLYLES--ETTEGLAEIIVSKFDypNRNlPKKvFISrel 314
WP_013668383 239 NLFEGGCHMPLGCYCRKTTTGYEVWTAKAK-DGES-FptRLYLKA--ESAAGLAEEIVEKFDp-DRKlPSSvFItrel 311
WP_014937556 232 NRLEGGCTAPIGAFAEFNEEEIKFQGRLCSLNGKECL--ELNETFAWKQGRNFGNELADKLL--ANG-GKA-IMDQIK 303
WP_024563901 228 RHLEGGCTAPIGARATISGNSITFEGRIASLDGSKEI--DLKEIAEWND--DLGVRFAQQVL--DNG-GKA-IMEEIK 297
WP_079240030 228 STLEGGCTAPIGAFAEIIGDQIRFKAALCSLDGKNCI--AVDENFVYTPEENFGEKFAKVVL--ENG-GKE-LMAEIK 299
WP_114985194 233 QVLEGGCSAPLGAFAEMYGGQVQFKAVLTSLDGHRRE--EIAMNMPVEHAASMADRAAEAMM--ERDtVMD-ILAEIR 305
WP_069797422 226 RTLEGGCTAPIGAIAVFEENKIKFSGRLNSLDGSKTI--NVVEEFEYDDSENYGKKFAEFVL--KNG-GKE-MMEEIK 297
WP_128150180 230 NVLEGGCTAPIGAHAKIKNDQLIFQGGIVSLDGKKKV--IIQDEFSIQSYSSIGKIMANKAK--ELG-AQD-IIDEIK 301
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