Conserved Protein Domain Family
OYE_like_4_FMN

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cd04735: OYE_like_4_FMN 
Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as electron acceptors in the catalytic reaction. Other members of OYE family include trimethylamine dehydrogenase, 2,4-dienoyl-CoA reductase, enoate reductase, pentaerythriol tetranitrate reductase, xenobiotic reductase, and morphinone reductase.
Statistics
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PSSM-Id: 240086
Aligned: 27 rows
Threshold Bit Score: 431.635
Created: 17-Jul-2006
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
Feature 1:putative active site [active site]
Evidence:
  • Citation:PMID 7881908
  • Comment:Based on similarty to other members of the family

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                         # #                               #                         
CAG42601    8 LFDKVELPngVELRNRFVLAPLTHISSnddGTISDVELPYIEKRSQdvGITINAASNVSDVGKAFPGQpSIAHDSDIEGL 87  Staphylococcus aur...
NP_975510   7 LFEPFELNg-FKLENRFVLSPMTLSLAtldGKITTQEADYVKRRAHsaPLQITGGVYFDEFGQLFEYGiSAKSDDDISSL 85  Mycoplasma mycoide...
NP_326603  11 LFQPLKIKn-FVLKNRFVLAPMALNTStddGIITDDDLAYAQRRSHsaPMAITGGTYINKYAQLFENGfANDRDEVLPGL 89  Mycoplasma pulmoni...
YP_089202   8 LFETVTFPngATISSRFAMGPMVIVGSesnGEIGADDLAYWQRRNDagSLLITGATAVSDYSDAYGNGlKLHKDELLDGW 87  Mannheimia succini...
CAD63831    8 LFEPYTLNndVVLKNRLVVAPLTIYDSgpdGELTPAAHNFWRNRFRgfGTWIVPFTNVHPSGIGFESP-NAFHEENLPTL 86  Lactobacillus plan...
CAG42070    7 LLQSIHLPngIKISNRFVLSPMTVNTStkeGYITKEDLAYAARRSNsaGMQVTGAAYIEPYGQLFEYGfNIDHDACIPGL 86  Staphylococcus aur...
YP_115834   5 LFKPYQIGn-FTLKNRFVFSPINLNLSe-mGQVCQADLDFFSARAHsaPMTITGGVYICKSGSLFKYGhSIENDSDIEGL 82  Mycoplasma hyopneu...
YP_089345   9 LFEPYTLNngVEIKNRLTVAPLTIYDSgkdGEMTETGRRFWQNRFEgfGLYIMPFTNVHPSGIGFESP-NAFDERHLPTL 87  Mannheimia succini...
NP_688070   8 LFRPLTLPngLSLENRFVLSPMVTNSStseGFVTDDDIAYAVRRAKsaPLQITGAAYITEYGQLFEYGfSVSKDEDIPGL 87  Streptococcus agal...
YP_089488   8 LFQPYTLNngVEIKNRLVVAPMTHFGSntdGTLGKQEHRFISNRAGdmGMFILAATLVQDGGKAFHGQpEAIHTSQLPSL 87  Mannheimia succini...
Feature 1                     #                                                               
CAG42601   88 KRLATAMKKnGAKALVQIHHGGAQALPELTPGGdvvapspislksfgqkqehsAREMtnEEIEQAIKDFGEATRRAIEAG 167 Staphylococcus aur...
NP_975510  86 TSLYQAMKTdSNCVILQLAHAGKFSKTSLKKYGylygpsyek---nhtpieheVLELpkEKIKQIIQDYKDATLRVIKAG 162 Mycoplasma mycoide...
NP_326603  90 TQMAKVMKKdGNLAILQIAHSWRFSIASLIRYKkvygpsagv---fltpfeheVTELtiEEIEGIIQDFENAVLRAIKAG 166 Mycoplasma pulmoni...
YP_089202  88 KQLAAVMKAkGNRAVVQLFHAGYRAAFTYKDKGvaysassk----eygfldypVTGMteAQIEDTLNEFAAAAKRAIDAG 163 Mannheimia succini...
CAD63831   87 KAYATISHEqGAKAIIQLAHAGIHADPAMTKGYdlmgps--------nlpymgVRAMtdSEVREMVNAFAYATELAISAG 158 Lactobacillus plan...
CAG42070   87 TNMASTMKQhGSLAIIQLAHAGRFSNQAILNFGkvygpspmt---lhspiehdVIAMshEKINSIIQQYRDATLRAIKAG 163 Staphylococcus aur...
YP_115834  83 AKLARAIKSkGSIAILQLIHAGSHSVSKIEKDGfcygpsaek---rnypvkykVYRLrqKQIKTIVRQYADACLRAIKAG 159 Mycoplasma hyopneu...
YP_089345  88 REYAEMAHSqGAKAVVQIAHSGLRADPAMTQGAelvaat--------gdyygcFRTMseQEVWDMVTNYAYAAELVLRAG 159 Mannheimia succini...
NP_688070  88 TKLAKAMKSkGAKAVLQLTHAGRFSSHTLARHGyvygpspmq---lqspyphqVKELthKDILRIIDEYVQATRRAIQAG 164 Streptococcus agal...
YP_089488  88 KATADIIKAqGAKAILQIHHGGKQAITELLNGKdkisas--------adeesgTRAAtiEEIHTLIDAFGNAADLAIQAG 159 Mannheimia succini...
Feature 1                #                                                        #           
CAG42601  168 FDGVEIHGANHYLIHQFVSPYYNRRNDVWANQyk-fPVAVIEEVLKAKEAYgn----kdFIVGYRLSPEEAESPGItm-- 240 Staphylococcus aur...
NP_975510 163 FNGVEISMAQRLLMQTFFSQIINKRTDEYSTTtfenRSRFCLEVVKAIREVidkhapknFIFGFRATPEETYGDILgyti 242 Mycoplasma mycoide...
NP_326603 167 FDGVEIASAQRLLQQAFFSKYSNQRKDKYGNQslesRALLTMQVLHRVQDVikkhahkdFILGFRATPEETIGEIIgysv 246 Mycoplasma pulmoni...
YP_089202 164 FDGIEIHGANRYLIHQFFSAVSNVRDDQWGGSle-nRARFALEVVKRIQEVikqyakadFILGYRISPEEIHREGNgftf 242 Mannheimia succini...
CAD63831  159 LDGVEIHGANGWLIQQFVSETYNQRTDHWGGSve-kRFNFPLAIIDAIEAVrhkyhrpdFIVGYRFSPEEPGEVGLtm-- 235 Lactobacillus plan...
CAG42070  164 FDGVEISIAQRLLIQTFFSTFSNKRTDHYGADslknRARLCLEVMRAVQEVidkeapdnFILGFRATPEETRGSDLgyti 243 Staphylococcus aur...
YP_115834 160 FDGVEISSAQKLLPQEFFSNYTNKRNDKYGCQnienRSRFLLEILEKVQKTilksknpnFLLGYRATPEERRGDNLgyti 239 Mycoplasma hyopneu...
YP_089345 160 FDGVEIHGANGWQIQQFFSASTNLRNDYWGGTle-kRMRFPLAIIDGIDEMrqkhnrpdFIIGYRFSPEEPGEDGItm-- 236 Mannheimia succini...
NP_688070 165 FDGVEISSAQRLLIQTFFSTFSNQRKDEYGPQtltnRCRLGLEVFKAVQKVireeaesdFILGFRATPEETRGSQIgysi 244 Streptococcus agal...
YP_089488 160 FDGVEIHGANNYLIQQFYSGHSNRRTDEWGGSre-nRMRFPLAVIDAVVAAkikhqrddFIIGYRFSPEEPEELGLtm-- 236 Mannheimia succini...
Feature 1                                                                                     
CAG42601  241 eITEELVNKISHm--pIDYIHVSMMDTHATTregkya----gqerlPLIHKWIn-GRMPLIGIGSIftADEALDAVEnvg 313 Staphylococcus aur...
NP_975510 243 eDFIQLVDKIIEig-kISYLAIASWGHDIYLnkvrsntkyknqlvnKVIYDVYk-NKLPVISSGGIntPDKCLEALKy-- 318 Mycoplasma mycoide...
NP_326603 247 eEFNWLMDKILDei-dISYLSLASWGKNIYKtkvrtkgkfynqlinKVVYEHIn-GRVPVIANGGInsLESAIEAIEh-- 322 Mycoplasma pulmoni...
YP_089202 243 dEALYLIDEVAKl--gVDYFNVSQSGVRGFAaepkaga-ymgqaisKVIKTRLv-GRALLLASGDLtsPDKILEAVTe-y 317 Mannheimia succini...
CAD63831  236 tETLALVDRLLDk--pLQYIHISLWNFYKKIrrggdv----kktrmEAVHDRIn-GRLPFIGVGDLfaEEQGLKAFNtgw 308 Lactobacillus plan...
CAG42070  244 dEFNQLIDWVMDvs-nIQYLAIASWGRHIYQntsrtpgdhfgrpvnQIVYEHLa-GRIPLIASGGInsPESALDALQh-- 319 Staphylococcus aur...
YP_115834 240 eNFLDFLDLIEKrgikISYLAIAGWGFDVFRdkvrsksnnfnrlisDVVYEKLq-GKIPVIASGSInsLEKSVKAIQf-- 316 Mycoplasma hyopneu...
YP_089345 237 kETLALVDALLEk--pLQYLHISLWDFYKKVrrgadt----hltrmQVVHDRIa-GRLPFFGSGNLytADDMLKAYQtgw 309 Mannheimia succini...
NP_688070 245 eEFMEFLEKILAia-qVDYLAIASWGHDVFRntirseg-vykgqlvNQVIFEHfgDRVPIMATGGInsASKVFEALQh-- 320 Streptococcus agal...
YP_089488 237 eDTLALVDVLKEk--pLQYLHISLWDFYKKArrgads----ntarlQLVHERIg-GKLPLIGVGNLftAQQILEAYQtgw 309 Mannheimia succini...
Feature 1           ##                                       
CAG42601  314 VDLVAIGRELLLDYQFVEKIKDGredeiinyFDPEREDNHHLTPNLW 360 Staphylococcus aureus subsp. aureus MSSA476
NP_975510 319 SDLVGLSSVFVADPEFVLKIKNEqidqinlsVKHDQLKDLKIPESSF 365 Mycoplasma mycoides subsp. mycoides SC str. PG1
NP_326603 323 VDLVGLSTVFVVEPEFVQKLMEKkenqinldITKANLEDLKIPPYAF 369 Mycoplasma pulmonis UAB CTIP
YP_089202 318 ADITSNATMVLLDPDTKNKIQSGredevslaVDETTIDDLKLPKAFY 364 Mannheimia succiniciproducens MBEL55E
CAD63831  309 ADLLAVGGSVELNPNLIELIKTGqedqiqseFDWNEMDSYRFTPAML 355 Lactobacillus plantarum WCFS1
CAG42070  320 ADMVGMSSPFVTEPDFVHKLAEQrphdinleFSMADLEDLAIPHAAF 366 Staphylococcus aureus subsp. aureus MSSA476
YP_115834 317 ADFIGISSAFVPDPDFVEKIEKNqpi--klsLEPKDFAKLKISKNAF 361 Mycoplasma hyopneumoniae 232
YP_089345 310 VESVSIGKSIMLNPNLVELIETGreseiesaFDWDKADYYRYTPAML 356 Mannheimia succiniciproducens MBEL55E
NP_688070 321 AHMIGASTPLVVDPEFLQKIKAKcsdqinlrIKVSDLEGLAIPKASF 367 Streptococcus agalactiae 2603V/R
YP_089488 310 AEFIALGKTVMVNPKIATMILNGqenqliteVDENQADHYGFPDFLW 356 Mannheimia succiniciproducens MBEL55E

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